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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center


Charles K. Singleton, Ph.D.

Professor of Biological Sciences
Chair, Biological Sciences Department

Contact Information:

Vanderbilt University Medical Center
Box 1634, Station B
Nashville, TN 37232

Research Specialty

Cell-cell and cell-environment signaling during development.

Research Description

We investigate a variety of regulatory phenomena related to various aspects of development in Dictyostelium. This includes studies on sensory histidine kinases, trans-sensor ammonia transporters, and eIF2-alpha kinases in relation to their role in regulating aspects of multicellular development. The common theme is how communication amoung cells and between cells and their environment is accomplished and implemented to allow coordinated morphological development and cell differentiation. Our studies include the mechamisms underlying the regulation of the timing of development, the choice between alternative developmental pathways, the coordination of differentiation and morphogenesis, and the transition from growth to multicellular development. Our main approaches are genetic, molecular genetic, and biochemical.