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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 
Ginger E.  Holt

Ginger E. Holt, M.D.

Professor of Orthopaedic Surgery and Rehabilitation
Orthopaedic Oncologist

Profile

Dr. Holt joined the Vanderbilt Orthopaedic Institute in 2003. Her clinical interests include bone and tissue sarcoma, cancer surgery, and adult reconstruction. Her research interests include cancer biology (metastic and sarcoma), fracture healing, and total joint biomechanics. Dr. Holt enjoys cycling, traveling, and spending time with her family.

Education
  • M.D. - University of Alabama at Birmingham, 1996
  • Fellowship - University of Colorado Hospital, 2003
  • Fellowship - University of Toronto, 2002
  • Residency - Vanderbilt University Medical Center, 2001
  • Internship - Vanderbilt University Medical Center, 1997
 
Publications
  • Crosby SN, Polkowski GG, Schwartz HS, Shinar AA, Holt GE. Metal-backed versus all-polyethylene tibias in megaprostheses of the distal femur. J Arthroplasty [print-electronic]. 2011 Apr; 26(3): 451-7. PMID: 20334995, PII: S0883-5403(10)00014-8, DOI: 10.1016/j.arth.2010.01.007, ISSN: 1532-8406.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20334995.
  • Dobbs MD, Lowas SR, Hernanz-Schulman M, Holt GE, Yu C, Kan JH. Impact of abdominopelvic CT on Ewing sarcoma management. Acad Radiol [print-electronic]. 2010 Oct; 17(10): 1288-91. PMID: 20634109, PII: S1076-6332(10)00318-1, DOI: 10.1016/j.acra.2010.06.010, ISSN: 1878-4046.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20634109.
  • Cates JM, Friedman DB, Seeley EH, Dupont WD, Schwartz HS, Holt GE, Caprioli RM, Young PP. Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis. Int J Exp Pathol [print-electronic]. 2010 Aug; 91(4): 335-49. PMID: 20353421, PMCID: PMC2962892, PII: IEP711, DOI: 10.1111/j.1365-2613.2010.00711.x, ISSN: 1365-2613.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20353421.
  • Dumas JE, Davis T, Holt GE, Yoshii T, Perrien DS, Nyman JS, Boyce T, Guelcher SA. Synthesis, characterization, and remodeling of weight-bearing allograft bone/polyurethane composites in the rabbit. Acta Biomater [print-electronic]. 2010 Jul; 6(7): 2394-406. PMID: 20109586, PII: S1742-7061(10)00041-3, DOI: 10.1016/j.actbio.2010.01.030, ISSN: 1878-7568.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20109586.
  • Mansour AA, Kelley MC, Hatmaker AR, Holt GE, Schwartz HS. Verification of musculoskeletal FDG-PET-CT findings performed for melanoma staging. Ann. Surg. Oncol [print-electronic]. 2010 Apr; 17(4): 1144-51. PMID: 19967460, DOI: 10.1245/s10434-009-0843-4, ISSN: 1534-4681.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19967460.
  • Giannico G, Holt GE, Homlar KC, Johnson J, Pinnt J, Bridge JA. Osteoblastoma characterized by a three-way translocation: report of a case and review of the literature. Cancer Genet. Cytogenet. 2009 Dec; 195(2): 168-71. PMID: 19963118, PII: S0165-4608(09)00377-X, DOI: 10.1016/j.cancergencyto.2009.06.024, ISSN: 1873-4456.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19963118.
  • Butler MA, Holt GE, Crosby SN, Weikert DR. Late posterior interosseous nerve palsy associated with loosening of radial head implant. J Shoulder Elbow Surg [print-electronic]. 2009 Nov; 18(6): e17-21. PMID: 19487131, PII: S1058-2746(09)00146-3, DOI: 10.1016/j.jse.2009.03.007, ISSN: 1532-6500.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19487131.
  • Holt GE, Christie MJ, Schwartz HS. Trabecular metal endoprosthetic limb salvage reconstruction of the lower limb. J Arthroplasty [print-electronic]. 2009 Oct; 24(7): 1079-85. PMID: 18834697, PII: S0883-5403(08)00700-6, DOI: 10.1016/j.arth.2008.08.010, ISSN: 1532-8406.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18834697.
  • Thiolloy S, Halpern J, Holt GE, Schwartz HS, Mundy GR, Matrisian LM, Lynch CC. Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis. Cancer Res. 2009 Aug 8/15/2009; 69(16): 6747-55. PMID: 19679556, PMCID: PMC2745595, PII: 69/16/6747, DOI: 10.1158/0008-5472.CAN-08-3949, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19679556.
  • Adelani MA, Stover DG, Halpern JL, Schwartz HS, Holt GE. Caveat arthroplasty. J Arthroplasty [print-electronic]. 2009 Aug; 24(5): 728-34. PMID: 18639434, PII: S0883-5403(08)00470-1, DOI: 10.1016/j.arth.2008.04.030, ISSN: 1532-8406.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18639434.
  • Herceg ME, Tsiatis AC, Halpern JL, Holt GE, Schwartz HS, Keedy VL, Cates JM. Cyclooxygenase 2 expression in soft tissue leiomyosarcoma. Anticancer Res. 2009 Aug; 29(8): 2913-7. PMID: 19661295, PII: 29/8/2913, ISSN: 1791-7530.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19661295.
  • Holt GE, Halpern JL, Lynch CC, Devin CJ, Schwartz HS. Imaging analysis of the in vivo bioreactor: a preliminary study. Clin. Orthop. Relat. Res [print-electronic]. 2008 Aug; 466(8): 1890-6. PMID: 18506563, PMCID: PMC2584254, DOI: 10.1007/s11999-008-0295-3, ISSN: 1528-1132.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18506563.
  • Adelani MA, Wupperman RM, Holt GE. Benign synovial disorders. J Am Acad Orthop Surg. 2008 May; 16(5): 268-75. PMID: 18460687, PII: 16/5/268, ISSN: 1067-151X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18460687.
  • Adelani MA, Holt GE, Dittus RS, Passman MA, Schwartz HS. Revascularization after segmental resection of lower extremity soft tissue sarcomas. J Surg Oncol. 2007 May 5/1/2007; 95(6): 455-60. PMID: 17458861, DOI: 10.1002/jso.20679, ISSN: 0022-4790.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17458861.
  • Devin C, Chong PY, Holt GE, Feurer I, Gonzalez A, Merchant N, Schwartz HS. Level-adjusted perioperative risk of sacral amputations. J Surg Oncol. 2006 Sep 9/1/2006; 94(3): 203-11. PMID: 16900511, DOI: 10.1002/jso.20477, ISSN: 0022-4790.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16900511.
  • Holt GE, Schwartz HS, Caldwell RL. Proteomic profiling in musculoskeletal oncology by MALDI mass spectrometry. Clin. Orthop. Relat. Res. 2006 Sep; 450: 105-10. PMID: 16906088, DOI: 10.1097/01.blo.0000229328.68287.93, ISSN: 0009-921X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16906088.
  • Holt GE, Thomson AB, Griffin AM, Bell R, Wunder J, Rougraff B, Schwartz HS. Multifocality and multifocal postradiation sarcomas. Clin. Orthop. Relat. Res. 2006 Sep; 450: 67-75. PMID: 16906076, DOI: 10.1097/01.blo.0000229301.75018.84, ISSN: 0009-921X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16906076.
  • Halpern J, Lynch CC, Fleming J, Hamming D, Martin MD, Schwartz HS, Matrisian LM, Holt GE. The application of a murine bone bioreactor as a model of tumor: bone interaction. Clin. Exp. Metastasis [print-electronic]. 2006; 23(7-8): 345-56. PMID: 17136574, DOI: 10.1007/s10585-006-9044-8, ISSN: 0262-0898.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17136574.
  • Holt GE, Halpern JL, Dovan TT, Hamming D, Schwartz HS. Evolution of an in vivo bioreactor. J. Orthop. Res [print-electronic]. 2005 Jul; 23(4): 916-23. PMID: 16023008, PII: S0736-0266(04)00245-1, DOI: 10.1016/j.orthres.2004.10.005, ISSN: 0736-0266.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16023008.
  • Holt GE, Griffin AM, Pintilie M, Wunder JS, Catton C, O'Sullivan B, Bell RS. Fractures following radiotherapy and limb-salvage surgery for lower extremity soft-tissue sarcomas. A comparison of high-dose and low-dose radiotherapy. J Bone Joint Surg Am. 2005 Feb; 87(2): 315-9. PMID: 15687153, PII: 87/2/315, DOI: 10.2106/JBJS.C.01714, ISSN: 0021-9355.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15687153.
  • Holt GE, Dennis DA. Use of custom triflanged acetabular components in revision total hip arthroplasty. Clin. Orthop. Relat. Res. 2004 Dec; (429): 209-14. PMID: 15577489, PII: 00003086-200412000-00032, ISSN: 0009-921X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15577489.
  • Holt GE, Dennis DA. The role of patellar resurfacing in total knee arthroplasty. Clin. Orthop. Relat. Res. 2003 Nov; (416): 76-83. PMID: 14646743, DOI: 10.1097/01.blo.0000092991.90435.fb, ISSN: 0009-921X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14646743.
  • Holt GE, Mencio GA. Pelvic C-clamp in a pediatric patient. J Orthop Trauma. 2003 Aug; 17(7): 525-7. PMID: 12902792, ISSN: 0890-5339.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12902792.
  • Holt GE, McCarty EC. Anterior hip dislocation with an associated vascular injury requiring amputation. J Trauma. 2003 Jul; 55(1): 135-8. PMID: 12855893, DOI: 10.1097/01.TA.0000073996.14689.AF, ISSN: 0022-5282.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12855893.
  • Garth WP, DiChristina DG, Holt GE. Chronic Patellofemoral Instability Treated By Proximal Anatomical Repair and Distal Realignment. Clin Orthop. 2000; ((377)): 132-44.
  • Holt GE, Feurer ID, Schwartz HS. An Analysis of Concordance among Hospital Databases and Physician Records. Annals of Surgical Oncology. 1998; 6((5)): 553-6.
  • Aarons D, Tong H, Holt G, Poirier G. Acrosome Reaction Induced by Immunoaggregation of a Proteinase Inhibitor Bound to the Murine Sperm Head. Molecular Reproduction and Development. 1991; ((30)): 258-64.