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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

Dan M.  Roden

Dan M. Roden, M.D.

William Stokes Professor of Experimental Therapeutics
Professor of Medicine and Pharmacology
Assistant Vice-Chancellor for Personalized Medicine
Director, Oates Institute for Experimental Therapeutics

Contact Information:

Clinical Pharmacology Division/Medicine
1285 MRBIV
Nashville, TN 37232-0575
Patients: 615-322-2318,

  • M.D. - McGill University, 1974
  • Fellowship - Vanderbilt University Medical Center, 1981
  • Fellowship - Vanderbilt University Medical Center, 1981
  • Residency - Royal Victoria Hospital, 1978
  • Internship - Royal Victoria Hospital, 1975
  • Post Graduate Training - McGill University Hospital
Research Specialty

Mechanisms and treatment of cardiac arrhythmias

Research Description

Abnormalities of cardiac rhythm are a common and serious public health problem. However, the therapies used to treat arrhythmias are often ineffective, and can sometimes even exacerbate arrhythmias. Research in this laboratory is directed at elucidating mechanisms underlying abnormalities of cardiac rhythm and mechanisms underlying variable responses to antiarrhythmic drug treatments. Since antiarrhythmic drugs affect the function of cardiac ion channels, it is one working hypothesis in the laboratory that variable responses to drug therapy may reflect variable function or expression of genes encoding ion channels or proteins involved in drug disposition. Thus, a major focus of work in the laboratory is elucidation of factor(s) that determine ion channel gene expression in cardiac tissue. Approaches include identification of new genes, identification of DNA polymorphisms and characterization of their functional effects on disease and drug responses, and modulation of expression in cultured heart cells (e.g. by antisense) and gene knockout in mice.

Clinical Interest

We are interested in variability in arrhythmia presentations and their response to therapies, particularly as a function of genetic background.