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Clinical Trial VICCHEM13110

Title

A Phase 1/2 Open-Label, Dose Escalation Study Investigating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ASP2215 in Patients with Relapsed or Refractory Acute Myeloid Leukemia

Principal Investigator(s)

Stephen Strickland

Details

  • Protocol No. VICCHEM13110
  • Open Date: 04/11/2014
  • Staging: Phase I/II
  • Age Group: Adults
  • Scope: National
  • Objective: Assess the safety and tolerability, including determination of the maximum tolerated dose (MTD) of oral ASP2215 in subjects with relapsed or treatment-refractory AML. ? Determine the pharmacokinetic (PK) parameters of ASP2215.
  • Disease Sites: Leukemia
  • Therapies: Molecular Targeted Agents / Immunotherapy / Biologics
  • Drugs: ASP2215
  • Participating Institutions: Vanderbilt University
  • National Clinical Trial ID: NCT02014558
  • Secondary Protocol No: 2215-CL-0101

Description

The purpose of this study is to see if a medicine called ASP2215 is both safe and effective as a treatment for patients with AML. This study also wants to investigate the effect of other drugs on ASP2215.

Eligibility

Ages Eligible for Study:18 Years and older
Genders Eligible for Study:Both
Accepts Healthy Volunteers:No

Criteria

Inclusion Criteria:
• Subject is defined as morphologically documented primary or secondary AML by the World Health Organization (WHO) criteria (2008) and fulfills one of the following:
• Refractory to at least 1 cycle of induction chemotherapy
• Relapsed after achieving remission with a prior therapy
• Subject has an Eastern Cooperative Oncology Group (ECOG) performance status <= 2.
• Subject's interval from prior treatment to time of study drug administration is at least 2 weeks for cytotoxic agents (except hydroxyurea given for controlling blast cells), or at least 5 half-lives for prior experimental agents or noncytotoxic agents.
Exclusion Criteria:
• Subject was diagnosed as acute promyelocytic leukemia (APL).
• Subject has BCR-ABL-positive leukemia (chronic myelogenous leukemia in blast crisis).
• Subject has active malignant tumors other than AML or Myelodysplastic syndrome (MDS).
• Subject has persistent nonhematological toxicities of >= Grade 2 (Common Terminology Criteria for Adverse Events v4), with symptoms and objective findings, from prior AML treatment (including chemotherapy, kinase inhibitors, immunotherapy, experimental agents, radiation, or surgery).
• Subject has had hematopoietic stem cell transplant (HSCT) and meets any of the following:
• Is within 2 months of transplant from C1D1
• Has clinically significant graft-versus-host disease requiring treatment
• Has >= Grade 2 persistent non-hematological toxicity related to the transplant Donor lymphocytes infusion (DLI) is not permitted <= 30 days prior to study registration or during the first cycle of treatment on the study in Cohort 1 and first two cycles of the treatment in Cohort 2
• Subject has clinically active central nervous system leukemia
• Subject has disseminated intravascular coagulation abnormality (DIC)
• Subject has had major surgery within 4 weeks prior to the first study dose.
• Subject has had radiation therapy within 4 weeks prior to the first study dose
• Subject has congestive heart failure New York Heart Association (NYHA) class 3 or 4, or subject with a history of congestive heart failure NYHA class 3 or 4 in the past, unless a screening echocardiogram performed within 3 months prior to study entry results in a left ventricular ejection fraction that is ≥ 45%
• Subject requires treatment with concomitant drugs that are strong inhibitors or inducers of Cytochrome P450-isozyme3A4 (CYP3A4) with the exception of antibiotics, antifungals, and antivirals that are used as standard of care post-transplant or to prevent or treat infections and other such drugs that are considered absolutely essential for the care of the subject
• Subject required treatment with concomitant drugs that target serotonin 5HT1R or 5HT2BR receptors or sigma nonspecific receptor with the exception of drugs that are considered absolutely essential for the care of the subject.
• Subject has an active uncontrolled infection
• Subject is known to have human immunodeficiency virus infection
• Subject has active hepatitis B or C, or other active hepatic disorder