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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 
Claus  Schneider

Claus Schneider, Ph.D.

Assistant Professor of Pharmacology
Researcher

Contact Information:

Vanderbilt University Medical Center, Department of Pharmacology
RRB 572, 23rd Ave S at Pierce
Nashville, TN 37232-6602
615-343-9539
Fax: 615-322-4707

Education
  • M.S., 1992, University of Wrzburg,Germany
  • Ph.D., 1997, University of Wrzburg, Germany
Research Specialty

Discovery and characterization of novel lipid mediators. Mechanisms of oxygenation of fatty acids. Chemopreventive activity of curcumin.

Research Description

We are studying the biochemistry of lipid signaling. We are interested in how lipid signaling hormones are formed and what their roles are in human health and disease.

1. Discovery and characterization of novel lipid mediators

The cyclooxygenase and lipoxygenase enzymes catalyze the first step in the formation of a diverse array of lipid mediators (“eicosanoids”) from arachidonic acid. We are interested in exploring novel pathways of how these mediators are formed, and to establish their role in the progression of inflammatory diseases like atherosclerosis or cancer.

2. Mechanisms of oxygenation of fatty acids

Lipid peroxidation and oxidative stress are elementary pathophysiological processes involved in the progression of many diseases, e.g., atherosclerosis, Alzheimer's, and cardiovascular diseases. The lipid aldehyde, 4-hydroxynonenal (HNE), has been recognized as one of the most cytotoxic products formed during lipid peroxidation almost three decades ago. Yet despite the wealth of information on its pathological properties, only little is known about its mechanism(s) of formation. We are using model autoxidation reactions with common and unusual fatty acid hydroperoxide precursors to identify mechanistically significant intermediates that shed a light on the pathways of formation of HNE. The products are analyzed using LC-MS, NMR, GC-MS, UV, and CD spectroscopy. Part of this research is carried out in collaboration with Ned Porters group in the Department of Chemistry.

3. Curcumin as a chemopreventive agent

Curcumin is the spice that gives curry its yellow color. It has also been used in traditional Asian medicine as an anti-inflammatory and wound-healing agent. In the past few years, curcumin has received increasing attention for use as a dietary cancer chemopreventive agent. We are studying the oxidative metabolism of curcumin, and we are testing the hypothesis that oxidative metabolites of curcumin are contributing to its chemopreventive activity.

Publications