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Alexandra Kovach, M.D.

Assistant Professor of Pathology, Microbiology and Immunology

Profile

My clinical responsibilities include pathology interpretation of in-house and referral cases in general hematopathology and pediatric pathology; I am fellowship trained and board certified in each of these sub-specialties. Approximately 30% of my appointment is devoted to translational investigation. My major academic interests are in lymphoma and lymphoid proliferations, particularly in young patients.

Education
  • B.A., Columbia College, Columbia University, New York, NY
  • M.D., with Special Qualification in Biomedical Research, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH
Postgraduate Training
  • Residency, Anatomic and Clinical Pathology - Massachusetts General Hospital, Boston, MA
  • Fellowship, Hematopathology - Massachusetts General Hospital
  • Fellowship, Pediatric Pathology - Boston Children's Hospital, Boston, MA
Publications
  • Kovach AE, Brunner AM, Fathi AT, Chen YB, Hasserjian RP. Prognostic Significance of Residual Acute Myeloid Leukemia in Bone Marrow Samples Taken Prior to Allogeneic Hematopoietic Cell Transplantation. Am. J. Clin. Pathol [print-electronic]. 2017 Jan 1/20/2017; PMID: 28108471, PII: aqw203, DOI: 10.1093/ajcp/aqw203, ISSN: 1943-7722.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/28108471.
  • Kovach AE, Brunner AM, Fathi AT, Chen YB, Hasserjian RP. Prognostic Significance of Residual Acute Myeloid Leukemia in Bone Marrow Samples Taken Prior to Allogeneic Hematopoietic Cell Transplantation. Am. J. Clin. Pathol [print-electronic]. 2017 Jan 1/20/2017; PMID: 28108471, PII: aqw203, DOI: 10.1093/ajcp/aqw203, ISSN: 1943-7722.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/28108471.
  • Kamionek M, Ahmadi Moghaddam P, Sakhdari A, Kovach AE, Welch M, Meng X, Dresser K, Tomaszewicz K, Cosar EF, Mark EJ, Fraire AE, Hutchinson L. Mutually exclusive extracellular signal-regulated kinase pathway mutations are present in different stages of multi-focal pulmonary Langerhans cell histiocytosis supporting clonal nature of the disease. Histopathology [print-electronic]. 2016 Sep; 69(3): 499-509. PMID: 26915300, DOI: 10.1111/his.12955, ISSN: 1365-2559.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26915300.
  • Louissaint A, Schafernak KT, Geyer JT, Kovach AE, Ghandi M, Gratzinger D, Roth CG, Paxton CN, Kim S, Namgyal C, Morin R, Morgan EA, Neuberg DS, South ST, Harris MH, Hasserjian RP, Hochberg EP, Garraway LA, Harris NL, Weinstock DM. Pediatric-type nodal follicular lymphoma: a biologically distinct lymphoma with frequent MAPK pathway mutations. Blood [print-electronic]. 2016 Aug 8/25/2016; 128(8): 1093-100. PMID: 27325104, PMCID: PMC5000844, PII: blood-2015-12-682591, DOI: 10.1182/blood-2015-12-682591, ISSN: 1528-0020.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27325104.
  • Feske SK, Goldberg M, Dudzinski DM, Gonzalez RG, Kovach AE. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 29-2015. A 38-Year-Old Pregnant Woman with Headache and Visual Symptoms. N. Engl. J. Med. 2015 Sep 9/17/2015; 373(12): 1154-64. PMID: 26376139, DOI: 10.1056/NEJMcpc1404335, ISSN: 1533-4406.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26376139.
  • Kovach AE, Nucera C, Lam QT, Nguyen A, Dias-Santagata D, Sadow PM. Genomic and immunohistochemical analysis in human adrenal cortical neoplasia reveal beta-catenin mutations as potential prognostic biomarker. Discoveries (Craiova). 2015 Apr; 3(2): PMID: 26317117, PMCID: PMC4548998, DOI: 10.15190/d.2015.32.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26317117.
  • Ackman JB, Verzosa S, Kovach AE, Louissaint A, Lanuti M, Wright CD, Shepard JA, Halpern EF. High rate of unnecessary thymectomy and its cause. Can computed tomography distinguish thymoma, lymphoma, thymic hyperplasia, and thymic cysts?. Eur J Radiol [print-electronic]. 2015 Mar; 84(3): 524-33. PMID: 25575742, PII: S0720-048X(14)00571-3, DOI: 10.1016/j.ejrad.2014.11.042, ISSN: 1872-7727.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25575742.
  • Carey CD, Gusenleitner D, Chapuy B, Kovach AE, Kluk MJ, Sun HH, Crossland RE, Bacon CM, Rand V, Dal Cin P, Le LP, Neuberg D, Sohani AR, Shipp MA, Monti S, Rodig SJ. Molecular classification of MYC-driven B-cell lymphomas by targeted gene expression profiling of fixed biopsy specimens. J Mol Diagn [print-electronic]. 2015 Jan; 17(1): 19-30. PMID: 25468432, PMCID: PMC4279427, PII: S1525-1578(14)00204-9, DOI: 10.1016/j.jmoldx.2014.08.006, ISSN: 1943-7811.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25468432.
  • Turetsky A, Lee K, Song J, Giedt RJ, Kim E, Kovach AE, Hochberg EP, Castro CM, Lee H, Weissleder R. On chip analysis of CNS lymphoma in cerebrospinal fluid. Theranostics. 2015; 5(8): 796-804. PMID: 26000053, PMCID: PMC4440438, PII: thnov05p0796, DOI: 10.7150/thno.11220, ISSN: 1838-7640.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26000053.
  • Kovach AE, DeLelys ME, Kelliher AS, Dillon LJ, Hasserjian RP, Ferry JA, Preffer FI, Sohani AR. Diagnostic utility of cerebrospinal fluid flow cytometry in patients with and without prior hematologic malignancy. Am. J. Hematol [print-electronic]. 2014 Oct; 89(10): 978-84. PMID: 25042070, DOI: 10.1002/ajh.23806, ISSN: 1096-8652.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25042070.
  • Kovach AE, Cheng GZ, Channick CL, Channick RN, Muniappan A, Gaissert HA, Kradin RL. Postradiofrequency ablation inflammatory pseudotumor associated with pulmonary venoocclusive disease: case report and review of the literature. Ann Diagn Pathol [print-electronic]. 2013 Oct; 17(5): 466-9. PMID: 23352326, PII: S1092-9134(12)00172-4, DOI: 10.1016/j.anndiagpath.2012.11.002, ISSN: 1532-8198.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23352326.
  • Onozato ML, Kovach AE, Yeap BY, Morales-Oyarvide V, Klepeis VE, Tammireddy S, Heist RS, Mark EJ, Dias-Santagata D, Iafrate AJ, Yagi Y, Mino-Kenudson M. Tumor islands in resected early-stage lung adenocarcinomas are associated with unique clinicopathologic and molecular characteristics and worse prognosis. Am. J. Surg. Pathol. 2013 Feb; 37(2): 287-94. PMID: 23095504, PMCID: PMC3545070, DOI: 10.1097/PAS.0b013e31826885fb, ISSN: 1532-0979.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23095504.