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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 

VICC toll-free number 1-877-936-8422

Claus  Schneider

Claus Schneider, Ph.D.

Assistant Professor of Pharmacology
Researcher

Contact Information:

Vanderbilt University Medical Center, Department of Pharmacology
RRB 572, 23rd Ave S at Pierce
Nashville, TN 37232-6602
615-343-9539
Fax: 615-322-4707

Education
  • M.S., 1992, University of Wrzburg,Germany
  • Ph.D., 1997, University of Wrzburg, Germany
Research Description

We are studying the biochemistry of lipid signaling. We are interested in how lipid signaling hormones are formed and what their roles are in human health and disease.

1. Discovery and characterization of novel lipid mediators
The cyclooxygenase and lipoxygenase enzymes catalyze the first step in the formation of a diverse array of lipid mediators (“eicosanoids”) from arachidonic acid. We are interested in exploring novel pathways of how these mediators are formed, and to establish their role in the progression of inflammatory diseases like atherosclerosis or cancer.

2. Mechanisms of oxygenation of fatty acids
Lipid peroxidation and oxidative stress are elementary pathophysiological processes involved in the progression of many diseases, e.g., atherosclerosis, Alzheimer's, and cardiovascular diseases. The lipid aldehyde, 4-hydroxynonenal (HNE), has been recognized as one of the most cytotoxic products formed during lipid peroxidation almost three decades ago. Yet despite the wealth of information on its pathological properties, only little is known about its mechanism(s) of formation. We are using model autoxidation reactions with common and unusual fatty acid hydroperoxide precursors to identify mechanistically significant intermediates that shed a light on the pathways of formation of HNE. The products are analyzed using LC-MS, NMR, GC-MS, UV, and CD spectroscopy. Part of this research is carried out in collaboration with Ned Porters group in the Department of Chemistry.

3. Curcumin as a chemopreventive agent
Curcumin is the spice that gives curry its yellow color. It has also been used in traditional Asian medicine as an anti-inflammatory and wound-healing agent. In the past few years, curcumin has received increasing attention for use as a dietary cancer chemopreventive agent. We are studying the oxidative metabolism of curcumin, and we are testing the hypothesis that oxidative metabolites of curcumin are contributing to its chemopreventive activity.

Publications
  • Orlando BJ, McDougle DR, Lucido MJ, Eng ET, Graham LA, Schneider C, Stokes DL, Das A, Malkowski MG. Cyclooxygenase-2 catalysis and inhibition in lipid bilayer nanodiscs. Arch. Biochem. Biophys [print-electronic]. 2014 Mar 3/15/2014; 546: 33-40. PMID: 24503478, PMCID: PMC3967765, PII: S0003-9861(14)00053-8, DOI: 10.1016/j.abb.2014.01.026, ISSN: 1096-0384.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24503478.
  • Gordon ON, Graham LA, Schneider C. Facile synthesis of deuterated and [(14) C]labeled analogs of vanillin and curcumin for use as mechanistic and analytical tools. J Labelled Comp Radiopharm [print-electronic]. 2013 Dec; 56(14): 696-9. PMID: 24339007, PMCID: PMC3943166, DOI: 10.1002/jlcr.3102, ISSN: 1099-1344.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24339007.
  • Brash AR, Boeglin WE, Stec DF, Voehler M, Schneider C, Cha JK. Isolation and characterization of two geometric allene oxide isomers synthesized from 9S-hydroperoxylinoleic acid by cytochrome P450 CYP74C3: stereochemical assignment of natural fatty acid allene oxides. J. Biol. Chem [print-electronic]. 2013 Jul 7/19/2013; 288(29): 20797-806. PMID: 23709224, PMCID: PMC3774351, PII: M113.482521, DOI: 10.1074/jbc.M113.482521, ISSN: 1083-351X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23709224.
  • Ketron AC, Gordon ON, Schneider C, Osheroff N. Oxidative metabolites of curcumin poison human type II topoisomerases. Biochemistry [print-electronic]. 2013 Jan 1/8/2013; 52(1): 221-7. PMID: 23253398, PMCID: PMC3541001, DOI: 10.1021/bi3014455, ISSN: 1520-4995.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23253398.
  • Brash AR, Schneider C, Hamberg M. Applications of stereospecifically-labeled Fatty acids in oxygenase and desaturase biochemistry. Lipids [print-electronic]. 2012 Feb; 47(2): 101-16. PMID: 21971646, PMCID: PMC3315059, DOI: 10.1007/s11745-011-3612-7, ISSN: 1558-9307.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21971646.
  • Tejera N, Boeglin WE, Suzuki T, Schneider C. COX-2-dependent and -independent biosynthesis of dihydroxy-arachidonic acids in activated human leukocytes. J. Lipid Res [print-electronic]. 2012 Jan; 53(1): 87-94. PMID: 22068350, PMCID: PMC3243484, PII: jlr.M017822, DOI: 10.1194/jlr.M017822, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22068350.
  • Gordon, ON, Schneider, C. Vanillin and ferulic acid: not the major degradation products of curcumin. 2012.
  • McElroy SJ, Hobbs S, Kallen M, Tejera N, Rosen MJ, Grishin A, Matta P, Schneider C, Upperman J, Ford H, Polk DB, Weitkamp JH. Transactivation of EGFR by LPS induces COX-2 expression in enterocytes. PLoS ONE [print-electronic]. 2012; 7(5): e38373. PMID: 22675459, PMCID: PMC3364993, PII: PONE-D-11-25419, DOI: 10.1371/journal.pone.0038373, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22675459.
  • Schneider C, Pozzi A. Cyclooxygenases and lipoxygenases in cancer. Cancer Metastasis Rev. 2011 Dec; 30(3-4): 277-94. PMID: 22002716, PMCID: PMC3798028, DOI: 10.1007/s10555-011-9310-3, ISSN: 1573-7233.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22002716.
  • Lee SH, Schneider C, Higdon AN, Darley-Usmar VM, Chung CY. Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis. Traffic [print-electronic]. 2011 Jul; 12(7): 878-89. PMID: 21438970, PMCID: PMC3115410, DOI: 10.1111/j.1600-0854.2011.01195.x, ISSN: 1600-0854.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21438970.
  • Griesser M, Suzuki T, Tejera N, Mont S, Boeglin WE, Pozzi A, Schneider C. Biosynthesis of hemiketal eicosanoids by cross-over of the 5-lipoxygenase and cyclooxygenase-2 pathways. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2011 Apr 4/26/2011; 108(17): 6945-50. PMID: 21482803, PMCID: PMC3084063, PII: 1019473108, DOI: 10.1073/pnas.1019473108, ISSN: 1091-6490.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21482803.
  • Griesser M, Pistis V, Suzuki T, Tejera N, Pratt DA, Schneider C. Autoxidative and cyclooxygenase-2 catalyzed transformation of the dietary chemopreventive agent curcumin. J. Biol. Chem [print-electronic]. 2011 Jan 1/14/2011; 286(2): 1114-24. PMID: 21071447, PMCID: PMC3020718, PII: M110.178806, DOI: 10.1074/jbc.M110.178806, ISSN: 1083-351X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21071447.
  • Liu W, Porter NA, Schneider C, Brash AR, Yin H. Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition. Free Radic. Biol. Med [print-electronic]. 2011 Jan 1/1/2011; 50(1): 166-78. PMID: 21047551, PMCID: PMC3014443, PII: S0891-5849(10)01348-1, DOI: 10.1016/j.freeradbiomed.2010.10.709, ISSN: 1873-4596.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21047551.
  • Mulugeta S, Suzuki T, Hernandez NT, Griesser M, Boeglin WE, Schneider C. Identification and absolute configuration of dihydroxy-arachidonic acids formed by oxygenation of 5S-HETE by native and aspirin-acetylated COX-2. J. Lipid Res [print-electronic]. 2010 Mar; 51(3): 575-85. PMID: 19752399, PMCID: PMC2817587, PII: jlr.M001719, DOI: 10.1194/jlr.M001719, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19752399.
  • Griesser M, Boeglin WE, Suzuki T, Schneider C. Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments. J. Lipid Res [print-electronic]. 2009 Dec; 50(12): 2455-62. PMID: 19553698, PMCID: PMC2781317, PII: M900181-JLR200, DOI: 10.1194/jlr.M900181-JLR200, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19553698.
  • Gao B, Boeglin WE, Zheng Y, Schneider C, Brash AR. Evidence for an ionic intermediate in the transformation of fatty acid hydroperoxide by a catalase-related allene oxide synthase from the Cyanobacterium Acaryochloris marina. J. Biol. Chem [print-electronic]. 2009 Aug 8/14/2009; 284(33): 22087-98. PMID: 19531485, PMCID: PMC2755933, PII: M109.013151, DOI: 10.1074/jbc.M109.013151, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19531485.
  • Niisuke K, Boeglin WE, Murray JJ, Schneider C, Brash AR. Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis. J. Lipid Res [print-electronic]. 2009 Jul; 50(7): 1448-55. PMID: 19244216, PMCID: PMC2694342, PII: M900025-JLR200, DOI: 10.1194/jlr.M900025-JLR200, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19244216.
  • Schneider C. An update on products and mechanisms of lipid peroxidation. Mol Nutr Food Res. 2009 Mar; 53(3): 315-21. PMID: 19006094, PMCID: PMC2868362, DOI: 10.1002/mnfr.200800131, ISSN: 1613-4133.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19006094.
  • Schneider C, Porter NA, Brash AR. Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation. J. Biol. Chem [print-electronic]. 2008 Jun 6/6/2008; 283(23): 15539-43. PMID: 18285327, PMCID: PMC2414272, PII: R800001200, DOI: 10.1074/jbc.R800001200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18285327.
  • Schneider C, Boeglin WE, Yin H, Porter NA, Brash AR. Intermolecular peroxyl radical reactions during autoxidation of hydroxy and hydroperoxy arachidonic acids generate a novel series of epoxidized products. Chem. Res. Toxicol [print-electronic]. 2008 Apr; 21(4): 895-903. PMID: 18324788, DOI: 10.1021/tx700357u, ISSN: 0893-228X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18324788.
  • Zheng Y, Boeglin WE, Schneider C, Brash AR. A 49-kDa mini-lipoxygenase from Anabaena sp. PCC 7120 retains catalytically complete functionality. J. Biol. Chem [print-electronic]. 2008 Feb 2/22/2008; 283(8): 5138-47. PMID: 18070874, PII: M705780200, DOI: 10.1074/jbc.M705780200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18070874.
  • Schneider C, Niisuke K, Boeglin WE, Voehler M, Stec DF, Porter NA, Brash AR. Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2007 Nov 11/27/2007; 104(48): 18941-5. PMID: 18025466, PMCID: PMC2141887, PII: 0707148104, DOI: 10.1073/pnas.0707148104, ISSN: 1091-6490.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18025466.
  • Brash AR, Yu Z, Boeglin WE, Schneider C. The hepoxilin connection in the epidermis. FEBS J [print-electronic]. 2007 Jul; 274(14): 3494-502. PMID: 17608720, PII: EJB5909, DOI: 10.1111/j.1742-4658.2007.05909.x, ISSN: 1742-464X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17608720.
  • Yu Z, Schneider C, Boeglin WE, Brash AR. Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha. Lipids [print-electronic]. 2007 Jun; 42(6): 491-7. PMID: 17436029, DOI: 10.1007/s11745-007-3054-4, ISSN: 0024-4201.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17436029.
  • Schneider C, Pratt DA, Porter NA, Brash AR. Control of oxygenation in lipoxygenase and cyclooxygenase catalysis. Chem. Biol. 2007 May; 14(5): 473-88. PMID: 17524979, PMCID: PMC2692746, PII: S1074-5521(07)00145-7, DOI: 10.1016/j.chembiol.2007.04.007, ISSN: 1074-5521.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17524979.
  • Schneider C, Yu Z, Boeglin WE, Zheng Y, Brash AR. Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatography. Meth. Enzymol. 2007; 433: 145-57. PMID: 17954233, PII: S0076-6879(07)33008-5, DOI: 10.1016/S0076-6879(07)33008-5, ISSN: 0076-6879.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17954233.
  • Yu Z, Schneider C, Boeglin WE, Brash AR. Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin. Arch. Biochem. Biophys [print-electronic]. 2006 Nov 11/15/2006; 455(2): 188-96. PMID: 17045234, PMCID: PMC2636205, PII: S0003-9861(06)00331-6, DOI: 10.1016/j.abb.2006.09.002, ISSN: 0003-9861.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17045234.
  • Furse KE, Pratt DA, Schneider C, Brash AR, Porter NA, Lybrand TP. Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity. Biochemistry. 2006 Mar 3/14/2006; 45(10): 3206-18. PMID: 16519515, PMCID: PMC2504531, DOI: 10.1021/bi052338h, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16519515.
  • Schneider C, Boeglin WE, Yin H, Stec DF, Voehler M. Convergent oxygenation of arachidonic acid by 5-lipoxygenase and cyclooxygenase-2. J. Am. Chem. Soc. 2006 Jan 1/25/2006; 128(3): 720-1. PMID: 16417352, PMCID: PMC2532595, DOI: 10.1021/ja056517y, ISSN: 0002-7863.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16417352.
  • Coffa G, Schneider C, Brash AR. A comprehensive model of positional and stereo control in lipoxygenases. Biochem. Biophys. Res. Commun [print-electronic]. 2005 Dec 12/9/2005; 338(1): 87-92. PMID: 16111652, PII: S0006-291X(05)01688-8, DOI: 10.1016/j.bbrc.2005.07.185, ISSN: 0006-291X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16111652.
  • Coffa G, Imber AN, Maguire BC, Laxmikanthan G, Schneider C, Gaffney BJ, Brash AR. On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant. J. Biol. Chem [print-electronic]. 2005 Nov 11/18/2005; 280(46): 38756-66. PMID: 16157595, PMCID: PMC1351262, PII: M504870200, DOI: 10.1074/jbc.M504870200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16157595.
  • Schneider C, Boeglin WE, Yin H, Ste DF, Hachey DL, Porter NA, Brash AR. Synthesis of dihydroperoxides of linoleic and linolenic acids and studies on their transformation to 4-hydroperoxynonenal. Lipids. 2005 Nov; 40(11): 1155-62. PMID: 16459928, ISSN: 0024-4201.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16459928.
  • Chang MS, Schneider C, Roberts RL, Shappell SB, Haselton FR, Boeglin WE, Brash AR. Detection and subcellular localization of two 15S-lipoxygenases in human cornea. Invest. Ophthalmol. Vis. Sci. 2005 Mar; 46(3): 849-56. PMID: 15728540, PII: 46/3/849, DOI: 10.1167/iovs.04-1166, ISSN: 0146-0404.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15728540.
  • Yu Z, Schneider C, Boeglin WE, Brash AR. Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3. Biochim. Biophys. Acta. 2005 Jan 1/5/2005; 1686(3): 238-47. PMID: 15629692, PII: S1388-1981(04)00184-2, DOI: 10.1016/j.bbalip.2004.10.007, ISSN: 0006-3002.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15629692.
  • Schneider C, Boeglin WE, Brash AR. Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activities. Biochem. J. 2005 Jan 1/1/2005; 385(Pt 1): 57-64. PMID: 15361066, PMCID: PMC1134673, PII: BJ20041115, DOI: 10.1042/BJ20041115, ISSN: 1470-8728.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15361066.
  • Schneider C. Chemistry and biology of vitamin E. Mol Nutr Food Res. 2005 Jan; 49(1): 7-30. PMID: 15580660, DOI: 10.1002/mnfr.200400049, ISSN: 1613-4125.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15580660.
  • Valmsen K, Boeglin WE, Järving I, Schneider C, Varvas K, Brash AR, Samel N. Structural and functional comparison of 15S- and 15R-specific cyclooxygenases from the coral Plexaura homomalla. Eur. J. Biochem. 2004 Sep; 271(17): 3533-8. PMID: 15317588, PII: EJB4289, DOI: 10.1111/j.0014-2956.2004.04289.x, ISSN: 0014-2956.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15317588.
  • Schneider C, Porter NA, Brash AR. Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal. Chem. Res. Toxicol. 2004 Jul; 17(7): 937-41. PMID: 15257619, DOI: 10.1021/tx049913n, ISSN: 0893-228X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15257619.
  • West JD, Ji C, Duncan ST, Amarnath V, Schneider C, Rizzo CJ, Brash AR, Marnett LJ. Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation. Chem. Res. Toxicol. 2004 Apr; 17(4): 453-62. PMID: 15089087, DOI: 10.1021/tx034248o, ISSN: 0893-228X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15089087.
  • Schneider C, Strayhorn WD, Brantley DM, Nanney LB, Yull FE, Brash AR. Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice. J. Invest. Dermatol. 2004 Mar; 122(3): 691-8. PMID: 15086555, PII: JID22329, DOI: 10.1111/j.0022-202X.2004.22329.x, ISSN: 0022-202X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15086555.
  • Schneider C, Boeglin WE, Brash AR. Identification of two cyclooxygenase active site residues, Leucine 384 and Glycine 526, that control carbon ring cyclization in prostaglandin biosynthesis. J. Biol. Chem [print-electronic]. 2004 Feb 2/6/2004; 279(6): 4404-14. PMID: 14594816, PII: M307431200, DOI: 10.1074/jbc.M307431200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14594816.
  • Yu Z, Schneider C, Boeglin WE, Marnett LJ, Brash AR. The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2003 Aug 8/5/2003; 100(16): 9162-7. PMID: 12881489, PMCID: PMC170889, PII: 1633612100, DOI: 10.1073/pnas.1633612100, ISSN: 0027-8424.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12881489.
  • Brash, Alan R., Jisaka, Mitsuo, Boeglin, William E., Schneider, Claus. On the basis for the positional specificity and stereo specificity of lipoxygenases. Int. Congress Series. 2003; 1233: 297-305.
  • Schneider C, Brash AR. Lipoxygenase-catalyzed formation of R-configuration hydroperoxides. Prostaglandins Other Lipid Mediat. 2002 Aug; 68-69: 291-301. PMID: 12432924, ISSN: 1098-8823.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12432924.
  • Schneider C, Manier ML, Hachey DL, Brash AR. Detection of the 15-acetate of prostaglandin E2 methyl ester as a prominent component of the prostaglandins in the gorgonian coral Plexaura homomalla. Lipids. 2002 Feb; 37(2): 217-21. PMID: 11908914, ISSN: 0024-4201.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11908914.
  • Schneider C, Boeglin WE, Prusakiewicz JJ, Rowlinson SW, Marnett LJ, Samel N, Brash AR. Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349. J. Biol. Chem [print-electronic]. 2002 Jan 1/4/2002; 277(1): 478-85. PMID: 11677234, PII: M107471200, DOI: 10.1074/jbc.M107471200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11677234.
  • Schneider C, Boeglin WE, Brash AR. Analysis of cyclooxygenase-substrate interactions using stereospecifically-labeled arachidonic acids. Adv. Exp. Med. Biol. 2002; 507: 49-53. PMID: 12664563, ISSN: 0065-2598.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12664563.
  • Kozak KR, Prusakiewicz JJ, Rowlinson SW, Schneider C, Marnett LJ. Amino acid determinants in cyclooxygenase-2 oxygenation of the endocannabinoid 2-arachidonylglycerol. J. Biol. Chem [print-electronic]. 2001 Aug 8/10/2001; 276(32): 30072-7. PMID: 11402053, PII: M104467200, DOI: 10.1074/jbc.M104467200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11402053.
  • Schneider C, Tallman KA, Porter NA, Brash AR. Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals. J. Biol. Chem [print-electronic]. 2001 Jun 6/15/2001; 276(24): 20831-8. PMID: 11259420, PII: M101821200, DOI: 10.1074/jbc.M101821200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11259420.
  • Schneider C, Keeney DS, Boeglin WE, Brash AR. Detection and cellular localization of 12R-lipoxygenase in human tonsils. Arch. Biochem. Biophys. 2001 Feb 2/15/2001; 386(2): 268-74. PMID: 11368351, PII: S0003-9861(00)92217-3, DOI: 10.1006/abbi.2000.2217, ISSN: 0003-9861.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11368351.
  • Tijet N, Schneider C, Muller BL, Brash AR. Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids. Arch. Biochem. Biophys. 2001 Feb 2/15/2001; 386(2): 281-9. PMID: 11368353, PII: S0003-9861(00)92218-5, DOI: 10.1006/abbi.2000.2218, ISSN: 0003-9861.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11368353.
  • Shappell SB, Gupta RA, Manning S, Whitehead R, Boeglin WE, Schneider C, Case T, Price J, Jack GS, Wheeler TM, Matusik RJ, Brash AR, Dubois RN. 15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells. Cancer Res. 2001 Jan 1/15/2001; 61(2): 497-503. PMID: 11212240, ISSN: 0008-5472.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11212240.
  • Schneider C, Boeglin WE, Brash AR. Enantiomeric separation of hydroxy eicosanoids by chiral column chromatography: effect of the alcohol modifier. Anal. Biochem. 2000 Dec 12/1/2000; 287(1): 186-9. PMID: 11078601, PII: S0003-2697(00)94847-4, DOI: 10.1006/abio.2000.4847, ISSN: 0003-2697.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11078601.
  • Schneider C, Boeglin WE, Lai S, Cha JK, Brash AR. Synthesis and applications of stereospecifically (3)H-labeled arachidonic acids as mechanistic probes for lipoxygenase and cyclooxygenase catalysis. Anal. Biochem. 2000 Aug 8/15/2000; 284(1): 125-35. PMID: 10933865, PII: S0003269700946700, DOI: 10.1006/abio.2000.4670, ISSN: 0003-2697.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10933865.
  • Rowlinson SW, Crews BC, Goodwin DC, Schneider C, Gierse JK, Marnett LJ. Spatial requirements for 15-(R)-hydroxy-5Z,8Z,11Z, 13E-eicosatetraenoic acid synthesis within the cyclooxygenase active site of murine COX-2. Why acetylated COX-1 does not synthesize 15-(R)-hete. J. Biol. Chem. 2000 Mar 3/3/2000; 275(9): 6586-91. PMID: 10692466, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10692466.
  • Schneider C, Brash AR. Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site. J. Biol. Chem. 2000 Feb 2/18/2000; 275(7): 4743-6. PMID: 10671506, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10671506.
  • Schneider, C. and Schreier, P. Catalytic properties of allene oxide synthase from flaxseed (Linum usitatissimum L.). Lipids. 1998; 33: 191-6.
  • Schneider, C., Amberg, A., Feurle, J., Ross, A., Roth, M., Toth, G., and Schreier, P. 2-[4'-Hydroxy-3'-methoxy)-phenoxy]-4-(4"-hydroxy-3"-methoxy-phenyl)-8-hydroxy-6-oxo-3-oxabicyclo[3.3.0]-7-octene: Unusual product of the soybean lipoxygenase-catalyzed oxygenation of curcumin. J. Mol. Catal. B: Enzymatic. 1998; 4: 219-27.
  • Herderich, M., Richling, E., Roscher, R., Schneider, C., Schwab, W., Humpf, H.-U., and Schreier, P. Application of atmospheric pressure ionization HPLC-MS-MS for the analysis of natural products. Chromatographia. 1997; 45: 127-32.
  • Schneider, C., Schreier, P., and Herderich, M. Analysis of lipoxygenase-derived fatty acid hydroperoxides by electrospray ionization tandem mass spectrometry. Lipids. 1997; 32: 331-6.
  • Schneider, C., Schreier, P., and Humpf, H.-U. Exciton-coupled circular dichroism (ECCD) in acyclic hydroxylated dienes: A sensitive method for the direct stereochemical assignment of lipoxygenase products. Chirality. 1997; 9: 563-7.
  • Schneider, C., Wein, M., Harmsen, D., and Schreier, P. A fatty acid alpha-ketol, a product of the plant lipoxygenase pathway, is oxidized to 3(Z)-dodecendioic acid by a bacterial monooxygenase. Biochem. Biophys. Res. Commun. 1997; 232: 364-6.