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Bryan J. Venters, Ph.D.

Assistant Professor of Molecular Physiology & Biophysics

Contact Information:

746A Robinson Research Building
Nashville, TN 37232
615-761-4533

Profile

A fundamental question in molecular biology is how human disease is programmed into the genome.  The overarching goal of my laboratory is to elucidate the transcription regulatory networks underlying oncogenic signaling pathways.  STAT transcription factors in the JAK-STAT pathway (Janus Kinase-Signal Transducer and Activator of Transcription) are among the most frequently activated oncogenic proteins in cancer cells.
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A fundamental question in molecular biology is how human disease is programmed into the genome.  The overarching goal of my laboratory is to elucidate the transcription regulatory networks underlying oncogenic signaling pathways.  STAT transcription factors in the JAK-STAT pathway (Janus Kinase-Signal Transducer and Activator of Transcription) are among the most frequently activated oncogenic proteins in cancer cells.  My current research is focused on discovering how the JAK-STAT pathway is involved in the disease process using genetic, molecular, and next-gen sequencing approaches.

Education
2008 - PhD, Pennsylvania State University2000 - BS, Oklahoma State University
Research Description

A fundamental question in molecular biology is how human disease is programmed into the genome. The overarching goal of my laboratory is to elucidate the transcription regulatory networks underlying oncogenic signaling pathways. STAT transcription factors in the JAK-STAT pathway (Janus Kinase-Signal Transducer and Activator of Transcription) are among the most frequently activated oncogenic proteins in cancer cells. My current research is focused on discovering how the JAK-STAT pathway is involved in the disease process using genetic, molecular, and next-gen sequencing approaches.

The goals of some current projects in my laboratory are to:

- Understand how STATs direct aberrant transcriptional programs in leukemia using stat-of-the-art functional genomics approaches

- Dissect the functional interdependencies among STATs on a genome-wide scale

- Identifying regulatory complexes that are recruited by the STAT transcription factors

- Discover novel molecular signatures in clinical samples with the future goal to better predict patient prognosis and identify new therapeutic targets

Publications
  • Venters BJ, Irvin JD, Gramlich P, Pugh BF. Genome-wide transcriptional dependence on conserved regions of Mot1. Mol. Cell. Biol [print-electronic]. 2011 Jun; 31(11): 2253-61. PMID: 21444714, PMCID: PMC3133245, PII: MCB.01464-10, DOI: 10.1128/MCB.01464-10, ISSN: 1098-5549.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21444714.
  • Venters BJ, Wachi S, Mavrich TN, Andersen BE, Jena P, Sinnamon AJ, Jain P, Rolleri NS, Jiang C, Hemeryck-Walsh C, Pugh BF. A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces. Mol. Cell. 2011 Feb 2/18/2011; 41(4): 480-92. PMID: 21329885, PMCID: PMC3057419, PII: S1097-2765(11)00042-6, DOI: 10.1016/j.molcel.2011.01.015, ISSN: 1097-4164.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21329885.
  • Venters BJ, Pugh BF. How eukaryotic genes are transcribed. Crit. Rev. Biochem. Mol. Biol. 2009 Jun; 44(2-3): 117-41. PMID: 19514890, PMCID: PMC2718758, DOI: 10.1080/10409230902858785, ISSN: 1549-7798.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19514890.
  • Venters BJ, Pugh BF. A canonical promoter organization of the transcription machinery and its regulators in the Saccharomyces genome. Genome Res [print-electronic]. 2009 Mar; 19(3): 360-71. PMID: 19124666, PMCID: PMC2661807, PII: gr.084970.108, DOI: 10.1101/gr.084970.108, ISSN: 1088-9051.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19124666.
  • Yao H, Li P, Venters BJ, Zheng S, Thompson PR, Pugh BF, Wang Y. Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis. J. Biol. Chem [print-electronic]. 2008 Jul 7/18/2008; 283(29): 20060-8. PMID: 18499678, PMCID: PMC2459274, PII: M802940200, DOI: 10.1074/jbc.M802940200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18499678.
  • Mavrich TN, Ioshikhes IP, Venters BJ, Jiang C, Tomsho LP, Qi J, Schuster SC, Albert I, Pugh BF. A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome. Genome Res [print-electronic]. 2008 Jul; 18(7): 1073-83. PMID: 18550805, PMCID: PMC2493396, PII: gr.078261.108, DOI: 10.1101/gr.078261.108, ISSN: 1088-9051.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18550805.
  • Mavrich TN, Jiang C, Ioshikhes IP, Li X, Venters BJ, Zanton SJ, Tomsho LP, Qi J, Glaser RL, Schuster SC, Gilmour DS, Albert I, Pugh BF. Nucleosome organization in the Drosophila genome. Nature [print-electronic]. 2008 May 5/15/2008; 453(7193): 358-62. PMID: 18408708, PMCID: PMC2735122, PII: nature06929, DOI: 10.1038/nature06929, ISSN: 1476-4687.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18408708.
  • Lee C, Li X, Hechmer A, Eisen M, Biggin MD, Venters BJ, Jiang C, Li J, Pugh BF, Gilmour DS. NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila. Mol. Cell. Biol [print-electronic]. 2008 May; 28(10): 3290-300. PMID: 18332113, PMCID: PMC2423147, PII: MCB.02224-07, DOI: 10.1128/MCB.02224-07, ISSN: 1098-5549.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18332113.
  • Cheng L, Naumann TA, Horswill AR, Hong SJ, Venters BJ, Tomsho JW, Benkovic SJ, Keiler KC. Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease. Protein Sci [print-electronic]. 2007 Aug; 16(8): 1535-42. PMID: 17600141, PMCID: PMC2203360, PII: ps.072933007, DOI: 10.1110/ps.072933007, ISSN: 0961-8368.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17600141.
  • Lessner FH, Venters BJ, Keiler KC. Proteolytic adaptor for transfer-messenger RNA-tagged proteins from alpha-proteobacteria. J. Bacteriol [print-electronic]. 2007 Jan; 189(1): 272-5. PMID: 17085560, PMCID: PMC1797230, PII: JB.01387-06, DOI: 10.1128/JB.01387-06, ISSN: 0021-9193.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17085560.
  • Venters BJ, Pugh BF. Chromatin meets RNA polymerase II. Genome Biol. 2007; 8(11): 319. PMID: 18001505, PMCID: PMC2258197, PII: gb-2007-8-11-319, DOI: 10.1186/gb-2007-8-11-319, ISSN: 1474-760X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18001505.