What are the Programs- - The supportive programs are designed to help you cope with distress you may experience from cancer or cancer treatment. What happens during the Programs- - A study team member will visit you during chemotherapy to guide you through different methods for coping such as counseling, gentle movement, writing, and/or relaxation strategies. - The programs can all be done while sitting in a chair. - You will be asked to do practices we teach you at daily home. Can I choose which Supportive Intervention Program I Receive- - You will be assigned to one of two supportive programs. What will I be asked to do- - Four 30-minute supportive programs during 4 consecutive chemotherapy treatments - Daily home practices - Four study questionnaires that take approximately 30 minutes each to complete - Three blood samples that will be collected during your routine blood draws - Brief daily surveys by phone for 2 weeks before and 2 weeks after the programs - Wear a small device on your wrist for 2 weeks before and 2 weeks after the programs

Criteria

Inclusion Criteria:
• Scheduled to receive first-line intravenous chemotherapy treatment for colorectal cancer (stages II-IV)
• Have an Eastern Cooperative Oncology Group (ECOG) performance status of =< 1
• Ability to understand and the willingness to sign an informed consent document written in English
Exclusion Criteria:
• Regularly engaged (>= 3 days/week) in moderate physical activity of any kind (e.g., yoga) over the past 4 weeks
• Has a self-reported history of diagnosed sleep disorders (e.g., obstructive sleep apnea, insomnia), comorbidities associated with poor sleep or fatigue (e.g., chronic fatigue syndrome), or a job with night shifts