Clinical Trial ECOGTHNE5508


Randomized Phase III Study of Maintenance Therapy with Bevacizumab, Premetrexed, or Combination of Bevacizumab and Premtrexed following Carboplatin, Paclitaxel and Bevacizumab for Advanced Non-Squamous NSCLC

Principal Investigator(s)

Leora Horn


  • Protocol No. ECOGTHNE5508
  • Open Date: 06/29/2011
  • Staging: Phase III
  • Age Group: Adults
  • Scope: National
  • Objective: To compare the overall survival associated with maintenance therapy with bevacizumab, pemetrexed or the combination in patients with advanced stage NSCLC
  • Disease Sites: Lung; Non Small Cell
  • Therapies: Chemotherapy - cytotoxic; Molecular Targeted Agents / Immunotherapy / Biologics
  • Drugs: Alimta; Avastin; Bevacizumab; Carboplatin; Paclitaxel; Pemetrexed
  • Participating Institutions: Vanderbilt University; Jackson-Madison County Hospital
  • National Clinical Trial ID: NCT01107626
  • Secondary Protocol No: E5508



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