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Anuradha (Bapsi)  Chakravarthy

Anuradha (Bapsi) Chakravarthy, M.D.

Professor, Program Director
Professor of Radiation Oncology
Radiation Oncologist

  • Appointments
    615-322-2555
    Physicians: 1-877-936-8422
  • Clinical Trials Information
  • Other Telephone Numbers
    Vanderbilt-Ingram Cancer Center Radiation Oncology
    (615) 322-2555

    Office
    615-322-2555
  • Faxes
    Vanderbilt-Ingram Cancer Center Radiation Oncology Fax
    (615) 343-3075

    Clinic Fax
    615-936-3363
  • Addresses
    Clinic
    The Vanderbilt Clinic (TVC) - Preston Research Building
    Department of Radiation Oncology, B1003
    1301 22nd Ave. South
    Nashville, TN 37323-5671

    Vanderbilt-Ingram Cancer Center Radiation Oncology
    22nd at Pierce Avenue, B1034
    Nashville, TN 37232-5671
    Website

Profile

Dr. Anuradha (Bapsi) Chakravarthy, known better to her patients and colleagues as Bapsi Chak, is a member of the faculty and Residency Director in the Department of Radiation Oncology at Vanderbilt University Medical Center.
Dr. Chak received her Doctor of Medicine degree from the George Washington University, Washington, D.C. Following a residency in Internal Medicine at the Mayo Clinic she completed a fellowship in Medical Oncology at the University of Maryland and Radiation Oncology at the Johns Hopkins University. She is board certified in both radiation oncology and medical oncology. She has served on several university committees including the Scientific Review Committee, the Institutional Review Board and the Data Safety and Monitoring Board. On a national level, Dr. Chak serves as Radiation Oncology Chair, Eastern Cooperative Oncology Group.
Dr. Chak's clinical interests involve treating malignancies of the breast and gastrointestinal tract (esophageal, pancreas, gastric, colorectal, and anal). Her research interests involve the development of markers to predict therapeutic response. Currently we treat many patients empirically with drugs that may benefit the population as a whole but not necessarily the individual. Using new technologies to analyze thousands of genes and proteins simultaneously from tumors, Dr. Chak hopes to identify molecular patterns that will predict an individual's response to specific agents. Dr. Chak works closely with basic scientists to help bring ideas developed in the laboratory directly to patient care. Dr. Chak also works with imaging scientists to determine whether non-invasive tools such as imaging can be used to predict therapeutic outcome.

Education
  • B.S. -The Johns Hopkins University Baltimore, Maryland
  • M.D.- George Washington University, Washington, DC
  • Resident in Internal Medicine- Mayo Clinic, Rochester, Minnesota
  • Resident in Radiation Oncology- The Johns Hopkins Univeristy, Baltimore, Maryland
  • Fellow in Medical Oncology- University of Maryland, Baltimore, Maryland
Publications
  • Atuegwu NC, Li X, Arlinghaus LR, Abramson RG, Williams JM, Chakravarthy AB, Abramson VG, Yankeelov TE. Longitudinal, intermodality registration of quantitative breast PET and MRI data acquired before and during neoadjuvant chemotherapy: preliminary results. Med Phys. 2014 May; 41(5): 52302. PMID: 24784395, PMCID: PMC4000383, DOI: 10.1118/1.4870966, ISSN: 0094-2405.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24784395.
  • Li X, Arlinghaus LR, Ayers GD, Chakravarthy AB, Abramson RG, Abramson VG, Atuegwu N, Farley J, Mayer IA, Kelley MC, Meszoely IM, Means-Powell J, Grau AM, Sanders M, Bhave SR, Yankeelov TE. DCE-MRI analysis methods for predicting the response of breast cancer to neoadjuvant chemotherapy: pilot study findings. Magn Reson Med [print-electronic]. 2014 Apr; 71(4): 1592-602. PMID: 23661583, PMCID: PMC3742614, DOI: 10.1002/mrm.24782, ISSN: 1522-2594.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23661583.
  • FitzHenry F, Wells N, Slater V, Dietrich MS, Wisawatapnimit P, Chakravarthy AB. A randomized placebo-controlled pilot study of the impact of healing touch on fatigue in breast cancer patients undergoing radiation therapy. Integr Cancer Ther [print-electronic]. 2014 Mar; 13(2): 105-13. PMID: 24105358, PII: 1534735413503545, DOI: 10.1177/1534735413503545, ISSN: 1552-695X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24105358.
  • Li X, Kang H, Arlinghaus LR, Abramson RG, Chakravarthy AB, Abramson VG, Farley J, Sanders M, Yankeelov TE. Analyzing Spatial Heterogeneity in DCE- and DW-MRI Parametric Maps to Optimize Prediction of Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer. Transl Oncol. 2014 Feb; 7(1): 14-22. PMID: 24772203, PMCID: PMC3998687, ISSN: 1936-5233.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24772203.
  • Abramson RG, Li X, Hoyt TL, Su PF, Arlinghaus LR, Wilson KJ, Abramson VG, Chakravarthy AB, Yankeelov TE. Early assessment of breast cancer response to neoadjuvant chemotherapy by semi-quantitative analysis of high-temporal resolution DCE-MRI: preliminary results. Magn Reson Imaging [print-electronic]. 2013 Nov; 31(9): 1457-64. PMID: 23954320, PMCID: PMC3807825, PII: S0730-725X(13)00233-6, DOI: 10.1016/j.mri.2013.07.002, ISSN: 1873-5894.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23954320.
  • Weis JA, Miga MI, Arlinghaus LR, Li X, Chakravarthy AB, Abramson V, Farley J, Yankeelov TE. A mechanically coupled reaction-diffusion model for predicting the response of breast tumors to neoadjuvant chemotherapy. Phys Med Biol [print-electronic]. 2013 Sep 9/7/2013; 58(17): 5851-66. PMID: 23920113, PMCID: PMC3791925, DOI: 10.1088/0031-9155/58/17/5851, ISSN: 1361-6560.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23920113.
  • Wang T, Wentz SC, Ausborn NL, Washington MK, Merchant N, Zhao Z, Shyr Y, Chakravarthy AB, Xia F. Pattern of breast cancer susceptibility gene 1 expression is a potential prognostic biomarker in resectable pancreatic ductal adenocarcinoma. Pancreas. 2013 Aug; 42(6): 977-82. PMID: 23851432, PMCID: PMC4026161, PII: 00006676-201308000-00013, DOI: 10.1097/MPA.0b013e318287885c, ISSN: 1536-4828.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23851432.
  • Castel LD, Hartmann KE, Mayer IA, Saville BR, Alvarez J, Boomershine CS, Abramson VG, Chakravarthy AB, Friedman DL, Cella DF. Time course of arthralgia among women initiating aromatase inhibitor therapy and a postmenopausal comparison group in a prospective cohort. Cancer [print-electronic]. 2013 Jul 7/1/2013; 119(13): 2375-82. PMID: 23575918, PMCID: PMC3687009, DOI: 10.1002/cncr.28016, ISSN: 1097-0142.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23575918.
  • Atuegwu NC, Arlinghaus LR, Li X, Chakravarthy AB, Abramson VG, Sanders ME, Yankeelov TE. Parameterizing the Logistic Model of Tumor Growth by DW-MRI and DCE-MRI Data to Predict Treatment Response and Changes in Breast Cancer Cellularity during Neoadjuvant Chemotherapy. Transl Oncol [electronic-print]. 2013 Jun; 6(3): 256-64. PMID: 23730404, PMCID: PMC3660793, ISSN: 1936-5233.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23730404.
  • Al-Greene NT, Means AL, Lu P, Jiang A, Schmidt CR, Chakravarthy AB, Merchant NB, Washington MK, Zhang B, Shyr Y, Deane NG, Beauchamp RD. Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma. PLoS ONE [electronic-print]. 2013; 8(7): e69660. PMID: 23922772, PMCID: PMC3726759, PII: PONE-D-13-05038, DOI: 10.1371/journal.pone.0069660, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23922772.
  • Chan E, Wise PE, Chakravarthy AB. Controversies in radiation for upper rectal cancers. J Natl Compr Canc Netw. 2012 Dec 12/1/2012; 10(12): 1567-72. PMID: 23221791, PII: 10/12/1567, ISSN: 1540-1413.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23221791.
  • Chakravarthy AB, Catalano PJ, Mondschein JK, Rosenthal DI, Haller DG, Whittington R, Spitz FR, Wagner H, Sigurdson ER, Tschetter LK, Bayer GK, Mulcahy MF, Benson AB. Phase II Trial of Paclitaxel/Cisplatin Followed by Surgery and Adjuvant Radiation Therapy and 5-Fluorouracil/Leucovorin for Gastric Cancer (ECOG E7296). Gastrointest Cancer Res. 2012 Nov; 5(6): 191-7. PMID: 23293700, PMCID: PMC3533847, ISSN: 1934-7820.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23293700.
  • Li X, Welch EB, Chakravarthy AB, Xu L, Arlinghaus LR, Farley J, Mayer IA, Kelley MC, Meszoely IM, Means-Powell J, Abramson VG, Grau AM, Gore JC, Yankeelov TE. Statistical comparison of dynamic contrast-enhanced MRI pharmacokinetic models in human breast cancer. Magn Reson Med [print-electronic]. 2012 Jul; 68(1): 261-71. PMID: 22127821, PMCID: PMC3291742, DOI: 10.1002/mrm.23205, ISSN: 1522-2594.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22127821.
  • Li X, Abramson RG, Arlinghaus LR, Chakravarthy AB, Abramson V, Mayer I, Farley J, Delbeke D, Yankeelov TE. An algorithm for longitudinal registration of PET/CT images acquired during neoadjuvant chemotherapy in breast cancer: preliminary results. EJNMMI Res. 2012; 2(1): 62. PMID: 23157877, PMCID: PMC3520720, PII: 2191-219X-2-62, DOI: 10.1186/2191-219X-2-62, ISSN: 2191-219X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23157877.
  • Snyder RA, Castaldo ET, Bailey CE, Phillips SE, Chakravarthy AB, Merchant NB. Survival Benefit of Adjuvant Radiation Therapy for Gastric Cancer following Gastrectomy and Extended Lymphadenectomy. Int J Surg Oncol [print-electronic]. 2012; 2012: 307670. PMID: 22778937, PMCID: PMC3388431, DOI: 10.1155/2012/307670, ISSN: 2090-1410.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22778937.
  • Atuegwu NC, Arlinghaus LR, Li X, Welch EB, Chakravarthy BA, Gore JC, Yankeelov TE. Integration of diffusion-weighted MRI data and a simple mathematical model to predict breast tumor cellularity during neoadjuvant chemotherapy. Magn Reson Med [print-electronic]. 2011 Dec; 66(6): 1689-96. PMID: 21956404, PMCID: PMC3218213, DOI: 10.1002/mrm.23203, ISSN: 1522-2594.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21956404.
  • Chakravarthy AB, Catalano PJ, Martenson JA, Mondschein JK, Wagner H, Mansour EG, Talamonti MS, Benson AB. Long-term follow-up of a Phase II trial of high-dose radiation with concurrent 5-fluorouracil and cisplatin in patients with anal cancer (ECOG E4292). Int. J. Radiat. Oncol. Biol. Phys [print-electronic]. 2011 Nov 11/15/2011; 81(4): e607-13. PMID: 21514072, PMCID: PMC3197794, PII: S0360-3016(11)00362-2, DOI: 10.1016/j.ijrobp.2011.02.042, ISSN: 1879-355X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21514072.
  • Li X, Welch EB, Arlinghaus LR, Chakravarthy AB, Xu L, Farley J, Loveless ME, Mayer IA, Kelley MC, Meszoely IM, Means-Powell JA, Abramson VG, Grau AM, Gore JC, Yankeelov TE. A novel AIF tracking method and comparison of DCE-MRI parameters using individual and population-based AIFs in human breast cancer. Phys Med Biol [print-electronic]. 2011 Sep 9/7/2011; 56(17): 5753-69. PMID: 21841212, PMCID: PMC3176673, PII: S0031-9155(11)87575-5, DOI: 10.1088/0031-9155/56/17/018, ISSN: 1361-6560.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21841212.
  • Jiang J, Yang ES, Jiang G, Nowsheen S, Wang H, Wang T, Wang Y, Billheimer D, Chakravarthy AB, Brown M, Haffty B, Xia F. P53-dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage. Cancer Res [print-electronic]. 2011 Aug 8/15/2011; 71(16): 5546-57. PMID: 21742769, PII: 0008-5472.CAN-10-3423, DOI: 10.1158/0008-5472.CAN-10-3423, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21742769.
  • Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J. Clin. Invest. 2011 Jul; 121(7): 2750-67. PMID: 21633166, PMCID: PMC3127435, PII: 45014, DOI: 10.1172/JCI45014, ISSN: 1558-8238.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21633166.
  • Mani S, Chen Y, Arlinghaus LR, Li X, Chakravarthy AB, Bhave SR, Welch EB, Levy MA, Yankeelov TE. Early prediction of the response of breast tumors to neoadjuvant chemotherapy using quantitative MRI and machine learning. AMIA Annu Symp Proc [print-electronic]. 2011; 2011: 868-77. PMID: 22195145, PMCID: PMC3243164, ISSN: 1942-597X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22195145.
  • Li X, Dawant BM, Welch EB, Chakravarthy AB, Freehardt D, Mayer I, Kelley M, Meszoely I, Gore JC, Yankeelov TE. A nonrigid registration algorithm for longitudinal breast MR images and the analysis of breast tumor response. Magn Reson Imaging [print-electronic]. 2009 Nov; 27(9): 1258-70. PMID: 19525078, PMCID: PMC2763059, PII: S0730-725X(09)00086-1, DOI: 10.1016/j.mri.2009.05.007, ISSN: 1873-5894.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19525078.
  • Cuneo KC, Geng L, Fu A, Orton D, Hallahan DE, Chakravarthy AB. SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation. Int. J. Radiat. Oncol. Biol. Phys. 2008 Jul 7/1/2008; 71(3): 873-9. PMID: 18514780, PII: S0360-3016(08)00407-0, DOI: 10.1016/j.ijrobp.2008.02.062, ISSN: 0360-3016.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18514780.
  • Kim DW, Blanke CD, Wu H, Shyr Y, Berlin J, Beauchamp RD, Chakravarthy B. Phase II study of preoperative paclitaxel/cisplatin with radiotherapy in locally advanced esophageal cancer. Int. J. Radiat. Oncol. Biol. Phys [print-electronic]. 2007 Feb 2/1/2007; 67(2): 397-404. PMID: 17097833, PII: S0360-3016(06)02837-9, DOI: 10.1016/j.ijrobp.2006.08.062, ISSN: 0360-3016.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17097833.
  • Yankeelov TE, Lepage M, Chakravarthy A, Broome EE, Niermann KJ, Kelley MC, Meszoely I, Mayer IA, Herman CR, McManus K, Price RR, Gore JC. Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results. Magn Reson Imaging [print-electronic]. 2007 Jan; 25(1): 1-13. PMID: 17222711, PMCID: PMC2634832, PII: S0730-725X(06)00289-X, DOI: 10.1016/j.mri.2006.09.006, ISSN: 0730-725X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17222711.
  • Chakravarthy AB, Kelley MC, McLaren B, Truica CI, Billheimer D, Mayer IA, Grau AM, Johnson DH, Simpson JF, Beauchamp RD, Jones C, Pietenpol JA. Neoadjuvant concurrent paclitaxel and radiation in stage II/III breast cancer. Clin. Cancer Res. 2006 Mar 3/1/2006; 12(5): 1570-6. PMID: 16533783, PII: 12/5/1570, DOI: 10.1158/1078-0432.CCR-05-2304, ISSN: 1078-0432.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16533783.
  • Tedesco KL, Berlin J, Rothenberg M, Choy H, Wyman K, Scott Pearson A, Daniel Beauchamp R, Merchant N, Lockhart AC, Shyr Y, Caillouette C, Chakravarthy B. A phase I study of concurrent 9-nitro-20(s)-camptothecin (9NC/Orathecin) and radiation therapy in the treatment of locally advanced adenocarcinoma of the pancreas. Radiother Oncol. 2005 Jul; 76(1): 54-8. PMID: 15921772, PII: S0167-8140(05)00169-6, DOI: 10.1016/j.radonc.2005.04.005, ISSN: 0167-8140.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15921772.
  • Tedesco KL, Berlin J, Blanke CD, Teng M, Choy H, Roberts J, Beauchamp RD, Leach S, Wyman K, Tarpley J, Shyr Y, Caillouette C, Chakravarthy B. Phase I trial of Orzel (UFT plus leucovorin), cisplatin, and radiotherapy in the treatment of potentially resectable esophageal cancer. Int. J. Radiat. Oncol. Biol. Phys. 2005 Apr 4/1/2005; 61(5): 1364-70. PMID: 15817338, PII: S0360-3016(04)02471-X, DOI: 10.1016/j.ijrobp.2004.08.050, ISSN: 0360-3016.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15817338.
  • Chakravarthy B, Pietenpol JA. Combined modality management of breast cancer: development of predictive markers through proteomics. Semin. Oncol. 2003 Aug; 30(4 Suppl 9): 23-36. PMID: 12908134, PII: S0093775403002677, ISSN: 0093-7754.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12908134.
  • Hallahan DE, Qu S, Geng L, Cmelak A, Chakravarthy A, Martin W, Scarfone C, Giorgio T. Radiation-mediated control of drug delivery. Am. J. Clin. Oncol. 2001 Oct; 24(5): 473-80. PMID: 11586099, ISSN: 0277-3732.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11586099.
  • Hallahan DE, Geng L, Cmelak AJ, Chakravarthy AB, Martin W, Scarfone C, Gonzalez A. Targeting drug delivery to radiation-induced neoantigens in tumor microvasculature. J Control Release. 2001 Jul 7/6/2001; 74(1-3): 183-91. PMID: 11489494, PII: S0168365901003352, ISSN: 0168-3659.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11489494.
  • Choy H, Chakravarthy A, Kim JS. Radiation therapy for non-small cell lung cancer (NSCLC). Cancer Treat. Res. 2001; 105: 121-48. PMID: 11224985, ISSN: 0927-3042.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11224985.
  • Choy H, Chakravarthy A, Devore RF, Jagasia M, Hande KR, Roberts JR, Johnson DH, Yunus F. Weekly irinotecan and concurrent radiation therapy for stage III unresectable NSCLC. Oncology (Williston Park, N.Y.). 2000 Jul; 14(7 Suppl 5): 43-6. PMID: 10981290, PII: 173444, ISSN: 0890-9091.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10981290.
  • Chakravarthy A, Choy H. A phase I trial of outpatient weekly irinotecan/carboplatin and concurrent radiation for stage III unresectable non small-cell lung cancer: a Vanderbilt-Ingram Cancer Center Affiliate Network Trial. Clin Lung Cancer. 2000 May; 1(4): 310-1. PMID: 14733637, ISSN: 1525-7304.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14733637.
  • Chakravarthy A, Nicholson B, Kelley M, Beauchamp D, Johnson D, Frexes-Steed M, Simpson J, Shyr Y, Pietenpol J. A pilot study of neoadjuvant paclitaxel and radiation with correlative molecular studies in stage II/III breast cancer. Clin. Breast Cancer. 2000 Apr; 1(1): 68-71. PMID: 11899393, PII: S1526-8209(11)70101-X, DOI: 10.3816/CBC.2000.n.007, ISSN: 1526-8209.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11899393.
  • Chakravarthy, A, Choy H. A Phase I Trial of outpatient Weekly irinotecan/carboplatin and concurrent radiation for Stage III unresectable non-small-cell lung cancer. Vanderbilt-Ingram Cancer Center Affiliate Network Trial, Brief communication, Clinical Lung Cancer. 2000; 1((4)): 310-1.
  • Chakravarthy, A, Nicholson B, Kelley M, Beauchamp D, Johnson D, Frexes-Steed M, Simpson J, Shyr Y, Pietenpol J. A pilot study of neoadjuvant paclitaxel and radiation therapy with correlative molecular studies in Stage II/III breast cancer. Clinical Breast Cancer. 2000; 1((1)): 68-71.
  • Chakravarthy A, Johnson D, Choy H. The role of radiation, with or without chemotherapy, in the management of NSCLC. Oncology (Williston Park, N.Y.). 1999 Oct; 13(10 Suppl 5): 93-100. PMID: 10550832, PII: 162949, ISSN: 0890-9091.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10550832.
  • Abrams RA, Grochow LB, Chakravarthy A, Sohn TA, Zahurek ML, Haulk TL, Ord S, Hruban RH, Lillemoe KD, Pitt HA, Cameron JL, Yeo CJ. Intensified adjuvant therapy for pancreatic and periampullary adenocarcinoma: survival results and observations regarding patterns of failure, radiotherapy and CA 19-9 levels. Int J Radiat Oncol Biol Phys. 1999; 44((5)): 151039-46.
  • Chakravarthy, A., Johnson, D., Choy, H. The Role of Radiation with or without Chemotherapy in the management of NSCLC. Oncology. 1999; 13: 10 (supp 5): 93-100.
  • Choy, H, Chakravarthy, A. Phase I trial of Irinotecan and concurrent radiation therapy for stage III non-small cell lung cancer. Cancer Conference Highlights. 1999; 4((6-7)): 12.
  • Mignano, J.E., Zahurak, M.L., Chakravarthy, A., Piantadosi, S., Dooley, W.C., Gage,I. Significance of axillary nodal extranodal soft tissue extension and indications for post-mastectomy irradiation. Cancer. 1999; 86((7)): 1258-62.