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Clinical Trial VICCMEL0287


Melanoma, Pigmented Lesion and Cutaneous Malignancy Tissue and Bio-Specimen Repository

Principal Investigator(s)

Rondi Kauffmann


  • Protocol No. VICCMEL0287
  • Open Date: 05/06/2003
  • Staging: N/A
  • Age Group: Adults
  • Scope: Local
  • Objective: The purposes of this study are to characterize the markers in the steps in melanoma progression; create a database that includes factors of different stages in the progression of melanoma; and to create a tissue bank that is linked to pathology specimens.
  • Disease Sites: Melanoma; Dermatologic
  • Therapies: Correlative
  • Drugs: None Specified
  • Participating Institutions: Vanderbilt University
  • Secondary Protocol No: VICCMEL0287


Studying gene expression is a way of looking at proteins, which are the building blocks of cells. Cancers are thought to arise by the accumulation of of damage to key genes involved in growth control. The purpose of this study is to look at patterns of expression of genes and proteins in melanoma and lesions at risk to develop into melanoma to better understand how cancers grow, spread and respond to therapy. In this study, we will collect tumor and normal tissue removed at the time of medically indicated surgery or skin biopsy in order to study patters of gene and protein expression in human melanomas and how they correlate to tumor biology. It is hoped that identifying and understanding the genes involved in this process will lead to improved cancer prevention and therapy, and in turn improved quality of life and survival of patients at risk for or with melanoma.

Tumor material will be collected at the time of medically indicated surgical procedures or through skin biopsies. Blood will be collected via venipuncture and lymphocytes (mononuclear cells) separated and processed as a source of normal DNA and normal cells.

Approximately 400 adult male and female subjects will take part in this study.

A major goal of this program is to establish a tissue repository (blood, DNA, frozen and fixed tissues, and pathologic specimens in pathology) for the current and future studies. Studies primarily aimed at understanding biologic features of melanoma development and progression.


Not provided. Please call for more information.