Clinical Trial COGACCL0933


A Randomized Open-Label Trial of Caspofungin versus Fluconazole to Prevent Invasive Fungal Infections in Children Undergoing Chemotherapy for Acute Myeloid Leukemia (AML)

Principal Investigator(s)

Haydar Frangoul


  • Protocol No. COGACCL0933
  • Open Date: 11/16/2011
  • Staging: Phase III
  • Age Group: Both Child and Adult
  • Scope: International
  • Objective: To determine if prophylaxis with caspofungin administered during periods of neutropenia following chemotherapy for acute myeloid leukemia (AML) is associated with a lower incidence of proven or probable invasive fungal infections (IFI) compared with fluconazole.
  • Disease Sites: Leukemia; Pediatric Leukemia
  • Therapies: None Specified
  • Drugs: Caspofungin; Fluconazole
  • Participating Institutions: Vanderbilt University
  • National Clinical Trial ID: NCT01307579
  • Secondary Protocol No: ACCL0933



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