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| Scott W. Hiebert, Ph.D. | |
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| Jordan D. Berlin, M.D. |
Signal Transduction & Cell Proliferation Research Program
- Program Leader: Scott W. Hiebert, Ph.D.
Co-Leader: Jordan D. Berlin, M.D.
Program Description
Scientific Goals
The Signal Transduction and Cell Proliferation Research Program is composed of a wide base of faculty committed to the investigation of cell growth control. A major goal of the program is to promote outstanding basic research in these areas and thus identify new growth control pathways that may be exploited for the development of novel therapeutic approaches. The program also provides basic science expertise upon which more translational programs within the Cancer Center can develop new approaches and understandings of particular cancers. Because of the diversity of pathways that regulate growth control, the Program membership is large and represents diverse interests within the signal transduction/cell proliferation area. This Research Program also brings together the study of humans, mammals, and model systems to allow a full understanding of the signaling pathways that control growth. The members include yeast geneticists, structural biologists, clinician-scientists, biochemists, developmental biologists, and cell and molecular biologists. However, the Program does maintain the primary overall focus of mitogenic signaling mechanisms and cellular transformation.
Specific Aims
The Program has two broad aims: 1) Increasing awareness of the research going on within each member’s laboratory and thereby encouraging collaborative interactions within the Program and 2) Providing the basic science expertise for translational approaches within the Cancer Center. For this latter goal, we have recruited Dr.Jordan Berlin to serve as Co-Leader of the Program. Dr. Berlin heads the Clinical Trials Office (CTO) within the Cancer Center and brings expertise in translating the observations in signaling to the clinic in several clinical trials.
Areas of Research Program Expertise
For the purpose of conceptual clarity, the research interests of the faculty in this Program can be classified and presented in four distinct but overlapping sub-areas or concentrations within the field of signal transduction. These are Growth Factors and their Receptors, Signal Intermediates, Gene Expression, and Cell Cycle Control. The research interests of program members follow the canonical signal transduction pathway from cell surface receptors, through signaling intermediates, into the nucleus to alter gene expression patterns and affect cell cycle progression, increase proliferation, affect apoptosis, and cause cellular transformation. The figure shown below illustrates a basic signaling pathway and indicates the general focus of each ST member, recognizing that many of our members work in multiple areas.
Program Members
Program members and academic departmental affiliations are listed below.
- Samuel E. Adunyah, Ph.D., Professor and Chair of Cancer Biology, Meharry
- Mary Ann Thompson Arildsen, M.D., Ph.D., Assistant Professor of Pathology
- Thomas M. Aune, Ph.D., Associate Professor of Medicine
- Stephen J. Brandt, M.D., Professor of Medicine, Cell and Developmental Biology, and Cancer Biology
- Matthew D. Breyer, M.D., Professor
- Richard M. Breyer, Ph.D., Professor
- H. Alex Brown, Ph.D., Ingram Associate Professor of Cancer Research
- Graham F. Carpenter, Ph.D., Ingram Professor of Cancer Research, Professor of Biochemistry, Professor of Medicine
- Bruce D. Carter, Ph.D., Associate Professor
- Chin Chiang, Ph.D., Associate Professor
- Christine H. Chung, M.D., Assistant Professor of Medicine
- Roger J. Colbran, Ph.D., Professor
- Pran K. Datta, Ph.D., Assistant Professor
- Utpal P. Davé, M.D., Assistant Professor
- Mark P. de Caestecker, M.D., Ph.D., Assistant Professor
- Josiane Eid, M.D., Assistant Professor of Cancer Biology
- Christine Marie Eischen, Ph.D., Associate Professor of Pathology, Associate Professor of Cancer Biology
- Michael Engel, M.D., Ph.D., Assistant Professor of Pediatrics
- Stephen R. Hann, Ph.D., Professor
- Jacek Hawiger, M.D., Ph.D., Oswald T Avery Distinguished Chair & Professor
- Scott W. Hiebert, Ph.D., Associate Director for Basic Research, Professor
- Susan Kasper, Ph.D., Assistant Professor of Urological Surgery and Cancer Biology
- Wasif N. Khan, Ph.D., Assistant Professor
- Andrzej M. Krezel, Ph.D., Assistant Professor
- Ethan Lee, M.D., Ph.D., Assistant Professor of Cell and Development Biology
- Daniel (Dan) C. Liebler, Ph.D., Professor of Biochemistry, Pharmacology and Biomedical Informatics, Director of Proteomics, Director, Ayers Institute
- Andrew J. Link, Ph.D., Associate Professor of Microbiology & Immunology and Biochemistry
- Mark A. Magnuson, M.D., Director, Vanderbilt Center for Stem Cell Biology, Professor of Molecular Physiology and Biophysics, Professor of Medicine, Asst Vice Chancellor for Research
- Timothy R. Peters, M.D., Assistant Professor of Pediatrics and Cell & Developmental Biology
- Jennifer A. Pietenpol, Ph.D., Director, Vanderbilt-Ingram Cancer Center, B.F. Byrd Jr. Professor of Oncology, Professor of Biochemistry
- D. Brent Polk, M.D., Professor of Pediatrics and Cell & Developmental Biology
- Albert B. Reynolds, Ph.D., Professor
- Ann W. Richmond, Ph.D., Professor of Cancer Biology, Medicine and Cell & Developmental Biology
- Jeffrey A. Sosman, M.D., Professor of Medicine (Hematology/Oncology)
- Roland W. Stein, Ph.D., Professor of Molecular Physiology & Biophysics, Professor of Cell & Developmental Biology
- LaMonica V. Stewart, Ph.D., Assistant Professor
- Zu-Wen Sun, Ph.D., Assistant Professor of Biochemistry
- David L. Tabb, Ph.D., Assistant Professor
- P. Anthony Weil, Ph.D., Professor of Molecular Physiology & Biophysics
- Susan R. Wente, Ph.D., Professor and Chair of Cell & Developmental Biology
- Elizabeth Yang, M.D., Ph.D., Associate Professor of Pediatrics, Cancer Biology, and Cell & Developmental Biology
- Wendell G. (Dell) Yarbrough, MD, FACS, Associate Professor Otolaryngology and Cancer Biology, Director, Barry Baker Laboratory for Head and Neck Oncology
