The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers
R. Daniel Beauchamp, M.D.
John Clinton Foshee Distinguished Chair in Surgery
Professor of Surgery
Professor of Cancer Biology
Chair of the Section of Surgical Sciences
VICC Member
Surgical Oncologist
- Appointments
615-322-2064
Physicians: 1-877-936-8422 - Clinical Trials Information
- Clinical Trials: 1-800-811-8480
- Online Self-Referral Form
- Other Telephone NumbersVanderbilt Breast Center One Hundred Oaks
615-322-2064; Referring Physicians: 615-343-9283
Office
615-322-2363 - FaxesVanderbilt Breast Center One Hundred Oaks Fax
615-343-7622 - AddressesVanderbilt Breast Center One Hundred Oaks
719 Thompson Lane, Suite 25000
Nashville, TN 37204
Website
Office
Vanderbilt University Medical Center
D-4316 Medical Center North
Nashville, TN 37232-2729
Profile
R. Daniel Beauchamp, M.D., F.A.C.S., has a clinical practice focused in Surgical Oncology. He cares for patients with a broad spectrum of malignancies, including gastrointestinal tract cancers including esophageal and colorectal cancers, breast cancer, melanoma and soft tissue sarcoma. Dr.
Read more ....
R. Daniel Beauchamp, M.D., F.A.C.S., has a clinical practice focused in Surgical Oncology. He cares for patients with a broad spectrum of malignancies, including gastrointestinal tract cancers including esophageal and colorectal cancers, breast cancer, melanoma and soft tissue sarcoma. Dr. Beauchamp participates in the multidisciplinary GI Oncology clinic every Wednesday and holds clinic in the Vanderbilt Breast Center on Thursday mornings.
Dr. Beauchamp is the John Clinton Foshee Distinguished Professor of Surgery, Chairman of the Section of Surgical Sciences, and Surgeon-in-Chief of Vanderbilt University Hospital and has held these positions since July 2001. He also has joint appointments as Professor in the departments of Cell and Developmental Biology and Cancer Biology. He also serves as Associate Director for Clinical/Translational Programs in the Vanderbilt-Ingram Cancer Center. Dr. Beauchamp joined the faculty of the Vanderbilt University Medical Center as Associate Professor in the Department of Surgery, Division of Surgical Oncology and Associate Professor of Cell Biology in December 1994. He served as the chief of the Division of Surgical Oncology from 1997 until 2001 when he assumed his current position as Chief of Surgery. His ongoing institutional administrative responsibilities also include the Chair of the Perioperative Enterprise Committee, and service on the Perioperative Executive Committee, the VMG Executive Committee, the Medical School Executive Committee, the Clinical Enterprise Group, the Quality Council, the ELEVATE Steering Committee, and the Surgical Critical Care Steering Committee.
In addition to clinical practice and administrative responsibilities, Dr. Beauchamp is an active investigator in the field of cancer biology and cancer clinical trials. He has published over 100 peer-reviewed articles in these fields and has had continuous funding from the National Institutes of Health for more than 18 years.
Education
- B.S., Texas Tech University, Lubbock, Texas, 1978
- M.D., The University of Texas Medical Branch, Galveston, Texas, 1982
Research Description
R. Daniel Beauchamp, MD, is the John Clinton Foshee Distinguished Professor of Surgery, Chairman of the Section of Surgical Sciences, and Surgeon-in-Chief of Vanderbilt University Hospital and has held these positions since July 2001 and on the faculty at Vanderbilt since December 1994. He holds joint appointments as professor in the departments of Cell and Developmental Biology and Cancer Biology. He also serves as Deputy Director of the Vanderbilt-Ingram Cancer Center. Dr. Beauchamp has two active R01 grants from NIH, and leads one of the main projects in the GI Cancer SPORE. Dr. Beauchamp's primary area of research interest has been in colorectal carcinogenesis, the biology of cancer cell invasion and metastasis, and in the identification of novel molecular biomarkers and therapeutic targets in colorectal and other alimentary tract malignancies. His work applies DNA microarray and proteomic technology to identify novel biomarkers and therapeutic targets in human colorectal cancer samples. He also uses molecular genetics, chemical biology and cell biological approaches to examine mechanistic questions in cancer biology in both cell culture and mouse models. In addition to the basic cancer research Dr. Beauchamp works in collaboration with his Medical Oncology and Radiation Oncology colleagues to accrue cancer patients to approved clinical trials. He has trained and mentored numerous junior faculty members, physician scientist fellows, medical students, graduate students and post-doctoral fellows in his laboratory. He is one of the few surgeon members of the ASCI.
Clinical Research Description
Dr. Beauchamp's clinical practice is primarily in General Surgical Oncology. He participates in the multidisciplinary gastrointestinal oncology clinic. Dr. Beauchamp's practice includes patients ith tumors of the esophagus, stomach, pancreas, colon and rectum. His group is actively pursuing improvement in outcomes for these tumors through application of multimodality therapy. In addition, Dr. Beauchamp has a large breast cancer and melanomapractice. He and his partners are skilled in the use of Sentinel lymph node mapping techniques and, stereotactic breast biopsy and participate in a multidisciplinary team along with Radiologists, Medical Oncologists, Pathologists, Radiation Oncologists and the Genetic counseling service to provide the most current and comprehensive diagnostic and therapeutic care available.
Publications
- Freeman, TJ, Smith, JJ, Chen, X, Washington, MK, Roland, JT, Means, AL, Eschrich, SA, Yeatman, TJ, Deane, NG, Beauchamp, RD Smad4-mediated signaling inhibits intestinal neoplasia by inhibiting expression of β-catenin. Gastroenterology, 142(3), 562-571.e2, 2012.
- Hanson, AJ, Wallace, HA, Freeman, TJ, Beauchamp, RD, Lee, LA, Lee, E XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. Mol Cell, 45(5), 619-28, 2012.
- Williams, CS, Zhang, B, Smith, JJ, Jayagopal, A, Barrett, CW, Pino, C, Russ, P, Presley, SH, Peng, D, Rosenblatt, DO, Haselton, FR, Yang, JL, Washington, MK, Chen, X, Eschrich, S, Yeatman, TJ, El-Rifai, W, Beauchamp, RD, Chang, MS BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma. J Clin Invest, 121(10), 4056-69, 2011.
- Singh, AB, Sharma, A, Smith, JJ, Krishnan, M, Chen, X, Eschrich, S, Washington, MK, Yeatman, TJ, Beauchamp, RD, Dhawan, P Claudin-1 up-regulates the repressor ZEB-1 to inhibit E-cadherin expression in colon cancer cells. Gastroenterology, 141(6), 2140-53, 2011.
- Dhawan, P, Ahmad, R, Chaturvedi, R, Smith, JJ, Midha, R, Mittal, MK, Krishnan, M, Chen, X, Eschrich, S, Yeatman, TJ, Harris, RC, Washington, MK, Wilson, KT, Beauchamp, RD, Singh, AB Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation. Oncogene, 30(29), 3234-47, 2011.
- Stoops, SL, Pearson, AS, Weaver, C, Waterson, AG, Days, E, Farmer, C, Brady, S, Weaver, CD, Beauchamp, RD, Lindsley, CW Identification and optimization of small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells. ACS Chem Biol, 6(5), 452-65, 2011.
- Kauffmann, RM, Landman, MP, Shelton, J, Dmochowski, RR, Bledsoe, SH, Hickson, GB, Beauchamp, RD, Dattilo, JB The use of a multidisciplinary morbidity and mortality conference to incorporate ACGME general competencies. J Surg Educ, 68(4), 303-8, 2011.
- Lapierre, LA, Caldwell, CM, Higginbotham, JN, Avant, KM, Hall, J, Beauchamp, RD, Goldenring, JR Transformation of rat intestinal epithelial cells by overexpression of Rab25 is microtubule dependent. Cytoskeleton (Hoboken), 68(2), 97-111, 2011.
- Smith, JJ, Deane, NG, Wu, F, Merchant, NB, Zhang, B, Jiang, A, Lu, P, Johnson, JC, Schmidt, C, Bailey, CE, Eschrich, S, Kis, C, Levy, S, Washington, MK, Heslin, MJ, Coffey, RJ, Yeatman, TJ, Shyr, Y, Beauchamp, RD Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Gastroenterology, 138(3), 958-68, 2010.
- Krishnan, M, Singh, AB, Smith, JJ, Sharma, A, Chen, X, Eschrich, S, Yeatman, TJ, Beauchamp, RD, Dhawan, P HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability. Oncogene, 29(2), 305-12, 2010.
- Nam, KT, Lee, HJ, Smith, JJ, Lapierre, LA, Kamath, VP, Chen, X, Aronow, BJ, Yeatman, TJ, Bhartur, SG, Calhoun, BC, Condie, B, Manley, NR, Beauchamp, RD, Coffey, RJ, Goldenring, JR Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J Clin Invest, 120(3), 840-9, 2010.
- Xu, BJ, Li, J, Beauchamp, RD, Shyr, Y, Li, M, Washington, MK, Yeatman, TJ, Whitehead, RH, Coffey, RJ, Caprioli, RM Identification of early intestinal neoplasia protein biomarkers using laser capture microdissection and MALDI MS. Mol Cell Proteomics, 8(5), 936-45, 2009.
- Kanies, CL, Smith, JJ, Kis, C, Schmidt, C, Levy, S, Khabar, KS, Morrow, J, Deane, N, Dixon, DA, Beauchamp, RD Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transition. Mol Cancer Res, 6(7), 1124-36, 2008.
- Smith, JJ, Deane, NG, Dhawan, P, Beauchamp, RD Regulation of metastasis in colorectal adenocarcinoma: a collision between development and tumor biology. Surgery, 144(3), 353-66, 2008.
- Kim, DW, Blanke, CD, Wu, H, Shyr, Y, Berlin, J, Beauchamp, RD, Chakravarthy, B Phase II study of preoperative paclitaxel/cisplatin with radiotherapy in locally advanced esophageal cancer. Int J Radiat Oncol Biol Phys, 67(2), 397-404, 2007.
- Shiou, SR, Singh, AB, Moorthy, K, Datta, PK, Washington, MK, Beauchamp, RD, Dhawan, P Smad4 regulates claudin-1 expression in a transforming growth factor-beta-independent manner in colon cancer cells. Cancer Res, 67(4), 1571-9, 2007.
- Li, JQ, Xu, BJ, Shakhtour, B, Deane, N, Merchant, N, Heslin, MJ, Washington, K, Coffey, RJ, Beauchamp, RD, Shyr, Y, Billheimer, D Variability of in situ proteomic profiling and implications for study design in colorectal tumors. Int J Oncol, 31(1), 103-11, 2007.
- Chakravarthy, AB, Kelley, MC, McLaren, B, Truica, CI, Billheimer, D, Mayer, IA, Grau, AM, Johnson, DH, Simpson, JF, Beauchamp, RD, Jones, C, Pietenpol, JA Neoadjuvant concurrent paclitaxel and radiation in stage II/III breast cancer. Clin Cancer Res, 12(5), 1570-6, 2006.
- Halder, SK, Anumanthan, G, Maddula, R, Mann, J, Chytil, A, Gonzalez, AL, Washington, MK, Moses, HL, Beauchamp, RD, Datta, PK Oncogenic Function of a Novel WD-Domain Protein, STRAP, in Human Carcinogenesis. Cancer Res, 66(12), 6156-66, 2006.
- Shiou, SR, Datta, PK, Dhawan, P, Law, BK, Yingling, JM, Dixon, DA, Beauchamp, RD Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta. J Biol Chem, 281(45), 33971-81, 2006.
- Johnson, JC, Schmidt, CR, Shrubsole, MJ, Billheimer, DD, Joshi, PR, Morrow, JD, Heslin, MJ, Washington, MK, Ness, RM, Zheng, W, Schwartz, DA, Coffey, RJ, Beauchamp, RD, Merchant, NB Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin Gastroenterol Hepatol, 4(11), 1358-65, 2006.
- Halder, SK, Beauchamp, RD, Datta, PK A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia, 7(5), 509-21, 2005.
- Deane, NG, Parker, MA, Beauchamp, RD Cell proliferation: a matter of time and place. Surgery, 138(1), 1-7, 2005.
- Dhawan, P, Singh, AB, Deane, NG, No, Y, Shiou, SR, Schmidt, C, Neff, J, Washington, MK, Beauchamp, RD Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Invest, 115(7), 1765-76, 2005.
- Tedesco, KL, Berlin, J, Blanke, CD, Teng, M, Choy, H, Roberts, J, Beauchamp, RD, Leach, S, Wyman, K, Tarpley, J, Shyr, Y, Caillouette, C, Chakravarthy, B Phase I trial of Orzel (UFT plus leucovorin), cisplatin, and radiotherapy in the treatment of potentially resectable esophageal cancer. Int J Radiat Oncol Biol Phys, 61(5), 1364-70, 2005.
- Poulose, BK, Ray, WA, Arbogast, PG, Needleman, J, Buerhaus, PI, Griffin, MR, Abumrad, NN, Beauchamp, RD, Holzman, MD Resident work hour limits and patient safety. Ann Surg, 241(6), 847-56; discussion 856-60, 2005.
- Halder, SK, Beauchamp, RD, Datta, PK Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis. Exp Cell Res, 307(1), 231-46, 2005.
- Beauchamp, RD The changing roles of a surgical department chair: adapting to a changing environment. Arch Surg, 140(3), 258-63, 2005.
- Li, JQ, Wu, F, Masaki, T, Kubo, A, Fujita, J, Dixon, DA, Beauchamp, RD, Ishida, T, Kuriyama, S, Imaida, K Correlation of Skp2 with carcinogenesis, invasion, metastasis, and prognosis in colorectal tumors. Int J Oncol, 25(1), 87-95, 2004.
- Beauchamp, RD Department of Surgery, Vanderbilt University Medical Center, Nashville, Tenn. Arch Surg, 139(8), 814-5, 2004.
- Deane, Natasha G, Lee, Haakil, Hamaamen, Jalal, Ruley, Anna, Washington, M Kay, LaFleur, Bonnie, Thorgeirsson, Snorri S, Price, Ronald, Beauchamp, R Daniel Enhanced tumor formation in cyclin D1 x transforming growth factor beta1 double transgenic mice with characterization by magnetic resonance imaging. Cancer Res, 64(4), 1315-22, 2004.
- Schmidt, CR, Gi, YJ, Coffey, RJ, Beauchamp, RD, Pearson, AS Oncogenic Ras dominates overexpression of E-cadherin in malignant transformation of intestinal epithelial cells. Surgery, 136(2), 303-9, 2004.
- Lawson, LL, Sandler, M, Martin, W, Beauchamp, RD, Kelley, MC Preoperative lymphoscintigraphy and internal mammary sentinel lymph node biopsy do not enhance the accuracy of lymphatic mapping for breast cancer. Am Surg, 70(12), 1050-5; discussion 1055-6, 2004.
- Mithani, SK, Balch, GC, Shiou, SR, Whitehead, RH, Datta, PK, Beauchamp, RD Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells. J Surg Res, 117(2), 296-305, 2004.
- Ahmed, Atique, Thompson, Jill, Emiliusen, Lisa, Murphy, Stephen, Beauchamp, R Daniel, Suzuki, Kaori, Alemany, Ramon, Harrington, Kevin, Vile, Richard G, A conditionally replicating adenovirus targeted to tumor cells through activated RAS/P-MAPK-selective mRNA stabilization.. Nat Biotechnol, 21771-7, 2003.
- Schmidt, Carl R, Washington, M Kay, Gi, Y J, Coffey, Robert J, Beauchamp, R Daniel, Pearson, A Scott Dysregulation of E-cadherin by oncogenic Ras in intestinal epithelial cells is blocked by inhibiting MAP kinase. Am J Surg, 186(5), 426-30, 2003.
- Berger, David, O'mahony, Christine, Sheng, Hongmiao, Shao, Jinyi, Albo, Daniel, Dubois, Raymond, Beauchamp, R Intestinal transformation results in transforming growth factor-beta-dependent alteration in tumor cell-cell matrix interactions. Surgery, 133(5), 568-579, 2003.
- Balch, Glen C, Mithani, Suhail K, Richards, Ken R, Beauchamp, R Daniel, Kelley, Mark C, Lymphatic mapping and sentinel lymphadenectomy after preoperative therapy for stage II and III breast cancer.. Ann Surg Oncol, 10616-21, 2003.
- Parker, M A, Deane, N G, Thompson, E A, Whitehead, R H, Mithani, S K, Washington, M K, Datta, P K, Dixon, D A, Beauchamp, R D Over-expression of cyclin D1 regulates Cdk4 protein synthesis. Cell Prolif, 36(6), 347-60, 2003.
- Dixon, Dan A, Balch, Glen C, Kedersha, Nancy, Anderson, Paul, Zimmerman, Guy A, Beauchamp, R Daniel, Prescott, Stephen M, Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1.. J Exp Med, 198475-81, 2003.
- Fujimoto, Koji, Beauchamp, R Daniel, Whitehead, Robert H Identification and isolation of candidate human colonic clonogenic cells based on cell surface integrin expression. Gastroenterology, 123(6), 1941-8, 2002.
- Roman, Christopher D, Morrow, Jason, Whitehead, Robert, Beauchamp, R Daniel Induction of cyclooxygenase-2 and invasiveness by transforming growth factor-beta(1) in immortalized mouse colonocytes expressing oncogenic Ras. J Gastrointest Surg, 6(3), 304-9, 2002.
- Saha, Debabrata, Roman, Christopher, Beauchamp, R Daniel New strategies for colorectal cancer prevention and treatment. World J Surg, 26(7), 762-6, 2002.
- Roman, Christopher D, Hanley, Greg A, Beauchamp, R Daniel Operative technique for safe pulmonary lobectomy in Sprague-Dawley rats. Contemp Top Lab Anim Sci, 41(2), 28-30, 2002.
- Berger, David H, Feng, Xin-Hua, Yao, Jun, Saha, Debabrata, Beauchamp, R Daniel, Lin, Xia, Resistance to transforming growth factor-beta occurs in the presence of normal Smad activation.. Surgery, 132310-6, 2002.
- Roman, Christopher D, Choy, Hak, Nanney, Lillian, Riordan, Colin, Parman, Kelly, Johnson, David, Beauchamp, R Daniel Vascular endothelial growth factor-mediated angiogenesis inhibition and postoperative wound healing in rats. J Surg Res, 105(1), 43-7, 2002.
- Deane, N G, Parker, M A, Aramandla, R, Diehl, L, Lee, W J, Washington, M K, Nanney, L B, Shyr, Y, Beauchamp, R D Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice. Cancer Res, 61(14), 5389-95, 2001.
- Saha, D, Datta, P K, Beauchamp, R D Oncogenic ras represses transforming growth factor-beta /Smad signaling by degrading tumor suppressor Smad4. J Biol Chem, 276(31), 29531-7, 2001.
- Zhang, Z, Sheng, H, Shao, J, Beauchamp, R D, DuBois, R N Posttranscriptional regulation of cyclooxygenase-2 in rat intestinal epithelial cells. Neoplasia, 2(6), 523-30, 2001.
- Fujimoto, K, Sheng, H, Shao, J, Beauchamp, R D Transforming growth factor-beta1 promotes invasiveness after cellular transformation with activated Ras in intestinal epithelial cells. Exp Cell Res, 266(2), 239-49, 2001.
- Fujimoto, K, Hosotani, R, Miyamoto, Y, Doi, R, Koshiba, T, Otaka, A, Fujii, N, Beauchamp, R D, Imamura, M Inhibition of pRb phosphorylation and cell cycle progression by an antennapedia-p16(INK4A) fusion peptide in pancreatic cancer cells. Cancer Lett, 159(2), 151-8, 2000.
- Jo, H, Zhang, R, Zhang, H, McKinsey, T A, Shao, J, Beauchamp, R D, Ballard, D W, Liang, P NF-kappa B is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis. Oncogene, 19(7), 841-9, 2000.
- Shao, J, Sheng, H, DuBois, R N, Beauchamp, R D Oncogenic Ras-mediated cell growth arrest and apoptosis are associated with increased ubiquitin-dependent cyclin D1 degradation. J Biol Chem, 275(30), 22916-24, 2000.
- Shao, J., Sheng, H.M., Dubois, R.N., and Beauchamp, R.D "Oncogenic Ras-mediated cell growth arrest and apoptosis is associated with increased ubiquitin-dependent cyclin D1 degradation." Journal of Biological Chemistry , 27522916-22924, 2000.
- Beauchamp, R D Presidential address: evolution. Surgery, 128(2), 123-32, 2000.
- Bulus N., Sheng H-M., Sizemore N., Oldham S.M., Barnett J.V., Coffey R.J., Beauchamp R.D. and Barnard J.A "Ras-mediated suppression of TFGRII expression in intestinal pedithelial cells involves a Raf-independent signaling." Neoplasia , 2(4), 357-364, 2000.
- Sheng, H., Shao, J., Williams, C.S., Prescott, S.M., Dubois, R.N., and Beauchamp, R.D "TGF-1 enhances Ha-Ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA." Journal of Biological Chemistry , 2756628-6635, 2000.
- Sheng, H, Shao, J, Dixon, D A, Williams, C S, Prescott, S M, DuBois, R N, Beauchamp, R D Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. J Biol Chem, 275(9), 6628-35, 2000.
- Rose, D M, Delbeke, D, Beauchamp, R D, Chapman, W C, Sandler, M P, Sharp, K W, Richards, W O, Wright, J K, Frexes, M E, Pinson, C W, Leach, S D 18Fluorodeoxyglucose-positron emission tomography in the management of patients with suspected pancreatic cancer. Ann Surg, 229(5), 729-37; discussion 737-8, 1999.
- Shao, J., Sheng, H.M., Aramandla, R., Pereira, M.A., Lubet, R.A., Hawk, E., Grogan, L., Kirshc, I.R., Washington, M.K., Beauchamp, R.D. and Dubois, R.N "Coordinate regulation of cyclooxygenase-2 and TGF-1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors." Carcinogenesis , 20(2), 185-191, 1999.
- Shao, J, Sheng, H, Aramandla, R, Pereira, M A, Lubet, R A, Hawk, E, Grogan, L, Kirsch, I R, Washington, M K, Beauchamp, R D, DuBois, R N Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. Carcinogenesis, 20(2), 185-91, 1999.
- Scoggins, C R, Meszoely, I M, Blanke, C D, Beauchamp, R D, Leach, S D Nonoperative management of primary colorectal cancer in patients with stage IV disease. Ann Surg Oncol, 6(7), 651-7, 1999.
- Delbeke, D, Rose, D M, Chapman, W C, Pinson, C W, Wright, J K, Beauchamp, R D, Shyr, Y, Leach, S D Optimal interpretation of FDG PET in the diagnosis, staging and management of pancreatic carcinoma. J Nucl Med, 40(11), 1784-91, 1999.
- Saha, D, Datta, P K, Sheng, H, Morrow, J D, Wada, M, Moses, H L, Beauchamp, R D Synergistic induction of cyclooxygenase-2 by transforming growth factor-beta1 and epidermal growth factor inhibits apoptosis in epithelial cells. Neoplasia, 1(6), 508-17, 1999.
- Sheng, H., Shao, J., O'Mahony, C.A., Lamps, L., Albo, D., Isakson, P.C., Berger, D.H., DuBois, R.N., and Beauchamp, R.D "Transformation of intestinal epithelial cells by chronic TGF-b1 treatment results in downregulation of the type II TGF-b receptor and induction of cyclooxygenase-2." Oncogene, 18855-867, 1999.
- Sheng, H, Shao, J, O'Mahony, C A, Lamps, L, Albo, D, Isakson, P C, Berger, D H, DuBois, R N, Beauchamp, R D Transformation of intestinal epithelial cells by chronic TGF-beta1 treatment results in downregulation of the type II TGF-beta receptor and induction of cyclooxygenase-2. Oncogene, 18(4), 855-67, 1999.
- Chinery, R., Beauchamp, R.D., Shyr, Y., Kirkland, S.C., Coffey, R.J., and Morrow, J.D "Antioxidants reduce cyclooxygenase -2 expression, prostaglandin production and proliferation in colorectal cancer cells." Cancer Research , 582323-2327, 1998.
- Chinery, R, Beauchamp, R D, Shyr, Y, Kirkland, S C, Coffey, R J, Morrow, J D Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells. Cancer Res, 58(11), 2323-7, 1998.
- Washington, K., Chiappori, A., Hamilton, K., Yu, S., Blanke, C., johnson, D., Sawyers, J., and Beauchamp, R.D "Expression of -catenin, -catenin, and E-cadherin in Barrett?s esophagus and esophageal adenocarcinomas." Modern Pathology , 11(9), 805-813, 1998.
- Sheng, H., Williams, C.S., Shao, J., Liang, P., DuBois, R.N., and Beauchamp, R.D "Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway." Journal of Biological Chemistry, 22120-22127, 1998.
- Sheng, H, Williams, C S, Shao, J, Liang, P, DuBois, R N, Beauchamp, R D Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway. J Biol Chem, 273(34), 22120-7, 1998.
- Sheng, H., Shao, J., Morrow, J., Beauchamp, R., DuBois, R "Modulation of Apoptosis and Bcl-2 Expression by Prostaglandin E2 in Human Colon Cancer Cells." Cancer Research , 58362-366, 1998.
- Sheng, H, Shao, J, Morrow, J D, Beauchamp, R D, DuBois, R N Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res, 58(2), 362-6, 1998.
- Sheng, H., Shao,J., Williams, C.S., Pereira, M.A., Taketo, M.M., Oshima, M., Reynolds, A.B., Washington, M.W., DuBois, R.N and Beauchamp, R.D "Nuclear translocation of b-catenin in hereditary and carcinogen- induced intestinal adenomas." Carcinogenesis , 19543-549, 1998.
- Sheng, H, Shao, J, Williams, C S, Pereira, M A, Taketo, M M, Oshima, M, Reynolds, A B, Washington, M K, DuBois, R N, Beauchamp, R D Nuclear translocation of beta-catenin in hereditary and carcinogen-induced intestinal adenomas. Carcinogenesis, 19(4), 543-9, 1998.
- Ko, T.C., Yu, W., Sakai, T., Sheng, H., Shao, J., Beauchamp, R.D and Thompson, E.A "TGF-b1 effects on proliferation of rat intestinal epithelial cells are due to inhibition of cyclin D1 expression." Oncogene , 163445-3454, 1998.
- Sheng, G., Shao, J., Sheng, H., Hooton, E., Isakson, P., Morrow, J., Coffey, R., DuBois, R., Beauchamp, R "A Selective Cyclooxygenase 2 Inhibitor Suppresses the Growth of H-ras-Transformed Rat Intestinal Epithelial Cells." Gastroenterology , 1131883-1891, 1997.
- Sheng, G G, Shao, J, Sheng, H, Hooton, E B, Isakson, P C, Morrow, J D, Coffey, R J, DuBois, R N, Beauchamp, R D A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells. Gastroenterology, 113(6), 1883-91, 1997.
- Chinery, R., Brockman, J.A., Peeler, M.O., Shyr, Y., Beauchamp, R.D., and Coffey, R.J "Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: A p53-independent induction of p21Waf1/Cip1 via C/EBP." Nature Medicine , 31-9, 1997.
- Chinery, R, Brockman, J A, Peeler, M O, Shyr, Y, Beauchamp, R D, Coffey, R J Antioxidants enhance the cytotoxicity of chemotherapeutic agents in colorectal cancer: a p53-independent induction of p21WAF1/CIP1 via C/EBPbeta. Nat Med, 3(11), 1233-41, 1997.
- Zhang, T., Nanney, L.B., Luongo, C., Lamps, L., Heppner, K.J., DuBois, R.N., and Beauchamp, R.D "Concurrent overexpression of cyclin D1 and Cdk4 in intestinal adenomas from min mice and human familial adenomatous polyposis patients." Cancer Research , 57169-175, 1997.
- Zhang, T, Nanney, L B, Luongo, C, Lamps, L, Heppner, K J, DuBois, R N, Beauchamp, R D Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res, 57(1), 169-75, 1997.
- Sheng, H., Shao, J., Hooton, E.B., Masahiko, T., DuBois, R.N., Beauchamp, R.D "Cyclooxygenase-2 induction and transforming growth factor (TGF)-b growth inhibition in rat intestinal epithelial cells." Cell Growth and Differentiation , 8463-470, 1997.
- Sheng, H, Shao, J, Hooton, E B, Tsujii, M, DuBois, R N, Beauchamp, R D Cyclooxygenase-2 induction and transforming growth factor beta growth inhibition in rat intestinal epithelial cells. Cell Growth Differ, 8(4), 463-70, 1997.
- Zhang, T., Nanney, L.B., Peeler, M.O., Williams, C.S., Lamps, L., Heppner, K.J., DuBois, R.N., and Beauchamp, R.D "Decreased TFG- type II receptor expression in intestinal adenomas from Min/+ Mice is associated with increased cyclin D1 and Cdk4 expression." Cancer Research, 571638-1643, 1997.
- Zhang, T, Nanney, L B, Peeler, M O, Williams, C S, Lamps, L, Heppner, K J, DuBois, R N, Beauchamp, R D Decreased transforming growth factor beta type II receptor expression in intestinal adenomas from Min/+ mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression. Cancer Res, 57(9), 1638-43, 1997.
- Sheng, H., Shao, J., Kirkland, S.C., Isakson, P., Coffey, R.J., Morrow, J., Beauchamp, R.D., DuBois R.N "Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2." The Journal of Clinical Investigation, 992254-2259, 1997.
- Sheng, H, Shao, J, Kirkland, S C, Isakson, P, Coffey, R J, Morrow, J, Beauchamp, R D, DuBois, R N Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest, 99(9), 2254-9, 1997.
- Williams, C S, Luongo, C, Radhika, A, Zhang, T, Lamps, L W, Nanney, L B, Beauchamp, R D, DuBois, R N Elevated cyclooxygenase-2 levels in Min mouse adenomas. Gastroenterology, 111(4), 1134-40, 1996.
- Williams, C.S., Luongo, C., Radhika, A., Zhang, R., Lamps, L.W., Nanney, L.B., Beauchamp, R.D., Dubois, R.N "Elevated cyclooxygenase-2 levels in min mouse adenomas." Gastroenterology , 1111134-1140, 1996.
- DuBois, R N, Shao, J, Tsujii, M, Sheng, H, Beauchamp, R D G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2. Cancer Res, 56(4), 733-7, 1996.
- DuBois, R. N., Shao, J., Masahiko, T., Sheng, H-M., Beauchamp, R.D "G1 delay in cells overexpressing prostaglandin endoperoxide synthase-21." Cancer Research , 56733-737, 1996.
- Beauchamp, R D, Sheng, H M, Shao, J Y, Thompson, E A, Ko, T C Intestinal cell cycle regulations. Interactions of cyclin D1, Cdk4, and p21Cip1. Ann Surg, 223(5), 620-7; discussion 627-8, 1996.
- Barnard, J.A., Beauchamp, R.D., Russell, W.E., DuBois, R.N., Coffey, R.J "Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology." Gastroenterology , 108564-580, 1995.
- Barnard, J A, Beauchamp, R D, Russell, W E, Dubois, R N, Coffey, R J Epidermal growth factor-related peptides and their relevance to gastrointestinal pathophysiology. Gastroenterology, 108(2), 564-80, 1995.
- Ko, T.C., Sheng, H.M.,,Reisman, D., Thompson, E.A., Beauchamp, R.D "Transforming growth factor- inhibits cyclin D1 Expression of intestinal epithelial clls." Oncongene , 10177-184, 1995.
- Beauchamp, R.D., Papaconstantinou, J., Henderson, A.M., Sheng, H-M., Townsend, C.M. Jr.,Thompson, J.C "Activation of hepatic proliferation-associated transcription factors by lipopolysaccharide." Surgery , 116367-377, 1994.
- Parekh, D., Ishizuka, J., Townsend, C.M. Jr., Haber, B., Beauchamp, R.D., Karp, G., Kim, S.W., Rajaraman, S., Greeley, G.H. Jr., Thompson, J.C "Characterization of a human pancreatic carcinoid in vitro: morphology, amine and peptide storage and secretion." Pancreas , 983-90, 1994.
- Sumi, S., Beauchamp, R.D., Townsend, C.M. Jr., Pour, P.M., Ishizuka, J., Thompson, J.C "Lovastatin inhibits pancreatic cancer growth regardless of ras mutation." Pancreas , 90657-661, 1994.
- Ko, T.C., Beauchamp, R.D., Townsend, C.M. Jr., Thompson, E.A., Thompson, J.C "Transforming growth factor beta inhibits rat intestinal cell growth by regulating cell cycle specific gene expression." American Journal of Surgery , 16714-20, 1994.
- Ko, T.C., Beauchamp, R.D., Townsend, C.M. Jr., Thompson, J.C "Glutamine is essential for epidermal growth factor-stimulated intestinal cell proliferation." Surgery , 114147-154, 1993.
- Guo, Y-S., Beauchamp, RD., Jin, G-F., Townsend, C.M. Jr., Thompson, J.C "Insulinlike growth factor-binding protein modulates the growth response to insulinlike growth factor 1 by human gastric cancer cells." Gastroenterology , 1041595-1604, 1993.
- Ishizuka, J., Beauchamp, R.D., Sato, K., Townsend, C.M. Jr., Thompson, J.C "Novel action of transforming growth factor 1 in functioning human pancreatic carcinoid cells." Journal of Cellular Physiology , 156112-118, 1993.
- Chung, D.H., Evers, B.M., Beauchamp, R.D., Upp, J.R. Jr., Rajaraman, S., Townsend, C.M. Jr., Thompson, J.C "Bombesin stimulates growth of human gastrinoma." Surgery , 1121059-1065, 1992.
- Polk, W H, Dempsey, P J, Russell, W E, Brown, P I, Beauchamp, R D, Barnard, J A, Coffey, R J Increased production of transforming growth factor alpha following acute gastric injury. Gastroenterology, 102(5), 1467-74, 1992.
- Sumi, S., Beauchamp, R.D., Townsend, C.M. Jr., Uchida, T., Murakami, M., Rajaraman, S., Ishizuka, J., Thompson, J.C "Inhibition of pancreatic adenocarcinoma cell growth by lovastatin." Gastroenterology , 103982-9, 1992.
- Beauchamp, R.D., Sheng, H-M., Alam, T., Townsend, C.M. Jr., Papaconstantinou, J "Posttranscriptional regulation of albumin and -fetoprotein messenger RNA by transforming growth factor- 1 requires de novo RNA and protein synthesis." Molecular Endocrinology , 61789-1796, 1992.
- Beauchamp, R.D., Sheng, H-M., Ishizuka, J., Townsend, C.M. Jr., Thompson, J.C "Transforming growth factor (TGF)- stimulates hepatic jun-B and fos-B proto-oncogenes and decreases albumin mRNA." Annals of Surgery , 216300-308, 1992.
- Ishizuka, J., Beauchamp, R.D., Evers, B.M., Townsend, C.M. Jr., Thompson, J.C "Unexpected growth-stimulatory effect of somatostatin analogue on cultured human pancreatic carcinoid cells." Biochemical and Biophysical Research Communications , 185577-581, 1992.
- Beauchamp, R D, Lyons, R M, Yang, E Y, Coffey, R J, Moses, H L Expression of and response to growth regulatory peptides by two human pancreatic carcinoma cell lines. Pancreas, 5(4), 369-80, 1990.
- Beauchamp, R D, Barnard, J A, McCutchen, C M, Cherner, J A, Coffey, R J Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal. J Clin Invest, 84(3), 1017-23, 1989.
- Barnard, J A, Beauchamp, R D, Coffey, R J, Moses, H L Regulation of intestinal epithelial cell growth by transforming growth factor type beta. Proc Natl Acad Sci U S A, 86(5), 1578-82, 1989.
You do not have JavaScript enabled. This site works better with JavaScript turned on.


