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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center


Medical Issues During Long-Term Recovery

Graft-Versus-Host Disease (GVHD)

Graft-versus-host disease (GVHD) is a common complication for patients who receive an allogeneic transplant from donor marrow or blood stem cells. Patients who have an autologous transplant, using their own cells, do not experience this.

In about 30-60% of patients undergoing allogeneic PBSCT/BMT, the donor T cells cause recipient tissue injury referred to as acute graft-versus-host disease (GVHD). Most patients will have mild to moderate acute GVHD that will respond to treatment. However, over 30% of transplant patients will eventually develop chronic GVHD, which can be a long-term and challenging to manage.

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Long-term Effects of Transplant Recovery

Transplant patients and their caregivers may have to deal with a number of other complications as well. 

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