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VICC toll-free number 1-877-936-8422

 Darren  Tyson

Darren Tyson, Ph.D.

Research Assistant Professor of Cancer Biology
Researcher

Contact Information:

Vanderbilt-Ingram Cancer Center
2220 Pierce Avenue , 771PRB
Nashville, TN 37232-6840
615-322-0375
Fax: 615-936-2911

Publications
  • Frick PL, Paudel BB, Tyson DR, Quaranta V. Quantifying heterogeneity and dynamics of clonal fitness in response to perturbation. J. Cell. Physiol. 2015 Jul; 230(7): 1403-12. PMID: 25600161, DOI: 10.1002/jcp.24888, ISSN: 1097-4652.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25600161.
  • Wirtz ED, Hoshino D, Maldonado AT, Tyson DR, Weaver AM. Response of head and neck squamous cell carcinoma cells carrying PIK3CA mutations to selected targeted therapies. JAMA Otolaryngol Head Neck Surg. 2015 Jun; 141(6): 543-9. PMID: 25855885, PMCID: PMC4474763, PII: 2213736, DOI: 10.1001/jamaoto.2015.0471, ISSN: 2168-619X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25855885.
  • Leander R, Allen EJ, Garbett SP, Tyson DR, Quaranta V. Derivation and experimental comparison of cell-division probability densities. J. Theor. Biol [print-electronic]. 2014 Oct 10/21/2014; 359: 129-35. PMID: 24931675, PII: S0022-5193(14)00341-5, DOI: 10.1016/j.jtbi.2014.06.004, ISSN: 1095-8541.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24931675.
  • Sewell A, Brown B, Biktasova A, Mills GB, Lu Y, Tyson DR, Issaeva N, Yarbrough WG. Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations in HPV-associated head and neck cancer. Clin. Cancer Res [print-electronic]. 2014 May 5/1/2014; 20(9): 2300-11. PMID: 24599934, PMCID: PMC4027970, PII: 1078-0432.CCR-13-2585, DOI: 10.1158/1078-0432.CCR-13-2585, ISSN: 1078-0432.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24599934.
  • Quaranta V, Tyson DR. What lies beneath: looking beyond tumor genetics shows the complexity of signaling networks underlying drug sensitivity. Sci Signal. 2013 Sep 9/24/2013; 6(294): pe32. PMID: 24065144, PII: 6/294/pe32, DOI: 10.1126/scisignal.2004715, ISSN: 1937-9145.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24065144.
  • Tyson DR, Quaranta V. Beyond genetics in personalized cancer treatment: assessing dynamics and heterogeneity of tumor responses. Per Med. 2013 May 5/1/2013; 10(3): 221-5. PMID: 24696699, PMCID: PMC3970774, DOI: 10.2217/pme.13.6, ISSN: 1741-0541.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24696699.
  • Tyson DR, Garbett SP, Frick PL, Quaranta V. Fractional proliferation: a method to deconvolve cell population dynamics from single-cell data. Nat. Methods [print-electronic]. 2012 Sep; 9(9): 923-8. PMID: 22886092, PMCID: PMC3459330, PII: nmeth.2138, DOI: 10.1038/nmeth.2138, ISSN: 1548-7105.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22886092.
  • Quaranta V, Tyson DR, Garbett SP, Weidow B, Harris MP, Georgescu W. Trait variability of cancer cells quantified by high-content automated microscopy of single cells. Meth. Enzymol. 2009; 467: 23-57. PMID: 19897088, PMCID: PMC2915824, PII: S0076-6879(09)67002-6, DOI: 10.1016/S0076-6879(09)67002-6, ISSN: 1557-7988.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19897088.
  • Shukla D, Box GN, Edwards RA, Tyson DR. Bone marrow stem cells for urologic tissue engineering. World J Urol [print-electronic]. 2008 Aug; 26(4): 341-9. PMID: 18654786, DOI: 10.1007/s00345-008-0311-y, ISSN: 0724-4983.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18654786.
  • Tyson DR, Ornstein DK. Proteomics of cancer of hormone-dependent tissues. Adv. Exp. Med. Biol. 2008; 630: 133-47. PMID: 18637489, ISSN: 0065-2598.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18637489.
  • Tyson DR, Inokuchi J, Tsunoda T, Lau A, Ornstein DK. Culture requirements of prostatic epithelial cell lines for acinar morphogenesis and lumen formation in vitro: role of extracellular calcium. Prostate. 2007 Nov 11/1/2007; 67(15): 1601-13. PMID: 17705248, DOI: 10.1002/pros.20628, ISSN: 0270-4137.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17705248.
  • Hsiang CH, Tunoda T, Whang YE, Tyson DR, Ornstein DK. The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells. Prostate. 2006 Sep 9/15/2006; 66(13): 1413-24. PMID: 16741918, DOI: 10.1002/pros.20457, ISSN: 0270-4137.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16741918.
  • Ornstein DK, Tyson DR. Proteomics for the identification of new prostate cancer biomarkers. Urol. Oncol. 2006 May; 24(3): 231-6. PMID: 16678055, PII: S1078-1439(05)00281-4, DOI: 10.1016/j.urolonc.2005.11.035, ISSN: 1078-1439.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16678055.
  • Medzihradszky KF, Darula Z, Perlson E, Fainzilber M, Chalkley RJ, Ball H, Greenbaum D, Bogyo M, Tyson DR, Bradshaw RA, Burlingame AL. O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes. Mol. Cell Proteomics [print-electronic]. 2004 May; 3(5): 429-40. PMID: 14752058, PII: M300140-MCP200, DOI: 10.1074/mcp.M300140-MCP200, ISSN: 1535-9476.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14752058.
  • Jimenez JC, Tyson DR, Dhar S, Nguyen T, Hamai Y, Bradshaw RA, Evans GR. Human embryonic kidney cells (HEK-293 cells): characterization and dose-response relationship for modulated release of nerve growth factor for nerve regeneration. Plast. Reconstr. Surg. 2004 Feb; 113(2): 605-10. PMID: 14758223, PII: 00006534-200402000-00020, DOI: 10.1097/01.PRS.0000101066.76548.E8, ISSN: 0032-1052.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14758223.
  • Tyson DR, Larkin S, Hamai Y, Bradshaw RA. PC12 cell activation by epidermal growth factor receptor: role of autophosphorylation sites. Int. J. Dev. Neurosci. 2003 Apr; 21(2): 63-74. PMID: 12615082, PII: S0736574802001399, ISSN: 0736-5748.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12615082.
  • Swarthout JT, Tyson DR, Jefcoat SC, Partridge NC. Induction of transcriptional activity of the cyclic adenosine monophosphate response element binding protein by parathyroid hormone and epidermal growth factor in osteoblastic cells. J. Bone Miner. Res. 2002 Aug; 17(8): 1401-7. PMID: 12162494, DOI: 10.1359/jbmr.2002.17.8.1401, ISSN: 0884-0431.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12162494.
  • Tyson DR, Swarthout JT, Jefcoat SC, Partridge NC. PTH induction of transcriptional activity of the cAMP response element-binding protein requires the serine 129 site and glycogen synthase kinase-3 activity, but not casein kinase II sites. Endocrinology. 2002 Feb; 143(2): 674-82. PMID: 11796524, DOI: 10.1210/endo.143.2.8626, ISSN: 0013-7227.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11796524.
  • Bajaj MS, Tyson DR, Steer SA, Kuppuswamy MN. Role of GATA motifs in tissue factor pathway inhibitor gene expression in malignant cells. Thromb. Res. 2001 Feb 2/1/2001; 101(3): 203-11. PMID: 11228343, PII: S0049-3848(00)00393-5, ISSN: 0049-3848.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11228343.
  • Selvamurugan N, Pulumati MR, Tyson DR, Partridge NC. Parathyroid hormone regulation of the rat collagenase-3 promoter by protein kinase A-dependent transactivation of core binding factor alpha1. J. Biol. Chem. 2000 Feb 2/18/2000; 275(7): 5037-42. PMID: 10671545, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10671545.
  • Tyson DR, Swarthout JT, Partridge NC. Increased osteoblastic c-fos expression by parathyroid hormone requires protein kinase A phosphorylation of the cyclic adenosine 3',5'-monophosphate response element-binding protein at serine 133. Endocrinology. 1999 Mar; 140(3): 1255-61. PMID: 10067851, DOI: 10.1210/endo.140.3.6567, ISSN: 0013-7227.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10067851.
  • Koe RC, Clohisy JC, Tyson DR, Pulumati MR, Cook TF, Partridge NC. Parathyroid hormone versus phorbol ester stimulation of activator protein-1 gene family members in rat osteosarcoma cells. Calcif. Tissue Int. 1997 Jul; 61(1): 52-8. PMID: 9192514, ISSN: 0171-967X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9192514.
  • Tyson DR, Kuppuswamy MN, Broze GJ, Bajaj SP. Revised DNA sequence of exon 1 and 5' flanking region of the human tissue factor pathway inhibitor gene. Thromb. Res. 1993 May 5/1/1993; 70(3): 269-73. PMID: 8327992, PII: 0049-3848(93)90134-A, ISSN: 0049-3848.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8327992.