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Bruce D.  Carter

Bruce D. Carter, Ph.D.

Professor of Biochemistry
Associate Director for Education and Training, Vanderbilt Brain Institute
Investigator, Kennedy Center for Research & Humanities
Director of Graduate Studies in Neuroscience
Researcher

Contact Information:

Vanderbilt University Medical Center
625 Light Hall
Nashville, TN 37232-0146
615-936-3041

Research Description

I. Mechanisms of neurotrophin signaling through the p75 receptor: Our lab studies the signaling mechanisms regulating neuronal survival. Programmed cell death in the nervous system is a naturally occurring process in mammalian development; however, abnormal apoptosis is the basis for many neuropathologies, e.g. Alzheimer''s and Parkinson''s disease and ischemic injury. The delicate balance between neuronal survival and death is regulated, in part, by a family of growth factors referred to as the neurotrophins. The target tissues to which the neurons project produce members of this family of trophic factors. The neurotrophins promote neuronal survival and differentiation through binding to the Trks, a family of tyrosine kinase receptors, and induce apoptosis through a 75kD receptor, p75. While significant progress has been made in elucidating the mechanisms by which the Trks promote survival, much less is known about how p75 induces cell death. We recently discovered that pro-death ligands promote p75 cleavage by ¿secretase, which releases a transcription factor, NRIF, to enter the nucleus. This process is required for the receptor''s apoptotic signal.This research will reveal the mechanisms underlying normal mammalian neural development and function. Moreover, understanding the regulation of neural cell survival is essential for developing therapeutic strategies for neuropathologies involving apoptosis, which include many diseases and nerve lesions.

II. Process by which apoptotic neurons are phagocytosed: Following the extensive apoptosis that occurs during development of the nervous system, the resulting neuronal corpses must be efficiently removed to prevent an inflammatory response, which can eventually lead to autoimmunity. Unfortunately, the molecular mechanisms underlying this phagocytic process in the nervous system are poorly understood. We recently demonstrated that satellite glial precursor cells are the primary phagocytes that engulf the many neuronal corpses in the developing dorsal root ganglia (DRG) and identified a novel engulfment receptor, Jedi1, as mediating the engulfment by glial precursors. Current efforts are aimed at determining the mechanisms by which Jedi1 signals engulfment and investigating its role in regulating phagocytosis in other regions of the developing nervous system.

III. Molecular mechanisms of myelin formation: The other area of research in the lab is to elucidate the mechanism by which myelin forms. Myelin is a multilamellar structure that ensheaths axons and allows for the rapid conduction of electrical signals, acts as a protective barrier for axons, regulates regeneration and provides trophic support for neurons. This structure is produced by Schwann cells in the peripheral nervous system and oligodendrocytes in the CNS. The formation of peripheral myelin during development is initiated by yet to be identified signals from the axon with which the Schwann cells are associated. The overall objective of this project is to elucidate the mechanisms regulating the formation of this essential neural structure. We found that activation of the transcription factor NF-¿B in Schwann cells is a critical factor for their differentiation into a myelinating phenotype and are currently investigating the role of NFkB in the normal differentiation process and in models of demyelinating neuropathies.

Publications
  • Yazlovitskaya EM, Tseng HY, Viquez O, Tu T, Mernaugh G, McKee KK, Riggins K, Quaranta V, Pathak A, Carter BD, Yurchenco P, Sonnenberg A, Böttcher RT, Pozzi A, Zent R. Integrin a3ß1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt. Mol. Biol. Cell [print-electronic]. 2015 May 5/15/2015; 26(10): 1857-74. PMID: 25808491, PMCID: PMC4436831, PII: mbc.E14-07-1203, DOI: 10.1091/mbc.E14-07-1203, ISSN: 1939-4586.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25808491.
  • Mobley BC, Kwon M, Kraemer BR, Hickman FE, Qiao J, Chung DH, Carter BD. Expression of MYCN in Multipotent Sympathoadrenal Progenitors Induces Proliferation and Neural Differentiation, but Is Not Sufficient for Tumorigenesis. PLoS ONE. 2015; 10(7): e0133897. PMID: 26222553, PMCID: PMC4519318, PII: PONE-D-15-06683, DOI: 10.1371/journal.pone.0133897, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26222553.
  • Kraemer BR, Snow JP, Vollbrecht P, Pathak A, Valentine WM, Deutch AY, Carter BD. A role for the p75 neurotrophin receptor in axonal degeneration and apoptosis induced by oxidative stress. J. Biol. Chem [print-electronic]. 2014 Aug 8/1/2014; 289(31): 21205-16. PMID: 24939843, PMCID: PMC4118083, PII: M114.563403, DOI: 10.1074/jbc.M114.563403, ISSN: 1083-351X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24939843.
  • Sullivan CS, Scheib JL, Ma Z, Dang RP, Schafer JM, Hickman FE, Brodsky FM, Ravichandran KS, Carter BD. The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism. Mol. Biol. Cell [print-electronic]. 2014 Jun 6/15/2014; 25(12): 1925-36. PMID: 24743597, PMCID: PMC4055271, PII: mbc.E13-11-0658, DOI: 10.1091/mbc.E13-11-0658, ISSN: 1939-4586.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24743597.
  • Escudero CA, Lazo OM, Galleguillos C, Parraguez JI, Lopez-Verrilli MA, Cabeza C, Leon L, Saeed U, Retamal C, Gonzalez A, Marzolo MP, Carter BD, Court FA, Bronfman FC. The p75 neurotrophin receptor evades the endolysosomal route in neuronal cells, favouring multivesicular bodies specialised for exosomal release. J. Cell. Sci [print-electronic]. 2014 May 5/1/2014; 127(Pt 9): 1966-79. PMID: 24569882, PMCID: PMC4004974, PII: jcs.141754, DOI: 10.1242/jcs.141754, ISSN: 1477-9137.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24569882.
  • Forsyth PA, Krishna N, Lawn S, Valadez JG, Qu X, Fenstermacher DA, Fournier M, Potthast L, Chinnaiyan P, Gibney GT, Zeinieh M, Barker PA, Carter BD, Cooper MK, Kenchappa RS. P75 neurotrophin receptor cleavage by a- and ¿-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells. J. Biol. Chem [print-electronic]. 2014 Mar 3/21/2014; 289(12): 8067-85. PMID: 24519935, PMCID: PMC3961639, PII: M113.513762, DOI: 10.1074/jbc.M113.513762, ISSN: 1083-351X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24519935.
  • Guo J, Wang L, Zhang Y, Wu J, Arpag S, Hu B, Imhof BA, Tian X, Carter BD, Suter U, Li J. Abnormal junctions and permeability of myelin in PMP22-deficient nerves. Ann. Neurol [print-electronic]. 2014 Feb; 75(2): 255-65. PMID: 24339129, PMCID: PMC4206215, DOI: 10.1002/ana.24086, ISSN: 1531-8249.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24339129.
  • Kraemer BR, Yoon SO, Carter BD. The biological functions and signaling mechanisms of the p75 neurotrophin receptor. Handb Exp Pharmacol. 2014; 220: 121-64. PMID: 24668472, DOI: 10.1007/978-3-642-45106-5_6, ISSN: 0171-2004.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24668472.
  • Lewin GR, Carter BD. Neurotrophic factors. Preface [editorial]. Handb Exp Pharmacol. 2014; 220: v-vi. PMID: 24941498, ISSN: 0171-2004.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24941498.
  • Schlebach JP, Peng D, Kroncke BM, Mittendorf KF, Narayan M, Carter BD, Sanders CR. Reversible folding of human peripheral myelin protein 22, a tetraspan membrane protein. Biochemistry [print-electronic]. 2013 May 5/14/2013; 52(19): 3229-41. PMID: 23639031, PMCID: PMC3762913, DOI: 10.1021/bi301635f, ISSN: 1520-4995.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23639031.
  • Limpert AS, Bai S, Narayan M, Wu J, Yoon SO, Carter BD, Lu QR. NF-¿B forms a complex with the chromatin remodeler BRG1 to regulate Schwann cell differentiation. J. Neurosci. 2013 Feb 2/6/2013; 33(6): 2388-97. PMID: 23392668, PMCID: PMC3711599, PII: 33/6/2388, DOI: 10.1523/JNEUROSCI.3223-12.2013, ISSN: 1529-2401.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23392668.
  • Wei C, Thatcher EJ, Olena AF, Cha DJ, Perdigoto AL, Marshall AF, Carter BD, Broadie K, Patton JG. MiR-153 regulates SNAP-25, synaptic transmission, and neuronal development. PLoS ONE [print-electronic]. 2013; 8(2): e57080. PMID: 23451149, PMCID: PMC3581580, PII: PONE-D-12-37460, DOI: 10.1371/journal.pone.0057080, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23451149.
  • Scheib JL, Sullivan CS, Carter BD. Jedi-1 and MEGF10 signal engulfment of apoptotic neurons through the tyrosine kinase Syk. J. Neurosci. 2012 Sep 9/19/2012; 32(38): 13022-31. PMID: 22993420, PMCID: PMC3464495, PII: 32/38/13022, DOI: 10.1523/JNEUROSCI.6350-11.2012, ISSN: 1529-2401.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22993420.
  • Benesh AE, Fleming JT, Chiang C, Carter BD, Tyska MJ. Expression and localization of myosin-1d in the developing nervous system. Brain Res [print-electronic]. 2012 Feb 2/27/2012; 1440: 9-22. PMID: 22284616, PMCID: PMC3278530, PII: S0006-8993(11)02323-7, DOI: 10.1016/j.brainres.2011.12.054, ISSN: 1872-6240.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22284616.
  • Tep C, Kim ML, Opincariu LI, Limpert AS, Chan JR, Appel B, Carter BD, Yoon SO. Brain-derived neurotrophic factor (BDNF) induces polarized signaling of small GTPase (Rac1) protein at the onset of Schwann cell myelination through partitioning-defective 3 (Par3) protein. J. Biol. Chem [print-electronic]. 2012 Jan 1/6/2012; 287(2): 1600-8. PMID: 22128191, PMCID: PMC3256919, PII: M111.312736, DOI: 10.1074/jbc.M111.312736, ISSN: 1083-351X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22128191.
  • Duggan KC, Hermanson DJ, Musee J, Prusakiewicz JJ, Scheib JL, Carter BD, Banerjee S, Oates JA, Marnett LJ. (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2. Nat. Chem. Biol. 2011 Nov; 7(11): 803-9. PMID: 22053353, PMCID: PMC3298755, ISSN: 1552-4469.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22053353.
  • Astuti D, Ricketts CJ, Chowdhury R, McDonough MA, Gentle D, Kirby G, Schlisio S, Kenchappa RS, Carter BD, Kaelin WG, Ratcliffe PJ, Schofield CJ, Latif F, Maher ER. Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility. Endocr. Relat. Cancer [electronic-print]. 2011 Feb; 18(1): 73-83. PMID: 20959442, PMCID: PMC3006001, PII: ERC-10-0113, DOI: 10.1677/ERC-10-0113, ISSN: 1479-6821.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20959442.
  • Perdigoto AL, Chaudhry N, Barnes GN, Filbin MT, Carter BD. A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons. Mol. Cell. Neurosci [print-electronic]. 2011 Jan; 46(1): 235-44. PMID: 20869442, PMCID: PMC3018674, PII: S1044-7431(10)00226-5, DOI: 10.1016/j.mcn.2010.09.006, ISSN: 1095-9327.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20869442.
  • Kenchappa RS, Tep C, Korade Z, Urra S, Bronfman FC, Yoon SO, Carter BD. P75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17. J. Biol. Chem [print-electronic]. 2010 Jun 6/25/2010; 285(26): 20358-68. PMID: 20421303, PMCID: PMC2888447, PII: M109.082834, DOI: 10.1074/jbc.M109.082834, ISSN: 1083-351X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20421303.
  • Carter BD, Feng N, Paolocci N. The p75 neurotrophin receptor, semaphorins, and sympathetic traffic in the heart [editorial]. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2010 Jun; 298(6): H1633-6. PMID: 20304820, PMCID: PMC2886656, PII: 00253.2010, DOI: 10.1152/ajpheart.00253.2010, ISSN: 1522-1539.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20304820.
  • Limpert AS, Carter BD. Axonal neuregulin 1 type III activates NF-kappaB in Schwann cells during myelin formation. J. Biol. Chem [print-electronic]. 2010 May 5/28/2010; 285(22): 16614-22. PMID: 20360002, PMCID: PMC2878070, PII: M109.098780, DOI: 10.1074/jbc.M109.098780, ISSN: 1083-351X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20360002.
  • Scheib JL, Carter BD. Eaters of the dead: glial precursors clear neuron corpses during development [editorial]. Cell Cycle [print-electronic]. 2010 May 5/15/2010; 9(10): 1867-8. PMID: 20436291, PMCID: PMC3093807, PII: 11678, ISSN: 1551-4005.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20436291.
  • Carter BD. Degeneration keeps axons on the straight and narrow. Nat. Neurosci. 2010 May; 13(5): 526-8. PMID: 20421896, PII: nn0510-526, DOI: 10.1038/nn0510-526, ISSN: 1546-1726.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20421896.
  • Wu HH, Bellmunt E, Scheib JL, Venegas V, Burkert C, Reichardt LF, Zhou Z, Fariñas I, Carter BD. Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor. Nat. Neurosci [print-electronic]. 2009 Dec; 12(12): 1534-41. PMID: 19915564, PMCID: PMC2834222, PII: nn.2446, DOI: 10.1038/nn.2446, ISSN: 1546-1726.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19915564.
  • Vilar M, Charalampopoulos I, Kenchappa RS, Reversi A, Klos-Applequist JM, Karaca E, Simi A, Spuch C, Choi S, Friedman WJ, Ericson J, Schiavo G, Carter BD, Ibáñez CF. Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor. J. Cell. Sci [print-electronic]. 2009 Sep 9/15/2009; 122(Pt 18): 3351-7. PMID: 19706676, PMCID: PMC2736866, PII: jcs.055061, DOI: 10.1242/jcs.055061, ISSN: 1477-9137.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19706676.
  • Korade Z, Kenchappa RS, Mirnics K, Carter BD. NRIF is a regulator of neuronal cholesterol biosynthesis genes. J. Mol. Neurosci [print-electronic]. 2009 Jun; 38(2): 152-8. PMID: 18677445, PMCID: PMC3118441, DOI: 10.1007/s12031-008-9136-9, ISSN: 0895-8696.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18677445.
  • Vilar M, Charalampopoulos I, Kenchappa RS, Simi A, Karaca E, Reversi A, Choi S, Bothwell M, Mingarro I, Friedman WJ, Schiavo G, Bastiaens PI, Verveer PJ, Carter BD, Ibáñez CF. Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron. 2009 Apr 4/16/2009; 62(1): 72-83. PMID: 19376068, PMCID: PMC2810632, PII: S0896-6273(09)00165-2, DOI: 10.1016/j.neuron.2009.02.020, ISSN: 1097-4199.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19376068.
  • Antar AA, Konopka JL, Campbell JA, Henry RA, Perdigoto AL, Carter BD, Pozzi A, Abel TW, Dermody TS. Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Cell Host Microbe. 2009 Jan 1/22/2009; 5(1): 59-71. PMID: 19154988, PMCID: PMC2642927, PII: S1931-3128(08)00398-3, DOI: 10.1016/j.chom.2008.12.001, ISSN: 1934-6069.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19154988.
  • Bertrand MJ, Kenchappa RS, Andrieu D, Leclercq-Smekens M, Nguyen HN, Carter BD, Muscatelli F, Barker PA, De Backer O. NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo. Cell Death Differ [print-electronic]. 2008 Dec; 15(12): 1921-9. PMID: 18772898, PMCID: PMC2735073, PII: cdd2008127, DOI: 10.1038/cdd.2008.127, ISSN: 1476-5403.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18772898.
  • Volosin M, Trotter C, Cragnolini A, Kenchappa RS, Light M, Hempstead BL, Carter BD, Friedman WJ. Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. J. Neurosci. 2008 Sep 9/24/2008; 28(39): 9870-9. PMID: 18815271, PMCID: PMC2578816, PII: 28/39/9870, DOI: 10.1523/JNEUROSCI.2841-08.2008, ISSN: 1529-2401.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18815271.
  • Yoon C, Korade Z, Carter BD. Protein kinase A-induced phosphorylation of the p65 subunit of nuclear factor-kappaB promotes Schwann cell differentiation into a myelinating phenotype. J. Neurosci. 2008 Apr 4/2/2008; 28(14): 3738-46. PMID: 18385332, PII: 28/14/3738, DOI: 10.1523/JNEUROSCI.4439-07.2008, ISSN: 1529-2401.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18385332.
  • Schlisio S, Kenchappa RS, Vredeveld LC, George RE, Stewart R, Greulich H, Shahriari K, Nguyen NV, Pigny P, Dahia PL, Pomeroy SL, Maris JM, Look AT, Meyerson M, Peeper DS, Carter BD, Kaelin WG. The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes Dev [print-electronic]. 2008 Apr 4/1/2008; 22(7): 884-93. PMID: 18334619, PMCID: PMC2279200, PII: gad.1648608, DOI: 10.1101/gad.1648608, ISSN: 0890-9369.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18334619.
  • Hundahl CA, Allen GC, Nyengaard JR, Dewilde S, Carter BD, Kelsen J, Hay-Schmidt A. Neuroglobin in the rat brain: localization. Neuroendocrinology [print-electronic]. 2008; 88(3): 173-82. PMID: 18451642, PII: 000129698, DOI: 10.1159/000129698, ISSN: 1423-0194.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18451642.
  • Qu S, Rinehart C, Wu HH, Wang SE, Carter B, Xin H, Kotlikoff M, Arteaga CL. Gene targeting of ErbB3 using a Cre-mediated unidirectional DNA inversion strategy. Genesis. 2006 Oct; 44(10): 477-86. PMID: 16991114, DOI: 10.1002/dvg.20243, ISSN: 1526-954X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16991114.
  • Kenchappa RS, Zampieri N, Chao MV, Barker PA, Teng HK, Hempstead BL, Carter BD. Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron. 2006 Apr 4/20/2006; 50(2): 219-32. PMID: 16630834, PII: S0896-6273(06)00179-6, DOI: 10.1016/j.neuron.2006.03.011, ISSN: 0896-6273.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16630834.
  • Carter BD. A Bex-cycle built for two. EMBO Rep. 2006 Apr; 7(4): 382-4. PMID: 16585938, PMCID: PMC1456923, PII: 7400675, DOI: 10.1038/sj.embor.7400675, ISSN: 1469-221X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16585938.
  • Geetha T, Kenchappa RS, Wooten MW, Carter BD. TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor. EMBO J [print-electronic]. 2005 Nov 11/16/2005; 24(22): 3859-68. PMID: 16252010, PMCID: PMC1283944, PII: 7600845, DOI: 10.1038/sj.emboj.7600845, ISSN: 0261-4189.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16252010.
  • Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG, Schlisio S. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell. 2005 Aug; 8(2): 155-67. PMID: 16098468, PII: S1535-6108(05)00224-2, DOI: 10.1016/j.ccr.2005.06.015, ISSN: 1535-6108.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16098468.
  • Linggi MS, Burke TL, Williams BB, Harrington A, Kraemer R, Hempstead BL, Yoon SO, Carter BD. Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor. J. Biol. Chem [print-electronic]. 2005 Apr 4/8/2005; 280(14): 13801-8. PMID: 15668238, PII: M410435200, DOI: 10.1074/jbc.M410435200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15668238.
  • Yeiser EC, Rutkoski NJ, Naito A, Inoue J, Carter BD. Neurotrophin signaling through the p75 receptor is deficient in traf6-/- mice. J. Neurosci. 2004 Nov 11/17/2004; 24(46): 10521-9. PMID: 15548667, PII: 24/46/10521, DOI: 10.1523/JNEUROSCI.1390-04.2004, ISSN: 1529-2401.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15548667.
  • Gentry JJ, Rutkoski NJ, Burke TL, Carter BD. A functional interaction between the p75 neurotrophin receptor interacting factors, TRAF6 and NRIF. J. Biol. Chem [print-electronic]. 2004 Apr 4/16/2004; 279(16): 16646-56. PMID: 14960584, PII: M309209200, DOI: 10.1074/jbc.M309209200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14960584.
  • Gentry JJ, Barker PA, Carter BD. The p75 neurotrophin receptor: multiple interactors and numerous functions. Prog. Brain Res. 2004; 146: 25-39. PMID: 14699954, PII: S0079-6123(03)46002-0, DOI: 10.1016/S0079-6123(03)46002-0, ISSN: 0079-6123.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14699954.
  • Nickols JC, Valentine W, Kanwal S, Carter BD. Activation of the transcription factor NF-kappaB in Schwann cells is required for peripheral myelin formation. Nat. Neurosci. 2003 Feb; 6(2): 161-7. PMID: 12514737, PII: nn995, DOI: 10.1038/nn995, ISSN: 1097-6256.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12514737.
  • Fainzilber M, Carter BD. From neurotrophins to immunotrophins. NGF 2002: The 7th international conference on NGF and related molecules. EMBO Rep. 2002 Nov; 3(11): 1029-34. PMID: 12429612, PMCID: PMC1307597, PII: 3/11/1029, DOI: 10.1093/embo-reports/kvf218, ISSN: 1469-221X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12429612.
  • Palmada M, Kanwal S, Rutkoski NJ, Gustafson-Brown C, Johnson RS, Wisdom R, Carter BD. C-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation. J. Cell Biol [print-electronic]. 2002 Aug 8/5/2002; 158(3): 453-61. PMID: 12163468, PMCID: PMC2173823, PII: jcb.200112129, DOI: 10.1083/jcb.200112129, ISSN: 0021-9525.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12163468.
  • Dobrowsky RT, Carter BD. P75 neurotrophin receptor signaling: mechanisms for neurotrophic modulation of cell stress?. J. Neurosci. Res. 2000 Aug 8/1/2000; 61(3): 237-43. PMID: 10900070, PII: 10.1002/1097-4547(20000801)61:3<237::AID-JNR1>3.0.CO;2-M, ISSN: 0360-4012.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10900070.
  • Gentry JJ, Casaccia-Bonnefil P, Carter BD. Nerve growth factor activation of nuclear factor kappaB through its p75 receptor is an anti-apoptotic signal in RN22 schwannoma cells. J. Biol. Chem. 2000 Mar 3/17/2000; 275(11): 7558-65. PMID: 10713062, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10713062.
  • Casademunt E, Carter BD, Benzel I, Frade JM, Dechant G, Barde YA. The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death. EMBO J. 1999 Nov 11/1/1999; 18(21): 6050-61. PMID: 10545116, PMCID: PMC1171670, DOI: 10.1093/emboj/18.21.6050, ISSN: 0261-4189.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10545116.
  • Dobrowsky RT, Carter BD. Coupling of the p75 neurotrophin receptor to sphingolipid signaling. Ann. N. Y. Acad. Sci. 1998 Jun 6/19/1998; 845: 32-45. PMID: 9668341, ISSN: 0077-8923.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9668341.
  • Chao, M., Casaccia-Bonnefil, P., Carter, B., Chittka, A., Kong, H. and Yoon, S.O. Neurotrophin receptors: mediators of life and death. Brain Res. Brain Res. Rev. 1998; 26: 295-301.
  • Yoon SO, Casaccia-Bonnefil P, Carter BD and Chao MV. Competitive signaling between TrkA and p75 NGF receptors determines cell survival. J Neurosci. 1998; 18: 3273-81.
  • Carter BD, Lewin GR. Neurotrophins live or let die: does p75NTR decide?. Neuron. 1997 Feb; 18(2): 187-90. PMID: 9052790, PII: S0896-6273(00)80259-7, ISSN: 0896-6273.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9052790.
  • Casaccia-Bonnefil P, Carter BD, Dobrowsky RT, Chao MV. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature. 1996 Oct 10/24/1996; 383(6602): 716-9. PMID: 8878481, DOI: 10.1038/383716a0, ISSN: 0028-0836.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8878481.
  • Strohmaier C, Carter BD, Urfer R, Barde YA, Dechant G. A splice variant of the neurotrophin receptor trkB with increased specificity for brain-derived neurotrophic factor. EMBO J. 1996 Jul 7/1/1996; 15(13): 3332-7. PMID: 8670834, PMCID: PMC451896, ISSN: 0261-4189.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8670834.
  • Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhäuser N, Böhm-Matthaei R, Baeuerle PA, Barde YA. Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75. Science. 1996 Apr 4/26/1996; 272(5261): 542-5. PMID: 8614802, ISSN: 0036-8075.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8614802.
  • Carter BD, Dechant G, Frade JM, Kaltschmidt C, Barde YA. Neurotrophins and their p75 receptor. Cold Spring Harb. Symp. Quant. Biol. 1996; 61: 407-15. PMID: 9246469, ISSN: 0091-7451.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9246469.
  • Carter BD, Zirrgiebel U, Barde YA. Differential regulation of p21ras activation in neurons by nerve growth factor and brain-derived neurotrophic factor. J. Biol. Chem. 1995 Sep 9/15/1995; 270(37): 21751-7. PMID: 7665594, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7665594.
  • Biffo S, Offenhäuser N, Carter BD, Barde YA. Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development. Development. 1995 Aug; 121(8): 2461-70. PMID: 7671810, ISSN: 0950-1991.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7671810.
  • Carter BD, Medzihradsky F. Go mediates the coupling of the mu opioid receptor to adenylyl cyclase in cloned neural cells and brain. Proc. Natl. Acad. Sci. U.S.A. 1993 May 5/1/1993; 90(9): 4062-6. PMID: 8097884, PMCID: PMC46446, ISSN: 0027-8424.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8097884.
  • Carter BD, Medzihradsky F. Receptor mechanisms of opioid tolerance in SH-SY5Y human neural cells. Mol. Pharmacol. 1993 Mar; 43(3): 465-73. PMID: 8383804, ISSN: 0026-895X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8383804.
  • Carter BD, Medzihradsky F. Opioid signal transduction in intact and fragmented SH-SY5Y neural cells. J. Neurochem. 1992 May; 58(5): 1611-9. PMID: 1560222, ISSN: 0022-3042.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1560222.
  • Medzihradsky, F. and B.D. Carter. Opioid receptor mechanisms. Chapt. 10 of Biochemistry and Physiology of Substance Abuse (Watson, R.R. ed.) CRC Press Inc., Boca Raton, Fl. 1991.
  • Clark MJ, Carter BD, Medzihradsky F. Selectivity of ligand binding to opioid receptors in brain membranes from the rat, monkey and guinea pig. Eur. J. Pharmacol. 1988 Apr 4/13/1988; 148(3): 343-51. PMID: 2898375, ISSN: 0014-2999.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2898375.