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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

Chin  Chiang

Chin Chiang, Ph.D.

Professor of Cell and Developmental Biology

Contact Information:

Vanderbilt University Medical Center
4110-A Medical Center North
Nashville, TN 37232-8240

Research Specialty

Hedgehog signaling in development and cancer

Research Description

Our research focuses on the role Sonic hedgehog signaling plays in the pathogenesis of the two most common types of pediatric cancers, soft tissue sarcomas and brain tumors. We study the tumor cells-of-origin, initiation and propagation. In addition, we are also interested in identifying tumor biomarkers and compounds that inhibit their growth. We use state of the art approaches that include stem cell manipulation, molecular genetics, orthotopic grafting, proteomics, genome-wide RNA sequencing and CHIP.

Another area of interest is to understand how the complex brain circuitry is established from a rather small number of neural stem cells. We study signaling pathways that regulate brain stem cell proliferation and differentiation.