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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

H. Charles  Manning

H. Charles Manning, Ph.D.

Associate Professor of Radiology and Radiological Sciences
Associate Professor of Biomedical Engineering
Associate Professor of Neurological Surgery
Director of Molecular Imaging Research; Center for Molecular Probes

Contact Information:

Vanderbilt University Institute of Imaging Science
1161 21st. Avenue South
Nashville, TN 37232-2310
Fax: 615-322-0734

Research Specialty

Molecular imaging, chemistry, small-molecule discovery, therapeutic efficacy screening, clinical trial modeling, imaging probe development, imaging validation

Research Description

Our multi-disciplinary research program involves the development, validation, and translation of non-invasive molecular imaging metrics to assess disease progression and response to therapy. Projects within our program emphasize molecular imaging of cancer, and notably imaging-based assessment of response to anti-cancer pharmaceuticals in colorectal and breast cancer. We are actively engaged in advancing novel methods to image molecular events in both humans and animal models that include receptor expression, proliferation, angiogenesis, and apoptosis. Among these methods include validation of imaging probes for novel applications, as well as high-throughput small-molecule discovery to develop novel imaging compounds.