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Clinical Trial COGAALL05B1


A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens

Principal Investigator(s)

Debra Friedman


  • Protocol No. COGAALL05B1
  • Open Date: 12/01/2006
  • Staging: N/A
  • Age Group: Children
  • Scope: National
  • Objective: To establish a mechanism to bank specimens of tumor cells and host germline DNA from patients with acute lymphoblastic leukemia (ALL) at first and subsequent relapse. To make these specimens available to qualified researchers to study the biology of ALL.
  • Disease Sites: Pediatrics; Leukemia
  • Therapies: Correlative
  • Drugs: None Specified
  • Participating Institutions: Vanderbilt University
  • National Clinical Trial ID: NCT00897325
  • Secondary Protocol No: AALL05B1


None Provided.


Ages Eligible for Study:N/A to 30 Years
Genders Eligible for Study:All
Accepts Healthy Volunteers:No


Inclusion Criteria:
• Diagnosis of acute lymphoblastic leukemia (ALL) or prior history of non-Hodgkin lymphoma
• In first or subsequent marrow relapse with ≥ 25% blasts in bone marrow and/or peripheral blood
• Bone marrow and/or peripheral blood samples (≥ 5 mL) required at the time of diagnosis of relapse
• No concurrent systemic antileukemic treatment administered for current relapse
• Intrathecal chemotherapy allowed
• On-therapy relapse allowed