Vanderbilt-Ingram Cancer Center

Publications

• Sohl, CD, Isin, EM, Eoff, RL, Marsch, GA, Stec, DF, Guengerich, FP Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding. J Biol Chem, 283(11), 7293-308, 2008.
• Isin, EM, Sohl, CD, Eoff, RL, Guengerich, FP Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene. Arch Biochem Biophys, 473(1), 69-75, 2008.
• Guengerich, FP Cytochrome p450 and chemical toxicology. Chem Res Toxicol, 21(1), 70-83, 2008.
• Dostalek, M, Hardy, KD, Milne, GL, Morrow, JD, Chen, C, Gonzalez, FJ, Gu, J, Ding, X, Johnson, DA, Johnson, JA, Martin, MV, Guengerich, FP Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems. J Biol Chem, 283(25), 17147-57, 2008.
• Stark, K, Dostalek, M, Guengerich, FP Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. FEBS J, 275(14), 3706-17, 2008.
• Loecken, EM, Guengerich, FP Reactions of glyceraldehyde 3-phosphate dehydrogenase sulfhydryl groups with bis-electrophiles produce DNA-protein cross-links but not mutations. Chem Res Toxicol, 21(2), 453-8, 2008.
• Stark, K, Wu, ZL, Bartleson, CJ, Guengerich, FP mRNA Distribution and Heterologous Expression of Orphan Cytochrome P450 20A1. Drug Metab Dispos, 2008.
• Watanabe, K, Liberman, RG, Skipper, PL, Tannenbaum, SR, Guengerich, FP Analysis of DNA Adducts Formed in Vivo in Rats and Mice from 1,2-Dibromoethane, 1,2-Dichloroethane, Dibromomethane, and Dichloromethane Using HPLC/Accelerator Mass Spectrometry and Relevance to Risk Estimates. Chem Res Toxicol, 20(11), 1594-600, 2007.
• Guengerich, FP, Macdonald, JS Applying mechanisms of chemical toxicity to predict drug safety. Chem Res Toxicol, 20(3), 344-69, 2007.
• Stark, K, Guengerich, FP Characterization of orphan human cytochromes P450. Drug Metab Rev, 39(2-3), 627-37, 2007.
• Isin, EM, Guengerich, FP Complex reactions catalyzed by cytochrome P450 enzymes. Biochim Biophys Acta, 1770(3), 314-29, 2007.
• Shimada, T, Murayama, N, Okada, K, Funae, Y, Yamazaki, H, Guengerich, FP Different Mechanisms for Inhibition of Human Cytochromes P450 1A1, 1A2, and 1B1 by Polycyclic Aromatic Inhibitors. Chem Res Toxicol, 20(3), 489-496, 2007.
• Chowdhury, G, Guengerich, FP Direct Detection and Mapping of Sites of Base Modification in DNA Fragments by Tandem Mass Spectrometry. Angew Chem Int Ed Engl, 2007.
• Chun, YJ, Shimada, T, Sanchez-Ponce, R, Martin, MV, Lei, L, Zhao, B, Kelly, SL, Waterman, MR, Lamb, DC, Guengerich, FP Electron transport pathway for a Streptomyces cytochrome P450: cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2). J Biol Chem, 282(24), 17486-500, 2007.
• Eoff, RL, Irimia, A, Angel, KC, Egli, M, Guengerich, FP Hydrogen bonding of 7,8-dihydro-8-oxodeoxyguanosine with a charged residue in the little finger domain determines miscoding events in Sulfolobus solfataricus DNA polymerase Dpo4. J Biol Chem, 282(27), 19831-43, 2007.
• Dostalek, M, Brooks, JD, Hardy, KD, Milne, GL, Moore, MM, Sharma, S, Morrow, JD, Guengerich, FP In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers. Mol Pharmacol, 72(6), 1419-24, 2007.
• Guengerich, FP Mechanisms of cytochrome P450 substrate oxidation: MiniReview. J Biochem Mol Toxicol, 21(4), 163-8, 2007.
• Eoff, RL, Angel, KC, Egli, M, Guengerich, FP Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase DPO4 steady-state and pre-steady-state kinetics and X-ray crystallography of correct and incorrect pairing. J Biol Chem, 2007.
• Isin, EM, Guengerich, FP Multiple sequential steps involved in the binding of inhibitors to cytochrome P450 3A4. J Biol Chem, 282(9), 6863-74, 2007.
• Irimia, A, Eoff, RL, Pallan, PS, Guengerich, FP, Egli, M Structure and activity of Y-class DNA polymerase DPO4 from sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene. J Biol Chem, 2007.
• Shanmugam, G, Goodenough, AK, Kozekov, ID, Guengerich, FP, Rizzo, CJ, Stone, MP Structure of the 1,N2-etheno-2''-deoxyguanosine adduct in duplex DNA at pH 8.6. Chem Res Toxicol, 20(11), 1601-11, 2007.
• Eoff, RL, Irimia, A, Egli, M, Guengerich, FP Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by "wobble" pairing between O6-methylguanine and cytosine, but accurate bypass is preferred. J Biol Chem, 282(2), 1456-67, 2007.
• Sanchez-Ponce, R, Guengerich, FP Untargeted analysis of mass spectrometry data for elucidation of metabolites and function of enzymes. Anal Chem, 79(9), 3355-62, 2007.
• Guengerich, FP A malleable catalyst dominates the metabolism of drugs. Proc Natl Acad Sci U S A, 103(37), 13565-6, 2006.
• Choi, JY, Stover, JS, Angel, KC, Chowdhury, G, Rizzo, CJ, Guengerich, FP Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI G3 site. J Biol Chem, 281(35), 25297-306, 2006.
• Irimia, A, Zang, H, Loukachevitch, LV, Eoff, RL, Guengerich, FP, Egli, M Calcium is a cofactor of polymerization but inhibits pyrophosphorolysis by the Sulfolobus solfataricus DNA polymerase Dpo4. Biochemistry, 45(19), 5949-56, 2006.
• Guengerich, FP Cytochrome P450s and other enzymes in drug metabolism and toxicity. AAPS J, 8(1), E101-11, 2006.
• Zang, H, Irimia, A, Choi, JY, Angel, KC, Loukachevitch, LV, Egli, M, Guengerich, FP Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4. J Biol Chem, 281(4), 2358-72, 2006.
• Lamb, DC, Guengerich, FP, Kelly, SL, Waterman, MR Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery. Expert Opin Drug Metab Toxicol, 2(1), 27-40, 2006.
• Wu, ZL, Bartleson, CJ, Ham, AJ, Guengerich, FP Heterologous expression, purification, and properties of human cytochrome P450 27C1. Arch Biochem Biophys, 445(1), 138-46, 2006.
• Shimada, T, Guengerich, FP Inhibition of Human Cytochrome P450 1A1-, 1A2-, and 1B1-Mediated Activation of Procarcinogens to Genotoxic Metabolites by Polycyclic Aromatic Hydrocarbons. Chem Res Toxicol, 19(2), 288-94, 2006.
• Guengerich, FP Interactions of carcinogen-bound DNA with individual DNA polymerases. Chem Rev, 106(2), 420-52, 2006.
• Choi, JY, Guengerich, FP Kinetic evidence for inefficient and error-prone bypass across bulky N2-guanine DNA adducts by human DNA polymerase iota. J Biol Chem, 281(18), 12315-24, 2006.
• Isin, EM, Guengerich, FP Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4. J Biol Chem, 2006.
• Watanabe, K, Guengerich, FP Limited reactivity of formyl chloride with glutathione and relevance to metabolism and toxicity of dichloromethane. Chem Res Toxicol, 19(8), 1091-6, 2006.
• Guengerich, FP, Martin, MV Purification of cytochromes P450: products of bacterial recombinant expression systems. Methods Mol Biol, 32031-7, 2006.
• Wu, ZL, Sohl, CD, Shimada, T, Guengerich, FP Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. Mol Pharmacol, 69(6), 2007-14, 2006.
• Choi, JY, Zang, H, Angel, KC, Kozekov, ID, Goodenough, AK, Rizzo, CJ, Guengerich, FP Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases. Chem Res Toxicol, 19(6), 879-86, 2006.
• Choi, JY, Chowdhury, G, Zang, H, Angel, KC, Vu, CC, Peterson, LA, Guengerich, FP Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerases. J Biol Chem, 281(50), 38244-56, 2006.
• Choi, JY, Angel, KC, Guengerich, FP Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase kappa. J Biol Chem, 281(30), 21062-72, 2006.
• Zang, H, Chowdhury, G, Angel, KC, Harris, TM, Guengerich, FP Translesion synthesis across polycyclic aromatic hydrocarbon diol epoxide adducts of deoxyadenosine by Sulfolobus solfataricus DNA polymerase Dpo4. Chem Res Toxicol, 19(6), 859-67, 2006.
• Stover, JS, Chowdhury, G, Zang, H, Guengerich, FP, Rizzo, CJ Translesion synthesis past the C8- and N2-deoxyguanosine adducts of the dietary mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the NarI recognition sequence by prokaryotic DNA polymerases. Chem Res Toxicol, 19(11), 1506-17, 2006.
• Chun, YJ, Shimada, T, Waterman, MR, Guengerich, FP Understanding electron transport systems of Streptomyces cytochrome P450. Biochem Soc Trans, 34(Pt 6), 1183-5, 2006.
• Guengerich, FP Activation of alkyl halides by glutathione transferases. Methods Enzymol, 401342-53, 2005.
• Choi, JY, Guengerich, FP Adduct size limits efficient and error-free bypass across bulky N2-guanine DNA lesions by human DNA polymerase eta. J Mol Biol, 352(1), 72-90, 2005.
• Kim, D, Wu, ZL, Guengerich, FP Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis. J Biol Chem, 280(48), 40319-27, 2005.
• Zhao, B, Guengerich, FP, Bellamine, A, Lamb, DC, Izumikawa, M, Lei, L, Podust, LM, Sundaramoorthy, M, Kalaitzis, JA, Reddy, LM, Kelly, SL, Moore, BS, Stec, D, Voehler, M, Falck, JR, Shimada, T, Waterman, MR Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2. J Biol Chem, 280(12), 11599-607, 2005.
• Wu, ZL, Aryal, P, Lozach, O, Meijer, L, Guengerich, FP Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6. Chem Biodivers, 2(1), 51-65, 2005.
• Krauser, JA, Guengerich, FP Cytochrome P450 3A4-catalyzed testosterone 6beta-hydroxylation stereochemistry, kinetic deuterium isotope effects, and rate-limiting steps. J Biol Chem, 280(20), 19496-506, 2005.
• Kim, D, Guengerich, FP Cytochrome P450 activation of arylamines and heterocyclic amines. Annu Rev Pharmacol Toxicol, 4527-49, 2005.
• Zang, H, Goodenough, AK, Choi, JY, Irimia, A, Loukachevitch, LV, Kozekov, ID, Angel, KC, Rizzo, CJ, Egli, M, Guengerich, FP DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4: analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N2-ethenoguanine. J Biol Chem, 280(33), 29750-64, 2005.
• VanderVeen, LA, Druckova, A, Riggins, JN, Sorrells, JL, Guengerich, FP, Marnett, LJ Differential DNA recognition and cleavage by EcoRI dependent on the dynamic equilibrium between the two forms of the malondialdehyde-deoxyguanosine adduct. Biochemistry, 44(13), 5024-33, 2005.
• Liebler, DC, Guengerich, FP Elucidating mechanisms of drug-induced toxicity. Nat Rev Drug Discov, 4(5), 410-20, 2005.
• Vélez-Cruz, R, Riggins, JN, Daniels, JS, Cai, H, Guengerich, FP, Marnett, LJ, Osheroff, N Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry, 44(10), 3972-81, 2005.
• Wu, ZL, Podust, LM, Guengerich, FP Expansion of substrate specificity of cytochrome P450 2A6 by random and site-directed mutagenesis. J Biol Chem, 280(49), 41090-100, 2005.
• Guengerich, FP, Wu, ZL, Bartleson, CJ Function of human cytochrome P450s: characterization of the orphans. Biochem Biophys Res Commun, 338(1), 465-9, 2005.
• Guengerich, FP Generation of reactive intermediates. J Biochem Mol Toxicol, 19(3), 173-4, 2005.
• Guengerich, FP How I became a biochemist. IUBMB Life, 57(10), 705-7, 2005.
• Shimada, T, Mernaugh, RL, Guengerich, FP Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes. Arch Biochem Biophys, 435(1), 207-16, 2005.
• Yun, CH, Kim, KH, Calcutt, MW, Guengerich, FP Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6. J Biol Chem, 2005.
• Zang, H, Fang, Q, Pegg, AE, Guengerich, FP Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase. J Biol Chem, 280(35), 30873-81, 2005.
• Zang, H, Harris, TM, Guengerich, FP Kinetics of Nucleotide Incorporation Opposite Polycyclic Aromatic Hydrocarbon-DNA Adducts by Processive Bacteriophage T7 DNA Polymerase. Chem Res Toxicol, 18(2), 389-400, 2005.
• Zang, H, Harris, TM, Guengerich, FP Kinetics of nucleotide incorporation opposite DNA bulky guanine N2 adducts by processive bacteriophage T7 DNA polymerase (exonuclease-) and HIV-1 reverse transcriptase. J Biol Chem, 280(2), 1165-78, 2005.
• Guengerich, FP Life and times in biochemical toxicology. Int J Toxicol, 24(1), 5-21, 2005.
• Guengerich, FP Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation. Arch Biochem Biophys, 433(2), 369-78, 2005.
• Guengerich, FP Reduction of cytochrome b5 by NADPH-cytochrome P450 reductase. Arch Biochem Biophys, 440(2), 204-11, 2005.
• Zhao, B, Guengerich, FP, Voehler, M, Waterman, MR Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer. J Biol Chem, 280(51), 42188-97, 2005.
• Goodenough, AK, Kozekov, ID, Zang, H, Choi, JY, Guengerich, FP, Harris, TM, Rizzo, CJ Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2''-deoxyguanosine. Chem Res Toxicol, 18(11), 1701-14, 2005.
• Valadez, JG, Liu, L, Loktionova, NA, Pegg, AE, Guengerich, FP Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase. Chem Res Toxicol, 17(7), 972-82, 2004.
• Choi, JY, Guengerich, FP Analysis of the effect of bulk at N2-alkylguanine DNA adducts on catalytic efficiency and fidelity of the processive DNA polymerases bacteriophage T7 exonuclease- and HIV-1 reverse transcriptase. J Biol Chem, 279(18), 19217-29, 2004.
• Kim, D, Guengerich, FP Cytochrome P450 Activation of Arylamines and Heterocyclic Amines. Annu Rev Pharmacol Toxicol, 2004.
• Guengerich, FP Cytochrome P450: what have we learned and what are the future issues. Drug Metab Rev, 36(2), 159-97, 2004.
• Kim, D, Guengerich, FP Enhancement of 7-methoxyresorufin O-demethylation activity of human cytochrome P450 1A2 by molecular breeding. Arch Biochem Biophys, 432(1), 102-8, 2004.
• Marsch, GA, Botta, S, Martin, MV, McCormick, WA, Guengerich, FP Formation and mass spectrometric analysis of DNA and nucleoside adducts by S-(1-acetoxymethyl)glutathione and by glutathione S-transferase-mediated activation of dihalomethanes. Chem Res Toxicol, 17(1), 45-54, 2004.
• Kim, D, Kadlubar, FF, Teitel, CH, Guengerich, FP Formation and reduction of aryl and heterocyclic nitroso compounds and significance in the flux of hydroxylamines. Chem Res Toxicol, 17(4), 529-36, 2004.
• Guengerich, FP, Sorrells, JL, Schmitt, S, Krauser, JA, Aryal, P, Meijer, L Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis. J Med Chem, 47(12), 3236-41, 2004.
• Guengerich, FP, Krauser, JA, Johnson, WW Rate-limiting steps in oxidations catalyzed by rabbit cytochrome P450 1A2. Biochemistry, 43(33), 10775-88, 2004.
• Valadez, JG, Guengerich, FP S-(2-chloroethyl)glutathione-generated p53 mutation spectra are influenced by differential repair rates more than sites of initial dna damage. J Biol Chem, 279(14), 13435-46, 2004.
• Kim, D, Guengerich, FP Selection of human cytochrome P450 1A2 mutants with enhanced catalytic activity for heterocyclic amine N-hydroxylation. Biochemistry, 43(4), 981-8, 2004.
• Krauser, JA, Voehler, M, Tseng, LH, Schefer, AB, Godejohann, M, Guengerich, FP Testosterone 1 beta-hydroxylation by human cytochrome P450 3A4. Eur J Biochem, 271(19), 3962-9, 2004.
• Guengerich, FP Where is toxicology headed in the future. Drug Metab Rev, 36(3-4), 475-86, 2004.
• Guengerich, FP Activation of dihaloalkanes by thiol-dependent mechanisms. J Biochem Mol Biol, 36(1), 20-7, 2003.
• Guengerich, FP, McCormick, WA, Wheeler, JB Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione transferases. Chem Res Toxicol, 16(11), 1493-9, 2003.
• Guengerich, FP Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions. Arch Biochem Biophys, 409(1), 59-71, 2003.
• Guengerich, FP Cytochromes P450, drugs, and diseases. Mol Interv, 3(4), 194-204, 2003.
• Guengerich, FP, Fang, Q, Liu, L, Hachey, DL, Pegg, AE O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145. Biochemistry, 42(37), 10965-70, 2003.
• Guengerich, FP, Hanna, IH, Martin, MV, Gillam, EM Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis. Biochemistry, 42(5), 1245-53, 2003.
• Guengerich, FP Cytochrome P450 enzymes in the generation of commercial products. Nat Rev Drug Discov, 1(5), 359-66, 2002.
• Guengerich, FP, Miller, GP, Hanna, IH, Martin, MV, Léger, S, Black, C, Chauret, N, Silva, JM, Trimble, LA, Yergey, JA, Nicoll-Griffith, DA Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding. Biochemistry, 41(36), 11025-34, 2002.
• Woodside, AM, Guengerich, FP Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine. Biochemistry, 41(3), 1027-38, 2002.
• Yoshioka, T, Krauser, JA, Guengerich, FP Microsomal oxidation of tribromoethylene and reactions of tribromoethylene oxide. Chem Res Toxicol, 15(11), 1414-20, 2002.
• Woodside, AM, Guengerich, FP Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes. Biochemistry, 41(3), 1039-50, 2002.
• Guengerich, FP N-hydroxyarylamines. Drug Metab Rev, 34(3), 607-23, 2002.
• Guengerich, FP, Miller, GP, Hanna, IH, Sato, H, Martin, MV Oxidation of methoxyphenethylamines by cytochrome P450 2D6. Analysis of rate-limiting steps. J Biol Chem, 277(37), 33711-9, 2002.
• Kim, D, Guengerich, FP Random mutagenesis by whole-plasmid PCR amplification. Methods Mol Biol, 192241-5, 2002.
• Guengerich, FP, Arneson, KO, Williams, KM, Deng, Z, Harris, TM Reaction of aflatoxin B(1) oxidation products with lysine. Chem Res Toxicol, 15(6), 780-92, 2002.
• Guengerich, FP, Voehler, M, Williams, KM, Deng, Z, Harris, TM Structure of the aflatoxin B(1) dialdehyde adduct formed from reaction with methylamine. Chem Res Toxicol, 15(6), 793-8, 2002.
• Yoshioka, T, Krauser, JA, Guengerich, FP Tetrachloroethylene oxide: hydrolytic products and reactions with phosphate and lysine. Chem Res Toxicol, 15(8), 1096-105, 2002.
• Guengerich, FP Update information on human P450s. Drug Metab Rev, 34(1-2), 7-15, 2002.
• Guengerich, FP, Wheeler, JB, Chun, YJ, Kim, D, Shimada, T, Aryal, P, Oda, Y, Gillam, EM Use of heterologously-expressed cytochrome P450 and glutathione transferase enzymes in toxicity assays. Toxicology, 181-182261-4, 2002.
• Miller, GP, Guengerich, FP Binding and oxidation of alkyl 4-nitrophenyl ethers by rabbit cytochrome P450 1A2: evidence for two binding sites. Biochemistry, 40(24), 7262-72, 2001.
• Marsch, GA, Mundkowski, RG, Morris, BJ, Manier, ML, Hartman, MK, Guengerich, FP Characterization of nucleoside and DNA adducts formed by S-(1-acetoxymethyl)glutathione and implications for dihalomethane-glutathione conjugates. Chem Res Toxicol, 14(5), 600-8, 2001.
• Guengerich, FP Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chem Res Toxicol, 14(6), 611-50, 2001.
• Wheeler, JB, Stourman, NV, Thier, R, Dommermuth, A, Vuilleumier, S, Rose, JA, Armstrong, RN, Guengerich, FP Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and dihalomethanes. Chem Res Toxicol, 14(8), 1118-27, 2001.
• Wheeler, JB, Stourman, NV, Armstrong, RN, Guengerich, FP Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and vicinal dihaloethanes. Chem Res Toxicol, 14(8), 1107-17, 2001.
• Nakamura, K, Hanna, IH, Cai, H, Nishimura, Y, Williams, KM, Guengerich, FP Coumarin substrates for cytochrome P450 2D6 fluorescence assays. Anal Biochem, 292(2), 280-6, 2001.
• Hanna, IH, Krauser, JA, Cai, H, Kim, MS, Guengerich, FP Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity. J Biol Chem, 276(43), 39553-61, 2001.
• Einolf, HJ, Guengerich, FP Fidelity of nucleotide insertion at 8-oxo-7,8-dihydroguanine by mammalian DNA polymerase delta. Steady-state and pre-steady-state kinetic analysis. J Biol Chem, 276(6), 3764-71, 2001.
• Guengerich, FP Forging the links between metabolism and carcinogenesis. Mutat Res, 488(3), 195-209, 2001.
• Guengerich, FP Functional genomics and proteomics applied to the study of nutritional metabolism. Nutr Rev, 59(8 Pt 1), 259-63, 2001.
• Hanna, IH, Kim, MS, Guengerich, FP Heterologous expression of cytochrome P450 2D6 mutants, electron transfer, and catalysis of bufuralol hydroxylation: the role of aspartate 301 in structural integrity. Arch Biochem Biophys, 393(2), 255-61, 2001.
• Miller, GP, Hanna, IH, Nishimura, Y, Guengerich, FP Oxidation of phenethylamine derivatives by cytochrome P450 2D6: the issue of substrate protonation in binding and catalysis. Biochemistry, 40(47), 14215-23, 2001.
• Yun, CH, Miller, GP, Guengerich, FP Oxidations of p-alkoxyacylanilides catalyzed by human cytochrome P450 1A2: structure-activity relationships and simulation of rate constants of individual steps in catalysis. Biochemistry, 40(14), 4521-30, 2001.
• Nakamura, K, Martin, MV, Guengerich, FP Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products. Arch Biochem Biophys, 395(1), 25-31, 2001.
• Cai, H, Guengerich, FP Reaction of trichloroethylene and trichloroethylene oxide with cytochrome P450 enzymes: inactivation and sites of modification. Chem Res Toxicol, 14(4), 451-8, 2001.
• Cai, H, Guengerich, FP Reaction of trichloroethylene oxide with proteins and dna: instability of adducts and modulation of functions. Chem Res Toxicol, 14(1), 54-61, 2001.
• Guengerich, FP, Cai, H, Johnson, WW, Parikh, A Reactive intermediates in biological systems: what have we learned and where are we going. Adv Exp Med Biol, 500639-50, 2001.
• Guengerich, FP, Cai, H, McMahon, M, Hayes, JD, Sutter, TR, Groopman, JD, Deng, Z, Harris, TM Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases. Chem Res Toxicol, 14(6), 727-37, 2001.
• Guengerich, FP Uncommon P450-catalyzed reactions. Curr Drug Metab, 2(2), 93-115, 2001.
• Guengerich, FP, Parikh, A, Yun, CH, Kim, D, Nakamura, K, Notley, LM, Gillam, EM What makes P450s work? Searches for answers with known and new P450s. Drug Metab Rev, 32(3-4), 267-81, 2001.
• Cai, H, Guengerich, FP Acylation of protein lysines by trichloroethylene oxide. Chem Res Toxicol, 13(5), 327-35, 2000.
• Hanna, IH, Dawling, S, Roodi, N, Guengerich, FP, Parl, FF Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity. Cancer Res, 60(13), 3440-4, 2000.
• Hosea, NA, Miller, GP, Guengerich, FP Elucidation of distinct ligand binding sites for cytochrome P450 3A4. Biochemistry, 39(20), 5929-39, 2000.
• Hanna, IH, Reed, JR, Guengerich, FP, Hollenberg, PF Expression of human cytochrome P450 2B6 in Escherichia coli: characterization of catalytic activity and expression levels in human liver. Arch Biochem Biophys, 376(1), 206-16, 2000.
• Einolf, HJ, Guengerich, FP Kinetic analysis of nucleotide incorporation by mammalian DNA polymerase delta. J Biol Chem, 275(21), 16316-22, 2000.
• Guengerich, FP Metabolism of chemical carcinogens. Carcinogenesis, 21(3), 345-51, 2000.
• Wandel, C, Kim, RB, Guengerich, FP, Wood, AJ Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro. Drug Metab Dispos, 28(8), 895-8, 2000.
• Yun, CH, Miller, GP, Guengerich, FP Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants. Biochemistry, 39(37), 11319-29, 2000.
• Plastaras, JP, Guengerich, FP, Nebert, DW, Marnett, LJ Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde. J Biol Chem, 275(16), 11784-90, 2000.
• Guengerich, FP Cytochrome P-450 3A4: regulation and role in drug metabolism. Annu Rev Pharmacol Toxicol, 391-17, 1999.
• Furge, LL, Guengerich, FP Explanation of pre-steady-state kinetics and decreased burst amplitude of HIV-1 reverse transcriptase at sites of modified DNA bases with an additional, nonproductive enzyme-DNA-nucleotide complex. Biochemistry, 38(15), 4818-25, 1999.
• Guengerich, FP, Mundkowski, RG, Voehler, M, Kadlubar, FF Formation and reactions of N(7)-aminoguanosine and derivatives. Chem Res Toxicol, 12(10), 906-16, 1999.
• Guengerich, FP, Langouët, S, Mican, AN, Akasaka, S, Müller, M, Persmark, M Formation of etheno adducts and their effects on DNA polymerases. IARC Sci Publ, (150), 137-45, 1999.
• Guengerich, FP, Parikh, A, Turesky, RJ, Josephy, PD Inter-individual differences in the metabolism of environmental toxicants: cytochrome P450 1A2 as a prototype. Mutat Res, 428(1-2), 115-24, 1999.
• Bell-Parikh, LC, Guengerich, FP Kinetics of cytochrome P450 2E1-catalyzed oxidation of ethanol to acetic acid via acetaldehyde. J Biol Chem, 274(34), 23833-40, 1999.
• Guengerich, FP, Johnson, WW Kinetics of hydrolysis and reaction of aflatoxin B1 exo-8,9-epoxide and relevance to toxicity and detoxication. Drug Metab Rev, 31(1), 141-58, 1999.
• Akasaka, S, Guengerich, FP Mutagenicity of site-specifically located 1,N2-ethenoguanine in Chinese hamster ovary cell chromosomal DNA. Chem Res Toxicol, 12(6), 501-7, 1999.
• Parikh, A, Josephy, PD, Guengerich, FP Selection and characterization of human cytochrome P450 1A2 mutants with altered catalytic properties. Biochemistry, 38(17), 5283-9, 1999.
• Guengerich, FP The Vanderbilt University Center in Molecular Toxicology: the first 30 years. Drug Metab Rev, 31(1), 1-11, 1999.
• Guengerich, FP, Johnson, WW, Shimada, T, Ueng, YF, Yamazaki, H, Langouët, S Activation and detoxication of aflatoxin B1. Mutat Res, 402(1-2), 121-8, 1998.
• Guengerich, FP, Shimada, T Activation of procarcinogens by human cytochrome P450 enzymes. Mutat Res, 400(1-2), 201-13, 1998.
• Langouët, S, Mican, AN, Müller, M, Fink, SP, Marnett, LJ, Muhle, SA, Guengerich, FP Misincorporation of nucleotides opposite five-membered exocyclic ring guanine derivatives by escherichia coli polymerases in vitro and in vivo: 1,N2-ethenoguanine, 5,6,7,9-tetrahydro-9-oxoimidazo[1, 2-a]purine, and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1, 2-a]purine. Biochemistry, 37(15), 5184-93, 1998.
• Hosea, NA, Guengerich, FP Oxidation of nonionic detergents by cytochrome P450 enzymes. Arch Biochem Biophys, 353(2), 365-73, 1998.
• Kim, MS, Guengerich, FP Polymerase blockage and misincorporation of dNTPs opposite the ethylene dibromide-derived DNA adducts S-[2-(N7-guanyl)ethyl]glutathione, S-[2-(N2-guanyl)ethyl]glutathione, and S-[2-(O6-guanyl)ethyl]glutathione. Chem Res Toxicol, 11(4), 311-6, 1998.
• Furge, LL, Guengerich, FP Pre-steady-state kinetics of nucleotide insertion following 8-oxo-7,8-dihydroguanine base pair mismatches by bacteriophage T7 DNA polymerase exo-. Biochemistry, 37(10), 3567-74, 1998.
• Guengerich, FP, Martin, MV Purification of cytochromes P450. Rat and human hepatic forms. Methods Mol Biol, 10735-53, 1998.
• Guengerich, FP, Hosea, NA, Martin, MV Purification of cytochromes P450: products of bacterial recombinant expression systems. Methods Mol Biol, 10777-83, 1998.
• Parikh, A, Guengerich, FP Random mutagenesis by whole-plasmid PCR amplification. Biotechniques, 24(3), 428-31, 1998.
• Shimada, T, Wunsch, RM, Hanna, IH, Sutter, TR, Guengerich, FP, Gillam, EM Recombinant human cytochrome P450 1B1 expression in Escherichia coli. Arch Biochem Biophys, 357(1), 111-20, 1998.
• Shimada, T, Yamazaki, H, Foroozesh, M, Hopkins, NE, Alworth, WL, Guengerich, FP Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2, and 1B1. Chem Res Toxicol, 11(9), 1048-56, 1998.
• Einolf, HJ, Schnetz-Boutaud, N, Guengerich, FP Steady-state and pre-steady-state kinetic analysis of 8-oxo-7,8-dihydroguanosine triphosphate incorporation and extension by replicative and repair DNA polymerases. Biochemistry, 37(38), 13300-12, 1998.
• Guengerich, FP The Environmental Genome Project: functional analysis of polymorphisms. Environ Health Perspect, 106(7), 365-8, 1998.
• Guengerich, FP, Hosea, NA, Parikh, A, Bell-Parikh, LC, Johnson, WW, Gillam, EM, Shimada, T Twenty years of biochemistry of human P450s: purification, expression, mechanism, and relevance to drugs. Drug Metab Dispos, 26(12), 1175-8, 1998.
• Johnson, WW, Yamazaki, H, Shimada, T, Ueng, YF, Guengerich, FP Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase. Chem Res Toxicol, 10(6), 672-6, 1997.
• Müller, M, Belas, FJ, Blair, IA, Guengerich, FP Analysis of 1,N2-ethenoguanine and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine in DNA treated with 2-chlorooxirane by high performance liquid chromatography/electrospray mass spectrometry and comparison of amounts to other DNA adducts. Chem Res Toxicol, 10(2), 242-7, 1997.
• Furge, LL, Guengerich, FP Analysis of nucleotide insertion and extension at 8-oxo-7,8-dihydroguanine by replicative T7 polymerase exo- and human immunodeficiency virus-1 reverse transcriptase using steady-state and pre-steady-state kinetics. Biochemistry, 36(21), 6475-87, 1997.
• Guengerich, FP, Kim, MS, Müller, M, Lowe, LG Chemical mechanisms of formation of DNA-carcinogen adducts, elucidation of potential of adducts for mutagenicity, and mechanisms of polymerase fidelity and mutation in the presence of adducts. Recent Results Cancer Res, 14349-63, 1997.
• Tateishi, T, Soucek, P, Caraco, Y, Guengerich, FP, Wood, AJ Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. Biochem Pharmacol, 53(1), 111-6, 1997.
• Guengerich, FP Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species. Chem Biol Interact, 106(3), 161-82, 1997.
• Johnson, WW, Ueng, YF, Widersten, M, Mannervik, B, Hayes, JD, Sherratt, PJ, Ketterer, B, Guengerich, FP Conjugation of highly reactive aflatoxin B1 exo-8,9-epoxide catalyzed by rat and human glutathione transferases: estimation of kinetic parameters. Biochemistry, 36(11), 3056-60, 1997.
• Ueng, YF, Kuwabara, T, Chun, YJ, Guengerich, FP Cooperativity in oxidations catalyzed by cytochrome P450 3A4. Biochemistry, 36(2), 370-81, 1997.
• Parikh, A, Gillam, EM, Guengerich, FP Drug metabolism by Escherichia coli expressing human cytochromes P450. Nat Biotechnol, 15(8), 784-8, 1997.
• Guengerich, FP, Vaz, AD, Raner, GN, Pernecky, SJ, Coon, MJ Evidence for a role of a perferryl-oxygen complex, FeO3+, in the N-oxygenation of amines by cytochrome P450 enzymes. Mol Pharmacol, 51(1), 147-51, 1997.
• Guengerich, FP, Parikh, A Expression of drug-metabolizing enzymes. Curr Opin Biotechnol, 8(5), 623-8, 1997.
• Parikh, A, Guengerich, FP Expression, purification, and characterization of a catalytically active human cytochrome P450 1A2:rat NADPH-cytochrome P450 reductase fusion protein. Protein Expr Purif, 9(3), 346-54, 1997.
• Guengerich, FP, Parikh, A, Johnson, EF, Richardson, TH, von Wachenfeldt, C, Cosme, J, Jung, F, Strassburg, CP, Manns, MP, Tukey, RH, Pritchard, M, Fournel-Gigleux, S, Burchell, B Heterologous expression of human drug-metabolizing enzymes. Drug Metab Dispos, 25(11), 1234-41, 1997.
• Guengerich, FP, Johnson, WW Kinetics of ferric cytochrome P450 reduction by NADPH-cytochrome P450 reductase: rapid reduction in the absence of substrate and variations among cytochrome P450 systems. Biochemistry, 36(48), 14741-50, 1997.
• Langouët, S, Müller, M, Guengerich, FP Misincorporation of dNTPs opposite 1,N2-ethenoguanine and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine in oligonucleotides by Escherichia coli polymerases I exo- and II exo-, T7 polymerase exo-, human immunodeficiency virus-1 reverse transcriptase, and rat polymerase beta. Biochemistry, 36(20), 6069-79, 1997.
• Bell, LC, Guengerich, FP Oxidation kinetics of ethanol by human cytochrome P450 2E1. Rate-limiting product release accounts for effects of isotopic hydrogen substitution and cytochrome b5 on steady-state kinetics. J Biol Chem, 272(47), 29643-51, 1997.
• Johnson, WW, Guengerich, FP Reaction of aflatoxin B1 exo-8,9-epoxide with DNA: kinetic analysis of covalent binding and DNA-induced hydrolysis. Proc Natl Acad Sci U S A, 94(12), 6121-5, 1997.
• Guengerich, FP Role of cytochrome P450 enzymes in drug-drug interactions. Adv Pharmacol, 437-35, 1997.
• Kim, MS, Guengerich, FP Synthesis of oligonucleotides containing the ethylene dibromide-derived DNA adducts S-[2-(N7-guanyl)ethyl]glutathione, S-[2-(N2-guanyl)ethyl]glutathione, and S-[2-(O6-guanyl)ethyl]glutathione at a single site. Chem Res Toxicol, 10(10), 1133-43, 1997.
• Shimada, T, Hayes, CL, Yamazaki, H, Amin, S, Hecht, SS, Guengerich, FP, Sutter, TR Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. Cancer Res, 56(13), 2979-84, 1996.
• Müller, M, Hutchinson, LK, Guengerich, FP Addition of deoxyribose to guanine and modified DNA based by Lactobacillus helveticus trans-N-deoxyribosylase. Chem Res Toxicol, 9(7), 1140-4, 1996.
• Chun, YJ, Shimada, T, Guengerich, FP Construction of a human cytochrome P450 1A1: rat NADPH-cytochrome P450 reductase fusion protein cDNA and expression in Escherichia coli, purification, and catalytic properties of the enzyme in bacterial cells and after purification. Arch Biochem Biophys, 330(1), 48-58, 1996.
• Chang, MS, Boeglin, WE, Guengerich, FP, Brash, AR Cytochrome P450-dependent transformations of 15R- and 15S-hydroperoxyeicosatetraenoic acids: stereoselective formation of epoxy alcohol products. Biochemistry, 35(2), 464-71, 1996.
• Lang, CC, Brown, RM, Kinirons, MT, Deathridge, MA, Guengerich, FP, Kelleher, D, O''Briain, DS, Ghishan, FK, Wood, AJ Decreased intestinal CYP3A in celiac disease: reversal after successful gluten-free diet: a potential source of interindividual variability in first-pass drug metabolism. Clin Pharmacol Ther, 59(1), 41-6, 1996.
• Müller, M, Belas, F, Ueno, H, Guengerich, FP Development of a mass spectrometric assay for 5,6,7,9-tetrahydro-7-hydroxy-9-oximidazo[1,2-alpha] purine in DNA modified by 2-chloro-oxirane. Adv Exp Med Biol, 38731-6, 1996.
• Guengerich, FP, Yun, CH, Macdonald, TL Evidence for a 1-electron oxidation mechanism in N-dealkylation of N,N-dialkylanilines by cytochrome P450 2B1. Kinetic hydrogen isotope effects, linear free energy relationships, comparisons with horseradish peroxidase, and studies with oxygen surrogates. J Biol Chem, 271(44), 27321-9, 1996.
• Tateishi, T, Krivoruk, Y, Ueng, YF, Wood, AJ, Guengerich, FP, Wood, M Identification of human liver cytochrome P-450 3A4 as the enzyme responsible for fentanyl and sufentanil N-dealkylation. Anesth Analg, 82(1), 167-72, 1996.
• Dong, MS, Bell, LC, Guo, Z, Phillips, DR, Blair, IA, Guengerich, FP Identification of retained N-formylmethionine in bacterial recombinant mammalian cytochrome P450 proteins with the N-terminal sequence MALLLAVFL...: roles of residues 3-5 in retention and membrane topology. Biochemistry, 35(31), 10031-40, 1996.
• Guengerich, FP In vitro techniques for studying drug metabolism. J Pharmacokinet Biopharm, 24(5), 521-33, 1996.
• Kim, RB, Yamazaki, H, Chiba, K, O'Shea, D, Mimura, M, Guengerich, FP, Ishizaki, T, Shimada, T, Wilkinson, GR In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians. J Pharmacol Exp Ther, 279(1), 4-11, 1996.
• Guengerich, FP, Johnson, WW, Ueng, YF, Yamazaki, H, Shimada, T Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer. Environ Health Perspect, 104 Suppl 3557-62, 1996.
• Yamazaki, H, Johnson, WW, Ueng, YF, Shimada, T, Guengerich, FP Lack of electron transfer from cytochrome b5 in stimulation of catalytic activities of cytochrome P450 3A4. Characterization of a reconstituted cytochrome P450 3A4/NADPH-cytochrome P450 reductase system and studies with apo-cytochrome b5. J Biol Chem, 271(44), 27438-44, 1996.
• Caraco, Y, Tateishi, T, Guengerich, FP, Wood, AJ Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity. Drug Metab Dispos, 24(7), 761-4, 1996.
• Guengerich, FP, Gillam, EM, Shimada, T New applications of bacterial systems to problems in toxicology. Crit Rev Toxicol, 26(5), 551-83, 1996.
• Anzenbacher, P, Niwa, T, Tolbert, LM, Sirimanne, SR, Guengerich, FP Oxidation of 9-alkylanthracenes by cytochrome P450 2B1, horseradish peroxidase, and iron tetraphenylporphine/iodosylbenzene systems: anaerobic and aerobic mechanisms. Biochemistry, 35(8), 2512-20, 1996.
• Guengerich, FP, Martin, MV, Guo, Z, Chun, YJ Purification of functional recombinant P450s from bacteria. Methods Enzymol, 27235-44, 1996.
• Dong, MS, Yamazaki, H, Guo, Z, Guengerich, FP Recombinant human cytochrome P450 1A2 and an N-terminal-truncated form: construction, purification, aggregation properties, and interactions with flavodoxin, ferredoxin, and NADPH-cytochrome P450 reductase. Arch Biochem Biophys, 327(1), 11-9, 1996.
• Lowe, LG, Guengerich, FP Steady-state and pre-steady-state kinetic analysis of dNTP insertion opposite 8-oxo-7,8-dihydroguanine by Escherichia coli polymerases I exo- and II exo-. Biochemistry, 35(30), 9840-9, 1996.
• Tateishi, T, Wood, AJ, Guengerich, FP, Wood, M Biotransformation of tritiated fentanyl in human liver microsomes. Monitoring metabolism using phenylacetic acid and 2-phenylethanol. Biochem Pharmacol, 50(11), 1921-4, 1995.
• Guengerich, FP, Thier, R, Persmark, M, Taylor, JB, Pemble, SE, Ketterer, B Conjugation of carcinogens by theta class glutathione s-transferases: mechanisms and relevance to variations in human risk. Pharmacogenetics, 5 Spec NoS103-7, 1995.
• Guengerich, FP Cytochrome P450 proteins and potential utilization in biodegradation. Environ Health Perspect, 103 Suppl 525-8, 1995.
• Thier, R, Müller, M, Taylor, JB, Pemble, SE, Ketterer, B, Guengerich, FP Enhancement of bacterial mutagenicity of bifunctional alkylating agents by expression of mammalian glutathione S-transferase. Chem Res Toxicol, 8(3), 465-72, 1995.
• Soucek, P, Martin, MV, Ueng, YF, Guengerich, FP Identification of a common cytochrome P450 epitope near the conserved heme-binding petide with antibodies raised against recombinant cytochrome P450 family 2 proteins. Biochemistry, 34(49), 16013-21, 1995.
• Guengerich, FP Influence of nutrients and other dietary materials on cytochrome P-450 enzymes. Am J Clin Nutr, 61(3 Suppl), 651S-658S, 1995.
• Guengerich, FP, Bell, LC, Okazaki, O Interpretations of cytochrome P450 mechanisms from kinetic studies. Biochimie, 77(7-8), 573-80, 1995.
• Guengerich, FP, Humphreys, WG, Yun, CH, Hammons, GJ, Kadlubar, FF, Seto, Y, Okazaki, O, Martin, MV Mechanisms of cytochrome P450 1A2-mediated formation of N-hydroxy arylamines and heterocyclic amines and their reaction with guanyl residues. Princess Takamatsu Symp, 2378-84, 1995.
• Ueng, YF, Shimada, T, Yamazaki, H, Guengerich, FP Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes. Chem Res Toxicol, 8(2), 218-25, 1995.
• Bauer, E, Guo, Z, Ueng, YF, Bell, LC, Zeldin, D, Guengerich, FP Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes. Chem Res Toxicol, 8(1), 136-42, 1995.
• Guengerich, FP, Okazaki, O, Seto, Y, Macdonald, TL Radical cation intermediates in N-dealkylation reactions. Xenobiotica, 25(7), 689-709, 1995.
• Yamazaki, H, Ueng, YF, Shimada, T, Guengerich, FP Roles of divalent metal ions in oxidations catalyzed by recombinant cytochrome P450 3A4 and replacement of NADPH--cytochrome P450 reductase with other flavoproteins, ferredoxin, and oxygen surrogates. Biochemistry, 34(26), 8380-9, 1995.
• Yamazaki, H, Guo, Z, Guengerich, FP Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylation. Drug Metab Dispos, 23(3), 438-40, 1995.
• Shimada, T, Gillam, EM, Sandhu, P, Guo, Z, Tukey, RH, Guengerich, FP Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays. Carcinogenesis, 15(11), 2523-9, 1994.
• Guengerich, FP Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity. Toxicol Lett, 70(2), 133-8, 1994.
• Guengerich, FP, Min, KS, Persmark, M, Kim, MS, Humphreys, WG, Cmarik, JM, Thier, R Dihaloalkanes and polyhaloalkenes. IARC Sci Publ, (125), 57-72, 1994.
• Guo, Z, Gillam, EM, Ohmori, S, Tukey, RH, Guengerich, FP Expression of modified human cytochrome P450 1A1 in Escherichia coli: effects of 5' substitution, stabilization, purification, spectral characterization, and catalytic properties. Arch Biochem Biophys, 312(2), 436-46, 1994.
• Sandhu, P, Guo, Z, Baba, T, Martin, MV, Tukey, RH, Guengerich, FP Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme. Arch Biochem Biophys, 309(1), 168-77, 1994.
• Gillam, EM, Guo, Z, Guengerich, FP Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties. Arch Biochem Biophys, 312(1), 59-66, 1994.
• Guengerich, FP, Shimada, T, Yun, CH, Yamazaki, H, Raney, KD, Thier, R, Coles, B, Harris, TM Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes. Environ Health Perspect, 102 Suppl 949-53, 1994.
• Guengerich, FP, Persmark, M Mechanism of formation of ethenoguanine adducts from 2-haloacetaldehydes: 13C-labeling patterns with 2-bromoacetaldehyde. Chem Res Toxicol, 7(2), 205-8, 1994.
• Persmark, M, Humphreys, WG, Okazaki, O, Raney, VM, Guengerich, FP Mechanisms of formation of 1,N6-ethenoadenine, 3,N4-ethenocytosine, 1,N2-ethenoguanine and N2,3-ethenoguanine DNA adducts from substituted oxiranes. IARC Sci Publ, (125), 437-41, 1994.
• Guengerich, FP Mechanisms of formation of DNA adducts from ethylene dihalides, vinyl halides, and arylamines. Drug Metab Rev, 26(1-2), 47-66, 1994.
• Guengerich, FP Metabolism and genotoxicity of dihaloalkanes. Adv Pharmacol, 27211-36, 1994.
• Persmark, M, Guengerich, FP Spectroscopic and thermodynamic characterization of the interaction of N7-guanyl thioether derivatives of d(TGCTG*CAAG) with potential complements. Biochemistry, 33(29), 8662-72, 1994.
• Okazaki, O, Guengerich, FP Evidence for specific base catalysis in N-dealkylation reactions catalyzed by cytochrome P450 and chloroperoxidase. Differences in rates of deprotonation of aminium radicals as an explanation for high kinetic hydrogen isotope effects observed with peroxidases. J Biol Chem, 268(3), 1546-52, 1993.
• Guengerich, FP, Gillam, EM, Ohmori, S, Sandhu, P, Brian, WR, Sari, MA, Iwasaki, M Expression of human cytochrome P450 enzymes in yeast and bacteria and relevance to studies on catalytic specificity. Toxicology, 82(1-3), 21-37, 1993.
• Thier, R, Taylor, JB, Pemble, SE, Humphreys, WG, Persmark, M, Ketterer, B, Guengerich, FP Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes. Proc Natl Acad Sci U S A, 90(18), 8576-80, 1993.
• Sandhu, P, Baba, T, Guengerich, FP Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity. Arch Biochem Biophys, 306(2), 443-50, 1993.
• Gillam, EM, Baba, T, Kim, BR, Ohmori, S, Guengerich, FP Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme. Arch Biochem Biophys, 305(1), 123-31, 1993.
• Guengerich, FP, Persmark, M, Humphreys, WG Formation of 1,N2- and N2,3-ethenoguanine from 2-halooxiranes: isotopic labeling studies and isolation of a hemiaminal derivative of N2-(2-oxoethyl)guanine. Chem Res Toxicol, 6(5), 635-48, 1993.
• Kim, MS, Guengerich, FP Interactions of N7-guanyl methyl- and thioether-substituted d(CATGCCT) derivatives with d(AGGNATG). Chem Res Toxicol, 6(6), 900-5, 1993.
• Seto, Y, Guengerich, FP Liquid chromatographic determination of para-substituted N,N-dialkylaniline N-oxides. J Chromatogr, 619(1), 71-7, 1993.
• Karara, A, Makita, K, Jacobson, HR, Falck, JR, Guengerich, FP, DuBois, RN, Capdevila, JH Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. J Biol Chem, 268(18), 13565-70, 1993.
• Okazaki, O, Persmark, M, Guengerich, FP N-nitroso-N-methylvinylamine: reaction of the epoxide with guanyl and adenyl moieties to yield adducts derived from both parts of the molecule. Chem Res Toxicol, 6(2), 168-73, 1993.
• Yun, CH, Okerholm, RA, Guengerich, FP Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation. Drug Metab Dispos, 21(3), 403-9, 1993.
• Seto, Y, Guengerich, FP Partitioning between N-dealkylation and N-oxygenation in the oxidation of N,N-dialkylarylamines catalyzed by cytochrome P450 2B1. J Biol Chem, 268(14), 9986-97, 1993.
• Guengerich, FP The 1992 Bernard B. Brodie Award Lecture. Bioactivation and detoxication of toxic and carcinogenic chemicals. Drug Metab Dispos, 21(1), 1-6, 1993.
• Guengerich, FP Characterization of human cytochrome P450 enzymes. FASEB J, 6(2), 745-8, 1992.
• Shimada, T, Yun, CH, Yamazaki, H, Gautier, JC, Beaune, PH, Guengerich, FP Characterization of human lung microsomal cytochrome P-450 1A1 and its role in the oxidation of chemical carcinogens. Mol Pharmacol, 41(5), 856-64, 1992.
• Yun, CH, Shimada, T, Guengerich, FP Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4'-methylene-bis(2-chloroaniline). Carcinogenesis, 13(2), 217-22, 1992.
• Capdevila, JH, Wei, S, Yan, J, Karara, A, Jacobson, HR, Falck, JR, Guengerich, FP, DuBois, RN Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading. J Biol Chem, 267(30), 21720-6, 1992.
• Guengerich, FP Cytochrome P450: advances and prospects. FASEB J, 6(2), 667-8, 1992.
• Guengerich, FP, Shimada, T, Raney, KD, Yun, CH, Meyer, DJ, Ketterer, B, Harris, TM, Groopman, JD, Kadlubar, FF Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology. Environ Health Perspect, 9875-80, 1992.
• Raney, KD, Meyer, DJ, Ketterer, B, Harris, TM, Guengerich, FP Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases. Chem Res Toxicol, 5(4), 470-8, 1992.
• Guengerich, FP Human cytochrome P-450 enzymes. Life Sci, 50(20), 1471-8, 1992.
• Fleming, CM, Branch, RA, Wilkinson, GR, Guengerich, FP Human liver microsomal N-hydroxylation of dapsone by cytochrome P-4503A4. Mol Pharmacol, 41(5), 975-80, 1992.
• Yun, CH, Wood, M, Wood, AJ, Guengerich, FP Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance. Anesthesiology, 77(3), 467-74, 1992.
• Humphreys, WG, Kadlubar, FF, Guengerich, FP Mechanism of C8 alkylation of guanine residues by activated arylamines: evidence for initial adduct formation at the N7 position. Proc Natl Acad Sci U S A, 89(17), 8278-82, 1992.
• Guengerich, FP Metabolic activation of carcinogens. Pharmacol Ther, 54(1), 17-61, 1992.
• Yun, CH, Hammons, GJ, Jones, G, Martin, MV, Hopkins, NE, Alworth, WL, Guengerich, FP Modification of cytochrome P450 1A2 enzymes by the mechanism-based inactivator 2-ethynylnaphthalene and the photoaffinity label 4-azidobiphenyl. Biochemistry, 31(43), 10556-63, 1992.
• Cmarik, JL, Humphreys, WG, Bruner, KL, Lloyd, RS, Tibbetts, C, Guengerich, FP Mutation spectrum and sequence alkylation selectivity resulting from modification of bacteriophage M13mp18 DNA with S-(2-chloroethyl)glutathione. Evidence for a role of S-(2-N7-guanyl)ethyl)glutathione as a mutagenic lesion formed from ethylene dibromide. J Biol Chem, 267(10), 6672-9, 1992.
• Guengerich, FP, Raney, KD, Kim, DH, Shimada, T, Meyer, DJ, Ketterer, B, Harris, TM Oxidation and conjugation of aflatoxins by humans and experimental animals. Prog Clin Biol Res, 374157-65, 1992.
• Raney, KD, Shimada, T, Kim, DH, Groopman, JD, Harris, TM, Guengerich, FP Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1. Chem Res Toxicol, 5(2), 202-10, 1992.
• Yun, CH, Shimada, T, Guengerich, FP Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(a)pyrene. Cancer Res, 52(7), 1868-74, 1992.
• Guengerich, FP Roles of the vinyl chloride oxidation products 1-chlorooxirane and 2-chloroacetaldehyde in the in vitro formation of etheno adducts of nucleic acid bases [corrected. Chem Res Toxicol, 5(1), 2-5, 1992.
• Raney, KD, Coles, B, Guengerich, FP, Harris, TM The endo-8,9-epoxide of aflatoxin B1: a new metabolite. Chem Res Toxicol, 5(3), 333-5, 1992.
• Shimada, T, Guengerich, FP Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes. Cancer Res, 51(19), 5284-91, 1991.
• Guengerich, FP, Turvy, CG Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples. J Pharmacol Exp Ther, 256(3), 1189-94, 1991.
• Guengerich, FP, Shimada, T, Bondon, A, Macdonald, TL Cytochrome P-450 oxidations and the generation of biologically reactive intermediates. Adv Exp Med Biol, 2831-11, 1991.
• Oida, T, Humphreys, WG, Guengerich, FP Effects of adduct formation derived from ethylene dibromide on DNA conformation. Nucleic Acids Symp Ser, (25), 135-6, 1991.
• Guengerich, FP, Kim, DH Enzymatic oxidation of ethyl carbamate to vinyl carbamate and its role as an intermediate in the formation of 1,N6-ethenoadenosine. Chem Res Toxicol, 4(4), 413-21, 1991.
• Humphreys, WG, Kim, DH, Guengerich, FP Isolation and characterization of N7-guanyl adducts derived from 1,2-dibromo-3-chloropropane. Chem Res Toxicol, 4(4), 445-53, 1991.
• Guengerich, FP Molecular advances for the cytochrome P-450 superfamily. Trends Pharmacol Sci, 12(8), 281-3, 1991.
• Guengerich, FP, Brian, WR, Iwasaki, M, Sari, MA, Bäärnhielm, C, Berntsson, P Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 IIIA4. J Med Chem, 34(6), 1838-44, 1991.
• Guengerich, FP, Shimada, T Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chem Res Toxicol, 4(4), 391-407, 1991.
• Oida, T, Humphreys, WG, Guengerich, FP Preparation and characterization of oligonucleotides containing S-[2-(N7-guanyl)ethyl]glutathione. Biochemistry, 30(43), 10513-22, 1991.
• Yun, CH, Shimada, T, Guengerich, FP Purification and characterization of human liver microsomal cytochrome P-450 2A6. Mol Pharmacol, 40(5), 679-85, 1991.
• Guengerich, FP Reactions and significance of cytochrome P-450 enzymes. J Biol Chem, 266(16), 10019-22, 1991.
• Guengerich, FP, Kim, DH, Iwasaki, M Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol, 4(2), 168-79, 1991.
• Srivastava, PK, Yun, CH, Beaune, PH, Ged, C, Guengerich, FP Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes. Mol Pharmacol, 40(1), 69-79, 1991.
• Humphreys, WG, Guengerich, FP Structure of formamidopyrimidine adducts as determined by NMR using specifically 15N-labeled guanosine. Chem Res Toxicol, 4(6), 632-6, 1991.
• Guengerich, FP, Shimada, T, Iwasaki, M, Butler, MA, Kadlubar, FF Activation of carcinogens by human liver cytochromes P-450. Basic Life Sci, 53381-96, 1990.
• Guengerich, FP, Shimada, T, Iwasaki, M, Martin, MV Activation of mutagens by human cytochrome P-450 enzymes. Prog Clin Biol Res, 340B87-96, 1990.
• Brian, WR, Sari, MA, Iwasaki, M, Shimada, T, Kaminsky, LS, Guengerich, FP Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae. Biochemistry, 29(51), 11280-92, 1990.
• Kim, DH, Humphreys, WG, Guengerich, FP Characterization of S-[2-(N1-adenyl)ethyl]glutathione as an adduct formed in RNA and DNA from 1,2-dibromoethane. Chem Res Toxicol, 3(6), 587-94, 1990.
• Humphreys, WG, Kim, DH, Cmarik, JL, Shimada, T, Guengerich, FP Comparison of the DNA-alkylating properties and mutagenic responses of a series of S-(2-haloethyl)-substituted cysteine and glutathione derivatives. Biochemistry, 29(45), 10342-50, 1990.
• Guengerich, FP, Humphreys, WG, Kim, DH, Oida, T, Cmarik, JL DNA-glutathione adducts derived from vic-dihaloalkanes: mechanisms of mutagenesis. Princess Takamatsu Symp, 21101-7, 1990.
• Kim, DH, Guengerich, FP Formation of the DNA adduct S-[2-(N7-guanyl)ethyl]glutathione from ethylene dibromide: effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation. Carcinogenesis, 11(3), 419-24, 1990.
• Guengerich, FP, Kim, DH In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids. Carcinogenesis, 11(12), 2275-9, 1990.
• Shimada, T, Guengerich, FP Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes. Cancer Res, 50(7), 2036-43, 1990.
• Guengerich, FP Inhibition of oral contraceptive steroid-metabolizing enzymes by steroids and drugs. Am J Obstet Gynecol, 163(6 Pt 2), 2159-63, 1990.
• Guengerich, FP Low kinetic hydrogen isotope effects in the dehydrogenation of 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester (nifedipine) by cytochrome P-450 enzymes are consistent with an electron/proton/electron transfer mechanism. Chem Res Toxicol, 3(1), 21-6, 1990.
• Guengerich, FP Mechanism-based inactivation of human liver microsomal cytochrome P-450 IIIA4 by gestodene. Chem Res Toxicol, 3(4), 363-71, 1990.
• Guengerich, FP, MacDonald, TL Mechanisms of cytochrome P-450 catalysis. FASEB J, 4(8), 2453-9, 1990.
• Guengerich, FP Metabolism of 17 alpha-ethynylestradiol in humans. Life Sci, 47(22), 1981-8, 1990.
• Guengerich, FP Purification and characterization of xenobiotic-metabolizing enzymes from lung tissue. Pharmacol Ther, 45(3), 299-307, 1990.
• Cmarik, JL, Inskeep, PB, Meredith, MJ, Meyer, DJ, Ketterer, B, Guengerich, FP Selectivity of rat and human glutathione S-transferases in activation of ethylene dibromide by glutathione conjugation and DNA binding and induction of unscheduled DNA synthesis in human hepatocytes. Cancer Res, 50(9), 2747-52, 1990.
• Guengerich, FP Characterization of human microsomal cytochrome P-450 enzymes. Annu Rev Pharmacol Toxicol, 29241-64, 1989.
• Bork, RW, Muto, T, Beaune, PH, Srivastava, PK, Lloyd, RS, Guengerich, FP Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity. J Biol Chem, 264(2), 910-9, 1989.
• Baertschi, SW, Raney, KD, Shimada, T, Harris, TM, Guengerich, FP Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses. Chem Res Toxicol, 2(2), 114-2, 1989.
• Shimada, T, Guengerich, FP Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. Proc Natl Acad Sci U S A, 86(2), 462-5, 1989.
• Kim, DH, Guengerich, FP Excretion of the mercapturic acid S-[2-(N7-guanyl)ethyl]-N-acetylcysteine in urine following administration of ethylene dibromide to rats. Cancer Res, 49(21), 5843-7, 1989.
• Brian, WR, Srivastava, PK, Umbenhauer, DR, Lloyd, RS, Guengerich, FP Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae. Biochemistry, 28(12), 4993-9, 1989.
• Wilkinson, GR, Guengerich, FP, Branch, RA Genetic polymorphism of S-mephenytoin hydroxylation. Pharmacol Ther, 43(1), 53-76, 1989.
• Brian, WR, Ged, C, Bellew, TM, Srivastava, PK, Bork, RW, Umbenhauer, DR, Lloyd, RS, Guengerich, FP Human liver mephenytoin 4'-hydroxylase cytochrome P-450 proteins and genes. Drug Metab Rev, 20(2-4), 449-65, 1989.
• Shimada, T, Iwasaki, M, Martin, MV, Guengerich, FP Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002. Cancer Res, 49(12), 3218-28, 1989.
• Bondon, A, Macdonald, TL, Harris, TM, Guengerich, FP Oxidation of cycloalkylamines by cytochrome P-450. Mechanism-based inactivation, adduct formation, ring expansion, and nitrone formation. J Biol Chem, 264(4), 1988-97, 1989.
• Guengerich, FP Oxidation of halogenated compounds by cytochrome P-450, peroxidases, and model metalloporphyrins. J Biol Chem, 264(29), 17098-205, 1989.
• Shimada, T, Martin, MV, Pruess-Schwartz, D, Marnett, LJ, Guengerich, FP Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. Cancer Res, 49(22), 6304-12, 1989.
• Ged, C, Umbenhauer, DR, Bellew, TM, Bork, RW, Srivastava, PK, Shinriki, N, Lloyd, RS, Guengerich, FP Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase. Biochemistry, 27(18), 6929-40, 1988.
• Guengerich, FP, Böcker, RH Cytochrome P-450-catalyzed dehydrogenation of 1,4-dihydropyridines. J Biol Chem, 263(17), 8168-75, 1988.
• Guengerich, FP, Peterson, LA, Böcker, RH Cytochrome P-450-catalyzed hydroxylation and carboxylic acid ester cleavage of Hantzsch pyridine esters. J Biol Chem, 263(17), 8176-83, 1988.
• Guengerich, FP Cytochromes P-450. Comp Biochem Physiol C, 89(1), 1-4, 1988.
• Guengerich, FP Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450. Mol Pharmacol, 33(5), 500-8, 1988.
• Knodell, RG, Dubey, RK, Wilkinson, GR, Guengerich, FP Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation. J Pharmacol Exp Ther, 245(3), 845-9, 1988.
• Guengerich, FP Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy. Cancer Res, 48(11), 2946-54, 1988.
• Guengerich, FP, Peterson, LA, Cmarik, JL, Koga, N, Inskeep, PB Activation of dihaloalkanes by glutathione conjugation and formation of DNA adducts. Environ Health Perspect, 7615-8, 1987.
• Guengerich, FP, Beaune, PH, Umbenhauer, DR, Churchill, PF, Bork, RW, Dannan, GA, Knodell, RG, Lloyd, RS, Martin, MV Cytochrome P-450 enzymes involved in genetic polymorphism of drug oxidation in humans. Biochem Soc Trans, 15(4), 576-8, 1987.
• Guengerich, FP, Churchill, PF, Jung, CY, Fleischer, S Target inactivation analysis applied to determination of molecular weights of rat liver proteins in the purified state and in microsomal membranes. Biochim Biophys Acta, 915(2), 246-53, 1987.