The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers
Florent Elefteriou, Ph.D.
See also:
Assistant Professor of Medicine
Assistant Professor of Cancer Biology
Assistant Professor of Pharmacology
VICC Member
Researcher
Contact Information:
MRB IV, Light Hall
room 1225E
615-322-7975
Education
- Ph.D., Claude-Bernard University
- Post doctoral training, Baylor College of Medicine
Research Description
Bone remodeling is regulated in vivo by a complex interplay between autocrine/paracrine and hormonal signals. Our studies, based on the use of mouse genetic models, demonstrated that this process is also regulated by the central nervous system, and that, as this finding implies, bone remodeling is an homeostatic process fully integrated to the regulation of the internal milieu via neurons, neuropeptides and hormones involved in the regulation of body weight, energy expenditure, reproduction or immunity. Our studies also identified the sympathetic nervous system as a critical regulator of bone remodeling. Our research currently focuses on the clinical implications of these findings from preclinical mouse models, with a special interest on osteoporosis and bone cancer metastasis.
The second main interest of our laboratory is to determine the role of Nf1 in bone cells and type I neurofibromatosis (NF1). Neurofibromatosis, caused by mutations in the Nf1 gene, is characterized by several skeletal complications including macrocephaly, scoliosis, bowing of the tibia and pseudo-arthrosis, but the origin of these skeletal dysplastic defects is unknown. By the use of mutant mouse models lacking Nf1 in osteoblasts, chondrocytes or mesenchymal stem cells, we are currently investigating the role of Nf1 signaling in the differentiation and function of bone cells, with the goal of identifying novel signaling pathways and transcription factors regulating bone growth, remodeling and repair, and to identify new therapeutic targets to treat bone diseases, including skeletal displasiae and fracture non-unions found in NF1 patients.
Publications
- Wang, W, Lian, N, Ma, Y, Li, L, Gallant, RC, Elefteriou, F, Yang, X Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh. Development, 139(3), 601-11, 2012.
- Campbell, JP, Merkel, AR, Masood-Campbell, SK, Elefteriou, F, Sterling, JA Models of bone metastasis. J Vis Exp, (67), e4260, 2012.
- Edwards, JR, Perrien, DS, Fleming, N, Nyman, JS, Ono, K, Connelly, L, Moore, MM, Lwin, ST, Yull, FE, Mundy, GR, Elefteriou, F Silent information regulator (Sir)T1 inhibits NF¿¿B signaling to maintain normal skeletal remodeling. J Bone Miner Res, 2012.
- Campbell, JP, Karolak, MR, Ma, Y, Perrien, DS, Masood-Campbell, SK, Penner, NL, Munoz, SA, Zijlstra, A, Yang, X, Sterling, JA, Elefteriou, F Stimulation of host bone marrow stromal cells by sympathetic nerves promotes breast cancer bone metastasis in mice. PLoS Biol, 10(7), e1001363, 2012.
- Elefteriou, F, Yang, X Genetic mouse models for bone studies--strengths and limitations. Bone, 49(6), 1242-54, 2011.
- Wang, W, Nyman, JS, Ono, K, Stevenson, DA, Yang, X, Elefteriou, F Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I. Hum Mol Genet, 20(20), 3910-24, 2011.
- Ma, Y, Nyman, JS, Tao, H, Moss, HH, Yang, X, Elefteriou, F β2-Adrenergic receptor signaling in osteoblasts contributes to the catabolic effect of glucocorticoids on bone. Endocrinology, 152(4), 1412-22, 2011.
- Wang, W, Nyman, JS, Moss, HE, Gutierrez, G, Mundy, GR, Yang, X, Elefteriou, F Local low-dose lovastatin delivery improves the bone-healing defect caused by Nf1 loss of function in osteoblasts. J Bone Miner Res, 25(7), 1658-67, 2010.
- Wang, W, Lian, N, Li, L, Moss, HE, Wang, W, Perrien, DS, Elefteriou, F, Yang, X Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription. Development, 136(24), 4143-53, 2009.
- Elefteriou, F, Kolanczyk, M, Schindeler, A, Viskochil, DH, Hock, JM, Schorry, EK, Crawford, AH, Friedman, JM, Little, D, Peltonen, J, Carey, JC, Feldman, D, Yu, X, Armstrong, L, Birch, P, Kendler, DL, Mundlos, S, Yang, FC, Agiostratidou, G, Hunter-Schaedle, K, Stevenson, DA Skeletal abnormalities in neurofibromatosis type 1: approaches to therapeutic options. Am J Med Genet A, 149A(10), 2327-38, 2009.
- Lian, N, Wang, W, Li, L, Elefteriou, F, Yang, X Vimentin inhibits ATF4-mediated osteocalcin transcription and osteoblast differentiation. J Biol Chem, 2009.
- Singh, MK, Elefteriou, F, Karsenty, G Cocaine and amphetamine-regulated transcript may regulate bone remodeling as a circulating molecule. Endocrinology, 149(8), 3933-41, 2008.
- Elefteriou, F Regulation of bone remodeling by the central and peripheral nervous system. Arch Biochem Biophys, 473(2), 231-6, 2008.
- Patel, MS, Elefteriou, F The New Field of Neuroskeletal Biology. Calcif Tissue Int, 2007.
- Elefteriou, F, Benson, MD, Sowa, H, Starbuck, M, Liu, X, Ron, D, Parada, LF, Karsenty, G ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab, 4(6), 441-51, 2006.
- Mundy, GR, Elefteriou, F Boning up on ephrin signaling. Cell, 126(3), 441-3, 2006.
- Elefteriou, F, Ahn, JD, Takeda, S, Starbuck, M, Yang, X, Liu, X, Kondo, H, Richards, WG, Bannon, TW, Noda, M, Clement, K, Vaisse, C, Karsenty, G Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature, 434(7032), 514-20, 2005.
- Elefteriou, F Neuronal signaling and the regulation of bone remodeling. Cell Mol Life Sci, 62(19-20), 2339-49, 2005.
- Cock, TA, Back, J, Elefteriou, F, Karsenty, G, Kastner, P, Chan, S, Auwerx, J Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen. EMBO Rep, 5(10), 1007-12, 2004.
- Cui, Y, Huang, L, Elefteriou, F, Yang, G, Shelton, JM, Giles, JE, Oz, OK, Pourbahrami, T, Lu, CY, Richardson, JA, Karsenty, G, Li, C Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol, 24(1), 258-69, 2004.
- Elefteriou, F, Takeda, S, Ebihara, K, Magre, J, Patano, N, Kim, CA, Ogawa, Y, Liu, X, Ware, SM, Craigen, WJ, Robert, JJ, Vinson, C, Nakao, K, Capeau, J, Karsenty, G Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci U S A, 101(9), 3258-63, 2004.
- Elefteriou, F, Karsenty, G [Bone mass regulation by leptin: a hypothalamic control of bone formation. Pathol Biol (Paris), 52(3), 148-53, 2004.
- Takeda, S, Elefteriou, F, Karsenty, G Common endocrine control of body weight, reproduction, and bone mass. Annu Rev Nutr, 23403-11, 2003.
- Elefteriou, F, Takeda, S, Liu, X, Armstrong, D, Karsenty, G Monosodium glutamate-sensitive hypothalamic neurons contribute to the control of bone mass. Endocrinology, 144(9), 3842-7, 2003.
- Levasseur, R, Barrios, R, Elefteriou, F, Glass, DA, Lieberman, MW, Karsenty, G Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice. Endocrinology, 144(7), 2761-4, 2003.
- Elefteriou, F, Ducy, P [Control of body mass by leptin occurs through the sympathetic nervous system. Med Sci (Paris), 19(4), 391-3, 2003.
- Takeda, S, Elefteriou, F, Levasseur, R, Liu, X, Zhao, L, Parker, KL, Armstrong, D, Ducy, P, Karsenty, G Leptin regulates bone formation via the sympathetic nervous system. Cell, 111(3), 305-17, 2002.
- Elefteriou, F, Exposito, JY, Garrone, R, Lethias, C Binding of tenascin-X to decorin. FEBS Lett, 495(1-2), 44-7, 2001.
- Lethias, C, Elefteriou, F, Parsiegla, G, Exposito, JY, Garrone, R Identification and characterization of a conformational heparin-binding site involving two fibronectin type III modules of bovine tenascin-X. J Biol Chem, 276(19), 16432-8, 2001.
- Elefteriou, F, Exposito, JY, Garrone, R, Lethias, C Cell adhesion to tenascin-X mapping of cell adhesion sites and identification of integrin receptors. Eur J Biochem, 263(3), 840-8, 1999.
- Elefteriou, F, Exposito, JY, Garrone, R, Lethias, C Characterization of the bovine tenascin-X. J Biol Chem, 272(36), 22866-74, 1997.
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