Skip to Content
Darryl J.  Bornhop

Darryl J. Bornhop, Ph.D.

Professor of Chemistry

Contact Information:

Vanderbilt University
5419 Stevenson
Nashville , TN 37203
Fax: 615-343-1234


Dr. Bornhop is Professor of Chemistry at Vanderbilt University and is an international expert on the development of lanthanide chelates for contrast detection of cancers.

Research Description


  • D.A. Markov, J.C. Latham, A. Kussrow, H.S. Sørensen, and Darryl J. Bornhop. Label-free, Free Solution Molecular Interaction Determinations by Interferometry. For submission to Science. 2006 Mar.
  • Latham JC, Markov DA, Sørensen HS, Bornhop DJ. Photobiotin surface chemistry improves label-free interferometric sensing of biochemical interactions. Angew. Chem. Int. Ed. Engl. 2006 Jan 1/30/2006; 45(6): 955-8. PMID: 16385602, DOI: 10.1002/anie.200502418, ISSN: 1433-7851.
    Available from:
  • J.C. Latham, D.A. Markov, H.S. Sørensen, and D.J. Bornhop. Photobiotin Surface Chemistry Improves Label-Free Interferometric Sensing of Biochemical Interactions. Angewandte Chemie International Edition. 2006; 45((6)): 955-8.
  • Smentek L, Andes Hess B, Cross JP, Charles Manning H, Bornhop DJ. Density-functional theory structures of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complexes for ions across the lanthanide series. J Chem Phys. 2005 Dec 12/22/2005; 123(24): 244302. PMID: 16396532, DOI: 10.1063/1.2139997, ISSN: 0021-9606.
    Available from:
  • Wang Z, Bornhop DJ. Dual-capillary backscatter interferometry for high-sensitivity nanoliter-volume refractive index detection with density gradient compensation. Anal. Chem. 2005 Dec 12/15/2005; 77(24): 7872-7. PMID: 16351132, DOI: 10.1021/ac050752h, ISSN: 0003-2700.
    Available from:
  • N.G. Deane, H.C. Manning, C.A. Foutch, M. Kay Washington, B.A. Aronow, D.J. Bornhop and R.J. Coffey. Molecular Imaging of Spontaneous Colonic Tumors in Smad3 Null Mice. Submitted to Cancer Research. 2005 Sep.
  • H.C. Manning, J.M.M. Griffin, T.S. Goebel, B. Bell, M. Motamedi, G.E. Kiefer and D.J. Bornhop. Lanthanide Chelates for Optical Imaging in Medicine. Submitted to J. American Chemical Society. 2005 Aug.
  • H.C. Manning, B. Anderson, L. Samuelson, S. Havaland and D.J. Bornhop. Expeditious Synthesis of P-protected Macrocycles In-route to Lanthanide Chelate Metal Complexes. Teterahedron Letters. 2005; 46((28)): 4707-710.
  • L. Smentek, B. A. Hess, Jr., J. P. Cross, H.C. Manning and D.J. Bornhop. Density Function Theory Structures of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid complexes for Ions Across the Lanthanide Series. J. Chemical Physics. 2005; 123: 244302.
  • Z. Wang and D.J. Bornhop, “Z. Wang and D.J. Bornhop. Dual-Capillary Backscatter Interferometry for High-Sensitivity Nanoliter Volume Refractive Index Detection with Gradient Compensation. Analytical Chemistry. 2005; 77: 7872-7.
  • Markov DA, Swinney K, Bornhop DJ. Label-free molecular interaction determinations with nanoscale interferometry. J. Am. Chem. Soc. 2004 Dec 12/22/2004; 126(50): 16659-64. PMID: 15600372, DOI: 10.1021/ja047820m, ISSN: 0002-7863.
    Available from:
  • Manning HC, Goebel T, Thompson RC, Price RR, Lee H, Bornhop DJ. Targeted molecular imaging agents for cellular-scale bimodal imaging. Bioconjug. Chem. 2004 Nov; 15(6): 1488-95. PMID: 15546219, DOI: 10.1021/bc049904q, ISSN: 1043-1802.
    Available from:
  • Markov DA, Dotson S, Wood S, Bornhop DJ. Noninvasive fluid flow measurements in microfluidic channels with backscatter interferometry. Electrophoresis. 2004 Nov; 25(21-22): 3805-9. PMID: 15565690, DOI: 10.1002/elps.200406139, ISSN: 0173-0835.
    Available from:
  • D. Markov, K. Swinney, and D.J. Bornhop. Label-Free Molecular Interaction Determinations with Nanoscale Interferometry. J. American Chemical Society. 2004; 126: 16659-64.
  • D.A. Markov, S. Dotson, S. Wood, and D.J. Bornhop. Non-Invasive Fluid Flow Measurements in Microfluidic Channels with Backscatter Interferometry. Electrophoresis. 2004; 25((21-22)): 3805-9.
  • H.C. Manning, J.M.M. Griffin, T.S. Goebel, M. A. Wegiel, R.C. Thompson, R.R. Price and D.J. Bornhop. A PBR Targeted Molecular Imaging Agent for Cellular-Scale Bi-modal Imaging. Bioconjugate Chemistry. 2004; 15: 1488-95.
  • X. Wang, G. Ku, M.A. Wegiel, D.J. Bornhop, G. Stoica and L.V. Wang. Non-invasive Photoacoustic Angiography of Animal Brains In Vivo with NIR Light and an Optical Contrast Agent. Optics Letters. 2004; 29((7)): 730-2.
  • H.C. Manning, A.M. Skwierawska, J.N. Marx and D.J. Bornhop. Rapid Removal of Benzyloxycarbonyl Groups from 1,4,7,10-Tetraazacyclodododecance Derivatives by Catalytic Transfer Hydrogenation. Synthetic Communications. 2003; 33((3)): 457-61.
  • H.S. Sørensen, H Pranov, N.B. Larsen, D.J. Bornhop and P.E. Andersen. Absolute Refractive Index Determination by Micro-Interfermometric Backscatter Detection. Analytical Chemistry. 2003; 75((8)): 1946-53.
  • T.S. Goebel, J.M.M. Griffin, B. Bell, M. Motamedi, and D.J. Bornhop. Lanthanide Chelate Contrast Agents for the Detection of Malignant Lesions in the Syrian Hamster Cheek Pouch. Applied Spectroscopy. 2003; 57((10)): 1216-22.
  • Z. Wang, K. Swinney and D.J. Bornhop. Attomole Sensitivity for Proteins and Polypeptides with On-chip CE and Universal Detection by Interferometric Backscatter. Electrophoresis. 2003; 24: 865-73.
  • D. Markov and D.J. Bornhop. Breaking the 10-7 for RI Measurements in Nanoliter Volumes. Analytical Chemistry. 2002; 74((20)): 5438-41.
  • D. Markov, K. Norville, D. Lu, K. Swinney and D.J. Bornhop. A Fourier Analysis Approach for Capillary Polarimetry. Electrophoresis. 2002; 23((5)): 809-12.
  • H.C. Manning, T. Goebel, J.N. Marx and D.J. Bornhop. Facile, Efficient Conjugation of a Trifunctional Lanthanide Chelate to a Peripheral Benzodiazepine Ligand Analogue. Organic Letters. 2002; 4((7)): 1075-8.
  • K. Swinney J. Nodorft and D.J. Bornhop. Nanoliter Volume Polarimetry. Applied Spectroscopy. 2002; 56((1)): 134-8.
  • K. Swinney and D.J. Bornhop. Quantification and Evaluation of Joule Heating in On-Chip CE. Electrophoresis. 2002; 23((4)): 621-5.
  • D. Markov and D.J. Bornhop. Nanoliter-scale Non-invasive Flow-Rate Quantification using Micro-Interferometric Backscatter and Phase Detection. Fresenius’ J. Analytical Chemistry. 2001; 371: 234-7.
  • D.J. Bornhop, C.H. Contag, K. Licha and C.J. Murphy. Advances in Contrast Agents, Reporters and Detection. J. Biomedical Optics. 2001; 6: 106-10.
  • J.M.M. Griffin, A.M. Skwierawska, H.C. Manning, J.N. Marx and D.J. Bornhop. Simple, High Yielding Synthesis of Trifunctional Fluorescent Lanthanide Chelates. Tetrahedron Letters. 2001; 42: 3823-8.
  • K. Swinney J. Nodorft and D.J. Bornhop. Capillary-Scale Polarimetry for Flowing Streams. Analyst. 2001; 126: 673.
  • K. Swinney and D.J. Bornhop. Non-Invasive Picoliter Volume Thermometry Based on Backscatter Interferometry. Electrophoresis. 2001; 22: 2032-6.
  • D.J. Bornhop and K. Swinney. Detection in Capillary Electrophoresis: A Review. Electrophoresis. 2000; 21: 1239-50.
  • K. Swinney and D.J. Bornhop. A Chip-Scale Universal Detector for Electrophoresis Based on Backscattering Interferometry. Analyst. 2000; 125: 1713-7.
  • K. Swinney and D.J. Bornhop. A Review of CE Detection Methodologies. CRC Critical Reviews in Analytical Chemistry. 2000; 30((1)): 1-30.
  • K. Swinney and D.J. Bornhop. D- Reaction Kinetics Studied in Nanoliter Volumes using a Capillary Polarimeter. Applied Spectroscopy. 2000; 54: 1458-69.
  • K. Swinney, D. Markov and D.J. Bornhop. Chip-Scale Universal Detection using Backscattering Interferometry. Analytical Chemistry. 2000; 72: 2690.
  • K. Swinney, D. Markov and D.J. Bornhop. Ultra-Small Volume Refractive Index Detection using Micro-Interferometry. Review of Scientific Instruments. 2000; 71((7)): 2684-93.
  • 33. D.J. Bornhop, D.S. Hubbard, M.P. Houlne, C. Adair, G.E. Kiefer, B.C. Pence and D.L. Morgan. Fluorescent Tissue Site-Selective Lanthanide Chelate, Tb-PTCMB for Enhanced Imaging of Cancer. Analytical Chemistry. 1999; 71: 2607-15.
  • K. Swinney and D.J. Bornhop. Universal Detection for Capillary Electrophoresis-Using Micro-Interferometric Backscatter Detection. J. MicroColumn Separation. 1999; 11: 596-604.
  • K. Swinney, D. Markov, J. Hankins and D.J. Bornhop. Micro-Interferometric Backscatter Detection using a Diode Laser. Analytica Chimica Acta. 1999; 400. A contribution to mark the 400th Volume and a result of the Measurement for the next Millennium conference in Egmond aan Zee, The Netherlands.: 265-80.
  • K. Swinney, J. Hankins and D.J. Bornhop. Laser-Based Capillary Polarimeter. J. Capillary Electrophoresis and Microchip Technology. 1999; 6: 93-6.
  • K. Swinney, J. Pennington and D.J. Bornhop. Ion Analysis by Capillary Electrophoresis using MIBD. J. Microchemical Society. 1999; 62: 154-63.
  • K. Swinney, J. Pennington and D.J. Bornhop. Universal Detection in Capillary Electrophoresis by Micro-Interferometric Backscatter. Analyst. Accelerated article and Hot Topic paper for The Journal. 1999; 124: 221-6.
  • M.M. Dickens, M.P. Houlne, S. Mitra and D.J. Bornhop. Method of Depixelating Micro-Endoscopic Images. Optical Engineering. 1999; 38: 1836-42.
  • M.P. Houlne, S.P. O’Briant, T. Goebel and D.J. Bornhop. Some Spectroscopic and Transport Properties of a Rare-Earth Chelate: Tb-PCTMP. Analyta Chimica Acta. 1999; 397: 267.
  • D.S. Hubbard, M.P. Houlne, G.E. Kiefer, H.F. Janssen, C. Hacker and D.J. Bornhop. Diagnostic Imaging Using Rare-Earth Chelates. Lasers in Medical Science. 1998; 13: 14-21.
  • D.S. Hubbard, M.P. Houlne, G.E. Kiefer, K. McMillan and D.J. Bornhop. Imaging and Quantitation of Tissue Selective Lanthanide Chelates. Bioimaging. 1998; 6: 63-70.
  • M.P. Houlne, D.S. Hubbard, G.E. Kiefer and D.J. Bornhop. Imaging and Quantitation of Tissue Selective Lanthanide Chelates Using an Endoscopic Fluorometer. J. Biomedical Optics. 1998; 3: 145-53.
  • C.K. Kenmore, S.E. Erskine and D.J. Bornhop. Refractive Index Detection in Packed Capillary HPLC by Interferometric Backscatter. J. Chromatography A. 1997; 762: 219-25.
  • M.P. Houlne and D.J. Bornhop. Semi-quantitative Two Dimensional Flow Transport Imaging using Micro-Endoscopic Probes. Optical Engineering. 1997; 36: 1982-91.
  • D.J. Bornhop and J. Hankins. Polarimetry in Capillary Dimensions. Analytical Chemistry. 1996; 68: 1677-84.
  • H. Tarigan, C.K. Kenmore, P. Neill and D.J. Bornhop. Capillary-Scale Refractive Index Detection by Interferometeric Backscatter. Analytical Chemistry. 1996; 68: 1762-70.
  • M.P. Houlne, T.S. Agent, G.F. Kiefer, K. McMillan and D.J. Bornhop. Spectroscopy Characterization and Tissue Imaging using Site-Selective Polyazacyclic Terbium (III) Chelates. Applied Spectroscopy. 1996; 10: 225-44.
  • D.J. Bornhop. Micro-Volume Index of Refraction Detection by Interferometric Backscatter. Applied Optics. 1995; 34: 3234-9.
  • M. Hackett, H. Wang, G.C. Miller and D.J. Bornhop. Rapid Scanning UV-Vis Detection for Capillary Gas Chromatography Using a Remote Flow Cell. J. Chromatography A. 1995; 695: 243-57.
  • D.J. Bornhop and G. Verga. Gasoline Analysis by Rapid Scanning Absorbance Detection and Capillary Gas Chromatography. TrAC. 1992; 11: 194-8.
  • D.J. Bornhop, L. Hlousek, M. Hackett, H. Wang and G.C. Miller. Remote Scanning Ultraviolet Detection for Capillary Gas Chromatography. Review of Scientific Instruments. 1992; 63: 191.
  • A. Bruno, A. Paluis and D.J. Bornhop. Cross-Beam RI-Absorbance Detection in the UV for Capillary Electrophoresis. Applied Spectroscopy. 1991; 45: 462-7.
  • D.J. Bornhop and J.G. Wangsgaard. GC-UV: Capillary Gas Chromatography with Rapid Scanning Ultraviolet Detection. HRC & CC. 1991; 14: 344-7.
  • B.E. Richter, D.J. Bornhop, J.T. Swanson, J.G. Wangsgaard and M.R. Anderson. Gas Chromatographic Type Detectors in SFC. J. Chromatography. 1989; 27: 303-8.
  • D.J. Bornhop and J.G. Wangsgaard. Optical Detection Methods in Supercritical Fluid Chromatography. J. Chromatography. 1989; 27: 293-302.
  • D.J. Bornhop, B.J. Murphy and L. Krieger-Jones. Chemiluminescence Sulfur Detection in Capillary Supercritical Fluid Chromatography. Analytical Chemistry. 1989; 61: 797-800.
  • S.R. Weinberger and D.J. Bornhop. Scanning UV Detection in Capillary Supercritical Fluid Chromatography. J. Microcolumn Separations. 1989; 1: 90-5.
  • D.J. Bornhop, S.S. Schmidt, and N.L. Porter. Use of Two Stimulaneous Detectors in Capillary Supercritical SFC. J. Chromatography. 1988; 459: 193-200.
  • N.J. Dovichim F. Zarrin, T.G. Nolan and D.J. Bornhop. Laser Detector for Capillary Liquid Chromatography. Spectro. Chim. Acta Part B. 1988; 43B: 639-49.
  • DJ Bornhop and NJ Dovichi. Simultaneous Laser-Based Refractive Index and Absorbance Determinations Within Micrometer Diameter Capillary Tubes. Analytical Chemistry. 1987; 59: 1632-6.
  • DJ Bornhop and NJ Dovichi. Subnanoliter Laser-Based Refractive Index Detector for 0.25-mm ID Capillary Liquid Chromatography. LC-GC. 1987; 5: 427-9.
  • DW Later, DJ Bornhop, ED Lee, JD Henion and RC Weibolt. Detection Techniques for Capillary Supercritical Fluid Chromatography: UV, MS and FTIR. Feature Article LC-GC. 1987; 5((9)): 804-16.
  • F Zarrin, DJ Bornhop and NJ Dovichi. Laser Doppler Velocimetry for Particle Size Determination by Light Scatter within the Sheath Flow Cuvette. Analytical Chemistry. 1987; 59: 854-60.
  • NL Porter, BE Richter, DJ Bornhop, DW Later adn FH Beyerlein. Fill Gas Effects on Reproducibility in Capillary SFC. HRC & CC. 1987; 10: 477-8.
  • DJ Bornhop and NJ Dovichi. Simple Nanoliter Refractive Index Detector. Analytical Chemistry. 1986; 58: 504-5.
  • DJ Bornhop, TG Nolan and NJ Dovichi. Sub-Nanoliter Laser-Based Refractive Index Detector for 0.25-mm ID Microbore Liquid Chromatography: Reversed-Phase Separation of Nanogram Amounts of Sugars. J. Chromatography. 1986; 384: 181-7.
  • TG Nolan, DJ Bornhop and NJ Dovichi. Crossed Beam Thermal-Lens detection for 0.25-mm ID Microbore Liquid Chromatography: Separation of 2,4-Dinitrophenylhydrzones. J. Chromatography. 1986; 384: 189-95.
  • S Kapila, DJ Bornhop, SE Manahan and GL Nickell. Design of a Combined Photoionization Detector and Photoionization-Based Electron Capture Detector. J. Chromatography. 1983; 259: 205-10.
  • DJ Bornhop and SE Manahan. Isotope Dilution Analysis of Exchangeable Water in Coal, Coal Char and Activated Coal Char. Analytical Letters. 1980; 13((A12)): 1041-61.
  • M.P. Houlne, F. Koch, T.S. Goebel and D.J. Bornhop. Structure Dependent Spectroscopic Properties of Europium and Terbium Chelate Complexes Used in Biomedical Imaging and Analysis. For submission to J. American Chemical Society.
  • S. Robertson, P.J. Sattu, D.L. Morgan, B.C. Pence and D.J. Bornhop. Staging of Colon Cancer in the DMH Sprague Dawley Rat Model using Micro-Endoscopy. In Preparation for Gastroenterology.