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Irina Kaverina, Ph.D.

Associate Professor of Cell and Developmental Biology
Researcher

Contact Information:

Vanderbilt University Medical Center
465 21st Ave S
3160 MRB3
Nashville, TN 37232-8240
615-936-5567
Fax: 615-936-5673

Profile

The Kaverina Lab conducts research on intracellular cytoskeletal microtubule network, its regulation and function in physiology and disease.

Education
  • M.S., Moscow State University
  • Ph.D., Cancer Research Center, Russian Academy of Medical Sciences
Research Description

Architecture of a eukaryotic cell largely depends on microtubules (MTs), 25-nm self-assembling polymers that serve as highways for organelle and molecular transport within a cell. During cell division, MTs drive chromosome segregation. In interphase cells, MTs position organelles and site-specific activities like exocytosis or actin assembly, thereby defining cell shape and polarity. For years, an intriguing question has been how MTs within a cell can perform multiple actions that are spatially and temporally distinct. It can only be possible if architecture, dynamics, and biochemistry of MT networks at the cellular or subcellular level are specialized according to specific functions.

Our lab is interested in:
1) Establishing principles of diversity and asymmetry within MT networks. We study the MT network as a combination of subsets of diverse origin, dynamics and molecular composition. We have identified a novel MT population, which forms at Golgi complex and are distinct from the centrosomal MT array. Elucidating their molecular and functional properties is one of our close goals.
2) Understanding how variations in MT networks are translated into specifics of cellular architecture and functioning. We aim to resolve general principles of this regulatory system as well as its cell-type-specific functions. In particular, we study MT-dependent regulation of: (a) Golgi complex organization and trafficking; (b) invasive podosomes in vascular smooth muscle cells; (c) insulin secretion from pancreatic beta cells.

The astrophysicist Bernard Haisch once said "Advances are made by answering questions. Discoveries are made by questioning answers." This approach is very appealing to us. Our research is based on dogma-challenging hypotheses that we test through a unique combination of cutting edge high-resolution microscopy techniques supported by molecular and biochemical approaches and merged with mathematical modeling.

Publications
  • Zhu X, Efimova N, Arnette C, Hanks SK, Kaverina I. Podosome dynamics and location in vascular smooth muscle cells require CLASP-dependent microtubule bending. Cytoskeleton (Hoboken) [print-electronic]. 2016 Jun; 73(6): 300-15. PMID: 27105779, DOI: 10.1002/cm.21302, ISSN: 1949-3592.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27105779.
  • Arnette C, Frye K, Kaverina I. Microtubule and Actin Interplay Drive Intracellular c-Src Trafficking. PLoS ONE. 2016; 11(2): e0148996. PMID: 26866809, PMCID: PMC4750819, PII: PONE-D-15-49833, DOI: 10.1371/journal.pone.0148996, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26866809.
  • Zhu X, Hu R, Brissova M, Stein RW, Powers AC, Gu G, Kaverina I. Microtubules Negatively Regulate Insulin Secretion in Pancreatic ß Cells. Dev. Cell. 2015 Sep 9/28/2015; 34(6): 656-68. PMID: 26418295, PMCID: PMC4594944, PII: S1534-5807(15)00554-7, DOI: 10.1016/j.devcel.2015.08.020, ISSN: 1878-1551.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26418295.
  • Tonucci FM, Hidalgo F, Ferretti A, Almada E, Favre C, Goldenring JR, Kaverina I, Kierbel A, Larocca MC. Centrosomal AKAP350 and CIP4 act in concert to define the polarized localization of the centrosome and Golgi in migratory cells. J. Cell. Sci [print-electronic]. 2015 Sep 9/1/2015; 128(17): 3277-89. PMID: 26208639, PMCID: PMC4582191, PII: jcs.170878, DOI: 10.1242/jcs.170878, ISSN: 1477-9137.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26208639.
  • Maki T, Grimaldi AD, Fuchigami S, Kaverina I, Hayashi I. CLASP2 Has Two Distinct TOG Domains That Contribute Differently to Microtubule Dynamics. J. Mol. Biol [print-electronic]. 2015 Jul 7/17/2015; 427(14): 2379-95. PMID: 26003921, PMCID: PMC4646087, PII: S0022-2836(15)00296-X, DOI: 10.1016/j.jmb.2015.05.012, ISSN: 1089-8638.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26003921.
  • Cleghorn WM, Branch KM, Kook S, Arnette C, Bulus N, Zent R, Kaverina I, Gurevich EV, Weaver AM, Gurevich VV. Arrestins regulate cell spreading and motility via focal adhesion dynamics. Mol. Biol. Cell [print-electronic]. 2015 Feb 2/15/2015; 26(4): 622-35. PMID: 25540425, PMCID: PMC4325834, PII: mbc.E14-02-0740, DOI: 10.1091/mbc.E14-02-0740, ISSN: 1939-4586.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25540425.
  • Grimaldi AD, Zanic M, Kaverina I. Encoding the microtubule structure: Allosteric interactions between the microtubule +TIP complex master regulators and TOG-domain proteins. Cell Cycle. 2015; 14(9): 1375-8. PMID: 25895033, PMCID: PMC4614873, DOI: 10.1080/15384101.2015.1026521, ISSN: 1551-4005.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25895033.
  • Sanders AA, Kaverina I. Nucleation and Dynamics of Golgi-derived Microtubules. Front Neurosci. 2015; 9: 431. PMID: 26617483, PMCID: PMC4639703, DOI: 10.3389/fnins.2015.00431, ISSN: 1662-4548.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26617483.
  • Efimova N, Grimaldi A, Bachmann A, Frye K, Zhu X, Feoktistov A, Straube A, Kaverina I. Podosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner. J. Cell. Sci [print-electronic]. 2014 Dec 12/15/2014; 127(Pt 24): 5179-88. PMID: 25344256, PMCID: PMC4265736, PII: jcs.149633, DOI: 10.1242/jcs.149633, ISSN: 1477-9137.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25344256.
  • Grimaldi AD, Maki T, Fitton BP, Roth D, Yampolsky D, Davidson MW, Svitkina T, Straube A, Hayashi I, Kaverina I. CLASPs are required for proper microtubule localization of end-binding proteins. Dev. Cell. 2014 Aug 8/11/2014; 30(3): 343-52. PMID: 25117684, PMCID: PMC4133696, PII: S1534-5807(14)00415-8, DOI: 10.1016/j.devcel.2014.06.026, ISSN: 1878-1551.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25117684.
  • Arnette C, Efimova N, Zhu X, Clark GJ, Kaverina I. Microtubule segment stabilization by RASSF1A is required for proper microtubule dynamics and Golgi integrity. Mol. Biol. Cell [print-electronic]. 2014 Mar; 25(6): 800-10. PMID: 24478455, PMCID: PMC3952850, PII: mbc.E13-07-0374, DOI: 10.1091/mbc.E13-07-0374, ISSN: 1939-4586.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24478455.
  • Alieva IB, Zemskov EA, Smurova KM, Kaverina IN, Verin AD. The leading role of microtubules in endothelial barrier dysfunction: disassembly of peripheral microtubules leaves behind the cytoskeletal reorganization. J. Cell. Biochem. 2013 Oct; 114(10): 2258-72. PMID: 23606375, PMCID: PMC3901434, DOI: 10.1002/jcb.24575, ISSN: 1097-4644.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23606375.
  • Zhu X, Kaverina I. Golgi as an MTOC: making microtubules for its own good. Histochem. Cell Biol [print-electronic]. 2013 Sep; 140(3): 361-7. PMID: 23821162, PMCID: PMC3748218, DOI: 10.1007/s00418-013-1119-4, ISSN: 1432-119X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23821162.
  • Maia AR, Zhu X, Miller P, Gu G, Maiato H, Kaverina I. Modulation of Golgi-associated microtubule nucleation throughout the cell cycle. Cytoskeleton (Hoboken) [print-electronic]. 2013 Jan; 70(1): 32-43. PMID: 23027431, PMCID: PMC3574797, DOI: 10.1002/cm.21079, ISSN: 1949-3592.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23027431.
  • Grimaldi AD, Fomicheva M, Kaverina I. Ice recovery assay for detection of Golgi-derived microtubules. Methods Cell Biol. 2013; 118: 401-15. PMID: 24295320, PMCID: PMC4135712, PII: B978-0-12-417164-0.00024-0, DOI: 10.1016/B978-0-12-417164-0.00024-0, ISSN: 0091-679X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24295320.
  • Maia AR, Garcia Z, Kabeche L, Barisic M, Maffini S, Macedo-Ribeiro S, Cheeseman IM, Compton DA, Kaverina I, Maiato H. Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments. J. Cell Biol [print-electronic]. 2012 Oct 10/15/2012; 199(2): 285-301. PMID: 23045552, PMCID: PMC3471233, PII: jcb.201203091, DOI: 10.1083/jcb.201203091, ISSN: 1540-8140.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23045552.
  • Vinogradova T, Paul R, Grimaldi AD, Loncarek J, Miller PM, Yampolsky D, Magidson V, Khodjakov A, Mogilner A, Kaverina I. Concerted effort of centrosomal and Golgi-derived microtubules is required for proper Golgi complex assembly but not for maintenance. Mol. Biol. Cell [print-electronic]. 2012 Mar; 23(5): 820-33. PMID: 22262454, PMCID: PMC3290642, PII: mbc.E11-06-0550, DOI: 10.1091/mbc.E11-06-0550, ISSN: 1939-4586.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22262454.
  • Kaverina I, Straube A. Regulation of cell migration by dynamic microtubules. Semin. Cell Dev. Biol [print-electronic]. 2011 Dec; 22(9): 968-74. PMID: 22001384, PMCID: PMC3256984, PII: S1084-9521(11)00173-X, DOI: 10.1016/j.semcdb.2011.09.017, ISSN: 1096-3634.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22001384.
  • Zhu X, Wang J, Moriguchi K, Liow LT, Ahmed S, Kaverina I, Murata-Hori M. Proper regulation of Cdc42 activity is required for tight actin concentration at the equator during cytokinesis in adherent mammalian cells. Exp. Cell Res [print-electronic]. 2011 Oct 10/1/2011; 317(16): 2384-9. PMID: 21763307, PMCID: PMC3282173, PII: S0014-4827(11)00275-8, DOI: 10.1016/j.yexcr.2011.06.019, ISSN: 1090-2422.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21763307.
  • Sung BH, Zhu X, Kaverina I, Weaver AM. Cortactin controls cell motility and lamellipodial dynamics by regulating ECM secretion. Curr. Biol. 2011 Sep 9/13/2011; 21(17): 1460-9. PMID: 21856159, PMCID: PMC3175319, PII: S0960-9822(11)00843-8, DOI: 10.1016/j.cub.2011.06.065, ISSN: 1879-0445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21856159.
  • Zhu X, Kaverina I. Quantification of asymmetric microtubule nucleation at subcellular structures. Methods Mol. Biol. 2011; 777: 235-44. PMID: 21773933, PMCID: PMC3282175, DOI: 10.1007/978-1-61779-252-6_17, ISSN: 1940-6029.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21773933.
  • Donato DM, Ryzhova LM, Meenderink LM, Kaverina I, Hanks SK. Dynamics and mechanism of p130Cas localization to focal adhesions. J. Biol. Chem [print-electronic]. 2010 Jul 7/2/2010; 285(27): 20769-79. PMID: 20430882, PMCID: PMC2898362, PII: M109.091207, DOI: 10.1074/jbc.M109.091207, ISSN: 1083-351X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20430882.
  • Meenderink LM, Ryzhova LM, Donato DM, Gochberg DF, Kaverina I, Hanks SK. P130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migration. PLoS ONE. 2010; 5(10): e13412. PMID: 20976150, PMCID: PMC2956669, DOI: 10.1371/journal.pone.0013412, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20976150.
  • Moynihan KL, Pooley R, Miller PM, Kaverina I, Bader DM. Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome. Mol. Biol. Cell [print-electronic]. 2009 Nov; 20(22): 4790-803. PMID: 19793914, PMCID: PMC2777108, PII: E09-07-0560, DOI: 10.1091/mbc.E09-07-0560, ISSN: 1939-4586.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19793914.
  • Miller PM, Folkmann AW, Maia AR, Efimova N, Efimov A, Kaverina I. Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells. Nat. Cell Biol [print-electronic]. 2009 Sep; 11(9): 1069-80. PMID: 19701196, PMCID: PMC2748871, PII: ncb1920, DOI: 10.1038/ncb1920, ISSN: 1476-4679.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19701196.
  • Vinogradova T, Miller PM, Kaverina I. Microtubule network asymmetry in motile cells: role of Golgi-derived array. Cell Cycle [print-electronic]. 2009 Jul 7/15/2009; 8(14): 2168-74. PMID: 19556895, PMCID: PMC3163838, PII: 9074, ISSN: 1551-4005.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19556895.
  • Efimov A, Kaverina I. Significance of microtubule catastrophes at focal adhesion sites. Cell Adh Migr [print-electronic]. 2009 Jul; 3(3): 285-7. PMID: 19483470, PMCID: PMC2712812, PII: 8858, ISSN: 1933-6926.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19483470.
  • Kolobova E, Efimov A, Kaverina I, Rishi AK, Schrader JW, Ham AJ, Larocca MC, Goldenring JR. Microtubule-dependent association of AKAP350A and CCAR1 with RNA stress granules. Exp. Cell Res [print-electronic]. 2009 Feb 2/1/2009; 315(3): 542-55. PMID: 19073175, PMCID: PMC2788823, PII: S0014-4827(08)00501-6, DOI: 10.1016/j.yexcr.2008.11.011, ISSN: 1090-2422.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19073175.
  • Broussard JA, Webb DJ, Kaverina I. Asymmetric focal adhesion disassembly in motile cells. Curr. Opin. Cell Biol. 2008 Feb; 20(1): 85-90. PMID: 18083360, PII: S0955-0674(07)00160-3, DOI: 10.1016/j.ceb.2007.10.009, ISSN: 0955-0674.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18083360.
  • Efimov A, Schiefermeier N, Grigoriev I, Ohi R, Brown MC, Turner CE, Small JV, Kaverina I. Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites. J. Cell. Sci. 2008 Jan 1/15/2008; 121(Pt 2): 196-204. PMID: 18187451, PMCID: PMC3164837, PII: 121/2/196, DOI: 10.1242/jcs.012666, ISSN: 0021-9533.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18187451.
  • Siesser PM, Meenderink LM, Ryzhova L, Michael KE, Dumbauld DW, García AJ, Kaverina I, Hanks SK. A FAK/Src chimera with gain-of-function properties promotes formation of large peripheral adhesions associated with dynamic actin assembly. Cell Motil. Cytoskeleton. 2008 Jan; 65(1): 25-39. PMID: 17922492, PMCID: PMC2387247, DOI: 10.1002/cm.20241, ISSN: 0886-1544.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17922492.
  • Efimov A, Kharitonov A, Efimova N, Loncarek J, Miller PM, Andreyeva N, Gleeson P, Galjart N, Maia AR, McLeod IX, Yates JR, Maiato H, Khodjakov A, Akhmanova A, Kaverina I. Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. Dev. Cell. 2007 Jun; 12(6): 917-30. PMID: 17543864, PMCID: PMC2705290, PII: S1534-5807(07)00149-9, DOI: 10.1016/j.devcel.2007.04.002, ISSN: 1534-5807.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17543864.
  • Voznesenskaia TG, Leonova AR, Kaverina IV. [Treatment of chronic back pain with antidepressant cymbalta: an experimental study]. Zh Nevrol Psikhiatr Im S S Korsakova. 2007; 107(7): 20-4. PMID: 18379477, ISSN: 1997-7298.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18379477.
  • Harris JE, Govindan JA, Yamamoto I, Schwartz J, Kaverina I, Greenstein D. Major sperm protein signaling promotes oocyte microtubule reorganization prior to fertilization in Caenorhabditis elegans. Dev. Biol [print-electronic]. 2006 Nov 11/1/2006; 299(1): 105-21. PMID: 16919258, PII: S0012-1606(06)00995-X, DOI: 10.1016/j.ydbio.2006.07.013, ISSN: 0012-1606.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16919258.
  • Balzac F, Avolio M, Degani S, Kaverina I, Torti M, Silengo L, Small JV, Retta SF. E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function. J. Cell. Sci. 2005 Oct 10/15/2005; 118(Pt 20): 4765-83. PMID: 16219685, PII: 118/20/4765, DOI: 10.1242/jcs.02584, ISSN: 0021-9533.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16219685.
  • Rid R, Schiefermeier N, Grigoriev I, Small JV, Kaverina I. The last but not the least: the origin and significance of trailing adhesions in fibroblastic cells. Cell Motil. Cytoskeleton. 2005 Jul; 61(3): 161-71. PMID: 15909298, DOI: 10.1002/cm.20076, ISSN: 0886-1544.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15909298.
  • Yanagisawa M, Kaverina IN, Wang A, Fujita Y, Reynolds AB, Anastasiadis PZ. A novel interaction between kinesin and p120 modulates p120 localization and function. J. Biol. Chem [print-electronic]. 2004 Mar 3/5/2004; 279(10): 9512-21. PMID: 14676216, PII: M310895200, DOI: 10.1074/jbc.M310895200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14676216.
  • Kaverina I, Stradal TE, Gimona M. Podosome formation in cultured A7r5 vascular smooth muscle cells requires Arp2/3-dependent de-novo actin polymerization at discrete microdomains. J. Cell. Sci. 2003 Dec 12/15/2003; 116(Pt 24): 4915-24. PMID: 14625385, PII: 116/24/4915, DOI: 10.1242/jcs.00818, ISSN: 0021-9533.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14625385.
  • Krylyshkina O, Anderson KI, Kaverina I, Upmann I, Manstein DJ, Small JV, Toomre DK. Nanometer targeting of microtubules to focal adhesions. J. Cell Biol [print-electronic]. 2003 Jun 6/9/2003; 161(5): 853-9. PMID: 12782685, PMCID: PMC2172972, PII: jcb.200301102, DOI: 10.1083/jcb.200301102, ISSN: 0021-9525.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12782685.
  • Gimona M, Kaverina I, Resch GP, Vignal E, Burgstaller G. Calponin repeats regulate actin filament stability and formation of podosomes in smooth muscle cells. Mol. Biol. Cell [print-electronic]. 2003 Jun; 14(6): 2482-91. PMID: 12808045, PMCID: PMC194896, PII: E02-11-0743, DOI: 10.1091/mbc.E02-11-0743, ISSN: 1059-1524.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12808045.
  • Small JV, Kaverina I. Microtubules meet substrate adhesions to arrange cell polarity. Curr. Opin. Cell Biol. 2003 Feb; 15(1): 40-7. PMID: 12517702, PII: S095506740200008X, ISSN: 0955-0674.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12517702.
  • Small JV, Geiger B, Kaverina I, Bershadsky A. How do microtubules guide migrating cells?. Nat. Rev. Mol. Cell Biol. 2002 Dec; 3(12): 957-64. PMID: 12461561, PII: nrm971, DOI: 10.1038/nrm971, ISSN: 1471-0072.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12461561.
  • Bhatt A, Kaverina I, Otey C, Huttenlocher A. Regulation of focal complex composition and disassembly by the calcium-dependent protease calpain. J. Cell. Sci. 2002 Sep 9/1/2002; 115(Pt 17): 3415-25. PMID: 12154072, ISSN: 0021-9533.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12154072.
  • Hoogenraad CC, Koekkoek B, Akhmanova A, Krugers H, Dortland B, Miedema M, van Alphen A, Kistler WM, Jaegle M, Koutsourakis M, Van Camp N, Verhoye M, van der Linden A, Kaverina I, Grosveld F, De Zeeuw CI, Galjart N. Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice. Nat. Genet [print-electronic]. 2002 Sep; 32(1): 116-27. PMID: 12195424, PII: ng954, DOI: 10.1038/ng954, ISSN: 1061-4036.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12195424.
  • Kaverina I, Krylyshkina O, Small JV. Regulation of substrate adhesion dynamics during cell motility. Int. J. Biochem. Cell Biol. 2002 Jul; 34(7): 746-61. PMID: 11950592, PII: S1357272501001716, ISSN: 1357-2725.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11950592.
  • Kaverina I, Krylyshkina O, Beningo K, Anderson K, Wang YL, Small JV. Tensile stress stimulates microtubule outgrowth in living cells. J. Cell. Sci. 2002 Jun 6/1/2002; 115(Pt 11): 2283-91. PMID: 12006613, ISSN: 0021-9533.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12006613.
  • Krylyshkina O, Kaverina I, Kranewitter W, Steffen W, Alonso MC, Cross RA, Small JV. Modulation of substrate adhesion dynamics via microtubule targeting requires kinesin-1. J. Cell Biol [print-electronic]. 2002 Jan 1/21/2002; 156(2): 349-59. PMID: 11807097, PMCID: PMC2199234, PII: jcb.200105051, DOI: 10.1083/jcb.200105051, ISSN: 0021-9525.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11807097.
  • Beningo KA, Dembo M, Kaverina I, Small JV, Wang YL. Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. J. Cell Biol. 2001 May 5/14/2001; 153(4): 881-8. PMID: 11352946, PMCID: PMC2192381, ISSN: 0021-9525.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11352946.
  • Kaverina I, Krylyshkina O, Gimona M, Beningo K, Wang YL, Small JV. Enforced polarisation and locomotion of fibroblasts lacking microtubules. Curr. Biol. 2000 Jun 6/15/2000; 10(12): 739-42. PMID: 10873805, PII: S0960-9822(00)00544-3, ISSN: 0960-9822.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10873805.
  • Oliferenko S, Kaverina I, Small JV, Huber LA. Hyaluronic acid (HA) binding to CD44 activates Rac1 and induces lamellipodia outgrowth. J. Cell Biol. 2000 Mar 3/20/2000; 148(6): 1159-64. PMID: 10725329, PMCID: PMC2174315, ISSN: 0021-9525.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10725329.
  • Kaverina I, Krylyshkina O, Small JV. Microtubule targeting of substrate contacts promotes their relaxation and dissociation. J. Cell Biol. 1999 Sep 9/6/1999; 146(5): 1033-44. PMID: 10477757, PMCID: PMC2169483, ISSN: 0021-9525.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10477757.
  • Small JV, Kaverina I, Krylyshkina O, Rottner K. Cytoskeleton cross-talk during cell motility. FEBS Lett. 1999 Jun 6/4/1999; 452(1-2): 96-9. PMID: 10376686, PII: S0014-5793(99)00530-X, ISSN: 0014-5793.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10376686.
  • Small JV, Rottner K, Kaverina I. Functional design in the actin cytoskeleton. Curr. Opin. Cell Biol. 1999 Feb; 11(1): 54-60. PMID: 10047522, PII: S0955-0674(99)80007-6, ISSN: 0955-0674.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10047522.
  • Zhurbitskaia VA, Rovenskii IuA, Kaverina IN. [Changes in morphology, cytoskeleton, and substrate dependence of proliferation induced by transfection of the rat immortalized embryonal fibroblasts with human papilloma E7 viral gene type 16]. Biull Eksp Biol Med. 1999 Jan; 127(1): 109-13. PMID: 10190020, ISSN: 0365-9615.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10190020.
  • Small JV, Rottner K, Kaverina I, Anderson KI. Assembling an actin cytoskeleton for cell attachment and movement. Biochim. Biophys. Acta. 1998 Sep 9/16/1998; 1404(3): 271-81. PMID: 9739149, PII: S0167-4889(98)00080-9, ISSN: 0006-3002.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9739149.
  • Kaverina I, Rottner K, Small JV. Targeting, capture, and stabilization of microtubules at early focal adhesions. J. Cell Biol. 1998 Jul 7/13/1998; 142(1): 181-90. PMID: 9660872, PMCID: PMC2133026, ISSN: 0021-9525.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9660872.
  • Alexandrova AY, Dugina VB, Ivanova OY, Kaverina IN, Vasiliev JM. Scatter factor induces segregation of multinuclear cells into several discrete motile domains. Cell Motil. Cytoskeleton. 1998; 39(2): 147-58. PMID: 9484956, PII: 10.1002/(SICI)1097-0169(1998)39:2<147::AID-CM5>3.0.CO;2-3, DOI: 10.1002/(SICI)1097-0169(1998)39:2<147::AID-CM5>3.0.CO;2-3, ISSN: 0886-1544.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9484956.
  • Kaverina IN, Minin AA, Gyoeva FK, Vasiliev JM. Kinesin-associated transport is involved in the regulation of cell adhesion. Cell Biol. Int. 1997 Apr; 21(4): 229-36. PMID: 9204536, PII: S1065-6995(97)90136-0, DOI: 10.1006/cbir.1997.0136, ISSN: 1065-6995.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9204536.
  • Tatosyan A, Yatsula B, Shtutman M, Moinova E, Kaverina I, Musatkina E, Leskov K, Mizenina O, Zueva E, Calothy G, Dezélée P. Two novel variants of the v-src oncogene isolated from low and high metastatic RSV-transformed hamster cells. Virology. 1996 Feb 2/15/1996; 216(2): 347-56. PMID: 8607264, PII: S0042-6822(96)90070-7, DOI: 10.1006/viro.1996.0070, ISSN: 0042-6822.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8607264.
  • Pletjushkina OJ, Ivanova OJ, Kaverina IN, Vasiliev JM. Taxol-treated fibroblasts acquire an epithelioid shape and a circular pattern of actin bundles. Exp. Cell Res. 1994 Jun; 212(2): 201-8. PMID: 7910561, PII: S0014-4827(84)71135-9, DOI: 10.1006/excr.1994.1135, ISSN: 0014-4827.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7910561.
  • Kaverina IN, Vasil'ev IuM. [The effect of the depolymerization and disintegration of the microtubular system on the cytoskeleton of untransformed and transformed cells]. Tsitologiia. 1991; 33(12): 49-53. PMID: 1688146, ISSN: 0041-3771.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1688146.
  • Svitkina TM, Kaverina IN. [Disorders of the actin cytoskeleton in transformed epithelial cells]. Tsitologiia. 1989 Dec; 31(12): 1441-7. PMID: 2637543, ISSN: 0041-3771.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2637543.