The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers

Barbara Fingleton, Ph.D.

Assistant Professor of Cancer Biology
VICC Member
Researcher

Contact Information:

Vanderbilt-Ingram Cancer Center
734 Preston Building
Nashvill, TN 37232-6840
615-936-5877
Fax: 615-936-2911

Education

  • B. Sc., Dublin City University, 1992
  • Ph.D., Dublin City University, 1996
  • Postdoctoral Fellow, Vanderbilt University, 2001

Research Specialty

Understanding function and how to therapeutically target inflammatory molecules in colitis and colon cancer

Research Description

My background is in the area of matrix metalloproteinases (MMPs) and how they contribute to cancer development and progression. I have been especially interested in testing drugs that can inhibit MMPs in cancer models and in understanding why such drugs have not been effective in human cancer patients. Lately, I have focused on some of the roles of specific MMPs in pre-cancerous inflammatory conditions, particularly colitis. We have identified a protective function for a specific MMP in colitis and are currently working on elucidating the mechanism. Additionally, I work on the cytokines IL4 and IL13 and their receptors ,and how these molecules can influence colon cancer development and progression. We use multiple mouse models combined with in vitro approaches to address the pleiotropic functions of these cytokines which affect both the epithelial cancer cells and the inflammatory infiltrate within tumors.

Publications


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