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Digna R.   Velez Edwards

Digna R. Velez Edwards, Ph.D., MS

Assistant Professor of Obstetrics and Gynecology

Contact Information:

2525 West End Avenue
Suite 600, 6th floor
Nashville, TN 37209
615-322-1288

Profile

Dr. Digna R. Velez Edwards is a genetic epidemiologist and an Assistant Professor in the Department of Obstetrics and Gynecology at Vanderbilt University. Dr. Velez Edwards received her Ph.D. in Human Genetics (2008) and Masters in Applied Statistics at Vanderbilt University (2007) with subsequent postdoctoral training in human genetics at the University of Miami (2008-2009).
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Dr. Digna R. Velez Edwards is a genetic epidemiologist and an Assistant Professor in the Department of Obstetrics and Gynecology at Vanderbilt University. Dr. Velez Edwards received her Ph.D. in Human Genetics (2008) and Masters in Applied Statistics at Vanderbilt University (2007) with subsequent postdoctoral training in human genetics at the University of Miami (2008-2009). She has established a research program focused on genetic and environment risk factors associated with women's health and reproductive outcomes, including gynecologic cancers. Since the start of her faculty appointment Dr. Velez Edwards has developed and coordinated a repository of biospecimens from participants in the Right from the Start pregnancy cohort to be used for genetic epidemiology studies examining reproductive health complications and risk for adverse pregnancy outcomes. She has several ongoing research projects utilizing this resource, as well as large clinical databases that link clinical information to DNA (BioVU). These studies focus on understanding the racial and/or ethnic disparities in genetic risk for several complex diseases including preterm birth, miscarriage, uterine fibroids, and pelvic organ prolapse. She has a funded R01 evaluating the genetic determinants of uterine fibroids in racially diverse populations and grant to identify novel rare variants associated with fibroids using an extreme phenotype design. She is also involved in the Ovarian Cancer Association Consortium (OCAC) functioning as the site PI for the use of BioVU in the consortium. She also has active projects on endometrial cancer and endometriosis.

Education
 
  • BS - Biological Sciences, Chemistry, and Spanish Vanderbilt University
  • MS - Applied Statistics Vanderbilt University
  • PhD - Human Genetics Vanderbilt University
 
Research Description

My research is focused on understanding and identifying genetic risk factors for complex diseases with a specific focus on genetic factors related to women’s health and reproductive outcomes. My labs current research projects focus on examining genetic risk factors for adverse pregnancy outcomes in a large epidemiologic pregnancy cohort. For these studies I am working with Right from the Start: A Study of Early Pregnancy Health (RFTS). RFTS is an ongoing, community-based prospective cohort study with the goal of advancing knowledge about maternal and fetal health from conception to birth. Since 1999, RFTS has enrolled more than 6,000 women, 20% prior to conception, in order to study determinants of fecundability, miscarriage, spontaneous preterm birth, and other adverse pregnancy outcomes. Data have been carefully collected with regard to quality control and the data set has reached sufficient size to have good power to investigate additional important etiologic and clinically relevant questions. We are collecting DNA samples from past and current RFTS participants and their children to ask new questions regarding the etiology of pregnancy and its adverse outcomes. Current studies focus on testing for interactions between genes and maternal exposures during pregnancy. These studies include examining maternal nonsteroidal-anti-inflammatory drug (NSAID) exposure during preconception and early pregnancy on risk for spontaneous abortion as well as studies examining environmental exposures, including bleeding and spotting during pregnancy, on risk for spontaneous preterm birth.

Publications
  • Michels KA, Hartmann KE, Archer KR, Ye F, Velez Edwards DR. The Relationship between Total Fibroid Burden and First Trimester Bleeding and Pain. Paediatr Perinat Epidemiol [print-electronic]. 2015 Nov 11/3/2015; PMID: 26525634, DOI: 10.1111/ppe.12256, ISSN: 1365-3016.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26525634.
  • Michels KA, Hartmann KE, Archer KR, Ye F, Velez Edwards DR. The Relationship between Total Fibroid Burden and First Trimester Bleeding and Pain. Paediatr Perinat Epidemiol [print-electronic]. 2015 Nov 11/3/2015; PMID: 26525634, DOI: 10.1111/ppe.12256, ISSN: 1365-3016.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26525634.
  • Mosley JD, Shaffer CM, Van Driest SL, Weeke PE, Wells QS, Karnes JH, Velez Edwards DR, Wei WQ, Teixeira PL, Bastarache L, Crawford DC, Li R, Manolio TA, Bottinger EP, McCarty CA, Linneman JG, Brilliant MH, Pacheco JA, Thompson W, Chisholm RL, Jarvik GP, Crosslin DR, Carrell DS, Baldwin E, Ralston J, Larson EB, Grafton J, Scrol A, Jouni H, Kullo IJ, Tromp G, Borthwick KM, Kuivaniemi H, Carey DJ, Ritchie MD, Bradford Y, Verma SS, Chute CG, Veluchamy A, Siddiqui MK, Palmer CN, Doney A, MahmoudPour SH, Maitland-van der Zee AH, Morris AD, Denny JC, Roden DM. A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough. Pharmacogenomics J [print-electronic]. 2015 Jul 7/14/2015; PMID: 26169577, PII: tpj201551, DOI: 10.1038/tpj.2015.51, ISSN: 1473-1150.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26169577.
  • Zhu X, Feng T, Tayo BO, Liang J, Young JH, Franceschini N, Smith JA, Yanek LR, Sun YV, Edwards TL, Chen W, Nalls M, Fox E, Sale M, Bottinger E, Rotimi C, , Liu Y, McKnight B, Liu K, Arnett DK, Chakravati A, Cooper RS, Redline S. Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension. Am. J. Hum. Genet [print-electronic]. 2015 Jan 1/8/2015; 96(1): 21-36. PMID: 25500260, PMCID: PMC4289691, PII: S0002-9297(14)00477-7, DOI: 10.1016/j.ajhg.2014.11.011, ISSN: 1537-6605.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25500260.
  • Giri A, Wu JM, Ward RM, Hartmann KE, Park AJ, North KE, Graff M, Wallace RB, Bareh G, Qi L, O'Sullivan MJ, Reiner AP, Edwards TL, Velez Edwards DR. Genetic Determinants of Pelvic Organ Prolapse among African American and Hispanic Women in the Women's Health Initiative. PLoS ONE. 2015; 10(11): e0141647. PMID: 26545240, PMCID: PMC4636147, PII: PONE-D-15-26602, DOI: 10.1371/journal.pone.0141647, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26545240.
  • Van Driest SL, McGregor TL, Velez Edwards DR, Saville BR, Kitchner TE, Hebbring SJ, Brilliant M, Jouni H, Kullo IJ, Creech CB, Kannankeril PJ, Vear SI, Brothers KB, Bowton EA, Shaffer CM, Patel N, Delaney JT, Bradford Y, Wilson S, Olson LM, Crawford DC, Potts AL, Ho RH, Roden DM, Denny JC. Genome-Wide Association Study of Serum Creatinine Levels during Vancomycin Therapy. PLoS ONE. 2015; 10(6): e0127791. PMID: 26030142, PMCID: PMC4452656, PII: PONE-D-14-55959, DOI: 10.1371/journal.pone.0127791, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26030142.
  • Feingold-Link L, Edwards TL, Jones S, Hartmann KE, Velez Edwards DR. Enhancing uterine fibroid research through utilization of biorepositories linked to electronic medical record data. J Womens Health (Larchmt). 2014 Dec; 23(12): 1027-32. PMID: 25495367, PMCID: PMC4267124, DOI: 10.1089/jwh.2014.4978, ISSN: 1931-843X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25495367.
  • Velez Edwards DR, Tsosie KS, Williams SM, Edwards TL, Russell SB. Admixture mapping identifies a locus at 15q21.2-22.3 associated with keloid formation in African Americans. Hum. Genet [print-electronic]. 2014 Dec; 133(12): 1513-23. PMID: 25280642, PMCID: PMC4334317, DOI: 10.1007/s00439-014-1490-9, ISSN: 1432-1203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25280642.
  • Aldridge TD, Hartmann KE, Michels KA, Velez Edwards DR. First-trimester antihistamine exposure and risk of spontaneous abortion or preterm birth. Pharmacoepidemiol Drug Saf [print-electronic]. 2014 Oct; 23(10): 1043-50. PMID: 24789281, DOI: 10.1002/pds.3637, ISSN: 1099-1557.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24789281.
  • Ward RM, Velez Edwards DR, Edwards T, Giri A, Jerome RN, Wu JM. Genetic epidemiology of pelvic organ prolapse: a systematic review. Am. J. Obstet. Gynecol [print-electronic]. 2014 Oct; 211(4): 326-35. PMID: 24721264, PMCID: PMC4213176, PII: S0002-9378(14)00344-5, DOI: 10.1016/j.ajog.2014.04.006, ISSN: 1097-6868.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24721264.
  • White MJ, Tacconelli A, Chen JS, Wejse C, Hill PC, Gomes VF, Velez-Edwards DR, Østergaard LJ, Hu T, Moore JH, Novelli G, Scott WK, Williams SM, Sirugo G. Epiregulin (EREG) and human V-ATPase (TCIRG1): genetic variation, ethnicity and pulmonary tuberculosis susceptibility in Guinea-Bissau and The Gambia. Genes Immun [print-electronic]. 2014 Sep; 15(6): 370-7. PMID: 24898387, PII: gene201428, DOI: 10.1038/gene.2014.28, ISSN: 1476-5470.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24898387.
  • Michels KA, Velez Edwards DR, Baird DD, Savitz DA, Hartmann KE. Uterine leiomyomata and cesarean birth risk: a prospective cohort with standardized imaging. Ann Epidemiol [print-electronic]. 2014 Feb; 24(2): 122-6. PMID: 24321612, PMCID: PMC3926444, PII: S1047-2797(13)00412-2, DOI: 10.1016/j.annepidem.2013.10.017, ISSN: 1873-2585.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24321612.
  • Velez Edwards DR, Hartmann KE. Racial differences in risk of spontaneous abortions associated with periconceptional over-the-counter nonsteroidal anti-inflammatory drug exposure. Ann Epidemiol [print-electronic]. 2014 Feb; 24(2): 111-115.e1. PMID: 24331921, PMCID: PMC3946756, PII: S1047-2797(13)00417-1, DOI: 10.1016/j.annepidem.2013.11.001, ISSN: 1873-2585.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24331921.
  • Edwards TL, Hartmann KE, Velez Edwards DR. Variants in BET1L and TNRC6B associate with increasing fibroid volume and fibroid type among European Americans. Hum. Genet [print-electronic]. 2013 Dec; 132(12): 1361-9. PMID: 23892540, PMCID: PMC3830582, DOI: 10.1007/s00439-013-1340-1, ISSN: 1432-1203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23892540.
  • Davis MF, Cummings AC, D'Aoust LN, Jiang L, Velez Edwards DR, Laux R, Reinhart-Mercer L, Fuzzell D, Scott WK, Pericak-Vance MA, Lee SL, Haines JL. Parkinson disease loci in the mid-western Amish. Hum. Genet [print-electronic]. 2013 Nov; 132(11): 1213-21. PMID: 23793441, PMCID: PMC3797866, DOI: 10.1007/s00439-013-1316-1, ISSN: 1432-1203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23793441.
  • Franceschini N, Fox E, Zhang Z, Edwards TL, Nalls MA, Sung YJ, Tayo BO, Sun YV, Gottesman O, Adeyemo A, Johnson AD, Young JH, Rice K, Duan Q, Chen F, Li Y, Tang H, Fornage M, Keene KL, Andrews JS, Smith JA, Faul JD, Guangfa Z, Guo W, Liu Y, Murray SS, Musani SK, Srinivasan S, Velez Edwards DR, Wang H, Becker LC, Bovet P, Bochud M, Broeckel U, Burnier M, Carty C, Chasman DI, Ehret G, Chen WM, Chen G, Chen W, Ding J, Dreisbach AW, Evans MK, Guo X, Garcia ME, Jensen R, Keller MF, Lettre G, Lotay V, Martin LW, Moore JH, Morrison AC, Mosley TH, Ogunniyi A, Palmas W, Papanicolaou G, Penman A, Polak JF, Ridker PM, Salako B, Singleton AB, Shriner D, Taylor KD, Vasan R, Wiggins K, Williams SM, Yanek LR, Zhao W, Zonderman AB, Becker DM, Berenson G, Boerwinkle E, Bottinger E, Cushman M, Eaton C, Nyberg F, Heiss G, Hirschhron JN, Howard VJ, Karczewsk KJ, Lanktree MB, Liu K, Liu Y, Loos R, Margolis K, Snyder M, , Psaty BM, Schork NJ, Weir DR, Rotimi CN, Sale MM, Harris T, Kardia SL, Hunt SC, Arnett D, Redline S, Cooper RS, Risch NJ, Rao DC, Rotter JI, Chakravarti A, Reiner AP, Levy D, Keating BJ, Zhu X. Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. Am. J. Hum. Genet [print-electronic]. 2013 Sep 9/5/2013; 93(3): 545-54. PMID: 23972371, PMCID: PMC3769920, PII: S0002-9297(13)00328-5, DOI: 10.1016/j.ajhg.2013.07.010, ISSN: 1537-6605.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23972371.
  • Velez Edwards DR, Baird DD, Hartmann KE. Association of age at menarche with increasing number of fibroids in a cohort of women who underwent standardized ultrasound assessment. Am. J. Epidemiol [print-electronic]. 2013 Aug 8/1/2013; 178(3): 426-33. PMID: 23817917, PMCID: PMC3727338, PII: kws585, DOI: 10.1093/aje/kws585, ISSN: 1476-6256.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23817917.
  • Edwards DR, Gilbert JR, Hicks JE, Myers JL, Jiang L, Cummings AC, Guo S, Gallins PJ, Konidari I, Caywood L, Reinhart-Mercer L, Fuzzell D, Knebusch C, Laux R, Jackson CE, Pericak-Vance MA, Haines JL, Scott WK. Linkage and association of successful aging to the 6q25 region in large Amish kindreds. Age (Dordr) [print-electronic]. 2013 Aug; 35(4): 1467-77. PMID: 22773346, PMCID: PMC3705095, DOI: 10.1007/s11357-012-9447-1, ISSN: 1574-4647.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22773346.
  • Edwards TL, Michels KA, Hartmann KE, Velez Edwards DR. BET1L and TNRC6B associate with uterine fibroid risk among European Americans. Hum. Genet [print-electronic]. 2013 Aug; 132(8): 943-53. PMID: 23604678, PMCID: PMC3715562, DOI: 10.1007/s00439-013-1306-3, ISSN: 1432-1203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23604678.
  • Mukherjee S, Velez Edwards DR, Baird DD, Savitz DA, Hartmann KE. Risk of miscarriage among black women and white women in a U.S. Prospective Cohort Study. Am. J. Epidemiol [print-electronic]. 2013 Jun 6/1/2013; 177(11): 1271-8. PMID: 23558353, PMCID: PMC3664339, PII: kws393, DOI: 10.1093/aje/kws393, ISSN: 1476-6256.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23558353.
  • Monda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, Ng MC, Adeyemo AA, Allison MA, Bielak LF, Chen G, Graff M, Irvin MR, Rhie SK, Li G, Liu Y, Liu Y, Lu Y, Nalls MA, Sun YV, Wojczynski MK, Yanek LR, Aldrich MC, Ademola A, Amos CI, Bandera EV, Bock CH, Britton A, Broeckel U, Cai Q, Caporaso NE, Carlson CS, Carpten J, Casey G, Chen WM, Chen F, Chen YD, Chiang CW, Coetzee GA, Demerath E, Deming-Halverson SL, Driver RW, Dubbert P, Feitosa MF, Feng Y, Freedman BI, Gillanders EM, Gottesman O, Guo X, Haritunians T, Harris T, Harris CC, Hennis AJ, Hernandez DG, McNeill LH, Howard TD, Howard BV, Howard VJ, Johnson KC, Kang SJ, Keating BJ, Kolb S, Kuller LH, Kutlar A, Langefeld CD, Lettre G, Lohman K, Lotay V, Lyon H, Manson JE, Maixner W, Meng YA, Monroe KR, Morhason-Bello I, Murphy AB, Mychaleckyj JC, Nadukuru R, Nathanson KL, Nayak U, N'diaye A, Nemesure B, Wu SY, Leske MC, Neslund-Dudas C, Neuhouser M, Nyante S, Ochs-Balcom H, Ogunniyi A, Ogundiran TO, Ojengbede O, Olopade OI, Palmer JR, Ruiz-Narvaez EA, Palmer ND, Press MF, Rampersaud E, Rasmussen-Torvik LJ, Rodriguez-Gil JL, Salako B, Schadt EE, Schwartz AG, Shriner DA, Siscovick D, Smith SB, Wassertheil-Smoller S, Speliotes EK, Spitz MR, Sucheston L, Taylor H, Tayo BO, Tucker MA, Van Den Berg DJ, Edwards DR, Wang Z, Wiencke JK, Winkler TW, Witte JS, Wrensch M, Wu X, Yang JJ, Levin AM, Young TR, Zakai NA, Cushman M, Zanetti KA, Zhao JH, Zhao W, Zheng Y, Zhou J, Ziegler RG, Zmuda JM, Fernandes JK, Gilkeson GS, Kamen DL, Hunt KJ, Spruill IJ, Ambrosone CB, Ambs S, Arnett DK, Atwood L, Becker DM, Berndt SI, Bernstein L, Blot WJ, Borecki IB, Bottinger EP, Bowden DW, Burke G, Chanock SJ, Cooper RS, Ding J, Duggan D, Evans MK, Fox C, Garvey WT, Bradfield JP, Hakonarson H, Grant SF, Hsing A, Chu L, Hu JJ, Huo D, Ingles SA, John EM, Jordan JM, Kabagambe EK, Kardia SL, Kittles RA, Goodman PJ, Klein EA, Kolonel LN, Le Marchand L, Liu S, McKnight B, Millikan RC, Mosley TH, Padhukasahasram B, Williams LK, Patel SR, Peters U, Pettaway CA, Peyser PA, Psaty BM, Redline S, Rotimi CN, Rybicki BA, Sale MM, Schreiner PJ, Signorello LB, Singleton AB, Stanford JL, Strom SS, Thun MJ, Vitolins M, Zheng W, Moore JH, Williams SM, Ketkar S, Zhu X, Zonderman AB, , , , , Kooperberg C, Papanicolaou GJ, Henderson BE, Reiner AP, Hirschhorn JN, Loos RJ, North KE, Haiman CA. A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat. Genet [print-electronic]. 2013 Jun; 45(6): 690-6. PMID: 23583978, PMCID: PMC3694490, PII: ng.2608, DOI: 10.1038/ng.2608, ISSN: 1546-1718.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23583978.
  • Velez Edwards DR, Likis FE, Andrews JC, Woodworth AL, Jerome RN, Fonnesbeck CJ, Nikki McKoy J, Hartmann KE. Progestogens for preterm birth prevention: a systematic review and meta-analysis by drug route. Arch. Gynecol. Obstet [print-electronic]. 2013 Jun; 287(6): 1059-66. PMID: 23532387, DOI: 10.1007/s00404-013-2789-9, ISSN: 1432-0711.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23532387.
  • Wu JM, Ward RM, Allen-Brady KL, Edwards TL, Norton PA, Hartmann KE, Hauser ER, Velez Edwards DR. Phenotyping clinical disorders: lessons learned from pelvic organ prolapse. Am. J. Obstet. Gynecol [print-electronic]. 2013 May; 208(5): 360-5. PMID: 23200709, PMCID: PMC3597745, PII: S0002-9378(12)02085-6, DOI: 10.1016/j.ajog.2012.11.030, ISSN: 1097-6868.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23200709.
  • Velez Edwards DR, Naj AC, Monda K, North KE, Neuhouser M, Magvanjav O, Kusimo I, Vitolins MZ, Manson JE, O'Sullivan MJ, Rampersaud E, Edwards TL. Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. Hum. Genet [print-electronic]. 2013 Mar; 132(3): 323-36. PMID: 23192594, PMCID: PMC3704217, DOI: 10.1007/s00439-012-1246-3, ISSN: 1432-1203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23192594.
  • Sirugo G, Edwards DR, Ryckman KK, Bisseye C, White MJ, Kebbeh B, Morris GA, Adegbola RA, Tacconelli A, Predazzi IM, Novelli G, Vannberg FO, Odunsi K, Page GP, Williams SM. PTX3 genetic variation and dizygotic twinning in the Gambia: could pleiotropy with innate immunity explain common dizygotic twinning in Africa?. Ann. Hum. Genet [print-electronic]. 2012 Nov; 76(6): 454-63. PMID: 22834944, PMCID: PMC3731069, DOI: 10.1111/j.1469-1809.2012.00723.x, ISSN: 1469-1809.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22834944.
  • Likis FE, Edwards DR, Andrews JC, Woodworth AL, Jerome RN, Fonnesbeck CJ, McKoy JN, Hartmann KE. Progestogens for preterm birth prevention: a systematic review and meta-analysis. Obstet Gynecol. 2012 Oct; 120(4): 897-907. PMID: 22955308, DOI: 10.1097/AOG.0b013e3182699a15, ISSN: 1873-233X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22955308.
  • Cummings AC, Jiang L, Velez Edwards DR, McCauley JL, Laux R, McFarland LL, Fuzzell D, Knebusch C, Caywood L, Reinhart-Mercer L, Nations L, Gilbert JR, Konidari I, Tramontana M, Cuccaro ML, Scott WK, Pericak-Vance MA, Haines JL. Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene. Ann. Hum. Genet. 2012 Sep; 76(5): 342-51. PMID: 22881374, PMCID: PMC3419486, DOI: 10.1111/j.1469-1809.2012.00721.x, ISSN: 1469-1809.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22881374.
  • Edwards DR, Aldridge T, Baird DD, Funk MJ, Savitz DA, Hartmann KE. Periconceptional over-the-counter nonsteroidal anti-inflammatory drug exposure and risk for spontaneous abortion. Obstet Gynecol. 2012 Jul; 120(1): 113-22. PMID: 22914399, PMCID: PMC3427532, PII: 00006250-201207000-00019, DOI: 10.1097/AOG.0b013e3182595671, ISSN: 1873-233X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22914399.
  • Plantinga TS, Johnson MD, Scott WK, van de Vosse E, Velez Edwards DR, Smith PB, Alexander BD, Yang JC, Kremer D, Laird GM, Oosting M, Joosten LA, van der Meer JW, van Dissel JT, Walsh TJ, Perfect JR, Kullberg BJ, Netea MG. Toll-like receptor 1 polymorphisms increase susceptibility to candidemia. J. Infect. Dis [print-electronic]. 2012 Mar 3/15/2012; 205(6): 934-43. PMID: 22301633, PMCID: PMC3282566, PII: jir867, DOI: 10.1093/infdis/jir867, ISSN: 1537-6613.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22301633.
  • Johnson MD, Plantinga TS, van de Vosse E, Velez Edwards DR, Smith PB, Alexander BD, Yang JC, Kremer D, Laird GM, Oosting M, Joosten LA, van der Meer JW, van Dissel JT, Walsh TJ, Perfect JR, Kullberg BJ, Scott WK, Netea MG. Cytokine gene polymorphisms and the outcome of invasive candidiasis: a prospective cohort study. Clin. Infect. Dis [print-electronic]. 2012 Feb 2/15/2012; 54(4): 502-10. PMID: 22144535, PMCID: PMC3269308, PII: cir827, DOI: 10.1093/cid/cir827, ISSN: 1537-6591.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22144535.
  • Edwards TL, Velez Edwards DR, Villegas R, Cohen SS, Buchowski MS, Fowke JH, Schlundt D, Long J, Cai Q, Zheng W, Shu XO, Hargreaves MK, Smith J, Williams SM, Signorello LB, Blot WJ, Matthews CE. HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes. Am. J. Epidemiol [print-electronic]. 2012 Jan 1/1/2012; 175(1): 11-21. PMID: 22106445, PMCID: PMC3244609, PII: kwr272, DOI: 10.1093/aje/kwr272, ISSN: 1476-6256.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22106445.
  • Velez Edwards DR, Baird DD, Hasan R, Savitz DA, Hartmann KE. First-trimester bleeding characteristics associate with increased risk of preterm birth: data from a prospective pregnancy cohort. Hum. Reprod [print-electronic]. 2012 Jan; 27(1): 54-60. PMID: 22052384, PMCID: PMC3241603, PII: der354, DOI: 10.1093/humrep/der354, ISSN: 1460-2350.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22052384.
  • Velez Edwards DR, Tacconelli A, Wejse C, Hill PC, Morris GA, Edwards TL, Gilbert JR, Myers JL, Park YS, Stryjewski ME, Abbate E, Estevan R, Rabna P, Novelli G, Hamilton CD, Adegbola R, Østergaar L, Williams SM, Scott WK, Sirugo G. MCP1 SNPs and pulmonary tuberculosis in cohorts from West Africa, the USA and Argentina: lack of association or epistasis with IL12B polymorphisms. PLoS ONE [print-electronic]. 2012; 7(2): e32275. PMID: 22384203, PMCID: PMC3288089, PII: PONE-D-11-18824, DOI: 10.1371/journal.pone.0032275, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22384203.
  • Rosentul DC, Plantinga TS, Oosting M, Scott WK, Velez Edwards DR, Smith PB, Alexander BD, Yang JC, Laird GM, Joosten LA, van der Meer JW, Perfect JR, Kullberg BJ, Netea MG, Johnson MD. Genetic variation in the dectin-1/CARD9 recognition pathway and susceptibility to candidemia. J. Infect. Dis. 2011 Oct 10/1/2011; 204(7): 1138-45. PMID: 21881131, PMCID: PMC3164426, PII: jir458, DOI: 10.1093/infdis/jir458, ISSN: 1537-6613.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21881131.
  • Edwards DR, Gilbert JR, Jiang L, Gallins PJ, Caywood L, Creason M, Fuzzell D, Knebusch C, Jackson CE, Pericak-Vance MA, Haines JL, Scott WK. Successful aging shows linkage to chromosomes 6, 7, and 14 in the Amish. Ann. Hum. Genet. 2011 Jul; 75(4): 516-28. PMID: 21668908, PMCID: PMC3756593, DOI: 10.1111/j.1469-1809.2011.00658.x, ISSN: 1469-1809.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21668908.
  • Edwards DR, Romero R, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Erez O, Chaiworapongsa T, Pearce BD, Bartlett J, Friel LA, Salisbury BA, Anant MK, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Menon R, Williams SM. Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-age. J. Matern. Fetal. Neonatal. Med [print-electronic]. 2011 Feb; 24(2): 362-80. PMID: 20617897, PMCID: PMC3104673, DOI: 10.3109/14767058.2010.497572, ISSN: 1476-4954.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20617897.
  • Hennig BJ, Velez-Edwards DR, Schim van der Loeff MF, Bisseye C, Edwards TL, Tacconelli A, Novelli G, Aaby P, Kaye S, Scott WK, Jaye A, Whittle HC, Williams SM, Hill AV, Sirugo G. CD4 intragenic SNPs associate with HIV-2 plasma viral load and CD4 count in a community-based study from Guinea-Bissau, West Africa. J. Acquir. Immune Defic. Syndr. 2011 Jan 1/1/2011; 56(1): 1-8. PMID: 20924289, DOI: 10.1097/QAI.0b013e3181f638ed, ISSN: 1944-7884.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20924289.
  • Morris GA, Edwards DR, Hill PC, Wejse C, Bisseye C, Olesen R, Edwards TL, Gilbert JR, Myers JL, Stryjewski ME, Abbate E, Estevan R, Hamilton CD, Tacconelli A, Novelli G, Brunetti E, Aaby P, Sodemann M, Østergaard L, Adegbola R, Williams SM, Scott WK, Sirugo G. Interleukin 12B (IL12B) genetic variation and pulmonary tuberculosis: a study of cohorts from The Gambia, Guinea-Bissau, United States and Argentina. PLoS ONE. 2011; 6(2): e16656. PMID: 21339808, PMCID: PMC3037276, DOI: 10.1371/journal.pone.0016656, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21339808.
  • Romero R, Friel LA, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Erez O, Chaiworapongsa T, Pearce BD, Bartlett J, Salisbury BA, Anant MK, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Am. J. Obstet. Gynecol [print-electronic]. 2010 Oct; 203(4): 361.e1-361.e30. PMID: 20673868, PMCID: PMC2989662, PII: S0002-9378(10)00669-1, DOI: 10.1016/j.ajog.2010.05.026, ISSN: 1097-6868.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20673868.
  • Sirugo G, Williams SM, Royal CD, Newport MJ, Hennig BJ, Mariani-Costantini R, Buonaguro FM, Velez Edwards DR, Ibrahim M, Soodyall H, Wonkam A, Ramesar R, Rotimi CN. Report on the 6th African Society of Human Genetics (AfSHG) Meeting, March 12-15, 2009, Yaounde, Cameroon. Am. J. Trop. Med. Hyg. 2010 Aug; 83(2): 226-9. PMID: 20682860, PMCID: PMC2911163, PII: 83/2/226, DOI: 10.4269/ajtmh.2010.10-0208, ISSN: 1476-1645.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20682860.
  • Romero R, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Chaiworapongsa T, Pearce BD, Friel LA, Bartlett J, Anant MK, Salisbury BA, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. Am. J. Obstet. Gynecol. 2010 May; 202(5): 431.e1-34. PMID: 20452482, PMCID: PMC3604889, PII: S0002-9378(10)00345-5, DOI: 10.1016/j.ajog.2010.03.026, ISSN: 1097-6868.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20452482.
  • Edwards DR, Gallins P, Polk M, Ayala-Haedo J, Schwartz SG, Kovach JL, Spencer K, Wang G, Agarwal A, Postel EA, Haines JL, Pericak-Vance M, Scott WK. Inverse association of female hormone replacement therapy with age-related macular degeneration and interactions with ARMS2 polymorphisms. Invest. Ophthalmol. Vis. Sci [print-electronic]. 2010 Apr; 51(4): 1873-9. PMID: 19933179, PMCID: PMC2868389, PII: iovs.09-4000, DOI: 10.1167/iovs.09-4000, ISSN: 1552-5783.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19933179.
  • Menon R, Fortunato SJ, Edwards DR, Williams SM. Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrations. Ann. Hum. Genet. 2010 Mar; 74(2): 165-83. PMID: 20369436, ISSN: 1469-1809.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20369436.
  • Velez DR, Wejse C, Stryjewski ME, Abbate E, Hulme WF, Myers JL, Estevan R, Patillo SG, Olesen R, Tacconelli A, Sirugo G, Gilbert JR, Hamilton CD, Scott WK. Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. Hum. Genet [print-electronic]. 2010 Jan; 127(1): 65-73. PMID: 19771452, PMCID: PMC2902366, DOI: 10.1007/s00439-009-0741-7, ISSN: 1432-1203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19771452.
  • Williams SM, Velez DR, Menon R. Geographic ancestry and markers of preterm birth. Expert Rev. Mol. Diagn. 2010 Jan; 10(1): 27-32. PMID: 20014920, DOI: 10.1586/erm.09.70, ISSN: 1744-8352.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20014920.
  • Dolan SM, Hollegaard MV, Merialdi M, Betran AP, Allen T, Abelow C, Nace J, Lin BK, Khoury MJ, Ioannidis JP, Bagade S, Zheng X, Dubin RA, Bertram L, Velez Edwards DR, Menon R. Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene). Public Health Genomics [print-electronic]. 2010; 13(7-8): 514-23. PMID: 20484876, PII: 000294202, DOI: 10.1159/000294202, ISSN: 1662-8063.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20484876.
  • Ryckman KK, Morken NH, White MJ, Velez DR, Menon R, Fortunato SJ, Magnus P, Williams SM, Jacobsson B. Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. PLoS ONE. 2010; 5(2): e9040. PMID: 20140262, PMCID: PMC2815792, DOI: 10.1371/journal.pone.0009040, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20140262.
  • Velez DR, Hulme WF, Myers JL, Weinberg JB, Levesque MC, Stryjewski ME, Abbate E, Estevan R, Patillo SG, Gilbert JR, Hamilton CD, Scott WK. NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans. Hum. Genet [print-electronic]. 2009 Nov; 126(5): 643-53. PMID: 19575238, PMCID: PMC2881538, DOI: 10.1007/s00439-009-0713-y, ISSN: 1432-1203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19575238.
  • Velez DR, Hulme WF, Myers JL, Stryjewski ME, Abbate E, Estevan R, Patillo SG, Gilbert JR, Hamilton CD, Scott WK. Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians. Int. J. Tuberc. Lung Dis. 2009 Sep; 13(9): 1068-76. PMID: 19723394, PMCID: PMC2902362, ISSN: 1815-7920.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19723394.
  • Sile S, Velez DR, Gillani NB, Narsia T, Moore JH, George AL, Vanoye CG, Williams SM. CLCNKB-T481S and essential hypertension in a Ghanaian population. J. Hypertens. 2009 Feb; 27(2): 298-304. PMID: 19226700, PMCID: PMC3845205, ISSN: 0263-6352.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19226700.
  • Velez DR, Fortunato S, Thorsen P, Lombardi SJ, Williams SM, Menon R. Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. Am. J. Obstet. Gynecol [print-electronic]. 2009 Feb; 200(2): 209.e1-27. PMID: 19019335, PII: S0002-9378(08)00987-3, DOI: 10.1016/j.ajog.2008.08.051, ISSN: 1097-6868.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19019335.
  • Edwards TL, Lewis K, Velez DR, Dudek S, Ritchie MD. Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models. Hum. Hered [print-electronic]. 2009; 67(3): 183-92. PMID: 19077437, PMCID: PMC3078287, PII: 000181157, DOI: 10.1159/000181157, ISSN: 1423-0062.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19077437.
  • Menon R, Pearce B, Velez DR, Merialdi M, Williams SM, Fortunato SJ, Thorsen P. Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. Reprod. Biol. Endocrinol. 2009; 7: 62. PMID: 19527514, PMCID: PMC2714850, PII: 1477-7827-7-62, DOI: 10.1186/1477-7827-7-62, ISSN: 1477-7827.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19527514.
  • Menon R, Velez DR, Morgan N, Lombardi SJ, Fortunato SJ, Williams SM. Genetic regulation of amniotic fluid TNF-alpha and soluble TNF receptor concentrations affected by race and preterm birth. Hum. Genet [print-electronic]. 2008 Oct; 124(3): 243-53. PMID: 18807256, DOI: 10.1007/s00439-008-0547-z, ISSN: 1432-1203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18807256.
  • Velez DR, Fortunato SJ, Morgan N, Edwards TL, Lombardi SJ, Williams SM, Menon R. Patterns of cytokine profiles differ with pregnancy outcome and ethnicity. Hum. Reprod [print-electronic]. 2008 Aug; 23(8): 1902-9. PMID: 18487217, PII: den170, DOI: 10.1093/humrep/den170, ISSN: 1460-2350.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18487217.
  • Velez DR, Fortunato SJ, Williams SM, Menon R. Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth. Hum. Mol. Genet [print-electronic]. 2008 Jun 6/1/2008; 17(11): 1619-30. PMID: 18276608, PII: ddn049, DOI: 10.1093/hmg/ddn049, ISSN: 1460-2083.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18276608.
  • Fortunato SJ, Menon R, Velez DR, Thorsen P, Williams SM. Racial disparity in maternal-fetal genetic epistasis in spontaneous preterm birth. Am. J. Obstet. Gynecol. 2008 Jun; 198(6): 666.e1-9; discussion 666.e9. PMID: 18538149, PII: S0002-9378(08)00139-7, DOI: 10.1016/j.ajog.2008.02.003, ISSN: 1097-6868.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18538149.
  • Velez DR, Menon R, Simhan H, Fortunato S, Canter JA, Williams SM. Mitochondrial DNA variant A4917G, smoking and spontaneous preterm birth. Mitochondrion [print-electronic]. 2008 Mar; 8(2): 130-5. PMID: 18082471, PII: S1567-7249(07)00253-X, DOI: 10.1016/j.mito.2007.10.007, ISSN: 1567-7249.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18082471.
  • Sile S, Velez DR, Gillani NB, Alexander CA, George AL, Williams SM. Haplotype diversity in four genes (CLCNKA, CLCNKB, BSND, NEDD4L) involved in renal salt reabsorption. Hum. Hered [print-electronic]. 2008; 65(1): 33-46. PMID: 17652939, PMCID: PMC2862756, PII: 000106060, DOI: 10.1159/000106060, ISSN: 1423-0062.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17652939.
  • Velez DR, Fortunato SJ, Thorsen P, Lombardi SJ, Williams SM, Menon R. Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. PLoS ONE. 2008; 3(9): e3283. PMID: 18818748, PMCID: PMC2553267, DOI: 10.1371/journal.pone.0003283, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18818748.
  • Sile S, Gillani NB, Velez DR, Vanoye CG, Yu C, Byrne LM, Gainer JV, Brown NJ, Williams SM, George AL. Functional BSND variants in essential hypertension. Am. J. Hypertens. 2007 Nov; 20(11): 1176-82. PMID: 17954364, PII: S0895-7061(07)00388-3, DOI: 10.1016/j.amjhyper.2007.07.003, ISSN: 0895-7061.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17954364.
  • Olesen R, Wejse C, Velez DR, Bisseye C, Sodemann M, Aaby P, Rabna P, Worwui A, Chapman H, Diatta M, Adegbola RA, Hill PC, Østergaard L, Williams SM, Sirugo G. DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans. Genes Immun [print-electronic]. 2007 Sep; 8(6): 456-67. PMID: 17611589, PII: 6364410, DOI: 10.1038/sj.gene.6364410, ISSN: 1466-4879.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17611589.
  • Velez DR, Menon R, Thorsen P, Jiang L, Simhan H, Morgan N, Fortunato SJ, Williams SM. Ethnic differences in interleukin 6 (IL-6) and IL6 receptor genes in spontaneous preterm birth and effects on amniotic fluid protein levels. Ann. Hum. Genet [print-electronic]. 2007 Sep; 71(Pt 5): 586-600. PMID: 17346257, PII: AHG352, DOI: 10.1111/j.1469-1809.2007.00352.x, ISSN: 0003-4800.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17346257.
  • Velez DR, White BC, Motsinger AA, Bush WS, Ritchie MD, Williams SM, Moore JH. A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genet. Epidemiol. 2007 May; 31(4): 306-15. PMID: 17323372, DOI: 10.1002/gepi.20211, ISSN: 0741-0395.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17323372.
  • Velez DR, Guruju M, Vinukonda G, Prater A, Kumar A, Williams SM. Angiotensinogen promoter sequence variants in essential hypertension. Am. J. Hypertens. 2006 Dec; 19(12): 1278-85. PMID: 17161775, PII: S0895-7061(06)00359-1, DOI: 10.1016/j.amjhyper.2006.05.020, ISSN: 0895-7061.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17161775.
  • Menon R, Velez DR, Simhan H, Ryckman K, Jiang L, Thorsen P, Vogel I, Jacobsson B, Merialdi M, Williams SM, Fortunato SJ. Multilocus interactions at maternal tumor necrosis factor-alpha, tumor necrosis factor receptors, interleukin-6 and interleukin-6 receptor genes predict spontaneous preterm labor in European-American women. Am. J. Obstet. Gynecol. 2006 Jun; 194(6): 1616-24. PMID: 16731080, PII: S0002-9378(06)00382-6, DOI: 10.1016/j.ajog.2006.03.059, ISSN: 1097-6868.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16731080.
  • Dudek SM, Motsinger AA, Velez DR, Williams SM, Ritchie MD. Data simulation software for whole-genome association and other studies in human genetics. Pac Symp Biocomput. 2006; 499-510. PMID: 17094264, ISSN: 2335-6936.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17094264.
  • Menon R, Velez DR, Thorsen P, Vogel I, Jacobsson B, Williams SM, Fortunato SJ. Ethnic differences in key candidate genes for spontaneous preterm birth: TNF-alpha and its receptors. Hum. Hered [print-electronic]. 2006; 62(2): 107-18. PMID: 17047334, PII: 96301, DOI: 10.1159/000096301, ISSN: 0001-5652.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17047334.