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Giovanna A.  Giannico

Giovanna A. Giannico, M.D.

Assistant Professor of Pathology, Microbiology and Immunology
Chief of Genitourinary Pathology, Department of Pathology, Microbiology and Immunology

Profile

Mechanisms of prostate cancer progression and recurrence; prostate cancer biomarker discovery. Histopathology and molecular mechanisms of humoral rejection in kidney transplant.

Education
  • M.D., University of Bari, Italy
Postgraduate Training
  • Residency, Vanderbilt University Medical Center
  • Fellowship, Vanderbilt University Medical Center
Publications
  • Kuba MG, Wasserman A, Vnencak-Jones CL, Bridge JA, Gellert L, Hameed O, Giannico GA. Primary Carcinoid Tumor of the Renal Pelvis Arising From Intestinal Metaplasia: An Unusual Histogenetic Pathway?. Appl. Immunohistochem. Mol. Morphol. 2017 Aug; 25(7): e49-e57. PMID: 27753663, DOI: 10.1097/PAI.0000000000000445, ISSN: 1533-4058.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27753663.
  • Giannico GA, Gown AM, Epstein JI, Revetta F, Bishop JA. Role of SATB2 in Distinguishing the Site of Origin in Glandular Lesions of the Bladder/Urinary Tract. Hum. Pathol [print-electronic]. 2017 Jul 7/12/2017; PMID: 28711650, PII: S0046-8177(17)30243-5, DOI: 10.1016/j.humpath.2017.07.002, ISSN: 1532-8392.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/28711650.
  • Cate F, Kapp ME, Arnold SA, Gellert LL, Hameed O, Clark PE, Wile G, Coogan A, Giannico GA. Core Needle Biopsy and Fine Needle Aspiration Alone or in Combination: Diagnostic Accuracy and Impact on Management of Renal Masses. J. Urol [print-electronic]. 2017 Jun; 197(6): 1396-402. PMID: 28093293, PII: S0022-5347(17)30064-2, DOI: 10.1016/j.juro.2017.01.038, ISSN: 1527-3792.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/28093293.
  • Giannico GA, Arnold SA, Gellert LL, Hameed O. New and Emerging Diagnostic and Prognostic Immunohistochemical Biomarkers in Prostate Pathology. Adv Anat Pathol. 2017 Jan; 24(1): 35-44. PMID: 27941540, PII: 00125480-201701000-00004, DOI: 10.1097/PAP.0000000000000136, ISSN: 1533-4031.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27941540.
  • Mehra R, Vats P, Cieslik M, Cao X, Su F, Shukla S, Udager AM, Wang R, Pan J, Kasaian K, Lonigro R, Siddiqui J, Premkumar K, Palapattu G, Weizer A, Hafez KS, Wolf JS, Sangoi AR, Trpkov K, Osunkoya AO, Zhou M, Giannico G, McKenney JK, Dhanasekaran SM, Chinnaiyan AM. Biallelic Alteration and Dysregulation of the Hippo Pathway in Mucinous Tubular and Spindle Cell Carcinoma of the Kidney. Cancer Discov [print-electronic]. 2016 Nov; 6(11): 1258-66. PMID: 27604489, PMCID: PMC5096979, PII: 2159-8290.CD-16-0267, DOI: 10.1158/2159-8290.CD-16-0267, ISSN: 2159-8290.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27604489.
  • Nunez AL, Giannico GA, Mukhtar F, Dailey V, El-Galley R, Hameed O. Frozen section evaluation of margins in radical prostatectomy specimens: a contemporary study and literature review. Ann Diagn Pathol [print-electronic]. 2016 Oct; 24: 11-8. PMID: 27649947, PII: S1092-9134(16)30189-7, DOI: 10.1016/j.anndiagpath.2016.08.002, ISSN: 1532-8198.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27649947.
  • Goldstein J, Goyal R, Roland JT, Gellert LL, Clark PE, Hameed O, Giannico GA. MAGI-2 Is a Sensitive and Specific Marker of Prostatic Adenocarcinoma: ¿A Comparison With AMACR. Am. J. Clin. Pathol. 2016 Sep; 146(3): 294-302. PMID: 27543977, PII: aqw111, DOI: 10.1093/ajcp/aqw111, ISSN: 1943-7722.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27543977.
  • Safdar NS, Giannico GA, Desouki MM. Utility of a standardized protocol for submitting clinically suspected endometrial polyps to the pathology laboratory. Ann Diagn Pathol [print-electronic]. 2016 Aug; 23: 29-31. PMID: 27402220, PMCID: PMC4959454, PII: S1092-9134(16)30101-0, DOI: 10.1016/j.anndiagpath.2016.05.002, ISSN: 1532-8198.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27402220.
  • Goldstein J, Borowsky AD, Goyal R, Roland JT, Arnold SA, Gellert LL, Clark PE, Hameed O, Giannico GA. MAGI-2 in prostate cancer: an immunohistochemical study. Hum. Pathol [print-electronic]. 2016 Jun; 52: 83-91. PMID: 26980016, PII: S0046-8177(16)00035-6, DOI: 10.1016/j.humpath.2016.01.003, ISSN: 1532-8392.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26980016.
  • Phillips S, Kapp M, Crowe D, Garces J, Fogo AB, Giannico GA. Endothelial activation, lymphangiogenesis, and humoral rejection of kidney transplants. Hum. Pathol [print-electronic]. 2016 May; 51: 86-95. PMID: 27067786, PII: S0046-8177(16)00022-8, DOI: 10.1016/j.humpath.2015.12.020, ISSN: 1532-8392.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27067786.
  • Kapp ME, Giannico GA, Desouki MM. Metastatic Breast Carcinoma to the Prostate Gland. Case Rep Oncol Med [print-electronic]. 2016; 2016: 8264140. PMID: 27429817, PMCID: PMC4939205, DOI: 10.1155/2016/8264140, ISSN: 2090-6706.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27429817.
  • Goyal R, Parwani AV, Gellert L, Hameed O, Giannico GA. A collision tumor of papillary renal cell carcinoma and oncocytoma: case report and literature review. Am. J. Clin. Pathol. 2015 Nov; 144(5): 811-6. PMID: 26486747, PII: 144/5/811, DOI: 10.1309/AJCPQ0P1YHDBZUFL, ISSN: 1943-7722.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26486747.
  • Giannico GA, Arnold S, Langone A, Schaefer H, Helderman JH, Shaffer D, Fogo AB. Non-immunoglobulin A mesangial immune complex glomerulonephritis in kidney transplants. Hum. Pathol [print-electronic]. 2015 Oct; 46(10): 1521-8. PMID: 26245687, PII: S0046-8177(15)00217-8, DOI: 10.1016/j.humpath.2015.06.012, ISSN: 1532-8392.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26245687.
  • Tan HL, Haffner MC, Esopi DM, Vaghasia AM, Giannico GA, Ross HM, Ghosh S, Hicks JL, Zheng Q, Sangoi AR, Yegnasubramanian S, Osunkoya AO, De Marzo AM, Epstein JI, Lotan TL. Prostate adenocarcinomas aberrantly expressing p63 are molecularly distinct from usual-type prostatic adenocarcinomas. Mod. Pathol [print-electronic]. 2015 Mar; 28(3): 446-56. PMID: 25216229, PMCID: PMC4344845, PII: modpathol2014115, DOI: 10.1038/modpathol.2014.115, ISSN: 1530-0285.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25216229.
  • Tang DH, Clark PE, Giannico G, Hameed O, Chang SS, Gellert LL. Lack of P16ink4a over expression in penile squamous cell carcinoma is associated with recurrence after lymph node dissection. J. Urol [print-electronic]. 2015 Feb; 193(2): 519-25. PMID: 25261804, PII: S0022-5347(14)04550-9, DOI: 10.1016/j.juro.2014.08.120, ISSN: 1527-3792.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25261804.
  • Palmer TD, Martínez CH, Vasquez C, Hebron KE, Jones-Paris C, Arnold SA, Chan SM, Chalasani V, Gomez-Lemus JA, Williams AK, Chin JL, Giannico GA, Ketova T, Lewis JD, Zijlstra A. Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression. Cancer Res [print-electronic]. 2014 Jan 1/1/2014; 74(1): 173-87. PMID: 24220242, PMCID: PMC3947299, PII: 0008-5472.CAN-13-0275, DOI: 10.1158/0008-5472.CAN-13-0275, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24220242.
  • Jones H, Gold MA, Giannico G, Troutman A, Vnencak-Jones CL, Schultenover SJ, Fadare O. Lymphoepithelioma-like carcinoma of the endometrium: immunophenotypic characterization of a rare tumor with microsatellite instability testing. Int. J. Gynecol. Pathol. 2014 Jan; 33(1): 64-73. PMID: 24300538, DOI: 10.1097/PGP.0b013e318276310b, ISSN: 1538-7151.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24300538.
  • Giannico GA, Ross HM, Lotan T, Epstein JI. Aberrant expression of p63 in adenocarcinoma of the prostate: a radical prostatectomy study. Am. J. Surg. Pathol. 2013 Sep; 37(9): 1401-6. PMID: 23774168, DOI: 10.1097/PAS.0b013e31828d5c32, ISSN: 1532-0979.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23774168.
  • Giannico G, Fogo AB. Lupus nephritis: is the kidney biopsy currently necessary in the management of lupus nephritis?. Clin J Am Soc Nephrol [print-electronic]. 2013 Jan; 8(1): 138-45. PMID: 22977215, PII: CJN.03400412, DOI: 10.2215/CJN.03400412, ISSN: 1555-905X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22977215.
  • Zoccali C, Ruggenenti P, Perna A, Leonardis D, Tripepi R, Tripepi G, Mallamaci F, Remuzzi G, . Phosphate may promote CKD progression and attenuate renoprotective effect of ACE inhibition. J. Am. Soc. Nephrol [print-electronic]. 2011 Oct; 22(10): 1923-30. PMID: 21852581, PMCID: PMC3279951, PII: ASN.2011020175, DOI: 10.1681/ASN.2011020175, ISSN: 1533-3450.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21852581.
  • Mallamaci F, Ruggenenti P, Perna A, Leonardis D, Tripepi R, Tripepi G, Remuzzi G, Zoccali C, . ACE inhibition is renoprotective among obese patients with proteinuria. J. Am. Soc. Nephrol [print-electronic]. 2011 Jun; 22(6): 1122-8. PMID: 21527660, PMCID: PMC3103731, PII: ASN.2010090969, DOI: 10.1681/ASN.2010090969, ISSN: 1533-3450.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21527660.
  • Espeli M, Bökers S, Giannico G, Dickinson HA, Bardsley V, Fogo AB, Smith KG. Local renal autoantibody production in lupus nephritis. J. Am. Soc. Nephrol [print-electronic]. 2011 Feb; 22(2): 296-305. PMID: 21088295, PMCID: PMC3029902, PII: ASN.2010050515, DOI: 10.1681/ASN.2010050515, ISSN: 1533-3450.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21088295.
  • Giannico G, Holt GE, Homlar KC, Johnson J, Pinnt J, Bridge JA. Osteoblastoma characterized by a three-way translocation: report of a case and review of the literature. Cancer Genet. Cytogenet. 2009 Dec; 195(2): 168-71. PMID: 19963118, PII: S0165-4608(09)00377-X, DOI: 10.1016/j.cancergencyto.2009.06.024, ISSN: 1873-4456.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19963118.
  • Giannico G, Yang H, Neilson EG, Fogo AB. Dystroglycan in the diagnosis of FSGS. Clin J Am Soc Nephrol [print-electronic]. 2009 Nov; 4(11): 1747-53. PMID: 19808230, PMCID: PMC2774958, PII: CJN.01510209, DOI: 10.2215/CJN.01510209, ISSN: 1555-905X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19808230.
  • Procaccini DA, Angelini P, Aucella F, Avanzi C, Brusasco S, Carta G, Cataldi G, Cogoni G, D'Agostino F, d'Elia F, Del Mastro G, Dell'aquila R, De Min AM, Feliciangeli G, Freddi P, Gallucci M, Giannico G, Gigante B, Infante B, Ktena M, Manno C, Marseglia CD, Navarra A, Pappani A, Pompa G, Querques M, Russo D, Sacchetti A, Sechi MA, Specchio A, Stallone C, Virgilio M, . [Health-related quality of life in patients with chronic kidney disease]. G Ital Nefrol. 2008 Nov; 25(6): 694-701. PMID: 19048570, ISSN: 0393-5590.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19048570.
  • Giannico G, Cortes P, Baccora MH, Hassett C, Taube DW, Yee J. Glibenclamide prevents increased extracellular matrix formation induced by high glucose concentration in mesangial cells. Am. J. Physiol. Renal Physiol [print-electronic]. 2007 Jan; 292(1): F57-65. PMID: 16896180, PII: 00210.2006, DOI: 10.1152/ajprenal.00210.2006, ISSN: 1931-857X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16896180.
  • Giannico G, Miller FJ, Fogo AB. Diabetic nephropathy. Am. J. Kidney Dis. 2006 May; 47(5): A42, e61-3. PMID: 16637105, ISSN: 1523-6838.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16637105.
  • Wang XP, Fogo AB, Colon S, Giannico G, Abul-Ezz SR, Miner JH, Borza DB. Distinct epitopes for anti-glomerular basement membrane alport alloantibodies and goodpasture autoantibodies within the noncollagenous domain of alpha3(IV) collagen: a janus-faced antigen. J. Am. Soc. Nephrol [print-electronic]. 2005 Dec; 16(12): 3563-71. PMID: 16236801, PII: ASN.2005060670, DOI: 10.1681/ASN.2005060670, ISSN: 1046-6673.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16236801.
  • Biederman JI, Vera E, Rankhaniya R, Hassett C, Giannico G, Yee J, Cortes P. Effects of sulfonylureas, alpha-endosulfine counterparts, on glomerulosclerosis in type 1 and type 2 models of diabetes. Kidney Int. 2005 Feb; 67(2): 554-65. PMID: 15673303, PII: KID67112, DOI: 10.1111/j.1523-1755.2005.67112.x, ISSN: 0085-2538.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15673303.
  • Giannico G, Mendez M, LaPointe MC. Regulation of the membrane-localized prostaglandin E synthases mPGES-1 and mPGES-2 in cardiac myocytes and fibroblasts. Am. J. Physiol. Heart Circ. Physiol [print-electronic]. 2005 Jan; 288(1): H165-74. PMID: 15358613, PII: 00726.2004, DOI: 10.1152/ajpheart.00726.2004, ISSN: 0363-6135.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15358613.
  • Giannico G, O'Reilly K, Fogo A.B.. Quiz page: Fabry's disease. Am J Kidney Dis. 2005; 2((46)): A42.
  • Manno C., Giannico G., Schena F.P.. Treatment of lupus nephritis. G It Nefrol. 2001; 2: 149-57.
  • Giannico G, Manno C, Schena FP. Treatment of glomerulonephritides associated with hepatitis C virus infection. Nephrol. Dial. Transplant. 2000; 15 Suppl 8: 34-8. PMID: 11261701, ISSN: 0931-0509.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11261701.
  • Giannico G., Manno C., Soccio M., Johnson R.J., Grayston J.T., Gesualdo L., Schena F.P.. Chlamydia Pneumoniae infection and systemic vasculitis: a possible association. G It Nefrol. 2000; 3: 245-9.