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Dineo  Khabele

Dineo Khabele, M.D.

Associate Professor of Obstetrics and Gynecology
Associate Professor of Cancer Biology
Gynecological Oncologist

  • Appointments
    615-936-8422
    Physicians: 1-877-936-8422
  • Clinical Trials Information
  • Other Telephone Numbers
    Gynecologic Oncology
    (615) 936-8422 or 1 (877) 936-8422

    Henry-Joyce Cancer Clinic
    (615) 936-8422 or 1 (877) 936-8422

    Office
    615-322-8072
  • Faxes
    Gynecologic Oncology Fax
    (615) 343-8403
    Henry-Joyce Cancer Clinic Fax
    (615) 343-8668
    Office Fax
    615-343-8403
  • Addresses
    Gynecologic Oncology
    1900 The Vanderbilt Clinic
    Nashville, TN 37232-5536
    Website

    Henry-Joyce Cancer Clinic
    1301 Medical Center Drive, Suite 1710
    Nashville, Tennessee 37232-7415
    Website

    Office
    Vanderbilt University Medical Center, Ob/Gyn Department
    1161 21st Ave S, B-1100 MCN
    Nashville , TN 37232-2519
Education
  • M.D., Columbia University
  • B.A., Columbia University
Research Description

Dr. Khabele conducts translational and clinical research studies in gynecologic oncology. The primary goal of the translational research program is to design personalized diagnostics and therapeutics (based on genetic and epigenetic alterations in DNA damage response, inflammatory, and cell death pathways) as molecular targets for ovarian cancer.

Publications
  • Desouki MM, Khabele D, Crispens MA, Fadare O. Ovarian mucinous tumor with malignant mural nodules: dedifferentiation or collision?. Int. J. Gynecol. Pathol. 2015 Jan; 34(1): 19-24. PMID: 25473748, DOI: 10.1097/PGP.0000000000000105, ISSN: 1538-7151.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25473748.
  • Konstantinopoulos PA, Wilson AJ, Saskowski J, Wass E, Khabele D. Suberoylanilide hydroxamic acid (SAHA) enhances olaparib activity by targeting homologous recombination DNA repair in ovarian cancer. Gynecol. Oncol [print-electronic]. 2014 Jun; 133(3): 599-606. PMID: 24631446, PMCID: PMC4347923, PII: S0090-8258(14)00239-X, DOI: 10.1016/j.ygyno.2014.03.007, ISSN: 1095-6859.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24631446.
  • Collins Y, Holcomb K, Chapman-Davis E, Khabele D, Farley JH. Gynecologic cancer disparities: a report from the Health Disparities Taskforce of the Society of Gynecologic Oncology. Gynecol. Oncol [print-electronic]. 2014 May; 133(2): 353-61. PMID: 24406291, PMCID: PMC4079541, PII: S0090-8258(14)00002-X, DOI: 10.1016/j.ygyno.2013.12.039, ISSN: 1095-6859.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24406291.
  • Desouki MM, Kallas SJ, Khabele D, Crispens MA, Hameed O, Fadare O. Differential vimentin expression in ovarian and uterine corpus endometrioid adenocarcinomas: diagnostic utility in distinguishing double primaries from metastatic tumors. Int. J. Gynecol. Pathol. 2014 May; 33(3): 274-81. PMID: 24681739, PMCID: PMC4144715, DOI: 10.1097/PGP.0b013e31829040b5, ISSN: 1538-7151.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24681739.
  • Hull PC, Williams EA, Khabele D, Dean C, Bond B, Sanderson M. HPV vaccine use among African American girls: qualitative formative research using a participatory social marketing approach. Gynecol. Oncol [print-electronic]. 2014 Mar; 132 Suppl 1: S13-20. PMID: 24491412, PMCID: PMC3966189, PII: S0090-8258(14)00106-1, DOI: 10.1016/j.ygyno.2014.01.046, ISSN: 1095-6859.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24491412.
  • Khabele D, Kabir SM, Dong Y, Lee E, Rice VM, Son DS. Preferential effect of akt2-dependent signaling on the cellular viability of ovarian cancer cells in response to EGF. J Cancer. 2014; 5(8): 670-8. PMID: 25258648, PMCID: PMC4174511, PII: jcav05p0670, DOI: 10.7150/jca.9688, ISSN: 1837-9664.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25258648.
  • Khabele D. The therapeutic potential of class I selective histone deacetylase inhibitors in ovarian cancer. Front Oncol. 2014; 4: 111. PMID: 24904826, PMCID: PMC4033132, DOI: 10.3389/fonc.2014.00111, ISSN: 2234-943X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24904826.
  • Fadare O, James S, Desouki MM, Khabele D. Coordinate patterns of estrogen receptor, progesterone receptor, and Wilms tumor 1 expression in the histopathologic distinction of ovarian from endometrial serous adenocarcinomas. Ann Diagn Pathol [print-electronic]. 2013 Oct; 17(5): 430-3. PMID: 23706170, PMCID: PMC4079538, PII: S1092-9134(13)00036-1, DOI: 10.1016/j.anndiagpath.2013.04.011, ISSN: 1532-8198.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23706170.
  • Wilson AJ, Liu AY, Roland J, Adebayo OB, Fletcher SA, Slaughter JC, Saskowski J, Crispens MA, Jones HW, James S, Fadare O, Khabele D. TR3 modulates platinum resistance in ovarian cancer. Cancer Res [print-electronic]. 2013 Aug 8/1/2013; 73(15): 4758-69. PMID: 23720056, PMCID: PMC3944084, PII: 0008-5472.CAN-12-4560, DOI: 10.1158/0008-5472.CAN-12-4560, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23720056.
  • Fadare O, Gwin K, Desouki MM, Crispens MA, Jones HW, Khabele D, Liang SX, Zheng W, Mohammed K, Hecht JL, Parkash V. The clinicopathologic significance of p53 and BAF-250a (ARID1A) expression in clear cell carcinoma of the endometrium. Mod. Pathol [print-electronic]. 2013 Aug; 26(8): 1101-10. PMID: 23524907, PMCID: PMC3886836, PII: modpathol201335, DOI: 10.1038/modpathol.2013.35, ISSN: 1530-0285.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23524907.
  • Fadare O, Liang SX, Crispens MA, Jones HW, Khabele D, Gwin K, Zheng W, Mohammed K, Parkash V, Hecht JL, Desouki MM. Expression of the oncofetal protein IGF2BP3 in endometrial clear cell carcinoma: assessment of frequency and significance. Hum. Pathol [print-electronic]. 2013 Aug; 44(8): 1508-15. PMID: 23465280, PMCID: PMC3888088, PII: S0046-8177(12)00451-0, DOI: 10.1016/j.humpath.2012.12.003, ISSN: 1532-8392.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23465280.
  • Fadare O, Khabele D. Salpingo-oophorectomy specimens for endometrial cancer staging: a comparative analysis of representative sampling versus whole tissue processing. Hum. Pathol [print-electronic]. 2013 Apr; 44(4): 643-50. PMID: 23084582, PMCID: PMC4079536, PII: S0046-8177(12)00272-9, DOI: 10.1016/j.humpath.2012.07.015, ISSN: 1532-8392.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23084582.
  • Ayuso A, Fadare O, Khabele D. A case of extrauterine endometrial stromal sarcoma in the colon diagnosed three decades after hysterectomy for benign disease. Case Rep Obstet Gynecol [print-electronic]. 2013; 2013: 202458. PMID: 23710389, PMCID: PMC3655501, DOI: 10.1155/2013/202458, ISSN: 2090-6684.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23710389.
  • Fadare O, Zheng W, Crispens MA, Jones HW, Khabele D, Gwin K, Liang SX, Mohammed K, Desouki MM, Parkash V, Hecht JL. Morphologic and other clinicopathologic features of endometrial clear cell carcinoma: a comprehensive analysis of 50 rigorously classified cases. Am J Cancer Res [print-electronic]. 2013; 3(1): 70-95. PMID: 23359866, PMCID: PMC3555196, ISSN: 2156-6976.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23359866.
  • Wells CE, Bhaskara S, Stengel KR, Zhao Y, Sirbu B, Chagot B, Cortez D, Khabele D, Chazin WJ, Cooper A, Jacques V, Rusche J, Eischen CM, McGirt LY, Hiebert SW. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS ONE [electronic-print]. 2013; 8(7): e68915. PMID: 23894374, PMCID: PMC3718806, PII: PONE-D-13-03947, DOI: 10.1371/journal.pone.0068915, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23894374.
  • Wilson AJ, Barham W, Saskowski J, Tikhomirov O, Chen L, Lee HJ, Yull F, Khabele D. Tracking NF-¿B activity in tumor cells during ovarian cancer progression in a syngeneic mouse model. J Ovarian Res. 2013; 6(1): 63. PMID: 24020521, PMCID: PMC3846584, PII: 1757-2215-6-63, DOI: 10.1186/1757-2215-6-63, ISSN: 1757-2215.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24020521.
  • Zaidi SS, Lakhani VT, Fadare O, Khabele D. Adrenal gland metastasis is an unusual manifestation of endometrial cancer. Case Rep Surg [print-electronic]. 2013; 2013: 428456. PMID: 23984164, PMCID: PMC3748408, DOI: 10.1155/2013/428456, ISSN: 2090-6900.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23984164.
  • Wilson AJ, Lalani AS, Wass E, Saskowski J, Khabele D. Romidepsin (FK228) combined with cisplatin stimulates DNA damage-induced cell death in ovarian cancer. Gynecol. Oncol [print-electronic]. 2012 Dec; 127(3): 579-86. PMID: 23010348, PMCID: PMC3541411, PII: S0090-8258(12)00772-X, DOI: 10.1016/j.ygyno.2012.09.016, ISSN: 1095-6859.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23010348.
  • Vargis E, Tang YW, Khabele D, Mahadevan-Jansen A. Near-infrared Raman Microspectroscopy Detects High-risk Human Papillomaviruses. Transl Oncol [print-electronic]. 2012 Jun; 5(3): 172-9. PMID: 22741036, PMCID: PMC3384271, ISSN: 1936-5233.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22741036.
  • Khabele D, Fadare O, Liu AY, Wilson AJ, Wass E, Osteen K, Crispens MA. An orthotopic model of platinum-sensitive high grade serous fallopian tube carcinoma. Int J Clin Exp Pathol [print-electronic]. 2012; 5(1): 37-45. PMID: 22295145, PMCID: PMC3267484, ISSN: 1936-2625.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22295145.
  • Wilson AJ, Cheng YQ, Khabele D. Thailandepsins are new small molecule class I HDAC inhibitors with potent cytotoxic activity in ovarian cancer cells: a preclinical study of epigenetic ovarian cancer therapy. J Ovarian Res. 2012; 5(1): 12. PMID: 22531354, PMCID: PMC3394212, PII: 1757-2215-5-12, DOI: 10.1186/1757-2215-5-12, ISSN: 1757-2215.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22531354.
  • Vargis E, Byrd T, Logan Q, Khabele D, Mahadevan-Jansen A. Sensitivity of Raman spectroscopy to normal patient variability. J Biomed Opt. 2011 Nov; 16(11): 117004. PMID: 22112136, PMCID: PMC3221719, DOI: 10.1117/1.3646210, ISSN: 1560-2281.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22112136.
  • Wilson AJ, Holson E, Wagner F, Zhang YL, Fass DM, Haggarty SJ, Bhaskara S, Hiebert SW, Schreiber SL, Khabele D. The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells. Cancer Biol. Ther [print-electronic]. 2011 Sep 9/15/2011; 12(6): 484-93. PMID: 21738006, PMCID: PMC3218590, PII: 15956, DOI: 10.4161/cbt.12.6.15956, ISSN: 1555-8576.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21738006.
  • Fadare O, Khabele D. Pleomorphic liposarcoma of the uterine corpus with focal smooth muscle differentiation. Int. J. Gynecol. Pathol. 2011 May; 30(3): 282-7. PMID: 21464725, DOI: 10.1097/PGP.0b013e31820086a4, ISSN: 1538-7151.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21464725.
  • Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW. Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell. 2010 Nov 11/16/2010; 18(5): 436-47. PMID: 21075309, PMCID: PMC3004468, PII: S1535-6108(10)00424-1, DOI: 10.1016/j.ccr.2010.10.022, ISSN: 1878-3686.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21075309.
  • Son DS, Wilson AJ, Parl AK, Khabele D. The effects of the histone deacetylase inhibitor romidepsin (FK228) are enhanced by aspirin (ASA) in COX-1 positive ovarian cancer cells through augmentation of p21. Cancer Biol. Ther [print-electronic]. 2010 Jun 6/1/2010; 9(11): 928-35. PMID: 20404564, PMCID: PMC4047717, PII: 11873, ISSN: 1555-8576.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20404564.
  • Klugman SD, Gross SJ, Liang J, Livne K, Gross B, Khabele D, Lopez-Jones M, Cordero DR, Reznik S. Expression of Keratin 8 and TNF-Related Apoptosis-I Inducing Ligand (TRAIL) in Down Syndrome Placentas [letter]. Placenta [print-electronic]. 2008 Apr; 29(4): 382-4. PMID: 18343496, PMCID: PMC2475678, PII: S0143-4004(08)00032-5, DOI: 10.1016/j.placenta.2008.01.013, ISSN: 0143-4004.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18343496.
  • Lyshchik A, Hobbs SB, Fleischer AC, Khabele D, Son DS, Gore JC, Price RR. Ovarian volume measurements in mice with high-resolution ultrasonography. J Ultrasound Med. 2007 Oct; 26(10): 1419-25. PMID: 17901144, PII: 26/10/1419, ISSN: 0278-4297.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17901144.
  • Son DS, Parl AK, Rice VM, Khabele D. Keratinocyte chemoattractant (KC)/human growth-regulated oncogene (GRO) chemokines and pro-inflammatory chemokine networks in mouse and human ovarian epithelial cancer cells. Cancer Biol. Ther [print-electronic]. 2007 Aug; 6(8): 1302-12. PMID: 17712227, PII: 4506, ISSN: 1555-8576.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17712227.
  • Daikoku T, Tranguch S, Chakrabarty A, Wang D, Khabele D, Orsulic S, Morrow JD, Dubois RN, Dey SK. Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer. Cancer Res. 2007 Jun 6/1/2007; 67(11): 5285-92. PMID: 17545608, PII: 67/11/5285, DOI: 10.1158/0008-5472.CAN-07-0828, ISSN: 0008-5472.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17545608.
  • Khabele D, Son DS, Parl AK, Goldberg GL, Augenlicht LH, Mariadason JM, Rice VM. Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy. Cancer Biol. Ther [print-electronic]. 2007 May; 6(5): 795-801. PMID: 17387270, PII: 4007, ISSN: 1555-8576.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17387270.
  • Gorelick C, Lopez-Jones M, Goldberg GL, Romney SL, Khabele D. Coenzyme Q10 and lipid-related gene induction in HeLa cells. Am. J. Obstet. Gynecol. 2004 May; 190(5): 1432-4. PMID: 15167860, PII: S0002937804001619, DOI: 10.1016/j.ajog.2004.01.076, ISSN: 0002-9378.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15167860.
  • Khabele D, Lopez-Jones M, Yang W, Arango D, Gross SJ, Augenlicht LH, Goldberg GL. Tumor necrosis factor-alpha related gene response to Epothilone B in ovarian cancer. Gynecol. Oncol. 2004 Apr; 93(1): 19-26. PMID: 15047209, PII: S0090825803008515, DOI: 10.1016/j.ygyno.2003.11.058, ISSN: 0090-8258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15047209.
  • Sood BM, Jones J, Gupta S, Khabele D, Guha C, Runowicz C, Goldberg G, Fields A, Anderson P, Vikram B. Patterns of failure after the multimodality treatment of uterine papillary serous carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 2003 Sep 9/1/2003; 57(1): 208-16. PMID: 12909235, PII: S0360301603005315, ISSN: 0360-3016.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12909235.
  • Khabele D, Runowicz CD, Fields AL, Anderson PS, Goldberg GL. Evaluation of low-dose intraperitoneal interferon-alpha for palliation of ascites in patients with non-ovarian gynecologic malignancies. Gynecol. Oncol. 2003 Jun; 89(3): 420-3. PMID: 12798705, PII: S0090825803000805, ISSN: 0090-8258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12798705.
  • Gross SJ, Ferreira JC, Morrow B, Dar P, Funke B, Khabele D, Merkatz I. Gene expression profile of trisomy 21 placentas: a potential approach for designing noninvasive techniques of prenatal diagnosis. Am. J. Obstet. Gynecol. 2002 Aug; 187(2): 457-62. PMID: 12193943, PII: S0002937802001527, ISSN: 0002-9378.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12193943.
  • Khabele D, Runowicz CD. Genetic counseling, testing, and screening for breast and ovarian cancer: practical and social considerations. Curr Womens Health Rep. 2002 Jun; 2(3): 163-9. PMID: 12099190, ISSN: 1534-5874.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12099190.
  • Khabele D, Chasen S. Cardiac tamponade as an unusual presentation of advanced breast cancer in pregnancy. J Reprod Med. 1999 Nov; 44(11): 989-91. PMID: 10589415, ISSN: 0024-7758.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10589415.
  • Xiao E, Xia L, Shanen D, Khabele D, Ferin M. Stimulatory effects of interleukin-induced activation of the hypothalamo-pituitary-adrenal axis on gonadotropin secretion in ovariectomized monkeys replaced with estradiol. Endocrinology. 1994 Nov; 135(5): 2093-8. PMID: 7956932, DOI: 10.1210/endo.135.5.7956932, ISSN: 0013-7227.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7956932.