The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers
Gordon R. Bernard, M.D.
See also:
Associate Vice Chancellor for Research
Senior Associate Dean for Clinical Sciences
Professor of Medicine
VICC Member
Researcher
Contact Information:
Vanderbilt University Medical Center
1161 21st Ave
Nashville, TN 37232-2650
615-343-0077
Research Specialty
Sepsis and Acute Respiratory Distress Syndrome
Publications
- Girard, TD, Ware, LB, Bernard, GR, Pandharipande, PP, Thompson, JL, Shintani, AK, Jackson, JC, Dittus, RS, Ely, EW Associations of markers of inflammation and coagulation with delirium during critical illness. Intensive Care Med, 38(12), 1965-73, 2012.
- Byrne, DW, Biaggioni, I, Bernard, GR, Helmer, TT, Boone, LR, Pulley, JM, Edwards, T, Dittus, RS Clinical and translational research studios: a multidisciplinary internal support program. Acad Med, 87(8), 1052-9, 2012.
- Rice, TW, Rubinson, L, Uyeki, TM, Vaughn, FL, John, BB, Miller, RR, Higgs, E, Randolph, AG, Smoot, BE, Thompson, BT, , Critical illness from 2009 pandemic influenza A virus and bacterial coinfection in the United States. Crit Care Med, 40(5), 1487-98, 2012.
- Pulley, JM, Denny, JC, Peterson, JF, Bernard, GR, Vnencak-Jones, CL, Ramirez, AH, Delaney, JT, Bowton, E, Brothers, K, Johnson, K, Crawford, DC, Schildcrout, J, Masys, DR, Dilks, HH, Wilke, RA, Clayton, EW, Shultz, E, Laposata, M, McPherson, J, Jirjis, JN, Roden, DM Operational implementation of prospective genotyping for personalized medicine: the design of the Vanderbilt PREDICT project. Clin Pharmacol Ther, 92(1), 87-95, 2012.
- Ware, LB, Koyama, T, Billheimer, D, Landeck, M, Johnson, E, Brady, S, Bernard, GR, Matthay, MA, , Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial. Ann Intensive Care, 1(1), 20, 2011.
- Rice, TW, Wheeler, AP, Thompson, BT, deBoisblanc, BP, Steingrub, J, Rock, P, , , , Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA, 306(14), 1574-81, 2011.
- Rice, TW, Mogan, S, Hays, MA, Bernard, GR, Jensen, GL, Wheeler, AP Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med, 39(5), 967-74, 2011.
- Harris, PA, Swafford, JA, Edwards, TL, Zhang, M, Nigavekar, SS, Yarbrough, TR, Lane, LD, Helmer, T, Lebo, LA, Mayo, G, Masys, DR, Bernard, GR, Pulley, JM StarBRITE: the Vanderbilt University Biomedical Research Integration, Translation and Education portal. J Biomed Inform, 44(4), 655-62, 2011.
- Rice, TW, Ware, LB, Haponik, EF, Chiles, C, Wheeler, AP, Bernard, GR, Steingrub, JS, Hite, RD, Matthay, MA, Wright, P, Ely, EW, , Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status. Crit Care, 15(2), R86, 2011.
- Rice, TW, Wheeler, AP, Bernard, GR, Vincent, JL, Angus, DC, Aikawa, N, Demeyer, I, Sainati, S, Amlot, N, Cao, C, Ii, M, Matsuda, H, Mouri, K, Cohen, J A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med, 38(8), 1685-94, 2010.
- Fremont, RD, Koyama, T, Calfee, CS, Wu, W, Dossett, LA, Bossert, FR, Mitchell, D, Wickersham, N, Bernard, GR, Matthay, MA, May, AK, Ware, LB Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma, 68(5), 1121-7, 2010.
- Pulley, JM, Harris, PA, Yarbrough, T, Swafford, J, Edwards, T, Bernard, GR An informatics-based tool to assist researchers in initiating research at an academic medical center: Vanderbilt Customized Action Plan. Acad Med, 85(1), 164-8, 2010.
- Girard, TD, Jackson, JC, Pandharipande, PP, Pun, BT, Thompson, JL, Shintani, AK, Gordon, SM, Canonico, AE, Dittus, RS, Bernard, GR, Ely, EW Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med, 38(7), 1513-20, 2010.
- Girard, TD, Pandharipande, PP, Carson, SS, Schmidt, GA, Wright, PE, Canonico, AE, Pun, BT, Thompson, JL, Shintani, AK, Meltzer, HY, Bernard, GR, Dittus, RS, Ely, EW, , Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med, 38(2), 428-37, 2010.
- Pulley, J, Hassan, NN, Bernard, GR, Jirjis, JN, Schildcrout, J, Robertson, D, Masys, DR, Harris, P Identifying unpredicted drug benefit through query of patient experiential knowledge: a proof of concept web-based system. Clin Transl Sci, 3(3), 98-103, 2010.
- Jackson, JC, Girard, TD, Gordon, SM, Thompson, JL, Shintani, AK, Thomason, JW, Pun, BT, Canonico, AE, Dunn, JG, Bernard, GR, Dittus, RS, Ely, EW Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial. Am J Respir Crit Care Med, 182(2), 183-91, 2010.
- Pulley, J, Clayton, E, Bernard, GR, Roden, DM, Masys, DR Principles of human subjects protections applied in an opt-out, de-identified biobank. Clin Transl Sci, 3(1), 42-8, 2010.
- Ware, LB, Koyama, T, Billheimer, DD, Wu, W, Bernard, GR, Thompson, BT, Brower, RG, Standiford, TJ, Martin, TR, Matthay, MA, , Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest, 137(2), 288-96, 2010.
- Bernard, GR Statins for acutely hospitalized patients: randomized controlled trials are long overdue. Crit Care, 14(2), 141, 2010.
- Pulley, JM, Bernard, GR Proven processes: The Vanderbilt Institute for clinical and translational research. Clin Transl Sci, 2(3), 180-2, 2009.
- Ely, E Wesley, Stephens, Rasheeda K, Jackson, James C, Thomason, Jason W W, Truman, Brenda, Gordon, Sharon, Dittus, Robert S, Bernard, Gordon R Current opinions regarding the importance, diagnosis, and management of delirium in the intensive care unit: a survey of 912 healthcare professionals. Crit Care Med, 32(1), 106-12, 2004.
- Jiang, Keyuan, Higgins, Stanley B, Swindell, Bridget B, Bernard, Gordon R CommLog: a communication log system for clinical trials. IEEE Trans Inf Technol Biomed, 7(4), 378-83, 2003.
- Bernard, Gordon R Drotrecogin alfa (activated) (recombinant human activated protein C) for the treatment of severe sepsis. Crit Care Med, 31(1 Suppl), S85-93, 2003.
- Ely, E Wesley, Laterre, Pierre-François, Angus, Derek C, Helterbrand, Jeffrey D, Levy, Howard, Dhainaut, Jean-François, Vincent, Jean-Louis, Macias, William L, Bernard, Gordon R, , Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med, 31(1), 12-9, 2003.
- Ely, E Wesley, Angus, Derek C, Williams, Mark D, Bates, Becky, Qualy, Rebecca, Bernard, Gordon R Drotrecogin alfa (activated) treatment of older patients with severe sepsis. Clin Infect Dis, 37(2), 187-95, 2003.
- Ely, E Wesley, Truman, Brenda, Shintani, Ayumi, Thomason, Jason W W, Wheeler, Arthur P, Gordon, Sharon, Francis, Joseph, Speroff, Theodore, Gautam, Shiva, Margolin, Richard, Sessler, Curtis N, Dittus, Robert S, Bernard, Gordon R Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA, 289(22), 2983-91, 2003.
- Bernard, Gordon R, Macias, William L, Joyce, David E, Williams, Mark D, Bailey, Joan, Vincent, Jean-Louis Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis. Crit Care, 7(2), 155-63, 2003.
- Ely, E Wesley, Wheeler, Arthur P, Thompson, B Taylor, Ancukiewicz, Marek, Steinberg, Kenneth P, Bernard, Gordon R Recovery rate and prognosis in older persons who develop acute lung injury and the acute respiratory distress syndrome. Ann Intern Med, 136(1), 25-36, 2002.
- Martin, G S, Bernard, G R, , Airway and lung in sepsis. Intensive Care Med, 27 Suppl 1S63-79, 2001.
- Ely, E W, Inouye, S K, Bernard, G R, Gordon, S, Francis, J, May, L, Truman, B, Speroff, T, Gautam, S, Margolin, R, Hart, R P, Dittus, R Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA, 286(21), 2703-10, 2001.
- Bernard, G R, Vincent, J L, Laterre, P F, LaRosa, S P, Dhainaut, J F, Lopez-Rodriguez, A, Steingrub, J S, Garber, G E, Helterbrand, J D, Ely, E W, Fisher, C J, , Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med, 344(10), 699-709, 2001.
- Ely, E W, Margolin, R, Francis, J, May, L, Truman, B, Dittus, R, Speroff, T, Gautam, S, Bernard, G R, Inouye , S K Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med, 29(7), 1370-9, 2001.
- Bernard, G R, Ely, E W, Wright, T J, Fraiz, J, Stasek, J E, Russell, J A, Mayers, I, Rosenfeld, B A, Morris, P E, Yan, S B, Helterbrand, J D Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis. Crit Care Med, 29(11), 2051-9, 2001.
- Conner, B D, Bernard, G R Acute respiratory distress syndrome. Potential pharmacologic interventions. Clin Chest Med, 21(3), 563-87, 2000.
- Mangialardi, R J, Martin, G S, Bernard, G R, Wheeler, A P, Christman, B W, Dupont, W D, Higgins, S B, Swindell, B B Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis. Ibuprofen in Sepsis Study Group. Crit Care Med, 28(9), 3137-45, 2000.
- Bernard, G R, Sopko, G, Cerra, F, Demling, R, Edmunds, H, Kaplan, S, Kessler, L, Masur, H, Parsons, P, Shure, D, Webb, C, Weidemann, H, Weinmann, G, Williams, D Pulmonary artery catheterization and clinical outcomes: National Heart, Lung, and Blood Institute and Food and Drug Administration Workshop Report. Consensus Statement. JAMA, 283(19), 2568-72, 2000.
- Arons, M M, Wheeler, A P, Bernard, G R, Christman, B W, Russell, J A, Schein, R, Summer, W R, Steinberg, K P, Fulkerson, W, Wright, P, Dupont, W D, Swindell, B B Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group. Crit Care Med, 27(4), 699-707, 1999.
- Bernard, G R Research in sepsis and acute respiratory distress syndrome: are we changing course. Crit Care Med, 27(2), 434-6, 1999.
- Wheeler, A P, Bernard, G R Treating patients with severe sepsis. N Engl J Med, 340(3), 207-14, 1999.
- Price, B J, Bernard, G R, Drew, K, Foss, J, Wheeler, A P Impact of a critical care pathway for unstable mechanically ventilated patients. Crit Care Nurs Clin North Am, 10(1), 75-85, 1998.
- Bernard, G R, Wheeler, A P, Arons, M M, Morris, P E, Paz, H L, Russell, J A, Wright, P E A trial of antioxidants N-acetylcysteine and procysteine in ARDS. The Antioxidant in ARDS Study Group. Chest, 112(1), 164-72, 1997.
- Bernard, G R, Wheeler, A P, Russell, J A, Schein, R, Summer, W R, Steinberg, K P, Fulkerson, W J, Wright, P E, Christman, B W, Dupont, W D, Higgins, S B, Swindell, B B The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. N Engl J Med, 336(13), 912-8, 1997.
- Wheeler, A P, Bernard, G R Applications of molecular biology and biotechnology: antibody therapy of sepsis. J Crit Care, 11(2), 77-94, 1996.
- Carmichael, L C, Dorinsky, P M, Higgins, S B, Bernard, G R, Dupont, W D, Swindell, B, Wheeler, A P Diagnosis and therapy of acute respiratory distress syndrome in adults: an international survey. J Crit Care, 11(1), 9-18, 1996.
- Weikert, L F, Bernard, G R Pharmacotherapy of sepsis. Clin Chest Med, 17(2), 289-305, 1996.
- Bernard, G R, Pou, N A, Coggeshall, J W, Carroll, F E, Snapper, J R Comparison of the pulmonary dysfunction caused by cardiogenic and noncardiogenic pulmonary edema. Chest, 108(3), 798-803, 1995.
- Higgins, S B, Jiang, K, Plummer, W D, Edens, T R, Stroud, M J, Swindell, B B, Wheeler, A P, Bernard, G R Pivot/Remote: a distributed database for remote data entry in multi-center clinical trials. Medinfo, 8 Pt 21097, 1995.
- Bernard, G R Sepsis trials. Intersection of investigation, regulation, funding, and practice. Am J Respir Crit Care Med, 152(1), 4-10, 1995.
- Wright, P E, Carmichael, L C, Bernard, G R Effect of bronchodilators on lung mechanics in the acute respiratory distress syndrome (ARDS). Chest, 106(5), 1517-23, 1994.
- Bernard, G R, Artigas, A, Brigham, K L, Carlet, J, Falke, K, Hudson, L, Lamy, M, LeGall, J R, Morris, A, Spragg, R Report of the American-European consensus conference on ARDS: definitions, mechanisms, relevant outcomes and clinical trial coordination. The Consensus Committee. Intensive Care Med, 20(3), 225-32, 1994.
- Morris, P E, Bernard, G R Significance of glutathione in lung disease and implications for therapy. Am J Med Sci, 307(2), 119-27, 1994.
- Bernard, G R, Artigas, A, Brigham, K L, Carlet, J, Falke, K, Hudson, L, Lamy, M, Legall, J R, Morris, A, Spragg, R The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med, 149(3 Pt 1), 818-24, 1994.
- Christman, B W, Bernard, G R Antilipid mediator and antioxidant therapy in adult respiratory distress syndrome. New Horiz, 1(4), 623-30, 1993.
- Wheeler, A P, Carroll, F E, Bernard, G R Radiographic issues in adult respiratory distress syndrome. New Horiz, 1(4), 471-7, 1993.
- Christman, B W, McPherson, C D, Newman, J H, King, G A, Bernard, G R, Groves, B M, Loyd, J E An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med, 327(2), 70-5, 1992.
- Schriver, E E, Davidson, J M, Sutcliffe, M C, Swindell, B B, Bernard, G R Comparison of elastin peptide concentrations in body fluids from healthy volunteers, smokers, and patients with chronic obstructive pulmonary disease. Am Rev Respir Dis, 145(4 Pt 1), 762-6, 1992.
- Hardie, W D, Wheeler, A P, Wright, P W, Swindell, B B, Bernard, G R Effect of cyclooxygenase inhibition on amphotericin B-induced lung injury in awake sheep. J Infect Dis, 166(1), 134-8, 1992.
- Wheeler, A P, Hardie, W D, Bernard, G R The role of cyclooxygenase products in lung injury induced by tumor necrosis factor in sheep. Am Rev Respir Dis, 145(3), 632-9, 1992.
- Higgins, S B, Jiang, K, Swindell, B B, Bernard, G R A graphical ICU workstation. Proc Annu Symp Comput Appl Med Care, 783-7, 1991.
- Morris, P, Bernard, G R Adult respiratory distress syndrome. Strategies to provide support and enhance oxygen delivery. Postgrad Med, 90(8), 163-6, 169-70, 172, 1991.
- Onrot, J, Bernard, G R, Biaggioni, I, Hollister, A S, Robertson, D Direct vasodilator effect of hyperventilation-induced hypocarbia in autonomic failure patients. Am J Med Sci, 301(5), 305-9, 1991.
- Hardie, W D, Wright, P E, Bernard, G R Effects of intravenous amphotericin B infusion on hemodynamics and airway mechanics in awake sheep. Chest, 99(2), 457-62, 1991.
- Watts, F L, Bernard, G R Effects of ritodrine infusion on hemodynamics and lung lymph in awake sheep. Pulm Pharmacol, 4(1), 32-6, 1991.
- Bernard, G R N-acetylcysteine in experimental and clinical acute lung injury. Am J Med, 91(3C), 54S-59S, 1991.
- Bernard, G R, Korley, V, Chee, P, Swindell, B, Ford-Hutchinson, A W, Tagari, P Persistent generation of peptido leukotrienes in patients with the adult respiratory distress syndrome. Am Rev Respir Dis, 144(2), 263-7, 1991.
- Bernard, G R, Reines, H D, Halushka, P V, Higgins, S B, Metz, C A, Swindell, B B, Wright, P E, Watts, F L, Vrbanac, J J Prostacyclin and thromboxane A2 formation is increased in human sepsis syndrome. Effects of cyclooxygenase inhibition. Am Rev Respir Dis, 144(5), 1095-101, 1991.
- Harris, T R, Bernard, G R, Brigham, K L, Higgins, S B, Rinaldo, J E, Borovetz, H S, Sibbald, W J, Kariman, K, Sprung, C L Lung microvascular transport properties measured by multiple indicator dilution methods in patients with adult respiratory distress syndrome. A comparison between patients reversing respiratory failure and those failing to reverse. Am Rev Respir Dis, 141(2), 272-80, 1990.
- Wheeler, A P, Bernard, G R Minimal positive end expiratory pressure (PEEP): a safe, effective, defensible practice. Clin Intensive Care, 1(4), 175-9, 1990.
- Bernard, G R Potential of N-acetylcysteine as treatment for the adult respiratory distress syndrome. Eur Respir J Suppl, 11496s-498s, 1990.
- Cowan, H B, Bernard, G R The adult respiratory distress syndrome. Compr Ther, 16(10), 66-71, 1990.
- Taylor, R F, Bernard, G R Airway complications from free-basing cocaine. Chest, 95(2), 476-7, 1989.
- Wright, P E, Marini, J J, Bernard, G R In vitro versus in vivo comparison of endotracheal tube airflow resistance. Am Rev Respir Dis, 140(1), 10-6, 1989.
- Wright, P E, Bernard, G R Mechanisms of late hemodynamic and airway dynamic responses to endotoxin in awake sheep. Am Rev Respir Dis, 140(3), 672-8, 1989.
- Wright, P E, Bernard, G R The role of airflow resistance in patients with the adult respiratory distress syndrome. Am Rev Respir Dis, 139(5), 1169-74, 1989.
- Lucht, W D, Bernard, G R, Butka, B, Brigham, K L Corticosteroids inhibit endotoxin-induced lung lymph neutrophil stimulating activity in sheep. Am J Med Sci, 296(2), 98-102, 1988.
- Wright, P, Ishihara, Y, Bernard, G R Effects of nitroprusside on lung mechanics and hemodynamics after endotoxemia in awake sheep. J Appl Physiol, 64(5), 2026-32, 1988.
- Bernard, G R, Luce, J M, Sprung, C L, Rinaldo, J E, Tate, R M, Sibbald, W J, Kariman, K, Higgins, S, Bradley, R, Metz, C A High-dose corticosteroids in patients with the adult respiratory distress syndrome. N Engl J Med, 317(25), 1565-70, 1987.
- Coggeshall, J W, Lefferts, P L, Butterfield, M J, Bernard, G R, Carroll, F E, Pou, N A, Snapper, J R Perilla ketone: a model of increased pulmonary microvascular permeability pulmonary edema in sheep. Am Rev Respir Dis, 136(6), 1453-8, 1987.
- Lucht, W D, English, D K, Bernard, G R, Serafin, W E, Brigham, K L Prevention of release of granulocyte aggregants into sheep lung lymph following endotoxemia by N-acetylcysteine. Am J Med Sci, 294(3), 161-7, 1987.
- May, D G, Stratton, C W, Denney, W D, Watts, F L, Bernard, G R, Branch, R A Vancomycin entry into lung lymph in sheep. Antimicrob Agents Chemother, 31(11), 1689-91, 1987.
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