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Gastrointestinal Cancers

The Gastrointestinal (GI) Oncology Program focuses on malignancies of the esophagus, stomach, small intestine, colon, rectum, anus, liver, gallbladder, pancreas and bile ducts.

Clinical Trials for Gastrointestinal Cancers

29 Open Trials

Trial Type Protocol No. &
Open Date
Summary

Basic Science

Colon
Rectal

VICCGI15122

01/15/2016

Research Use of Human Biospecimens from Colorectal Cancer Patients (Pilot Study)

Basic Science

VICCGI0283

06/01/2002

Novel Gastrointestinal Cancer Markers in Tissue and Biofluids

Diagnostic

Colon
Rectal

VICCGI1781

10/17/2017

Glutamine PET Imaging of Colorectal Cancer

Diagnostic

Liver

VICCGI14124

03/13/2015

PET Imaging of Hepatocellular Carcinoma with 18F-FSPG

Other

Liver

VICCGI1523

07/01/2015

Radiation-Emitting SIR-Spheres in Non-resectable (RESIN) Liver Tumor Patient Study

Other

Colon
Rectal

VICCGI0721

01/09/2007

Vanderbilt Hereditary Colorectal Cancer Registry

Prevention

Liver

VICCPED1698

06/23/2017

A Phase 3, Randomized, Adaptive Study Comparing the Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients Undergoing Hematopoietic Stem Cell Transplant

Prevention

Colon

GIS0820-M

07/09/2013

A double blind placebo controlled trial of eflornithine and sulindac to prevent recurrence of high risk adenomas and second primary colon ca in patients with stage 0-III colon ca; phase III - Preventing Adenomas of the Colon with Eflornithine and Sulindac

Treatment

Liver

VICCGI1754

11/22/2017

A Pivotal Trial of ARQ 087 in Subjects with FGFR2 Gene Fusion Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma

Treatment

Colon
Lung
Non Small Cell
Rectal

VICCMD1763

11/14/2017

A Phase 2 Study of MEDI4736 (Durvalumab) and Tremelimumab Alone or in Combination with High or Low-Dose Radiation in Metastatic Colorectal and NSCLC

Treatment

Liver

VICCGI16149

11/10/2017

An Open-Label Multicenter Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of H3B-6527 in Subjects with Advanced Hepatocellular Carcinoma or Intrahepatic Cholangiocarcinoma

Treatment

Esophageal
Gastric/Gastroesophageal
Head/Neck
Lung
Miscellaneous

VICCPHI1748

11/09/2017

A Phase I, Open-label, Uncontrolled, Multicenter, Dose-escalation Study of M3541 in Combination with Palliative Radiotherapy in Subjects with Solid Tumors

Treatment

Colon
Lung
Non Small Cell
Rectal

VICCMD16159

11/07/2017

A Phase 1/2 Study Exploring the Safety, Tolerability, Effect on the Tumor Microenvironment, and Efficacy of Azacitidine in Combination with Pembrolizumab and Epacadostat in Subjects with Advanced Solid Tumors and Previously Treated Stage IIIB or Stage IV Non?Small Cell Lung Cancer and Stage IV Microsatellite-Stable Colorectal Cancer

Treatment

Colon
Liver
Lung
Melanoma
Miscellaneous
Rectal
Thyroid

VICCMD15107

11/07/2017

A Phase 1/2a Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of PLX8394 in Patients with Advanced, Unresectable Solid Tumors

Treatment

Colon
Rectal

VICCGI1703

08/23/2017

Phase I/II Study to Evaluate the Safety, Efficacy, and Novel PET/CT Imaging Biomarkers of CB-839 in Combination with Panitumumab and Irinotecan in Patients with Metastatic and Refractory RAS Wildtype Colorectal Cancer

Treatment

Colon
Lung
Miscellaneous
Non Small Cell
Pancreatic
Rectal
Small Cell

VICCMD1710

08/03/2017

A Phase 1/2, Open-Label, Dose-Escalation, Safety, Tolerability, and Efficacy Study of Epacadostat in Combination with a PD-1 Inhibitor and Chemotherapy in Subjects with Advanced or Metastatic Solid Tumors (ECHO-207)

Treatment

Colon
Rectal

VICCGI1665

06/01/2017

A Multicenter, Randomized, Open-label, 3-Arm Phase 3 Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5- Fluorouracil (5-FU)/Folinic Acid (FA) /Irinotecan (FOLFIRI)/Cetuximab with a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients with BRAF V600E-mutant Metastatic Colorectal Cancer

Treatment

Pancreatic

ECOGGIA021501

03/06/2017

Preoperative Extended Chemotherapy vs. Chemotherapy plus Hypofractionated Radiation Therapy for Borderline Resectable Adenocarcinoma of the Head of the Pancreas

Treatment

VICCGI1679

03/03/2017

A Pilot Study to Investigate the Safety and Efficacy of Avelumab Monotherapy in Patients with Advanced or Metastatic Adenocarcinoma of the Small Intestine

Treatment

Esophageal
Gastric/Gastroesophageal

VICCGI1655

12/14/2016

A Randomized, Multicenter, Double Blind, Phase III Study of Nivolumab or Placebo in Subjects with Resected Lower Esophageal, or Gastroesophageal Junction Cancer

Treatment

Liver

VICCMD15133

10/06/2016

A Phase 1 Study to Assess the Safety, Tolerability and Pharmacokinetics of PV-10 Chemoablation of Cancer Metastatic to the Liver or Hepatocellular Carcinoma not Amenable to Resection or Transplant

Treatment

Bladder
Colon
Gastric/Gastroesophageal
Kidney (Renal Cell)
Rectal
Urologic

VICCGI15126

05/03/2016

A Phase 1b/2 Study of Ibrutinib Combination Therapy in Selected Advanced Gastrointestinal And Genitourinary Tumors

Treatment

Colon
Head/Neck
Liver
Lung
Miscellaneous
Neuro-Oncology
Rectal
Sarcoma
Thyroid

VICCMD15110

04/05/2016

A Phase II Basket Study of the Oral TRK Inhibitor LOXO-101 in Subjects with NTRK Fusion-Positive Tumors

Treatment

Colon
Head/Neck
Lung
Lymphoma
Melanoma
Non Small Cell
Ovarian
Rectal

VICCPHI1531

03/01/2016

A Phase 1/2 Study of the Safety, Tolerability, and Efficacy of Epacadostat Administered in Combination With Nivolumab in Select Advanced Cancers

Treatment

Gastric/Gastroesophageal

VICCGI1515

01/05/2016

A Phase 1 Open-Label, Dose-Finding Study Evaluating Safety and Pharmacokinetics of FPA144 in Patients with Advanced Solid Tumors

Treatment

Bladder
Breast
Hematologic
Leukemia
Lymphoma
Multiple Myeloma
Myelodysplastic Syndrome
Pancreatic
Urologic

VICCHEMP1558

10/09/2015

A Phase 1/2, Open-Label, Dose-Escalation, Safety and Tolerability Study of INCB052793 in Subjects With Advanced Malignancies

Treatment

Bladder
Colon
Esophageal
Gastric/Gastroesophageal
Neuro-Oncology
Ovarian
Urologic
Uterine

VICCMD1403

06/02/2014

An Open Label, Phase II Study of Neratinib in Patients with Solid Tumors with Somatic Human Epidermal Growth Factor Receptor (EGFR, HER2, HER3) Mutations or EGFR Gene Amplification

Treatment

Liver

CTSUGI80702-M

05/05/2011

A Phase III Trial of 6 versus 12 Treatments of Adjuvant FOLFOX plus Celecoxib or placebo for patients with Resected Stage III Colon Cancer

Treatment

Liver

CTSUGIC80802-M

12/07/2010

Phase III randomized study of sorafenib (IND 69896, NSC 724772) plus doxorubicin versus sorafenib in patients with advanced hepatocellular carcinoma (HCC)