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Christopher V. Wright, Ph.D.

Louise B. McGavock Professor of Cell and Developmental Biology
Researcher

Contact Information:

Vanderbilt University Medical Center
3140 Medical Research Building III
Nashville, TN 37232-8240
615-343-8256

Education
  • D.Phil., University of Oxford, Oxford, United Kingdom (1984)
  • B.Sc., University of Warwick, Coventry, United Kingdom (1980) 
Research Description

Vertebrate embryos form from initially symmetric fertilized eggs as a result of progressively more complex interactions between differently programmed groups of daughter cells that arise from the cleavage of the zygote. We are studying secreted intercellular signaling molecules or transcription factors that dictate cell fates in different parts of the embryo. These include the TGF -superfamily members nodal and BMP4 (and their transmembrane kinase receptors), and homeodomain-containing transcription factors, which are expressed according to the type of extracellular signals received by a cell. Our main model systems are the frog and mouse. Frog embryos can be microinjected with plasmids, mRNA, proteins and antibodies, and the large number of embryos available allows biochemical studies. In contrast, the mouse allows genetic analysis of function. We can transgenically misexpress proteins, or genes can be inactivated or mutated by gene recombination in ES cells. The latter can be done globally, or tissue-specifically, by inactivation techniques that can be targeted to chosen tissues and switched on/off as required.

Proof of the power of these strategies comes from our finding that inactivating the pdx-1 homeobox gene completely prevents the formation of the pancreas; similar defects have been found in newborn humans with pdx-1 mutations.

Furthermore, PDX-1 is probably an essential transcriptional regulator of the insulin gene, and/or other genes involved in cell function in the Islets of Langerhans of the adult pancreas. We are determining the cis-elements activating pdx-1 in the embryonic pancreas and adult endocrine cells, studying endocrine/exocrine lineage pathways, and determining the precise role of pdx-1 and other transcriptional regulators such as the bHLH factor Ptf1a in pancreas formation, function and insulin expression. We are specifically interested in identifying pancreatic stem cells and finding ways to convert embryonic or adult stem cells (which may come from the bone marrow, nervous system, or from within the pancreas itself) into pancreatic tissue, ultimately for transplantation therapy of diabetes. We have recently found evidence that the expression of Ptf1a dictates an organ choice of endodermal stem cells between duodenal and pancreatic fates. These studies involved nactivating Ptf1a in mouse, together with lineage tracing techniques for following cells after inactivation.

Different vertebrates have variable numbers of nodal-related genes, which encode intercellular signaling molecules that induce profound alterations in cell fate or behaviours such as migration. A particularly exciting discovery made a few years ago was that a frog nodal-related gene, Xnr-1, is expressed only on the embryo's left side, where it acts to specify a "left-right" asymmetry involved in the formation of the stereotypical and required internal asymmetric anatomy of the heart, vascular system, and viscera. We are mapping the cis-acting sequences controlling Xnr-1 expression to characterize the factors activating its expression in these fascinating patterns, and investigating the extracellular regulation of this cell-cell signaling molecule. In addition, our finding that the classical zebrafish mutant, cyclops, corresponds to a lesion in a nodal-related gene has introduced new concepts regarding the timing and players involved in establishing precursors of the floor plate, an organizing tissue located ventrally in the neural tube that is required for normal CNS patterning.

Our long-term goal is to provide insight into the molecular mechanisms responsible for the coordinated development of complex organ systems, with deep relevance to human congenital birth defects.

Publications
  • Blum M, Schweickert A, Vick P, Wright CV, Danilchik MV. Symmetry breakage in the vertebrate embryo: when does it happen and how does it work?. Dev. Biol [print-electronic]. 2014 Sep 9/1/2014; 393(1): 109-23. PMID: 24972089, PMCID: PMC4481729, PII: S0012-1606(14)00310-8, DOI: 10.1016/j.ydbio.2014.06.014, ISSN: 1095-564X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24972089.
  • Van de Casteele M, Leuckx G, Cai Y, Yuchi Y, Coppens V, De Groef S, Van Gassen N, Baeyens L, Heremans Y, Wright CV, Heimberg H. Partial duct ligation: ß-cell proliferation and beyond. Diabetes. 2014 Aug; 63(8): 2567-77. PMID: 25060885, PII: 63/8/2567, DOI: 10.2337/db13-0831, ISSN: 1939-327X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25060885.
  • Halpern ME, Hobert O, Wright CV. Left-right asymmetry: advances and enigmas. Genesis. 2014 Jun; 52(6): 451-4. PMID: 24943067, DOI: 10.1002/dvg.22791, ISSN: 1526-968X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24943067.
  • Reinert RB, Cai Q, Hong JY, Plank JL, Aamodt K, Prasad N, Aramandla R, Dai C, Levy SE, Pozzi A, Labosky PA, Wright CV, Brissova M, Powers AC. Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding. Development [print-electronic]. 2014 Apr; 141(7): 1480-91. PMID: 24574008, PMCID: PMC3957372, PII: dev.098657, DOI: 10.1242/dev.098657, ISSN: 1477-9129.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24574008.
  • von Figura G, Morris JP, Wright CV, Hebrok M. Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut [print-electronic]. 2014 Apr; 63(4): 656-64. PMID: 23645620, PMCID: PMC3883808, PII: gutjnl-2012-304287, DOI: 10.1136/gutjnl-2012-304287, ISSN: 1468-3288.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23645620.
  • Rieck S, Wright C. PIQ-ing into chromatin architecture. Nat. Biotechnol. 2014 Feb; 32(2): 138-40. PMID: 24509760, PII: nbt.2824, DOI: 10.1038/nbt.2824, ISSN: 1546-1696.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24509760.
  • Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CV, Van de Casteele M, German MS, Bouwens L, Heimberg H. Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice. Nat. Biotechnol [print-electronic]. 2014 Jan; 32(1): 76-83. PMID: 24240391, PMCID: PMC4096987, PII: nbt.2747, DOI: 10.1038/nbt.2747, ISSN: 1546-1696.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24240391.
  • Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC. Identification and manipulation of biliary metaplasia in pancreatic tumors. Gastroenterology [print-electronic]. 2014 Jan; 146(1): 233-44.e5. PMID: 23999170, PMCID: PMC3870045, PII: S0016-5085(13)01273-0, DOI: 10.1053/j.gastro.2013.08.053, ISSN: 1528-0012.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23999170.
  • Seto Y, Nakatani T, Masuyama N, Taya S, Kumai M, Minaki Y, Hamaguchi A, Inoue YU, Inoue T, Miyashita S, Fujiyama T, Yamada M, Chapman H, Campbell K, Magnuson MA, Wright CV, Kawaguchi Y, Ikenaka K, Takebayashi H, Ishiwata S, Ono Y, Hoshino M. Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum. Nat Commun. 2014; 5: 3337. PMID: 24535035, PII: ncomms4337, DOI: 10.1038/ncomms4337, ISSN: 2041-1723.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24535035.
  • Fleming JT, He W, Hao C, Ketova T, Pan FC, Wright CC, Litingtung Y, Chiang C. The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors. Dev. Cell. 2013 Nov 11/11/2013; 27(3): 278-92. PMID: 24229643, PMCID: PMC3860749, PII: S1534-5807(13)00605-9, DOI: 10.1016/j.devcel.2013.10.008, ISSN: 1878-1551.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24229643.
  • Guo L, Inada A, Aguayo-Mazzucato C, Hollister-Lock J, Fujitani Y, Weir GC, Wright CV, Sharma A, Bonner-Weir S. PDX1 in ducts is not required for postnatal formation of ß-cells but is necessary for their subsequent maturation. Diabetes [print-electronic]. 2013 Oct; 62(10): 3459-68. PMID: 23775765, PMCID: PMC3781453, PII: db12-1833, DOI: 10.2337/db12-1833, ISSN: 1939-327X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23775765.
  • Lawson AK, Wright CV, Fitzgerald LF. The evaluation of sexual harassment litigants: reducing discrepancies in the diagnosis of posttraumatic stress disorder. Law Hum Behav [print-electronic]. 2013 Oct; 37(5): 337-47. PMID: 23544390, PII: 2013-11405-001, DOI: 10.1037/lhb0000024, ISSN: 1573-661X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23544390.
  • Sugiyama T, Benitez CM, Ghodasara A, Liu L, McLean GW, Lee J, Blauwkamp TA, Nusse R, Wright CV, Gu G, Kim SK. Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2013 Jul 7/30/2013; 110(31): 12691-6. PMID: 23852729, PMCID: PMC3732989, PII: 1304507110, DOI: 10.1073/pnas.1304507110, ISSN: 1091-6490.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23852729.
  • Lancman JJ, Zvenigorodsky N, Gates KP, Zhang D, Solomon K, Humphrey RK, Kuo T, Setiawan L, Verkade H, Chi YI, Jhala US, Wright CV, Stainier DY, Dong PD. Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb. Development [print-electronic]. 2013 Jul; 140(13): 2669-79. PMID: 23720049, PMCID: PMC3678338, PII: dev.090993, DOI: 10.1242/dev.090993, ISSN: 1477-9129.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23720049.
  • Liu J, Willet SG, Bankaitis ED, Xu Y, Wright CV, Gu G. Non-parallel recombination limits Cre-LoxP-based reporters as precise indicators of conditional genetic manipulation. Genesis [print-electronic]. 2013 Jun; 51(6): 436-42. PMID: 23441020, PMCID: PMC3696028, DOI: 10.1002/dvg.22384, ISSN: 1526-968X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23441020.
  • Pan FC, Bankaitis ED, Boyer D, Xu X, Van de Casteele M, Magnuson MA, Heimberg H, Wright CV. Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development [print-electronic]. 2013 Feb; 140(4): 751-64. PMID: 23325761, PMCID: PMC3557774, PII: dev.090159, DOI: 10.1242/dev.090159, ISSN: 1477-9129.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23325761.
  • Kopp JL, von Figura G, Mayes E, Liu FF, Dubois CL, Morris JP, Pan FC, Akiyama H, Wright CV, Jensen K, Hebrok M, Sander M. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell [print-electronic]. 2012 Dec 12/11/2012; 22(6): 737-50. PMID: 23201164, PMCID: PMC3568632, PII: S1535-6108(12)00449-7, DOI: 10.1016/j.ccr.2012.10.025, ISSN: 1878-3686.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23201164.
  • Rieck S, Bankaitis ED, Wright CV. Lineage determinants in early endocrine development. Semin. Cell Dev. Biol [print-electronic]. 2012 Aug; 23(6): 673-84. PMID: 22728667, PMCID: PMC3922538, PII: S1084-9521(12)00115-2, DOI: 10.1016/j.semcdb.2012.06.005, ISSN: 1096-3634.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22728667.
  • Potter LA, Choi E, Hipkens SB, Wright CV, Magnuson MA. A recombinase-mediated cassette exchange-derived cyan fluorescent protein reporter allele for Pdx1. Genesis [print-electronic]. 2012 Apr; 50(4): 384-92. PMID: 21913313, PMCID: PMC3870909, DOI: 10.1002/dvg.20804, ISSN: 1526-968X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21913313.
  • Kopinke D, Brailsford M, Pan FC, Magnuson MA, Wright CV, Murtaugh LC. Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev. Biol [print-electronic]. 2012 Feb 2/1/2012; 362(1): 57-64. PMID: 22146645, PMCID: PMC3254730, PII: S0012-1606(11)01392-3, DOI: 10.1016/j.ydbio.2011.11.010, ISSN: 1095-564X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22146645.
  • Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV. Context-specific a- to-ß-cell reprogramming by forced Pdx1 expression. Genes Dev. 2011 Aug 8/15/2011; 25(16): 1680-5. PMID: 21852533, PMCID: PMC3165933, PII: 25/16/1680, DOI: 10.1101/gad.16875711, ISSN: 1549-5477.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21852533.
  • Dorrell C, Grompe MT, Pan FC, Zhong Y, Canaday PS, Shultz LD, Greiner DL, Wright CV, Streeter PR, Grompe M. Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Mol. Cell. Endocrinol [print-electronic]. 2011 Jun 6/6/2011; 339(1-2): 144-50. PMID: 21539888, PMCID: PMC3112273, PII: S0303-7207(11)00206-1, DOI: 10.1016/j.mce.2011.04.008, ISSN: 1872-8057.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21539888.
  • Pan FC, Wright C. Pancreas organogenesis: from bud to plexus to gland. Dev. Dyn. 2011 Mar; 240(3): 530-65. PMID: 21337462, DOI: 10.1002/dvdy.22584, ISSN: 1097-0177.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21337462.
  • Marjoram L, Wright C. Rapid differential transport of Nodal and Lefty on sulfated proteoglycan-rich extracellular matrix regulates left-right asymmetry in Xenopus. Development. 2011 Feb; 138(3): 475-85. PMID: 21205792, PMCID: PMC3014634, PII: 138/3/475, DOI: 10.1242/dev.056010, ISSN: 1477-9129.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21205792.
  • Wang S, Yan J, Anderson DA, Xu Y, Kanal MC, Cao Z, Wright CV, Gu G. Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas. Dev. Biol [print-electronic]. 2010 Mar 3/1/2010; 339(1): 26-37. PMID: 20025861, PMCID: PMC2824035, PII: S0012-1606(09)01398-0, DOI: 10.1016/j.ydbio.2009.12.009, ISSN: 1095-564X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20025861.
  • Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L. Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J. Biol. Chem [print-electronic]. 2009 Nov 11/6/2009; 284(45): 31236-48. PMID: 19759004, PMCID: PMC2781522, PII: M109.048694, DOI: 10.1074/jbc.M109.048694, ISSN: 1083-351X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19759004.
  • Betley JN, Wright CV, Kawaguchi Y, Erdélyi F, Szabó G, Jessell TM, Kaltschmidt JA. Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit. Cell. 2009 Oct 10/2/2009; 139(1): 161-74. PMID: 19804761, PMCID: PMC2812434, PII: S0092-8674(09)01048-4, DOI: 10.1016/j.cell.2009.08.027, ISSN: 1097-4172.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19804761.
  • Skuntz S, Mankoo B, Nguyen MT, Hustert E, Nakayama A, Tournier-Lasserve E, Wright CV, Pachnis V, Bharti K, Arnheiter H. Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. Dev. Biol [print-electronic]. 2009 Aug 8/15/2009; 332(2): 383-95. PMID: 19520072, PMCID: PMC2898144, PII: S0012-1606(09)00917-8, DOI: 10.1016/j.ydbio.2009.06.006, ISSN: 1095-564X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19520072.
  • Yang YP, Wright C. Chemicals turn human embryonic stem cells towards beta cells. Nature chemical biology. 2009 Apr; 5(4) Sect. 195,6.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19295520.
  • Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Kawaguchi M, Terao M, Doi R, Wright CV, Hoshino M, Chiba T, Uemoto S. Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes in mice. Diabetes [print-electronic]. 2008 Sep; 57(9): 2421-31. PMID: 18591390, PMCID: PMC2518493, PII: db07-1558, DOI: 10.2337/db07-1558, ISSN: 1939-327X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18591390.
  • Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA. Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev. Biol [print-electronic]. 2008 Apr 4/1/2008; 316(1): 74-86. PMID: 18294628, PMCID: PMC2425677, PII: S0012-1606(08)00034-1, DOI: 10.1016/j.ydbio.2008.01.011, ISSN: 1095-564X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18294628.
  • Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV. Pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev. Biol [print-electronic]. 2008 Feb 2/15/2008; 314(2): 406-17. PMID: 18155690, PMCID: PMC2269701, PII: S0012-1606(07)01464-9, DOI: 10.1016/j.ydbio.2007.10.038, ISSN: 1095-564X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18155690.
  • Dokmanovic-Chouinard M, Chung WK, Chevre JC, Watson E, Yonan J, Wiegand B, Bromberg Y, Wakae N, Wright CV, Overton J, Ghosh S, Sathe GM, Ammala CE, Brown KK, Ito R, LeDuc C, Solomon K, Fischer SG, Leibel RL. Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genet. 2008; 4(7): e1000137. PMID: 18654634, PMCID: PMC2464733, DOI: 10.1371/journal.pgen.1000137, ISSN: 1553-7404.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18654634.
  • Keller DM, McWeeney S, Arsenlis A, Drouin J, Wright CV, Wang H, Wollheim CB, White P, Kaestner KH, Goodman RH. Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. J. Biol. Chem [print-electronic]. 2007 Nov 11/2/2007; 282(44): 32084-92. PMID: 17761679, PII: M700899200, DOI: 10.1074/jbc.M700899200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17761679.
  • Westmoreland JJ, Takahashi S, Wright CV. Xenopus Lefty requires proprotein cleavage but not N-linked glycosylation to inhibit nodal signaling. Dev. Dyn. 2007 Aug; 236(8): 2050-61. PMID: 17584861, DOI: 10.1002/dvdy.21210, ISSN: 1058-8388.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17584861.
  • Wiebe PO, Kormish JD, Roper VT, Fujitani Y, Alston NI, Zaret KS, Wright CV, Stein RW, Gannon M. Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Mol. Cell. Biol [print-electronic]. 2007 Jun; 27(11): 4093-104. PMID: 17403901, PMCID: PMC1900007, PII: MCB.01978-06, DOI: 10.1128/MCB.01978-06, ISSN: 0270-7306.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17403901.
  • Jarikji ZH, Vanamala S, Beck CW, Wright CV, Leach SD, Horb ME. Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreas. Dev. Biol [print-electronic]. 2007 Apr 4/15/2007; 304(2): 786-99. PMID: 17320068, PII: S0012-1606(07)00063-2, DOI: 10.1016/j.ydbio.2007.01.027, ISSN: 0012-1606.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17320068.
  • Morton JP, Mongeau ME, Klimstra DS, Morris JP, Lee YC, Kawaguchi Y, Wright CV, Hebrok M, Lewis BC. Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2007 Mar 3/20/2007; 104(12): 5103-8. PMID: 17372229, PMCID: PMC1828712, PII: 0701158104, DOI: 10.1073/pnas.0701158104, ISSN: 0027-8424.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17372229.
  • Pascual M, Abasolo I, Mingorance-Le Meur A, Martínez A, Del Rio JA, Wright CV, Real FX, Soriano E. Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2007 Mar 3/20/2007; 104(12): 5193-8. PMID: 17360405, PMCID: PMC1829285, PII: 0605699104, DOI: 10.1073/pnas.0605699104, ISSN: 0027-8424.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17360405.
  • Ohi Y, Wright CV. Anteriorward shifting of asymmetric Xnr1 expression and contralateral communication in left-right specification in Xenopus. Dev. Biol [print-electronic]. 2007 Jan 1/15/2007; 301(2): 447-63. PMID: 16959238, PMCID: PMC2567117, PII: S0012-1606(06)01091-8, DOI: 10.1016/j.ydbio.2006.08.021, ISSN: 0012-1606.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16959238.
  • Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, Fujitani S, Wright CV, Moses HL. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev. 2006 Nov 11/15/2006; 20(22): 3147-60. PMID: 17114585, PMCID: PMC1635149, PII: 20/22/3147, DOI: 10.1101/gad.1475506, ISSN: 0890-9369.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17114585.
  • Fujitani Y, Fujitani S, Luo H, Qiu F, Burlison J, Long Q, Kawaguchi Y, Edlund H, MacDonald RJ, Furukawa T, Fujikado T, Magnuson MA, Xiang M, Wright CV. Ptf1a determines horizontal and amacrine cell fates during mouse retinal development. Development. 2006 Nov; 133(22): 4439-50. PMID: 17075007, PII: 133/22/4439, DOI: 10.1242/dev.02598, ISSN: 0950-1991.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17075007.
  • Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev. Biol [print-electronic]. 2006 Oct 10/15/2006; 298(2): 616-31. PMID: 16962573, PII: S0012-1606(06)01026-8, DOI: 10.1016/j.ydbio.2006.07.020, ISSN: 0012-1606.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16962573.
  • Takahashi S, Onuma Y, Yokota C, Westmoreland JJ, Asashima M, Wright CV. Nodal-related gene Xnr5 is amplified in the Xenopus genome. Genesis. 2006 Jul; 44(7): 309-21. PMID: 16791846, DOI: 10.1002/dvg.20217, ISSN: 1526-954X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16791846.
  • Miyatsuka T, Kaneto H, Shiraiwa T, Matsuoka TA, Yamamoto K, Kato K, Nakamura Y, Akira S, Takeda K, Kajimoto Y, Yamasaki Y, Sandgren EP, Kawaguchi Y, Wright CV, Fujitani Y. Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev. 2006 Jun 6/1/2006; 20(11): 1435-40. PMID: 16751181, PMCID: PMC1475756, PII: 20/11/1435, DOI: 10.1101/gad.1412806, ISSN: 0890-9369.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16751181.
  • Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Koizumi M, Boyer DF, Fujimoto K, Doi R, Kageyama R, Wright CV, Chiba T. Ectopic pancreas formation in Hes1 -knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J. Clin. Invest [print-electronic]. 2006 Jun; 116(6): 1484-93. PMID: 16710472, PMCID: PMC1462947, DOI: 10.1172/JCI27704, ISSN: 0021-9738.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16710472.
  • Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Kuhara T, Horiguchi M, Koizumi M, Fujimoto K, Doi R, Wright CV, Chiba T. Loss of the major duodenal papilla results in brown pigment biliary stone formation in pdx1 null mice. Gastroenterology. 2006 Mar; 130(3): 855-67. PMID: 16530524, PII: S0016-5085(05)02316-4, DOI: 10.1053/j.gastro.2005.11.031, ISSN: 0016-5085.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16530524.
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  • Nomura S, Settle SH, Leys CM, Means AL, Peek RM, Leach SD, Wright CV, Coffey RJ, Goldenring JR. Evidence for repatterning of the gastric fundic epithelium associated with Ménétrier's disease and TGFalpha overexpression. Gastroenterology. 2005 May; 128(5): 1292-305. PMID: 15887112, PII: S0016508505004038, ISSN: 0016-5085.
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  • Jepeal LI, Fujitani Y, Boylan MO, Wilson CN, Wright CV, Wolfe MM. Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1. Endocrinology [print-electronic]. 2005 Jan; 146(1): 383-91. PMID: 15486225, PII: en.2004-0223, DOI: 10.1210/en.2004-0223, ISSN: 0013-7227.
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  • Mankoo BS, Skuntz S, Harrigan I, Grigorieva E, Candia A, Wright CV, Arnheiter H, Pachnis V. The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites. Development. 2003 Oct; 130(19): 4655-64. PMID: 12925591, PII: 130/19/4655, DOI: 10.1242/dev.00687, ISSN: 0950-1991.
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  • Means AL, Ray KC, Singh AB, Washington MK, Whitehead RH, Harris RC, Wright CV, Coffey RJ, Leach SD. Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology. 2003 Apr; 124(4): 1020-36. PMID: 12671899, PII: S0016508503000647, DOI: 10.1053/gast.2003.50150, ISSN: 0016-5085.
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  • Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH, Wright CV, White MF, Arden KC, Accili D. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J. Clin. Invest. 2002 Dec; 110(12): 1839-47. PMID: 12488434, PMCID: PMC151657, DOI: 10.1172/JCI16857, ISSN: 0021-9738.
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  • Nakae J, Biggs WH, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D. Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat. Genet [print-electronic]. 2002 Oct; 32(2): 245-53. PMID: 12219087, PII: ng890, DOI: 10.1038/ng890, ISSN: 1061-4036.
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  • Samaras SE, Cissell MA, Gerrish K, Wright CV, Gannon M, Stein R. Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6. Mol. Cell. Biol. 2002 Jul; 22(13): 4702-13. PMID: 12052878, PMCID: PMC133887, ISSN: 0270-7306.
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  • Erter CE, Wilm TP, Basler N, Wright CV, Solnica-Krezel L. Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo. Development. 2001 Sep; 128(18): 3571-83. PMID: 11566861, ISSN: 0950-1991.
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  • Toyama R, O'Connell ML, Wright CV, Kuehn MR, Dawid IB. Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish. Development. 1995 Feb; 121(2): 383-91. PMID: 7768180, ISSN: 0950-1991.
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  • Guz Y, Montminy MR, Stein R, Leonard J, Gamer LW, Wright CV, Teitelman G. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development. 1995 Jan; 121(1): 11-8. PMID: 7867492, ISSN: 0950-1991.
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  • Pierceall WE, Reale MA, Candia AF, Wright CV, Cho KR, Fearon ER. Expression of a homologue of the deleted in colorectal cancer (DCC) gene in the nervous system of developing Xenopus embryos. Dev. Biol. 1994 Dec; 166(2): 654-65. PMID: 7813784, PII: S0012-1606(84)71345-5, DOI: 10.1006/dbio.1994.1345, ISSN: 0012-1606.
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  • Peshavaria M, Gamer L, Henderson E, Teitelman G, Wright CV, Stein R. XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. Mol. Endocrinol. 1994 Jun; 8(6): 806-16. PMID: 7935494, DOI: 10.1210/mend.8.6.7935494, ISSN: 0888-8809.
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  • Barnes JD, Crosby JL, Jones CM, Wright CV, Hogan BL. Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. Dev. Biol. 1994 Jan; 161(1): 168-78. PMID: 7904966, PII: S0012-1606(84)71018-9, DOI: 10.1006/dbio.1994.1018, ISSN: 0012-1606.
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  • Lawler S, Candia AF, Ebner R, Shum L, Lopez AR, Moses HL, Wright CV, Derynck R. The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta 1. Development. 1994 Jan; 120(1): 165-75. PMID: 8119124, ISSN: 0950-1991.
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  • Candia AF, Hu J, Crosby J, Lalley PA, Noden D, Nadeau JH, Wright CV. Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development. 1992 Dec; 116(4): 1123-36. PMID: 1363541, ISSN: 0950-1991.
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  • Pancreatic plasticity and reprogramming ¿¿¿ novel directions towards disease therapy.