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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

Darryl J.  Bornhop

Darryl J. Bornhop, Ph.D.

Professor of Chemistry

Contact Information:

Vanderbilt University
5419 Stevenson
Nashville , TN 37203
Fax: 615-343-1234


Dr. Bornhop is Professor of Chemistry at Vanderbilt University and is an international expert on the development of lanthanide chelates for contrast detection of cancers.

Research Specialty

In vivo imaging probes, high throughput chemical screening

  • S. Robertson, P.J. Sattu, D.L. Morgan, B.C. Pence and D.J. Bornhop "Staging of Colon Cancer in the DMH Sprague Dawley Rat Model using Micro-Endoscopy." In Preparation for Gastroenterology, .
  • M.P. Houlne, F. Koch, T.S. Goebel and D.J. Bornhop "Structure Dependent Spectroscopic Properties of Europium and Terbium Chelate Complexes Used in Biomedical Imaging and Analysis." For submission to J. American Chemical Society, .
  • N.G. Deane, H.C. Manning, C.A. Foutch, M. Kay Washington, B.A. Aronow, D.J. Bornhop and R.J. Coffey "Molecular Imaging of Spontaneous Colonic Tumors in Smad3 Null Mice." Submitted to Cancer Research, September 2005.
  • D.A. Markov, J.C. Latham, A. Kussrow, H.S. Sørensen, and Darryl J. Bornhop "Label-free, Free Solution Molecular Interaction Determinations by Interferometry." For submission to Science, March 2006.
  • H.C. Manning, J.M.M. Griffin, T.S. Goebel, B. Bell, M. Motamedi, G.E. Kiefer and D.J. Bornhop "Lanthanide Chelates for Optical Imaging in Medicine." Submitted to J. American Chemical Society, August 2005.
  • J.C. Latham, D.A. Markov, H.S. Sørensen, and D.J. Bornhop "Photobiotin Surface Chemistry Improves Label-Free Interferometric Sensing of Biochemical Interactions." Angewandte Chemie International Edition, 45(6), 955-958, 2006.
  • Latham, JC, Markov, DA, Sørensen, HS, Bornhop, DJ Photobiotin surface chemistry improves label-free interferometric sensing of biochemical interactions. Angew Chem Int Ed Engl, 45(6), 955-8, 2006.
  • L. Smentek, B. A. Hess, Jr., J. P. Cross, H.C. Manning and D.J. Bornhop "Density Function Theory Structures of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complexes for Ions Across the Lanthanide Series." J. Chemical Physics, 123244302, 2005.
  • Smentek, L, Andes Hess, B, Cross, JP, Charles Manning, H, Bornhop, DJ Density-functional theory structures of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complexes for ions across the lanthanide series. J Chem Phys, 123(24), 244302, 2005.
  • Z. Wang and D.J. Bornhop, “Z. Wang and D.J. Bornhop "Dual-Capillary Backscatter Interferometry for High-Sensitivity Nanoliter Volume Refractive Index Detection with Gradient Compensation." Analytical Chemistry, 777872-7877, 2005.
  • Wang, Z, Bornhop, DJ Dual-capillary backscatter interferometry for high-sensitivity nanoliter-volume refractive index detection with density gradient compensation. Anal Chem, 77(24), 7872-7, 2005.
  • H.C. Manning, B. Anderson, L. Samuelson, S. Havaland and D.J. Bornhop "Expeditious Synthesis of P-protected Macrocycles In-route to Lanthanide Chelate Metal Complexes." Teterahedron Letters, 46(28), 4707-710, 2005.
  • H.C. Manning, J.M.M. Griffin, T.S. Goebel, M. A. Wegiel, R.C. Thompson, R.R. Price and D.J. Bornhop "A PBR Targeted Molecular Imaging Agent for Cellular-Scale Bi-modal Imaging." Bioconjugate Chemistry, 151488-1495, 2004.
  • D. Markov, K. Swinney, and D.J. Bornhop "Label-Free Molecular Interaction Determinations with Nanoscale Interferometry." J. American Chemical Society, 12616659-16664, 2004.
  • Markov, DA, Swinney, K, Bornhop, DJ Label-free molecular interaction determinations with nanoscale interferometry. J Am Chem Soc, 126(50), 16659-64, 2004.
  • D.A. Markov, S. Dotson, S. Wood, and D.J. Bornhop "Non-Invasive Fluid Flow Measurements in Microfluidic Channels with Backscatter Interferometry." Electrophoresis, 25(21-22), 3805-3809, 2004.
  • X. Wang, G. Ku, M.A. Wegiel, D.J. Bornhop, G. Stoica and L.V. Wang "Non-invasive Photoacoustic Angiography of Animal Brains In Vivo with NIR Light and an Optical Contrast Agent." Optics Letters, 29(7), 730-732, 2004.
  • Markov, DA, Dotson, S, Wood, S, Bornhop, DJ Noninvasive fluid flow measurements in microfluidic channels with backscatter interferometry. Electrophoresis, 25(21-22), 3805-9, 2004.
  • Manning, HC, Goebel, T, Thompson, RC, Price, RR, Lee, H, Bornhop, DJ Targeted molecular imaging agents for cellular-scale bimodal imaging. Bioconjug Chem, 15(6), 1488-95, 2004.
  • H.S. Sørensen, H Pranov, N.B. Larsen, D.J. Bornhop and P.E. Andersen "Absolute Refractive Index Determination by Micro-Interfermometric Backscatter Detection." Analytical Chemistry, 75(8), 1946-1953, 2003.
  • Z. Wang, K. Swinney and D.J. Bornhop "Attomole Sensitivity for Proteins and Polypeptides with On-chip CE and Universal Detection by Interferometric Backscatter." Electrophoresis, 24865-873, 2003.
  • T.S. Goebel, J.M.M. Griffin, B. Bell, M. Motamedi, and D.J. Bornhop "Lanthanide Chelate Contrast Agents for the Detection of Malignant Lesions in the Syrian Hamster Cheek Pouch." Applied Spectroscopy, 57(10), 1216-1222, 2003.
  • H.C. Manning, A.M. Skwierawska, J.N. Marx and D.J. Bornhop "Rapid Removal of Benzyloxycarbonyl Groups from 1,4,7,10-Tetraazacyclodododecance Derivatives by Catalytic Transfer Hydrogenation." Synthetic Communications, 33(3), 457-461, 2003.
  • D. Markov, K. Norville, D. Lu, K. Swinney and D.J. Bornhop "A Fourier Analysis Approach for Capillary Polarimetry." Electrophoresis, 23(5), 809-812, 2002.
  • D. Markov and D.J. Bornhop "Breaking the 10-7 for RI Measurements in Nanoliter Volumes." Analytical Chemistry, 74(20), 5438-5441, 2002.
  • H.C. Manning, T. Goebel, J.N. Marx and D.J. Bornhop "Facile, Efficient Conjugation of a Trifunctional Lanthanide Chelate to a Peripheral Benzodiazepine Ligand Analogue." Organic Letters, 4(7), 1075-1078, 2002.
  • K. Swinney J. Nodorft and D.J. Bornhop "Nanoliter Volume Polarimetry." Applied Spectroscopy, 56(1), 134-138, 2002.
  • K. Swinney and D.J. Bornhop "Quantification and Evaluation of Joule Heating in On-Chip CE." Electrophoresis, 23(4), 621-625, 2002.
  • D.J. Bornhop, C.H. Contag, K. Licha and C.J. Murphy "Advances in Contrast Agents, Reporters and Detection." J. Biomedical Optics, 6106-110, 2001.
  • K. Swinney J. Nodorft and D.J. Bornhop "Capillary-Scale Polarimetry for Flowing Streams." Analyst, 126673-675. (Published on the Web as an Advance Article), 2001.
  • D. Markov and D.J. Bornhop "Nanoliter-scale Non-invasive Flow-Rate Quantification using Micro-Interferometric Backscatter and Phase Detection." Fresenius’ J. Analytical Chemistry, 371234-237, 2001.
  • K. Swinney and D.J. Bornhop "Non-Invasive Picoliter Volume Thermometry Based on Backscatter Interferometry." Electrophoresis, 222032-2036, 2001.
  • J.M.M. Griffin, A.M. Skwierawska, H.C. Manning, J.N. Marx and D.J. Bornhop "Simple, High Yielding Synthesis of Trifunctional Fluorescent Lanthanide Chelates." Tetrahedron Letters, 423823-3828, 2001.
  • K. Swinney and D.J. Bornhop "A Chip-Scale Universal Detector for Electrophoresis Based on Backscattering Interferometry." Analyst, 1251713-1717, 2000.
  • K. Swinney and D.J. Bornhop "A Review of CE Detection Methodologies." CRC Critical Reviews in Analytical Chemistry, 30(1), 1-30, 2000.
  • K. Swinney, D. Markov and D.J. Bornhop "Chip-Scale Universal Detection using Backscattering Interferometry." Analytical Chemistry, 722690-2695. This was an Accelerated Article., 2000.
  • K. Swinney and D.J. Bornhop "D- Reaction Kinetics Studied in Nanoliter Volumes using a Capillary Polarimeter." Applied Spectroscopy, 541458-1469, 2000.
  • D.J. Bornhop and K. Swinney "Detection in Capillary Electrophoresis: A Review." Electrophoresis, 211239-1250, 2000.
  • K. Swinney, D. Markov and D.J. Bornhop "Ultra-Small Volume Refractive Index Detection using Micro-Interferometry." Review of Scientific Instruments, 71(7), 2684-2693, 2000.
  • 33. D.J. Bornhop, D.S. Hubbard, M.P. Houlne, C. Adair, G.E. Kiefer, B.C. Pence and D.L. Morgan "Fluorescent Tissue Site-Selective Lanthanide Chelate, Tb-PTCMB for Enhanced Imaging of Cancer." Analytical Chemistry, 712607-2615, 1999.
  • K. Swinney, J. Pennington and D.J. Bornhop "Ion Analysis by Capillary Electrophoresis using MIBD." J. Microchemical Society, 62154-163, 1999.
  • K. Swinney, J. Hankins and D.J. Bornhop "Laser-Based Capillary Polarimeter." J. Capillary Electrophoresis and Microchip Technology, 693-96, 1999.
  • M.M. Dickens, M.P. Houlne, S. Mitra and D.J. Bornhop "Method of Depixelating Micro-Endoscopic Images." Optical Engineering, 381836-1842, 1999.
  • K. Swinney, D. Markov, J. Hankins and D.J. Bornhop "Micro-Interferometric Backscatter Detection using a Diode Laser." Analytica Chimica Acta, 400. A contribution to mark the 400th Volume and a result of the Measurement for the next Millennium conference in Egmond aan Zee, The Netherlands.265-280, 1999.
  • M.P. Houlne, S.P. O’Briant, T. Goebel and D.J. Bornhop "Some Spectroscopic and Transport Properties of a Rare-Earth Chelate: Tb-PCTMP." Analyta Chimica Acta, 397267-278. Special issue on the research of the emerging leaders in analytical chemistry., 1999.
  • K. Swinney and D.J. Bornhop "Universal Detection for Capillary Electrophoresis-Using Micro-Interferometric Backscatter Detection." J. MicroColumn Separation, 11596-604, 1999.
  • K. Swinney, J. Pennington and D.J. Bornhop "Universal Detection in Capillary Electrophoresis by Micro-Interferometric Backscatter." Analyst. Accelerated article and Hot Topic paper for The Journal. , 124221-226, 1999.
  • D.S. Hubbard, M.P. Houlne, G.E. Kiefer, H.F. Janssen, C. Hacker and D.J. Bornhop "Diagnostic Imaging Using Rare-Earth Chelates." Lasers in Medical Science, 1314-21, 1998.
  • D.S. Hubbard, M.P. Houlne, G.E. Kiefer, K. McMillan and D.J. Bornhop "Imaging and Quantitation of Tissue Selective Lanthanide Chelates." Bioimaging, 663-70, 1998.
  • M.P. Houlne, D.S. Hubbard, G.E. Kiefer and D.J. Bornhop "Imaging and Quantitation of Tissue Selective Lanthanide Chelates Using an Endoscopic Fluorometer." J. Biomedical Optics, 3145-153, 1998.
  • C.K. Kenmore, S.E. Erskine and D.J. Bornhop "Refractive Index Detection in Packed Capillary HPLC by Interferometric Backscatter." J. Chromatography A, 762219-225, 1997.
  • M.P. Houlne and D.J. Bornhop "Semi-quantitative Two Dimensional Flow Transport Imaging using Micro-Endoscopic Probes." Optical Engineering, 361982-1991, 1997.
  • H. Tarigan, C.K. Kenmore, P. Neill and D.J. Bornhop "Capillary-Scale Refractive Index Detection by Interferometeric Backscatter." Analytical Chemistry, 681762-1770, 1996.
  • D.J. Bornhop and J. Hankins "Polarimetry in Capillary Dimensions." Analytical Chemistry, 681677-1684, 1996.
  • M.P. Houlne, T.S. Agent, G.F. Kiefer, K. McMillan and D.J. Bornhop "Spectroscopy Characterization and Tissue Imaging using Site-Selective Polyazacyclic Terbium (III) Chelates." Applied Spectroscopy, 10225-244, 1996.
  • D.J. Bornhop "Micro-Volume Index of Refraction Detection by Interferometric Backscatter." Applied Optics, 343234-3239, 1995.
  • M. Hackett, H. Wang, G.C. Miller and D.J. Bornhop "Rapid Scanning UV-Vis Detection for Capillary Gas Chromatography Using a Remote Flow Cell." J. Chromatography A, 695243-257, 1995.
  • D.J. Bornhop and G. Verga "Gasoline Analysis by Rapid Scanning Absorbance Detection and Capillary Gas Chromatography." TrAC, 11194-198 , 1992.
  • D.J. Bornhop, L. Hlousek, M. Hackett, H. Wang and G.C. Miller "Remote Scanning Ultraviolet Detection for Capillary Gas Chromatography." Review of Scientific Instruments, 63191, 1992.
  • A. Bruno, A. Paluis and D.J. Bornhop "Cross-Beam RI-Absorbance Detection in the UV for Capillary Electrophoresis." Applied Spectroscopy, 45462-467, 1991.
  • D.J. Bornhop and J.G. Wangsgaard "GC-UV: Capillary Gas Chromatography with Rapid Scanning Ultraviolet Detection." HRC & CC, 14344-347, 1991.
  • D.J. Bornhop, B.J. Murphy and L. Krieger-Jones "Chemiluminescence Sulfur Detection in Capillary Supercritical Fluid Chromatography." Analytical Chemistry, 61797-800, 1989.
  • B.E. Richter, D.J. Bornhop, J.T. Swanson, J.G. Wangsgaard and M.R. Anderson "Gas Chromatographic Type Detectors in SFC." J. Chromatography, 27303-308, 1989.
  • D.J. Bornhop and J.G. Wangsgaard "Optical Detection Methods in Supercritical Fluid Chromatography." J. Chromatography, 27293-302, 1989.
  • S.R. Weinberger and D.J. Bornhop "Scanning UV Detection in Capillary Supercritical Fluid Chromatography." J. Microcolumn Separations, 190-95, 1989.
  • N.J. Dovichim F. Zarrin, T.G. Nolan and D.J. Bornhop "Laser Detector for Capillary Liquid Chromatography." Spectro. Chim. Acta Part B, 43B639-649, 1988.
  • D.J. Bornhop, S.S. Schmidt, and N.L. Porter "Use of Two Stimulaneous Detectors in Capillary Supercritical SFC." J. Chromatography, 459193-200, 1988.
  • DW Later, DJ Bornhop, ED Lee, JD Henion and RC Weibolt "Detection Techniques for Capillary Supercritical Fluid Chromatography: UV, MS and FTIR." Feature Article LC-GC, 5(9), 804-816, 1987.
  • NL Porter, BE Richter, DJ Bornhop, DW Later adn FH Beyerlein "Fill Gas Effects on Reproducibility in Capillary SFC." HRC & CC, 10477-478, 1987.
  • F Zarrin, DJ Bornhop and NJ Dovichi "Laser Doppler Velocimetry for Particle Size Determination by Light Scatter within the Sheath Flow Cuvette." Analytical Chemistry, 59854-860, 1987.
  • DJ Bornhop and NJ Dovichi "Simultaneous Laser-Based Refractive Index and Absorbance Determinations Within Micrometer Diameter Capillary Tubes." Analytical Chemistry, 591632-1636, 1987.
  • DJ Bornhop and NJ Dovichi "Subnanoliter Laser-Based Refractive Index Detector for 0.25-mm ID Capillary Liquid Chromatography." LC-GC, 5427-429, 1987.
  • TG Nolan, DJ Bornhop and NJ Dovichi "Crossed Beam Thermal-Lens detection for 0.25-mm ID Microbore Liquid Chromatography: Separation of 2,4-Dinitrophenylhydrzones." J. Chromatography, 384189-195, 1986.
  • DJ Bornhop and NJ Dovichi "Simple Nanoliter Refractive Index Detector." Analytical Chemistry, 58504-505, 1986.
  • DJ Bornhop, TG Nolan and NJ Dovichi "Sub-Nanoliter Laser-Based Refractive Index Detector for 0.25-mm ID Microbore Liquid Chromatography: Reversed-Phase Separation of Nanogram Amounts of Sugars." J. Chromatography, 384181-187, 1986.
  • S Kapila, DJ Bornhop, SE Manahan and GL Nickell "Design of a Combined Photoionization Detector and Photoionization-Based Electron Capture Detector." J. Chromatography, 259205-210, 1983.
  • DJ Bornhop and SE Manahan "Isotope Dilution Analysis of Exchangeable Water in Coal, Coal Char and Activated Coal Char." Analytical Letters, 13(A12), 1041-1061, 1980.