Vanderbilt-Ingram Cancer Center

See also:

• The Vanderbilt Sarcoma Center
• Orthopedics and Rehabilitation
• BRET: Biomedical Research Education & Training Faculty Listing
• PubMed Listing of Dr. Schwartz's Publications

Learn More About Herbert S. Schwartz's Specialties:

• Carcinoma of Unknown Primary
• Ewing Sarcoma
• Ewing Sarcoma (Childhood)
• Kaposi Sarcoma
• Malignant Fibrous Histiocytoma of Bone
• Non-Hodgkin Lymphoma
• Non-Hodgkin Lymphoma (Childhood)
• Osteosarcoma
• Osteosarcoma (Childhood)
• Rhabdomyosarcoma
• Skin Cancer (Non-Melanoma)
• Soft Tissue Sarcoma
• Soft Tissue Sarcoma (Childhood)

Dr. Schwartz has been at Vanderbilt since 1987 and is currently the most senior and experienced full-time academic orthopaedic oncologist in the mid-southern United States. There are only approximately 50 such specialists in the country. Referrals from all over the United States and foreign countries are commonly seen in oncology clinic.   Dr.
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Publications

• Alamanda VK, Crosby SN, Archer KR, Song Y, Schwartz HS, Holt GE "Amputation for extremity soft tissue sarcoma does not increase overall survival: a retrospective cohort study." Eur J Surg Oncol, 38(12), 1178-83, 2012.
• Alamanda VK, Crosby SN, Archer KR, Song Y, Schwartz HS, Holt GE "Primary Excision Compared with Re-Excision of Extremity Soft Tissue Sarcomas¿¿¿ Is Anything New?." J Surg Oncol, 105(7), 662-7, 2012.
• Jiro Ichikawa MD, PhD, Heather A Cole BS, Robert A Magnussen MD, Nicholas A Mignemi BS, Matthew Butler MD, Ginger E Holt MD, Hirotaka Haro MD, PhD, Doha Ihati MD, Justin MM Cates MD, PhD, Heidi E Hamm PhD, Herbert S Schwartz MD, Jonathan G Schoenecker MD, PhD. "The ProCoagulant Nature of Osteosarcoma." CANCER, 118(9), 2494-2506, 2012.
• Jiro Ichikawa MD, PhD, Heather A Cole BS, Robert A Magnussen MD, Nicholas A Mignemi BS, Matthew Butler MD, Ginger E Holt MD, Hirotaka Haro MD, PhD, Doha Ihati MD, Justin MM Cates MD, PhD, Heidi E Hamm PhD, Herbert S Schwartz MD, Jonathan G Schoenecker MD, PhD "Thrombin Induces Osteosarcoma Growth, a Function Inhibited by Low Molecular Weight Heparin In Vitro and In Vivo. ProCoagulant Nature of Osteosarcoma." CANCER, 1182494-2506, 2012.
• Brandon A. Ramo, Anthony M. Griffin, Corey S. Gill, Douglas J. McDonald, Jay S. Wunder, Peter Ferguson, Robert S. Bell, Sharon E. Phillips, Herbert S. Schwartz, Ginger E. Holt. "Incidence of Symptomatic Venous Thromboembolism in Lower Extremity Oncologic Endoprostheses.." JBJS , 93A(9), 847-854, 2011.
• Crosby, SN, Polkowski, GG, Schwartz, HS, Shinar, AA, Holt, GE Metal-Backed Versus All-Polyethylene Tibias in Megaprostheses of the Distal Femur. J Arthroplasty, 2010.
• Sommer J, Itani DM, Homlar KC, Keedy VL, Halpern JL, Holt GE, Schwartz HS, Coffin CM, Kelley MJ, Cates JM. "Methylthioadenosine phosphorylase and activated insulin-like growth factor-1 receptor/insulin receptor: potential therapeutic targets in chordoma.." J Pathology, 220608-17., 2010.
• Cates, JM, Friedman, DB, Seeley, EH, Dupont, WD, Schwartz, HS, Holt, GE, Caprioli, RM, Young, PP Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis. Int J Exp Pathol, 91(4), 335-49, 2010.
• JG Schoenecker, N Mignemi, C Stutz, Q Liu, J Edwards, C Lynch, G Holt, HS Schwartz, GA Mencio, H Hamm. "Therapeutic Aprotinin Stimulates Osteoblast Proliferation but Inhibits Differentiation and Bone Matrix Mineralization.." Spine, 351008-16., 2010.
• Mansour, AA, Kelley, MC, Hatmaker, AR, Holt, GE, Schwartz, HS Verification of musculoskeletal FDG-PET-CT findings performed for melanoma staging. Ann Surg Oncol, 17(4), 1144-51, 2010.
• Adelani, MA, Stover, DG, Halpern, JL, Schwartz, HS, Holt, GE Caveat Arthroplasty. J Arthroplasty, 24728-34., 2009.
• Herceg, ME, Tsiatis, AC, Halpern, JL, Holt, GE, Schwartz, HS, Keedy, VL, Cates, JM Cyclooxygenase 2 expression in soft tissue leiomyosarcoma. Anticancer Res, 29(8), 2913-7, 2009.
• Biermann, JS, Holt, GE, Lewis, VO, Schwartz, HS, Yaszemski, MJ Metastatic bone disease: diagnosis, evaluation, and treatment. J Bone Joint Surg Am, 91(6), 1518-30, 2009.
• Thiolloy, S, Halpern, J, Holt, GE, Schwartz, HS, Mundy, GR, Matrisian, LM, Lynch, CC Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis. Cancer Res, 69(16), 6747-55, 2009.
• Holt, GE, Christie, MJ, Schwartz, HS Trabecular Metal Endoprosthetic Limb Salvage Reconstruction of the Lower Limb. J Arthroplasty, 241079-85., 2009.
• Holt, GE, Halpern, JL, Lynch, CC, Devin, CJ, Schwartz, HS Imaging analysis of the in vivo bioreactor: a preliminary study. Clin Orthop Relat Res, 466(8), 1890-6, 2008.
• Adelani, MA, Holt, GE, Dittus, RS, Passman, MA, Schwartz, HS Revascularization after segmental resection of lower extremity soft tissue sarcomas. J Surg Oncol, 95(6), 455-60, 2007.
• Klingler, L, Trammell, R, Allan, DG, Butler, MG, Schwartz, HS Clonality studies in sacral chordoma. Cancer Genet Cytogenet, 171(1), 68-71, 2006.
• Devin, C, Chong, PY, Holt, GE, Feurer, I, Gonzalez, A, Merchant, N, Schwartz, HS Level-adjusted perioperative risk of sacral amputations. J Surg Oncol, 94(3), 203-11, 2006.
• Caldwell, R.L., Gonzalez, A., Oppenheimer, S.R., Schwartz, H.S., Caprioli, R.L. "Molecular Assessment of the Tumor Protein Microenvironment Using Imaging Mass Spectrometry.." Cancer Genomics and Proteomics, 3(5), 279-288, 2006.
• Holt, GE, Thomson, AB, Griffin, AM, Bell, R, Wunder, J, Rougraff, B, Schwartz, HS Multifocality and multifocal postradiation sarcomas. Clin Orthop Relat Res, 45067-75, 2006.
• Holt, GE, Schwartz, HS, Caldwell, RL Proteomic profiling in musculoskeletal oncology by MALDI mass spectrometry. Clin Orthop Relat Res, 450105-10, 2006.
• Pitchford, CW, Schwartz, HS, Atkinson, JB, Cates, JM Soft tissue perineurioma in a patient with neurofibromatosis type 2: a tumor not previously associated with the NF2 syndrome. Am J Surg Pathol, 30(12), 1624-9, 2006.
• Halpern, J, Lynch, CC, Fleming, J, Hamming, D, Martin, MD, Schwartz, HS, Matrisian, LM, Holt, GE The application of a murine bone bioreactor as a model of tumor: bone interaction. Clin Exp Metastasis, 23(7-8), 345-56, 2006.
• Halpern JL, Lynch CC, Fleming J, Hamming D, Martin MD, Schwartz HS, Matrisian LM, Holt GE. "The application of a murine bone bioreactor as a model of tumor: bone interaction.." Clin Exp Metastases. , 23(7-8), 345-56, 2006.
• Moore, DR, Halpern, JL, Schwartz, HS Allograft ankle arthrodesis: a limb salvage technique for distal tibial tumors. Clin Orthop Relat Res, 440213-21, 2005.
• Holt, GE, Halpern, JL, Dovan, TT, Hamming, D, Schwartz, HS Evolution of an in vivo bioreactor. J Orthop Res, 23(4), 916-23, 2005.
• Rubin, G, Dean, A Schwartz, HS "Orthopaedic Malpractice Claims in the VA Medical System." Journal of the Southern Orthopaedic Association, 12(2), 56-59, 2003.
• Rubin, G, Dean, A, Schwartz, HS Orthopaedic malpractice claims in the VA medical system. J South Orthop Assoc, 12(2), 56-9, 2003.
• Jasko, JJ, Wood, JH, Schwartz, HS Publication rates of abstracts presented at annual musculoskeletal tumor society meetings. Clin Orthop Relat Res, (415), 98-103, 2003.
• Schwartz, HS, Eskew, JD, Butler, MG Clonality studies in giant cell tumor of bone. J Orthop Res, 20(2), 387-90, 2002.
• Juliao, SF, Rand, N, Schwartz, HS Galectin-3: a biologic marker and diagnostic aid for chordoma. Clin Orthop Relat Res, (397), 70-5, 2002.
• Zhang K, Dion N, Fuchs B, Damron T, Gitelis S, Schwartz, HS, et al "The human homolog of yeast SEP1 is a novel candidate tumor suppressor gene in osteogenic sarcoma." Gene, (298), 121-127, 2002.
• Juliao SF, Dawson JM, Lennington WJ, Schwartz HS "Purification and Characterization of Canine Collagens I and II." Journal of Histotechnology, 24(1), 51-56, 2001 Mar.
• Eisenburg, BL, Alektiar, K, Ballo, M, DeLaney, TF, Ettinger, D, Harmon, D, Harris, J, Joyce, M, Kraybill, WG, Leider, S, Lucas, D, Peterson, I, Pollock, RE, Pritchard, D, Schwartz, HS, Yasko, AW, Pisters, PT, Patel, SR, watson, J, , Radiation Therapy Oncology Group. Research Plan 2002-2006. Sarcoma Committee. Int J Radiat Oncol Biol Phys, 51(3 Suppl 2), 53-5, 2001.
• Sciadini, MF, Dawson, JM, Banit, D, Juliao, SF, Johnson, KD, Lennington, WJ, Schwartz, HS Growth factor modulation of distraction osteogenesis in a segmental defect model. Clin Orthop Relat Res, (381), 266-77, 2000.
• Klingler, L, Shooks, J, Fiedler, PN, Marney, A, Butler, MG, Schwartz, HS Microsatellite instability in sacral chordoma. J Surg Oncol, 73(2), 100-3, 2000.
• Esther, RJ, Lamps, L, Schwartz, HS Marjolin ulcers: secondary carcinomas in chronic wounds. J South Orthop Assoc, 8(3), 181-7, 1999.
• Murrey, DB, Wright, RW, Seiler, JG, Day, TE, Schwartz, HS Publication rates of abstracts presented at the 1993 annual Academy meeting. Clin Orthop Relat Res, (359), 247-53, 1999.
• Holt G, Feurer ID, Schwartz HS, Bridge JA, Neff JR, Butler MG "An analysis of concordance among hospital databases and physician records." Annals of Surgical Oncology, 5(6), 553-556, 1998 Sep.
• Holt, G, Feurer, ID, Schwartz, HS An analysis of concordance among hospital databases and physician records. Ann Surg Oncol, 5(6), 553-6, 1998.
• Aue, G, Hedges, LK, Schwartz, HS, Bridge, JA, Neff, JR, Butler, MG Clear cell sarcoma or malignant melanoma of soft parts: molecular analysis of microsatellite instability with clinical correlation. Cancer Genet Cytogenet, 105(1), 24-8, 1998.
• Butler MG, Tilburt J, DeVries A, Buraldhar B, Aue G, Hedges L, Atkinson J, Schwartz HS "Comparison of Chromosome Telomere Integrity in Multiple Tissue from Subjects of Different Ages." Cancer Genetics & Cytogenetics, 105138-144, 1998.
• Talwalkar, VR, Scheiner, M, Hedges, LK, Butler, MG, Schwartz, HS Microsatellite instability in malignant melanoma. Cancer Genet Cytogenet, 104(2), 111-4, 1998.
• Martin, SS, Hurt, WG, Hedges, LK, Butler, MG, Schwartz, HS Microsatellite instability in sarcomas. Ann Surg Oncol, 5(4), 356-60, 1998.
• Aue, G, Muralidhar, B, Schwartz, HS, Butler, MG Telomerase activity in skeletal sarcomas. Ann Surg Oncol, 5(7), 627-34, 1998.
• Schwartz, HS Update on giant cell tumor of bone. Compr Ther, 24(10), 488-93, 1998.
• Schwartz, HS, Spengler, DM Needle tract recurrences after closed biopsy for sarcoma: three cases and review of the literature. Ann Surg Oncol, 4(3), 228-36, 1997.
• Schwartz, HS, Walker, R Recognizable magnetic resonance imaging characteristics of intramuscular myxoma. Orthopedics, 20(5), 431-5, 1997.
• Schwartz HS, and Butler, MG "Robertsonian Translocations in Paget's Disease of Bone- Letter to the Editor." Journal of Orthopaedic Research, 15788-789, 1997.
• Schwartz, HS, Butler, MG Robertsonian translocations in Paget''s disease of bone. J Orthop Res, 15(5), 788-9, 1997.
• Chmell, MJ, Schwartz, HS Analysis of variables affecting wound healing after musculoskeletal sarcoma resections. J Surg Oncol, 61(3), 185-9, 1996.
• Schwartz, HS, Limbird, TJ Caveat arthroscopy: definition and guidelines for prevention. J South Orthop Assoc, 5(2), 96-100, 1996.
• Butler, MG, Sciadini, M, Hedges, LK, Schwartz, HS Chromosome telomere integrity of human solid neoplasms. Cancer Genet Cytogenet, 86(1), 50-3, 1996.
• DeBoer, DK, Schwartz, HS, Thelman, S, Reynolds, VH Heterogeneous survival rates for isolated skeletal metastases from melanoma. Clin Orthop Relat Res, (323), 277-83, 1996.
• Scheiner, M, Hedges, L, Schwartz, HS, Butler, MG Lack of microsatellite instability in giant cell tumor of bone. Cancer Genet Cytogenet, 88(1), 35-8, 1996.
• Wyrsch, B, McFerran, MA, McAndrew, M, Limbird, TJ, Harper, MC, Johnson, KD, Schwartz, HS Operative treatment of fractures of the tibial plafond. A randomized, prospective study. J Bone Joint Surg Am, 78(11), 1646-57, 1996.
• Dawson, JM, DeBoer, DK, Spengler, DM, Schwartz, HS The spinal nail: a new implant for short-segment anterior instrumentation of the thoracolumbar spine. J Spinal Disord, 9(4), 299-305, 1996.
• Butler, MG, Dahir, GA, Hedges, LK, Juliao, SF, Sciadini, MF, Schwartz, HS Cytogenetic, telomere, and telomerase studies in five surgically managed lumbosacral chordomas. Cancer Genet Cytogenet, 85(1), 51-7, 1995.
• Wang, H, Rodgers, WH, Chmell, MJ, Svitek, C, Schwartz, HS Osteosarcoma oncogene expression detected by in situ hybridization. J Orthop Res, 13(5), 671-8, 1995.
• Chmell, MJ, McAndrew, MP, Thomas, R, Schwartz, HS Structural allografts for reconstruction of lower extremity open fractures with 10 centimeters or more of acute segmental defects. J Orthop Trauma, 9(3), 222-6, 1995.
• Kells, AF, Coats, SR, Schwartz, HS, Hoover, RL TGF-beta and PDGF act synergistically in affecting the growth of human osteoblast-enriched cultures. Connect Tissue Res, 31(2), 117-24, 1995.
• Schwartz, HS, Juliao, SF, Sciadini, MF, Miller, LK, Butler, MG Telomerase activity and oncogenesis in giant cell tumor of bone. Cancer, 75(5), 1094-9, 1995.
• Dahir, GA, Vnencak-Jones, CL, Schwartz, HS, Butler, MG Dosage and allelic restriction fragment studies and PCR analysis of the H-ras locus in giant cell tumor of bone. Cancer Genet Cytogenet, 74(2), 95-8, 1994.
• Buchwald, A, Schwartz, HS Extensive palm thorn hematoma with associated hematuria. Am J Emerg Med, 12(2), 259-60, 1994.
• Wright, RW, Schwartz, HS Pathologic acetabular fractures: new concepts in surgical management. Semin Arthroplasty, 5(2), 95-105, 1994.
• Stephens, GC, Lennington, WJ, Schwartz, HS Primary lymphoma and Paget's disease of the femur. Am J Clin Pathol, 101(6), 783-6, 1994.
• Harrington, MA, Keller, TS, Seiler, JG, Weikert, DR, Moeljanto, E, Schwartz, HS Geometric properties and the predicted mechanical behavior of adult human clavicles. J Biomech, 26(4-5), 417-26, 1993.
• Schwartz, HS Giant cell tumor of bone. Compr Ther, 19(2), 64-8, 1993.
• Hourigan, AJ, Kells, AF, Schwartz, HS In vitro photodynamic therapy of musculoskeletal neoplasms. J Orthop Res, 11(5), 633-7, 1993.
• Stephens, GC, Schwartz, HS Lumbosacral chordoma resection: image integration and surgical planning. J Surg Oncol, 54(4), 226-32, 1993.
• Butler, MG, Dahir, GA, Schwartz, HS Molecular analysis of transforming growth factor beta in giant cell tumor of bone. Cancer Genet Cytogenet, 66(2), 108-12, 1993.
• Schwartz, HS, Dahir, GA, Butler, MG Telomere reduction in giant cell tumor of bone and with aging. Cancer Genet Cytogenet, 71(2), 132-8, 1993.
• McFerran, MA, Smith, SW, Boulas, HJ, Schwartz, HS Complications encountered in the treatment of pilon fractures. J Orthop Trauma, 6(2), 195-200, 1992.
• Schwartz, HS, Allen, GA, Chudoba, I, Butler, MG Cytogenetic abnormalities in a rare case of giant cell osteogenic sarcoma. Cancer Genet Cytogenet, 58(1), 60-5, 1992.
• Kells, AF, Schwartz, HS, Bascom, CC, Hoover, RL Identification and analysis of transforming growth factor beta receptors on primary osteoblast-enriched cultures derived from adult human bone. Connect Tissue Res, 27(4), 197-209, 1992.
• Schwartz, HS, Jones, CK The efficacy of gallium scintigraphy in detecting malignant soft tissue neoplasms. Ann Surg, 215(1), 78-82, 1992.
• Stiles, RG, Spottswood, SE, Jolgren, DL, Stewart, JR, DeVito, DP, Schwartz, HS An unusual appearance of an aneurysmal bone cyst of the thoracic spine. J Spinal Disord, 4(1), 104-9, 1991.
• Weikert, DR, Schwartz, HS Intramedullary nailing for impending pathological subtrochanteric fractures. J Bone Joint Surg Br, 73(4), 668-70, 1991.
• Cramer, KE, Schwartz, HS Open biopsy without wound closure for skeletal neoplasms. J Surg Oncol, 47(2), 75-8, 1991.
• Schwartz, HS, Butler, MG, Jenkins, RB, Miller, DA, Moses, HL Telomeric associations and consistent growth factor overexpression detected in giant cell tumor of bone. Cancer Genet Cytogenet, 56(2), 263-76, 1991.
• Schwartz, HS, Shockley, TE, Lennington, WJ, Mackey, ES The significance of skeletal magnetic resonance imaging after open bone biopsy. J Orthop Res, 9(1), 120-30, 1991.
• Furia, JP, Schwartz, HS Hereditary multiple diaphyseal sclerosis: a tumor simulator. Orthopedics, 13(11), 1267-74, 1990.
• Stiehl, JB, Schwartz, HS Long-term results of pronation-external rotation ankle fracture-dislocations treated with anatomical open reduction, internal fixation. J Orthop Trauma, 4(3), 339-45, 1990.
• Schwartz, HS, Pinto, M Osteoblastomas of the cervical spine. J Spinal Disord, 3(2), 179-82, 1990.
• Schwartz, HS Traumatic Charcot spine. J Spinal Disord, 3(3), 269-75, 1990.
• Schwartz, HS, Jenkins, RB, Dahl, RJ, Dewald, GW Cytogenetic analyses on giant-cell tumors of bone. Clin Orthop Relat Res, (240), 250-60, 1989.
• Schwartz, HS, Unni, KK, Pritchard, DJ Pigmented villonodular synovitis. A retrospective review of affected large joints. Clin Orthop Relat Res, (247), 243-55, 1989.
• Schwartz HS, Frassica FJ, and Sim FH "Rotationplasty: An option for Limb Salvage in Childhood Osteosarcoma." Orthopaedics, 12257-263, 1989.
• Schwartz, HS, Frassica, FJ, Sim, FH Rotationplasty: an option for limb salvage in childhood osteosarcoma. Orthopedics, 12(2), 257-63, 1989.
• Frassica FJ, Schwartz HS, Pairolero PC, and Sim FH "Rotation-plasty: Surgical Technique of Resection and Reconstruction in the Treatment of Osteosarcoma About the Knee in Children." Clinical Anatomy, 1105-116, 1988.
• Schwartz HS, Pritchard DJ, Sim FH, Weiss SW, and Beabout JW "Epithelioid Sarcoma." Orthopaedics, 91299-1302, 1987.
• Schwartz, HS, Pritchard, DJ, Sim, FH, Weiss, SW, Beabout, JW Epithelioid sarcoma. Orthopedics, 10(9), 1299-302, 1987.
• Schwartz HS, Weiss SW, Sim FH, Beobout JW "Liposarcoma of the Soft Tissues." Orthopaedics, 101065-1068, 1987.
• Schwartz, HS, Weiss, SW, Sim, FH, Beabout, JW Liposarcoma of the soft tissues. Orthopedics, 10(7), 1065-8, 1987.
• Schwartz HS, Zimmerman NB, Simon MA, Wroble RR, Miller EA, and Bonfiglio M "The Malignant Potential of Multiple Enchondromatosis." J. Bone and Joint Surgery, 69A269-274, 1987.
• Phillips, WA, Schwartz, HS, Keller, CS, Woodward, HR, Rudd, WS, Spiegel, PG, Laros, GS A prospective, randomized study of the management of severe ankle fractures. J Bone Joint Surg Am, 67(1), 67-78, 1985.