The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers
Graham F. Carpenter, Ph.D.
See also:
Ingram Professor of Cancer Research
Professor of Biochemistry
Professor of Medicine
VICC Member
Researcher
Contact Information:
Vanderbilt University Medical Center
647 Light Hall
Nashville, TN 37232-0146
615-322-6678
Research Specialty
Growth Factor Signal Transduction/Trafficking of Growth Factor Receptors
Research Description
The focus of research in this laboratory is understanding the mechanisms by which growth factors regulate the proliferation of mammalian cells. In particular, we utilize the polypeptide mitogen epidermal growth factor (EGF) and cultures of mammalian cells as a model system. Specific research interests at the present time involve two interrelated aspects of the mechanism of action of EGF. The first area centers on the generation of second messenger molecules or intracellular signals in response to the binding of EGF to its receptor on the surface of target cells. The receptor, a transmembrane protein, contains an intrinsic tyrosine kinase activity in the cytoplasmic domain. Recently, this laboratory identified a particular phospholipase C isozyme (PLC-gamma 1) as an important phosphorylation substrate of the EGF receptor. Also, we have shown that tyrosine phosphorylation of PLC-gamma 1 increases its catalytic activity to generate the second messenger molecules IP3 and diacylglycerol. Various approaches are now being used to understand the biology and biochemistry of this protein. This includes targeted disruption of the PLC-gamma 1 gene in mice, analysis of the biological properties of PLC-gamma 1 null cells derived from such mice, and mutagenesis of the PLC-gamma 1 molecule.
The second focus of research involves receptor tyrosine kinases, known as ErbB receptors, that bind the EGF/heregulin growth factors and mediate cell proliferation/differentiation. In particular, the laboratory is focused on the proteolytic processing as a mechanism for nuclear translocation and signal transduction for the ErbB-4 receptor. Also, a project focused on the trafficking of ErbB-1 to the nucleus without proteolytic processing is underway.
Publications
- Liao, HJ, Carpenter, G Role of the sec61 translocon in EGF receptor trafficking to the nucleus and gene expression. Mol Biol Cell, 18(3), 1064-72, 2007.
- Liao, HJ, de Los Santos, J, Carpenter, G Contrasting role of phospholipase C-gamma1 in the expression of immediate early genes induced by epidermal or platelet-derived growth factors. Exp Cell Res, 312(6), 807-16, 2006.
- Linggi, B, Carpenter, G ErbB receptors: new insights on mechanisms and biology. Trends Cell Biol, 16(12), 649-56, 2006.
- Thiel, KW, Carpenter, G ErbB-4 and TNF-alpha converting enzyme localization to membrane microdomains. Biochem Biophys Res Commun, 350(3), 629-33, 2006.
- Linggi, B, Carpenter, G ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression. J Biol Chem, 281(35), 25373-80, 2006.
- Wang, SE, Narasanna, A, Perez-Torres, M, Xiang, B, Wu, FY, Yang, S, Carpenter, G, Gazdar, AF, Muthuswamy, SK, Arteaga, CL HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell, 10(1), 25-38, 2006.
- Linggi, B, Cheng, QC, Rao, AR, Carpenter, G The ErbB-4 s80 intracellular domain is a constitutively active tyrosine kinase. Oncogene, 25(1), 160-3, 2006.
- Tikhomirov, O, Carpenter, G Bax activation and translocation to mitochondria mediate EGF-induced programmed cell death. J Cell Sci, 118(Pt 24), 5681-90, 2005.
- Tikhomirov, O, Dikov, M, Carpenter, G Identification of proteolytic fragments from ErbB-2 that induce apoptosis. Oncogene, 24(24), 3906-13, 2005.
- Tvorogov, D, Wang, XJ, Zent, R, Carpenter, G Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion. J Cell Sci, 118(Pt 3), 601-10, 2005.
- Arasada, RR, Carpenter, G Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular domain fragment. J Biol Chem, 280(35), 30783-7, 2005.
- Tikhomirov, O, Carpenter, G Ligand-induced, p38-dependent apoptosis in cells expressing high levels of epidermal growth factor receptor and ErbB-2. J Biol Chem, 279(13), 12988-96, 2004.
- Cheng, QC, Tikhomirov, O, Zhou, W, Carpenter, G Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment. J Biol Chem, 278(40), 38421-7, 2003.
- Carpenter, G ErbB-4: mechanism of action and biology. Exp Cell Res, 284(1), 66-77, 2003.
- Tikhomirov, O, Carpenter, G Identification of ErbB-2 kinase domain motifs required for geldanamycin-induced degradation. Cancer Res, 63(1), 39-43, 2003.
- Carpenter, G Nuclear localization and possible functions of receptor tyrosine kinases. Curr Opin Cell Biol, 15(2), 143-8, 2003.
- Ni, CY, Yuan, H, Carpenter, G Role of the ErbB-4 carboxyl terminus in gamma-secretase cleavage. J Biol Chem, 278(7), 4561-5, 2003.
- Liao, HJ, Kume, T, McKay, C, Xu, MJ, Ihle, JN, Carpenter, G Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice. J Biol Chem, 277(11), 9335-41, 2002.
- Tvorogov, D, Carpenter, G EGF-dependent association of phospholipase C-gamma1 with c-Cbl. Exp Cell Res, 277(1), 86-94, 2002.
- Zhou, W, Carpenter, G ErbB-4: a receptor tyrosine kinase. Inflamm Res, 51(2), 91-101, 2002.
- Chattopadhyay, A, Carpenter, G PLC-gamma1 is required for IGF-I protection from cell death induced by loss of extracellular matrix adhesion. J Cell Sci, 115(Pt 10), 2233-9, 2002.
- Tikhomirov, O, Carpenter, G Caspase-dependent cleavage of ErbB-2 by geldanamycin and staurosporin. J Biol Chem, 276(36), 33675-80, 2001.
- Wang, XJ, Liao, HJ, Chattopadhyay, A, Carpenter, G EGF-dependent translocation of green fluorescent protein-tagged PLC-gamma1 to the plasma membrane and endosomes. Exp Cell Res, 267(1), 28-36, 2001.
- Zhou, W, Carpenter, G Heregulin-dependent translocation and hyperphosphorylation of ErbB-2. Oncogene, 20(29), 3918-20, 2001.
- Liao, HJ, Ji, QS, Carpenter, G Phospholipase C-gamma1 is required for the induction of immediate early genes by platelet-derived growth factor. J Biol Chem, 276(12), 8627-30, 2001.
- Ni, CY, Murphy, MP, Golde, TE, Carpenter, G gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science, 294(5549), 2179-81, 2001.
- Carpenter, G EGF receptor transactivation mediated by the proteolytic production of EGF-like agonists. Sci STKE, 2000(15), PE1, 2000.
- Tikhomirov, O, Carpenter, G Geldanamycin induces ErbB-2 degradation by proteolytic fragmentation. J Biol Chem, 275(34), 26625-31, 2000.
- Zhou, W, Carpenter, G Heregulin-dependent trafficking and cleavage of ErbB-4. J Biol Chem, 275(44), 34737-43, 2000.
- Ji, QS, Carpenter, G Role of basal calcium in the EGF activation of MAP kinases. Oncogene, 19(14), 1853-6, 2000.
- Carpenter, G The EGF receptor: a nexus for trafficking and signaling. Bioessays, 22(8), 697-707, 2000.
- Carpenter, G Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways. J Cell Biol, 146(4), 697-702, 1999.
- Zhang, X, Chattopadhyay, A, Ji, QS, Owen, JD, Ruest, PJ, Carpenter, G, Hanks, SK Focal adhesion kinase promotes phospholipase C-gamma1 activity. Proc Natl Acad Sci U S A, 96(16), 9021-6, 1999.
- Xu, Y, Carpenter, G Identification of cadherin tyrosine residues that are phosphorylated and mediate Shc association. J Cell Biochem, 75(2), 264-71, 1999.
- Carpenter, G, Ji, Q Phospholipase C-gamma as a signal-transducing element. Exp Cell Res, 253(1), 15-24, 1999.
- Ji, QS, Chattopadhyay, A, Vecchi, M, Carpenter, G Physiological requirement for both SH2 domains for phospholipase C-gamma1 function and interaction with platelet-derived growth factor receptors. Mol Cell Biol, 19(7), 4961-70, 1999.
- Horstman, DA, Chattopadhyay, A, Carpenter, G The influence of deletion mutations on phospholipase C-gamma 1 activity. Arch Biochem Biophys, 361(1), 149-55, 1999.
- Chattopadhyay, A, Vecchi, M, Ji, Q, Mernaugh, R, Carpenter, G The role of individual SH2 domains in mediating association of phospholipase C-gamma1 with the activated EGF receptor. J Biol Chem, 274(37), 26091-7, 1999.
- Hess, JA, Ji, QS, Carpenter, G, Exton, JH Analysis of platelet-derived growth factor-induced phospholipase D activation in mouse embryo fibroblasts lacking phospholipase C-gamma1. J Biol Chem, 273(32), 20517-24, 1998.
- Sun, L, Carpenter, G Epidermal growth factor activation of NF-kappaB is mediated through IkappaBalpha degradation and intracellular free calcium. Oncogene, 16(16), 2095-102, 1998.
- Ji, QS, Ermini, S, Baulida, J, Sun, FL, Carpenter, G Epidermal growth factor signaling and mitogenesis in Plcg1 null mouse embryonic fibroblasts. Mol Biol Cell, 9(4), 749-57, 1998.
- Vecchi, M, Rudolph-Owen, LA, Brown, CL, Dempsey, PJ, Carpenter, G Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin. J Biol Chem, 273(32), 20589-95, 1998.
- Vecchi, M, Carpenter, G Constitutive proteolysis of the ErbB-4 receptor tyrosine kinase by a unique, sequential mechanism. J Cell Biol, 139(4), 995-1003, 1997.
- Ji, QS, Winnier, GE, Niswender, KD, Horstman, D, Wisdom, R, Magnuson, MA, Carpenter, G Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Proc Natl Acad Sci U S A, 94(7), 2999-3003, 1997.
- Baulida, J, Carpenter, G Heregulin degradation in the absence of rapid receptor-mediated internalization. Exp Cell Res, 232(1), 167-72, 1997.
- Penta, K, Carpenter, G Interaction of phospholipase C-gamma with activated growth factor receptor tyrosine kinases. Adv Exp Med Biol, 400B971-81, 1997.
- Xu, Y, Guo, DF, Davidson, M, Inagami, T, Carpenter, G Interaction of the adaptor protein Shc and the adhesion molecule cadherin. J Biol Chem, 272(21), 13463-6, 1997.
- Kamat, A, Carpenter, G Phospholipase C-gamma1: regulation of enzyme function and role in growth factor-dependent signal transduction. Cytokine Growth Factor Rev, 8(2), 109-17, 1997.
- Baulida, J, Kraus, MH, Alimandi, M, Di Fiore, PP, Carpenter, G All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J Biol Chem, 271(9), 5251-7, 1996.
- Horstman, DA, DeStefano, K, Carpenter, G Enhanced phospholipase C-gamma1 activity produced by association of independently expressed X and Y domain polypeptides. Proc Natl Acad Sci U S A, 93(15), 7518-21, 1996.
- Vecchi, M, Baulida, J, Carpenter, G Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activation. J Biol Chem, 271(31), 18989-95, 1996.
- Horstman, DA, Ball, R, Carpenter, G Baculovirus expression and purification of the second messenger enzyme phospholipase C-gamma 1, a tyrosine kinase substrate. Protein Expr Purif, 6(3), 278-83, 1995.
- Polk, DB, McCollum, GW, Carpenter, G Cell density-dependent regulation of PLC gamma 1 tyrosine phosphorylation and catalytic activity in an intestinal cell line (IEC-6). J Cell Physiol, 162(3), 427-33, 1995.
- Carpenter, G, Soler, C, Baulida, J, Beguinot, L, Sorkin, A Interaction of signaling and trafficking proteins with the carboxyterminus of the epidermal growth factor receptor. Ann N Y Acad Sci, 76644-51, 1995.
- Sorkin, A, McKinsey, T, Shih, W, Kirchhausen, T, Carpenter, G Stoichiometric interaction of the epidermal growth factor receptor with the clathrin-associated protein complex AP-2. J Biol Chem, 270(2), 619-25, 1995.
- Soler, C, Felipe, A, Carpenter, G Epidermal growth factor increases protein and messenger RNA expression levels of Ras GTPase activating protein. Cell Growth Differ, 5(5), 519-26, 1994.
- Soler, C, Beguinot, L, Carpenter, G Individual epidermal growth factor receptor autophosphorylation sites do not stringently define association motifs for several SH2-containing proteins. J Biol Chem, 269(16), 12320-4, 1994.
- Fernald, AW, Jones, GA, Carpenter, G Limited proteolysis of phospholipase C-gamma 1 indicates stable association of X and Y domains with enhanced catalytic activity. Biochem J, 302 ( Pt 2)503-9, 1994.
- Soler, C, Alvarez, CV, Beguinot, L, Carpenter, G Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites. Oncogene, 9(8), 2207-15, 1994.
- Liu, SM, Carpenter, G Differential heat stress stability of epidermal growth factor receptor and erbB-2 receptor tyrosine kinase activities. J Cell Physiol, 157(2), 237-42, 1993.
- Carpenter, G EGF: new tricks for an old growth factor. Curr Opin Cell Biol, 5(2), 261-4, 1993.
- Hernández-Sotomayor, SM, Arteaga, CL, Soler, C, Carpenter, G Epidermal growth factor stimulates substrate-selective protein-tyrosine-phosphatase activity. Proc Natl Acad Sci U S A, 90(16), 7691-5, 1993.
- Sorkin, A, Carpenter, G Interaction of activated EGF receptors with coated pit adaptins. Science, 261(5121), 612-5, 1993.
- Hernández-Sotomayor, SM, Carpenter, G Non-catalytic activation of phospholipase C-gamma 1 in vitro by epidermal growth factor receptor. Biochem J, 293 ( Pt 2)507-11, 1993.
- Sorkin, A, Di Fiore, PP, Carpenter, G The carboxyl terminus of epidermal growth factor receptor/erbB-2 chimerae is internalization impaired. Oncogene, 8(11), 3021-8, 1993.
- Jones, GA, Carpenter, G The regulation of phospholipase C-gamma 1 by phosphatidic acid. Assessment of kinetic parameters. J Biol Chem, 268(28), 20845-50, 1993.
- Carpenter, G, Hernández-Sotomayor, T, Jones, G Tyrosine phosphorylation of phospholipase C-gamma 1. Adv Second Messenger Phosphoprotein Res, 28179-85, 1993.
- Soler, C, Beguinot, L, Sorkin, A, Carpenter, G Tyrosine phosphorylation of ras GTPase-activating protein does not require association with the epidermal growth factor receptor. J Biol Chem, 268(29), 22010-9, 1993.
- Liu, SM, Carpenter, G Activity of the epidermal-growth-factor receptor and phospholipase C-gamma 1 in heat-stressed fibroblasts and A-431 cells. Biochem J, 286 ( Pt 2)541-7, 1992.
- Nanney, LB, Gates, RE, Todderud, G, King, LE, Carpenter, G Altered distribution of phospholipase C-gamma 1 in benign hyperproliferative epidermal diseases. Cell Growth Differ, 3(4), 233-9, 1992.
- Waters, CM, Overholser, KA, Sorkin, A, Carpenter, G Analysis of the influences of the E5 transforming protein on kinetic parameters of epidermal growth factor binding and metabolism. J Cell Physiol, 152(2), 253-63, 1992.
- Soderquist, AM, Todderud, G, Carpenter, G Elevated membrane association of phospholipase C-gamma 1 in MDA-468 mammary tumor cells. Cancer Res, 52(16), 4526-9, 1992.
- Hernández-Sotomayor, SM, Carpenter, G Epidermal growth factor receptor: elements of intracellular communication. J Membr Biol, 128(2), 81-9, 1992.
- Carpenter, G, Hernández-Sotomayor, SM, Nishibe, S, Todderud, G, Mumby, M, Wahl, M Growth factor phosphorylation of PLC-gamma 1. Ciba Found Symp, 164223-33; discussion 233-9, 1992.
- Wahl, MI, Jones, GA, Nishibe, S, Rhee, SG, Carpenter, G Growth factor stimulation of phospholipase C-gamma 1 activity. Comparative properties of control and activated enzymes. J Biol Chem, 267(15), 10447-56, 1992.
- Sorkin, A, Helin, K, Waters, CM, Carpenter, G, Beguinot, L Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors. J Biol Chem, 267(12), 8672-8, 1992.
- Carpenter, G Receptor tyrosine kinase substrates: src homology domains and signal transduction. FASEB J, 6(14), 3283-9, 1992.
- Jones, G, Carpenter, G Regulation of phospholipase C isozymes. Prog Growth Factor Res, 4(2), 97-106, 1992.
- Brown, AB, Carpenter, G Acute regulation of the epidermal growth factor receptor in response to nerve growth factor. J Neurochem, 57(5), 1740-9, 1991.
- Oberg, KC, Carpenter, G Dexamethasone and retinoic acid regulate the expression of epidermal growth factor receptor mRNA by distinct mechanisms. J Cell Physiol, 149(2), 244-51, 1991.
- Sorkin, A, Carpenter, G Dimerization of internalized epidermal growth factor receptors. J Biol Chem, 266(34), 23453-60, 1991.
- Arteaga, CL, Johnson, MD, Todderud, G, Coffey, RJ, Carpenter, G, Page, DL Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas. Proc Natl Acad Sci U S A, 88(23), 10435-9, 1991.
- Sorkin, A, Waters, C, Overholser, KA, Carpenter, G Multiple autophosphorylation site mutations of the epidermal growth factor receptor. Analysis of kinase activity and endocytosis. J Biol Chem, 266(13), 8355-62, 1991.
- Hernández-Sotomayor, SM, Mumby, M, Carpenter, G Okadaic acid-induced hyperphosphorylation of the epidermal growth factor receptor. Comparison with receptor phosphorylation and functions affected by another tumor promoter, 12-O-tetradecanoylphorbol-13-acetate. J Biol Chem, 266(31), 21281-6, 1991.
- Wahl, M, Carpenter, G Selective phospholipase C activation. Bioessays, 13(3), 107-13, 1991.
- Carpenter, G, Cohen, S Epidermal growth factor. J Biol Chem, 265(14), 7709-12, 1990.
- Ball, RL, Tanner, KD, Carpenter, G Epidermal growth factor potentiates cyclic AMP accumulation in A-431 cells. J Biol Chem, 265(22), 12836-45, 1990.
- Wahl, MI, Nishibe, S, Kim, JW, Kim, H, Rhee, SG, Carpenter, G Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells. J Biol Chem, 265(7), 3944-8, 1990.
- Nishibe, S, Wahl, MI, Hernández-Sotomayor, SM, Tonks, NK, Rhee, SG, Carpenter, G Increase of the catalytic activity of phospholipase C-gamma 1 by tyrosine phosphorylation. Science, 250(4985), 1253-6, 1990.
- Johnson, MD, Gray, ME, Carpenter, G, Pepinsky, RB, Stahlman, MT Ontogeny of epidermal growth factor receptor and lipocortin-1 in fetal and neonatal human lungs. Hum Pathol, 21(2), 182-91, 1990.
- Carpenter, G PLC and PKC: a tale of two messengers. Receptor-mediated stimulation of phosphoinositide metabolism and protein kinase C, Sixth International Symposium on Cellular Endocrinology sponsored by the W. Alton Jones Cell Science Center, Lake Placid, NY, USA, August 12-15, 1990. New Biol, 2(11), 965-9, 1990.
- Waters, CM, Oberg, KC, Carpenter, G, Overholser, KA Rate constants for binding, dissociation, and internalization of EGF: effect of receptor occupancy and ligand concentration. Biochemistry, 29(14), 3563-9, 1990.
- Carpenter, G Rocky Mountain kinase fever. Receptor-Mediated Second Messenger Pathways: A UCLA symposium sponsored by ICI Pharmaceuticals and Smith Kline and French, Keystone, CO, USA, January 27-February 3, 1990. New Biol, 2(5), 421-5, 1990.
- Nishibe, S, Wahl, MI, Wedegaertner, PB, Kim, JW, Rhee, SG, Carpenter, G, Kim, JJ Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains. Proc Natl Acad Sci U S A, 87(1), 424-8, 1990.
- Todderud, G, Wahl, MI, Rhee, SG, Carpenter, G Stimulation of phospholipase C-gamma 1 membrane association by epidermal growth factor. Science, 249(4966), 296-8, 1990.
- Nishibe, S, Carpenter, G Tyrosine phosphorylation and the regulation of cell growth: growth factor-stimulated tyrosine phosphorylation of phospholipase C. Semin Cancer Biol, 1(4), 285-92, 1990.
- Oberg, KC, Carpenter, G Dexamethasone acts as a negative regulator of epidermal growth factor receptor synthesis in fetal rat lung cells. Mol Endocrinol, 3(6), 915-22, 1989.
- Oberg, KC, Carpenter, G EGF-induced PGE2 release is synergistically enhanced in retinoic acid treated fetal rat lung cells. Biochem Biophys Res Commun, 162(3), 1515-21, 1989.
- Wahl, MI, Nishibe, S, Suh, PG, Rhee, SG, Carpenter, G Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium. Proc Natl Acad Sci U S A, 86(5), 1568-72, 1989.
- Todderud, G, Carpenter, G Epidermal growth factor: the receptor and its function. Biofactors, 2(1), 11-5, 1989.
- Wahl, MI, Nishibe, S, Carpenter, G Growth factor signaling pathways: phosphoinositide metabolism and phosphorylation of phospholipase C. Cancer Cells, 1(4), 101-7, 1989.
- Seiler, JG, Milek, MA, Carpenter, GK, Swiontkowski, MF Intraoperative assessment of median nerve blood flow during carpal tunnel release with laser Doppler flowmetry. J Hand Surg [Am], 14(6), 986-91, 1989.
- Nötzli, HP, Swiontkowski, MF, Thaxter, ST, Carpenter, GK, Wyatt, R Laser Doppler flowmetry for bone blood flow measurements: helium-neon laser light attenuation and depth of perfusion assessment. J Orthop Res, 7(3), 413-24, 1989.
- Johnson, MD, Gray, ME, Carpenter, G, Pepinsky, RB, Sundell, H, Stahlman, MT Ontogeny of epidermal growth factor receptor/kinase and of lipocortin-1 in the ovine lung. Pediatr Res, 25(5), 535-41, 1989.
- Wahl, MI, Olashaw, NE, Nishibe, S, Rhee, SG, Pledger, WJ, Carpenter, G Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells. Mol Cell Biol, 9(7), 2934-43, 1989.
- Nishibe, S, Wahl, MI, Rhee, SG, Carpenter, G Tyrosine phosphorylation of phospholipase C-II in vitro by the epidermal growth factor receptor. J Biol Chem, 264(18), 10335-8, 1989.
- Oberg, KC, Soderquist, AM, Carpenter, G Accumulation of epidermal growth factor receptors in retinoic acid-treated fetal rat lung cells is due to enhanced receptor synthesis. Mol Endocrinol, 2(10), 959-65, 1988.
- Wahl, MI, Daniel, TO, Carpenter, G Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells. Science, 241(4868), 968-70, 1988.
- Mroczkowski, B, Carpenter, G Epidermal growth factor. Prog Clin Biol Res, 262207-16, 1988.
- Zendegui, JG, Inman, WH, Carpenter, G Modulation of the mitogenic response of an epidermal growth factor-dependent keratinocyte cell line by dexamethasone, insulin, and transforming growth factor-beta. J Cell Physiol, 136(2), 257-65, 1988.
- Todderud, G, Carpenter, G Presence of mannose phosphate on the epidermal growth factor receptor in A-431 cells. J Biol Chem, 263(34), 17893-6, 1988.
- Miller-Davis, S, McKeehan, W, Carpenter, G Prostatropin and acidic FGF also support proliferation of an EGF-dependent keratinocyte cell line. Exp Cell Res, 179(2), 595-9, 1988.
- Wahl, M, Carpenter, G Regulation of epidermal growth factor-stimulated formation of inositol phosphates in A-431 cells by calcium and protein kinase C. J Biol Chem, 263(16), 7581-90, 1988.
- Soderquist, AM, Stoscheck, C, Carpenter, G Similarities in glycosylation and transport between the secreted and plasma membrane forms of the epidermal growth factor receptor in A-431 cells. J Cell Physiol, 136(3), 447-54, 1988.
- Soderquist, AM, Todderud, G, Carpenter, G The role of carbohydrate as a post-translational modification of the receptor for epidermal growth factor. Adv Exp Med Biol, 231569-82, 1988.
- Wahl, M, Carpenter, G Characterization and control of EGF-stimulated formation of inositol phosphates in A-431 cells. Prog Clin Biol Res, 24987-98, 1987.
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