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Clinical Trial VICCPED0987


The ADVANCE Trial: A Multicenter Validation Study of Biomarkers of Vincristine Peripheral Neuropathy in Children with Acute Lymphoblastic Leukemia

Principal Investigator(s)

Richard Ho


  • Protocol No. VICCPED0987
  • Open Date: 04/08/2010
  • Staging: N/A
  • Age Group: Children
  • Scope: National
  • Objective: To examine the correlation between genotype for CYP3A5 and vincristine-induced peripheral neuropathy, pharmacokinetics and efficacy. To examine the correlation between known pharmacogenetic polymorphisms in the vinca alkaloid pharmacologic pathway and vincristine-induced peripheral neuropathy, pharmacokinetics, and efficacy
  • Disease Sites: Pediatrics; Leukemia
  • Therapies: Correlative
  • Drugs: None Specified
  • Participating Institutions: Vanderbilt University
  • National Clinical Trial ID: NCTNA
  • Secondary Protocol No: ADVANCE


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