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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 

W. Gray (Jay) Jerome, Ph.D.

Associate Professor of Cancer Biology
Associate Professor of Pathology, Microbiology and Immunology
Researcher

Contact Information:

Vanderbilt University Medical Center
U-2206 MCN, 1161 21st Ave . S.
Nashville, TN 37232
615-322-5530
Fax: 615-343-7023

Research Description

Research in the laboratory is focused on vascular biology and how changes in the vasculature can affect heart disease, stroke, and cancer. The studies correlate microscopy and biochemistry evidence to determine what changes occur and how these changes affect the disease process. Currently, three interrelated studies are ongoing.

In the first, we are trying to learn why in atherosclerosis the lysosomes of macrophages and smooth muscle cells in the artery wall become bloated with cholesterol. To do this, we use cultured macrophages and look at the uptake and processing of cholesterol. The cholesterol is delivered to the cells within modified lipoproteins. This is similar to what occurs in vivo. We compare quantitative microscopic observations on the uptake and fate of the lipoproteins with measures of key biochemical pathways in cholesterol metabolism. In this way we are beginning to dissect why lysosomes cannot clear their cholesterol load. To relate these tissue culture experiments to the disease process, we also compare the appearance of these tissue culture cells to that exhibited by cells during various stages of atherosclerosis. This is also allowing us to investigate the effect this bloating has on progression of the disease. Among our findings, we have shown that lysosomal cholesterol accumulation occurs in two stages. In the initial stage, cholesteryl esters delivered by lipoproteins are broken down in th lysosome but the resulting unesterified cholesterol cannot escape the lysosome. In later stages, and perhaps related to the free cholesterol accumulation, hydrolysis of the cholesteryl esters is inhibited. This produces lysosomes rich in both free and esterified cholesterol.

In the second set of studies, we are exploring how triglycerides can alter intracellular cholesterol metabolism. We have found that triglycerides significantly increase the rate of cholesterol metabolism and cellular clearance of cholesterol. We are now trying to define the mechanisms by which this occurs.

In a new line of investigation in the laboratory, we are investigating how inhibition of cholesterol use can effect cell proliferation. Under conditions where cholesterol is scarce, cell proliferation, such as that seen in tumors, is slowed. The cell can acquire cholesterol exogenously or synthesize it internally. Each pool of cholesterol appears to have a slight different trafficking mechanism within the cells. It is still not clear whether an inhibition of use of one pool can be compensated by use of cholesterol from the other pool. Cholesterol restriction is a potential means of slowing some tumor growth. However, to fully understand the potential, much more knowledge of cholesterol trafficking and utilization within different cell types is required. . . .

Publications
  • Kojima T, Van Deusen M, Jerome WG, Garrett CG, Sivasankar MP, Novaleski CK, Rousseau B. Quantification of acute vocal fold epithelial surface damage with increasing time and magnitude doses of vibration exposure. PLoS ONE. 2014; 9(3): e91615. PMID: 24626217, PMCID: PMC3953437, PII: PONE-D-13-46718, DOI: 10.1371/journal.pone.0091615, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24626217.
  • Baudoin JP, Jerome WG, Kübel C, de Jonge N. Whole-cell analysis of low-density lipoprotein uptake by macrophages using STEM tomography. PLoS ONE [print-electronic]. 2013; 8(1): e55022. PMID: 23383042, PMCID: PMC3561407, PII: PONE-D-12-27385, DOI: 10.1371/journal.pone.0055022, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23383042.
  • Yamamoto S, Yancey PG, Ikizler TA, Jerome WG, Kaseda R, Cox B, Bian A, Shintani A, Fogo AB, Linton MF, Fazio S, Kon V. Dysfunctional high-density lipoprotein in patients on chronic hemodialysis. J. Am. Coll. Cardiol [print-electronic]. 2012 Dec 12/11/2012; 60(23): 2372-9. PMID: 23141484, PII: S0735-1097(12)04651-7, DOI: 10.1016/j.jacc.2012.09.013, ISSN: 1558-3597.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23141484.
  • Ooms LS, Jerome WG, Dermody TS, Chappell JD. Reovirus replication protein µ2 influences cell tropism by promoting particle assembly within viral inclusions. J. Virol [print-electronic]. 2012 Oct; 86(20): 10979-87. PMID: 22837214, PMCID: PMC3457141, PII: JVI.01172-12, DOI: 10.1128/JVI.01172-12, ISSN: 1098-5514.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22837214.
  • Kirkbride KC, Hong NH, French CL, Clark ES, Jerome WG, Weaver AM. Regulation of late endosomal/lysosomal maturation and trafficking by cortactin affects Golgi morphology. Cytoskeleton (Hoboken) [print-electronic]. 2012 Sep; 69(9): 625-43. PMID: 22991200, PMCID: PMC3746372, DOI: 10.1002/cm.21051, ISSN: 1949-3592.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22991200.
  • Sorci-Thomas MG, Owen JS, Fulp B, Bhat S, Zhu X, Parks JS, Shah D, Jerome WG, Gerelus M, Zabalawi M, Thomas MJ. Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers. J. Lipid Res [print-electronic]. 2012 Sep; 53(9): 1890-909. PMID: 22750655, PMCID: PMC3413229, PII: jlr.M026674, DOI: 10.1194/jlr.M026674, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22750655.
  • Cai Q, Brissova M, Reinert RB, Pan FC, Brahmachary P, Jeansson M, Shostak A, Radhika A, Poffenberger G, Quaggin SE, Jerome WG, Dumont DJ, Powers AC. Enhanced expression of VEGF-A in ß cells increases endothelial cell number but impairs islet morphogenesis and ß cell proliferation. Dev. Biol [print-electronic]. 2012 Jul 7/1/2012; 367(1): 40-54. PMID: 22546694, PMCID: PMC3391601, PII: S0012-1606(12)00211-4, DOI: 10.1016/j.ydbio.2012.04.022, ISSN: 1095-564X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22546694.
  • Deng X, Morris J, Dressmen J, Tubb MR, Tso P, Jerome WG, Davidson WS, Thompson TB. The structure of dimeric apolipoprotein A-IV and its mechanism of self-association. Structure. 2012 May 5/9/2012; 20(5): 767-79. PMID: 22579246, PMCID: PMC3354570, PII: S0969-2126(12)00100-1, DOI: 10.1016/j.str.2012.02.020, ISSN: 1878-4186.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22579246.
  • Weibel GL, Joshi MR, Jerome WG, Bates SR, Yu KJ, Phillips MC, Rothblat GH. Cytoskeleton disruption in J774 macrophages: consequences for lipid droplet formation and cholesterol flux. Biochim. Biophys. Acta [print-electronic]. 2012 Mar; 1821(3): 464-72. PMID: 22015387, PMCID: PMC3274585, PII: S1388-1981(11)00185-5, DOI: 10.1016/j.bbalip.2011.09.015, ISSN: 0006-3002.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22015387.
  • Yu SS, Lau CM, Thomas SN, Jerome WG, Maron DJ, Dickerson JH, Hubbell JA, Giorgio TD. Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages. Int J Nanomedicine [print-electronic]. 2012; 7: 799-813. PMID: 22359457, PMCID: PMC3284223, PII: ijn-7-799, DOI: 10.2147/IJN.S28531, ISSN: 1178-2013.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22359457.
  • Huang R, Silva RA, Jerome WG, Kontush A, Chapman MJ, Curtiss LK, Hodges TJ, Davidson WS. Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma. Nat. Struct. Mol. Biol [print-electronic]. 2011 Apr; 18(4): 416-22. PMID: 21399642, PMCID: PMC3079355, PII: nsmb.2028, DOI: 10.1038/nsmb.2028, ISSN: 1545-9985.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21399642.
  • [place unknown: publisher unknown]; 2011.
  • Gauthamadasa K, Rosales C, Pownall HJ, Macha S, Jerome WG, Huang R, Silva RA. Speciated human high-density lipoprotein protein proximity profiles. Biochemistry [print-electronic]. 2010 Dec 12/21/2010; 49(50): 10656-65. PMID: 21073165, PMCID: PMC3006032, DOI: 10.1021/bi1015452, ISSN: 1520-4995.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21073165.
  • Jerome WG. Lysosomes, cholesterol and atherosclerosis. Clin Lipidol. 2010 Dec 12/1/2010; 5(6): 853-65. PMID: 21643524, PMCID: PMC3105626, DOI: 10.2217/clp.10.70, ISSN: 1758-4299.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21643524.
  • Vaezi MF, Slaughter JC, Smith BS, Washington MK, Jerome WG, Garrett CG, Hagaman D, Goutte M. Dilated intercellular space in chronic laryngitis and gastro-oesophageal reflux disease: at baseline and post-lansoprazole therapy. Aliment. Pharmacol. Ther. 2010 Oct; 32(7): 916-24. PMID: 20735783, DOI: 10.1111/j.1365-2036.2010.04420.x, ISSN: 1365-2036.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20735783.
  • Jiang M, Fernandez S, Jerome WG, He Y, Yu X, Cai H, Boone B, Yi Y, Magnuson MA, Roy-Burman P, Matusik RJ, Shappell SB, Hayward SW. Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy. Cell Death Differ [print-electronic]. 2010 Mar; 17(3): 469-81. PMID: 19834493, PMCID: PMC2821953, PII: cdd2009148, DOI: 10.1038/cdd.2009.148, ISSN: 1476-5403.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19834493.
  • Gu F, Jones MK, Chen J, Patterson JC, Catte A, Jerome WG, Li L, Segrest JP. Structures of discoidal high density lipoproteins: a combined computational-experimental approach. J. Biol. Chem [print-electronic]. 2010 Feb 2/12/2010; 285(7): 4652-65. PMID: 19948731, PMCID: PMC2836071, PII: M109.069914, DOI: 10.1074/jbc.M109.069914, ISSN: 1083-351X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19948731.
  • Jiang M, Jerome WG, Hayward SW. Autophagy in nuclear receptor PPARgamma-deficient mouse prostatic carcinogenesis. Autophagy [print-electronic]. 2010 Jan; 6(1): 175-6. PMID: 20009560, PII: 10700, ISSN: 1554-8635.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20009560.
  • Ullery-Ricewick JC, Cox BE, Griffin EE, Jerome WG. Triglyceride alters lysosomal cholesterol ester metabolism in cholesteryl ester-laden macrophage foam cells. J. Lipid Res [print-electronic]. 2009 Oct; 50(10): 2014-26. PMID: 19461120, PMCID: PMC2739755, PII: M800659-JLR200, DOI: 10.1194/jlr.M800659-JLR200, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19461120.
  • Chen B, Ren X, Neville T, Jerome WG, Hoyt DW, Sparks D, Ren G, Wang J. Apolipoprotein AI tertiary structures determine stability and phospholipid-binding activity of discoidal high-density lipoprotein particles of different sizes. Protein Sci. 2009 May; 18(5): 921-35. PMID: 19384992, PMCID: PMC2771295, DOI: 10.1002/pro.101, ISSN: 1469-896X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19384992.
  • Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR. Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ. Res [print-electronic]. 2009 Feb 2/27/2009; 104(4): 455-65. PMID: 19122179, PMCID: PMC2680702, PII: CIRCRESAHA.108.182568, DOI: 10.1161/CIRCRESAHA.108.182568, ISSN: 1524-4571.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19122179.
  • Cao Z, Li C, Higginbotham JN, Franklin JL, Tabb DL, Graves-Deal R, Hill S, Cheek K, Jerome WG, Lapierre LA, Goldenring JR, Ham AJ, Coffey RJ. Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Mol. Cell Proteomics [print-electronic]. 2008 Sep; 7(9): 1651-67. PMID: 18504258, PMCID: PMC2528074, PII: M700155-MCP200, DOI: 10.1074/mcp.M700155-MCP200, ISSN: 1535-9484.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18504258.
  • Silva RA, Huang R, Morris J, Fang J, Gracheva EO, Ren G, Kontush A, Jerome WG, Rye KA, Davidson WS. Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2008 Aug 8/26/2008; 105(34): 12176-81. PMID: 18719128, PMCID: PMC2527885, PII: 0803626105, DOI: 10.1073/pnas.0803626105, ISSN: 1091-6490.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18719128.
  • Jerome WG, Cox BE, Griffin EE, Ullery JC. Lysosomal cholesterol accumulation inhibits subsequent hydrolysis of lipoprotein cholesteryl ester. Microsc. Microanal [print-electronic]. 2008 Apr; 14(2): 138-49. PMID: 18312718, PMCID: PMC2837357, PII: S1431927608080069, DOI: 10.1017/S1431927608080069, ISSN: 1431-9276.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18312718.
  • Zhang Y, Vasudevan S, Sojitrawala R, Zhao W, Cui C, Xu C, Fan D, Newhouse Y, Balestra R, Jerome WG, Weisgraber K, Li Q, Wang J. A monomeric, biologically active, full-length human apolipoprotein E. Biochemistry [print-electronic]. 2007 Sep 9/18/2007; 46(37): 10722-32. PMID: 17715945, DOI: 10.1021/bi700672v, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17715945.
  • Fan D, Qiu S, Overton CD, Yancey PG, Swift LL, Jerome WG, Linton MF, Fazio S. Impaired secretion of apolipoprotein E2 from macrophages. J. Biol. Chem [print-electronic]. 2007 May 5/4/2007; 282(18): 13746-53. PMID: 17341585, PII: M611754200, DOI: 10.1074/jbc.M611754200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17341585.
  • Cox BE, Griffin EE, Ullery JC, Jerome WG. Effects of cellular cholesterol loading on macrophage foam cell lysosome acidification. J. Lipid Res [print-electronic]. 2007 May; 48(5): 1012-21. PMID: 17308299, PII: M600390-JLR200, DOI: 10.1194/jlr.M600390-JLR200, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17308299.
  • Yancey PG, Jerome WG, Yu H, Griffin EE, Cox BE, Babaev VR, Fazio S, Linton MF. Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI. J. Lipid Res [print-electronic]. 2007 May; 48(5): 1140-9. PMID: 17299204, PII: M600539-JLR200, DOI: 10.1194/jlr.M600539-JLR200, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17299204.
  • Brissova M, Shostak A, Shiota M, Wiebe PO, Poffenberger G, Kantz J, Chen Z, Carr C, Jerome WG, Chen J, Baldwin HS, Nicholson W, Bader DM, Jetton T, Gannon M, Powers AC. Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes. 2006 Nov; 55(11): 2974-85. PMID: 17065333, PII: 55/11/2974, DOI: 10.2337/db06-0690, ISSN: 0012-1797.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17065333.
  • Catte A, Patterson JC, Jones MK, Jerome WG, Bashtovyy D, Su Z, Gu F, Chen J, Aliste MP, Harvey SC, Li L, Weinstein G, Segrest JP. Novel changes in discoidal high density lipoprotein morphology: a molecular dynamics study. Biophys. J [print-electronic]. 2006 Jun 6/15/2006; 90(12): 4345-60. PMID: 16581834, PMCID: PMC1471865, PII: biophysj.105.071456, DOI: 10.1529/biophysj.105.071456, ISSN: 0006-3495.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16581834.
  • Jerome WG. Advanced atherosclerotic foam cell formation has features of an acquired lysosomal storage disorder. Rejuvenation Res. 2006; 9(2): 245-55. PMID: 16706652, DOI: 10.1089/rej.2006.9.245, ISSN: 1549-1684.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16706652.
  • Wilkinson M, Cline M, Jerome WG. Cytopathic herpesvirus infection in a green iguana (Iguana iguana). J. Zoo Wildl. Med. 2005 Dec; 36(4): 724-6. PMID: 17312736, DOI: 10.1638/03-067.1, ISSN: 1042-7260.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17312736.
  • Ren X, Zhao L, Sivashanmugam A, Miao Y, Korando L, Yang Z, Reardon CA, Getz GS, Brouillette CG, Jerome WG, Wang J. Engineering mouse apolipoprotein A-I into a monomeric, active protein useful for structural determination. Biochemistry. 2005 Nov 11/15/2005; 44(45): 14907-19. PMID: 16274238, DOI: 10.1021/bi0508385, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16274238.
  • Griffin EE, Ullery JC, Cox BE, Jerome WG. Aggregated LDL and lipid dispersions induce lysosomal cholesteryl ester accumulation in macrophage foam cells. J. Lipid Res [print-electronic]. 2005 Oct; 46(10): 2052-60. PMID: 16024919, PII: M500059-JLR200, DOI: 10.1194/jlr.M500059-JLR200, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16024919.
  • de Grey AD, Alvarez PJ, Brady RO, Cuervo AM, Jerome WG, McCarty PL, Nixon RA, Rittmann BE, Sparrow JR. Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases. Ageing Res. Rev. 2005 Aug; 4(3): 315-38. PMID: 16040282, PII: S1568-1637(05)00011-5, DOI: 10.1016/j.arr.2005.03.008, ISSN: 1568-1637.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16040282.
  • Settle SH, Washington K, Lind C, Itzkowitz S, Fiske WH, Burdick JS, Jerome WG, Ray M, Weinstein W, Coffey RJ. Chronic treatment of Ménétrier's disease with Erbitux: clinical efficacy and insight into pathophysiology. Clin. Gastroenterol. Hepatol. 2005 Jul; 3(7): 654-9. PMID: 16206497, ISSN: 1542-3565.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16206497.
  • Swift LL, Kakkad B, Boone C, Jovanovska A, Jerome WG, Mohler PJ, Ong DE. Microsomal triglyceride transfer protein expression in adipocytes: a new component in fat metabolism. FEBS Lett. 2005 Jun 6/6/2005; 579(14): 3183-9. PMID: 15922333, PII: S0014-5793(05)00584-3, DOI: 10.1016/j.febslet.2005.05.009, ISSN: 0014-5793.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15922333.
  • Jerome WG, Handt S, Hantgan RR. Endothelial cells organize fibrin clots into structures that are more resistant to lysis. Microsc. Microanal. 2005 Jun; 11(3): 268-77. PMID: 16060980, PII: S143192760505052X, DOI: 10.1017/S143192760505052X, ISSN: 1431-9276.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16060980.
  • Dove DE, Su YR, Zhang W, Jerome WG, Swift LL, Linton MF, Fazio S. ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology in macrophages. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2005 Jan; 25(1): 128-34. PMID: 15499044, PII: 01.ATV.0000148323.94021.e5, DOI: 10.1161/01.ATV.0000148323.94021.e5, ISSN: 1524-4636.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15499044.
  • W. Gray Jerome, Stefan Handt, Roy R. Hantgan. Endothelial Cells Organize Fibrin Clots into Structures That Are More Resistant to Lysis. Microscopy and Microanalysis. 2005; 11((3)): 268-77.
  • Fan D, Li Q, Korando L, Jerome WG, Wang J. A monomeric human apolipoprotein E carboxyl-terminal domain. Biochemistry. 2004 May 5/4/2004; 43(17): 5055-64. PMID: 15109264, DOI: 10.1021/bi035958w, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15109264.
  • Li C, Franklin JL, Graves-Deal R, Jerome WG, Cao Z, Coffey RJ. Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2004 Apr 4/13/2004; 101(15): 5571-6. PMID: 15064403, PMCID: PMC397424, PII: 0401294101, DOI: 10.1073/pnas.0401294101, ISSN: 0027-8424.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15064403.
  • Prentice E, Jerome WG, Yoshimori T, Mizushima N, Denison MR. Coronavirus replication complex formation utilizes components of cellular autophagy. J. Biol. Chem [print-electronic]. 2004 Mar 3/12/2004; 279(11): 10136-41. PMID: 14699140, PII: M306124200, DOI: 10.1074/jbc.M306124200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14699140.
  • Swift LL, Zhu MY, Kakkad B, Jovanovska A, Neely MD, Valyi-Nagy K, Roberts RL, Ong DE, Jerome WG. Subcellular localization of microsomal triglyceride transfer protein. J. Lipid Res [print-electronic]. 2003 Oct; 44(10): 1841-9. PMID: 12837846, PII: M300276-JLR200, DOI: 10.1194/jlr.M300276-JLR200, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12837846.
  • Jerome WG, Yancey PG. The role of microscopy in understanding atherosclerotic lysosomal lipid metabolism. Microsc. Microanal. 2003 Feb; 9(1): 54-67. PMID: 12597787, PII: S1431927603030010, DOI: 10.1017/S1431927603030010, ISSN: 1431-9276.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12597787.
  • Grant K, Jerome WG. Laser capture microdissection as an aid to ultrastructural analysis. Microsc. Microanal. 2002 Jun; 8(3): 170-5. PMID: 12539787, ISSN: 1431-9276.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12539787.
  • Hantgan RR, Stahle MC, Jerome WG, Nagaswami C, Weisel JW. Tirofiban blocks platelet adhesion to fibrin with minimal perturbation of GpIIb/IIIa structure. Thromb. Haemost. 2002 May; 87(5): 910-7. PMID: 12038797, ISSN: 0340-6245.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12038797.
  • Yancey PG, Miles S, Schwegel J, Jerome WG. Uptake and trafficking of mildly oxidized LDL and acetylated LDL in THP-1 cells does not explain the differences in lysosomal metabolism of these two lipoproteins. Microsc. Microanal. 2002 Apr; 8(2): 81-93. PMID: 12533238, PII: S1431927601020013, DOI: 10.1017.S1431927601020013, ISSN: 1431-9276.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12533238.
  • Hantgan RR, Stahle M, Del Gaizo V, Adams M, Lasher T, Jerome WG, McKenzie M, Lyles DS. AlphaIIb's cytoplasmic domain is not required for ligand-induced clustering of integrin alphaIIbbeta3. Biochim. Biophys. Acta. 2001 Jul 7/25/2001; 1540(1): 82-95. PMID: 11476897, PII: S0167-4889(01)00120-3, ISSN: 0006-3002.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11476897.
  • Yancey PG, Jerome WG. Lysosomal cholesterol derived from mildly oxidized low density lipoprotein is resistant to efflux. J. Lipid Res. 2001 Mar; 42(3): 317-27. PMID: 11254742, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11254742.
  • Bonnefoy A, Liu Q, Jerome WG, Legrand C, Frojmovic MM. Platelets in suspension require preactivation to adhere to immobilized fibrinogen. Ann. N. Y. Acad. Sci. 2001; 936: 459-63. PMID: 11460502, ISSN: 0077-8923.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11460502.
  • Yancey PG, Jerome WG. Lysosomal cholesterol derived from mildly oxidized low density lipoprotein is resistant to efflux. 2001.
  • Cashell AW, Jerome WG, Flores E. Signet ring stromal tumor of the ovary occurring in conjunction with brenner tumor. Gynecol. Oncol. 2000 May; 77(2): 323-6. PMID: 10785488, PII: S0090-8258(00)95763-9, DOI: 10.1006/gyno.2000.5763, ISSN: 0090-8258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10785488.
  • Stokes AH, Lewis DY, Lash LH, Jerome WG, Grant KW, Aschner M, Vrana KE. Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by L-BSO and apoptosis. Brain Res. 2000 Mar 3/6/2000; 858(1): 1-8. PMID: 10700589, PII: S0006-8993(99)02329-X, ISSN: 0006-8993.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10700589.
  • Kellner-Weibel G, Yancey PG, Jerome WG, Walser T, Mason RP, Phillips MC, Rothblat GH. Crystallization of free cholesterol in model macrophage foam cells. Arterioscler. Thromb. Vasc. Biol. 1999 Aug; 19(8): 1891-8. PMID: 10446067, ISSN: 1079-5642.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10446067.
  • Avart SJ, Bernard DW, Jerome WG, Glick JM. Cholesteryl ester hydrolysis in J774 macrophages occurs in the cytoplasm and lysosomes. J. Lipid Res. 1999 Mar; 40(3): 405-14. PMID: 10064728, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10064728.
  • Kellner-Weibel G, Yancey PG, Jerome WG, Walser T, Mason RP, Phillips MC,Rothblat GH. Crystallization of free cholesterol in model macrophage foam cells. 1999.
  • Hantgan RR, Jerome WG, Hursting MJ. No effect of clot age or thrombolysis on argatroban's inhibition of thrombin. Blood. 1998 Sep 9/15/1998; 92(6): 2064-74. PMID: 9731064, ISSN: 0006-4971.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9731064.
  • Jerome WG, Cash C, Webber R, Horton R, Yancey PG. Lysosomal lipid accumulation from oxidized low density lipoprotein is correlated with hypertrophy of the Golgi apparatus and trans-Golgi network. J. Lipid Res. 1998 Jul; 39(7): 1362-71. PMID: 9684738, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9684738.
  • Yancey PG, Jerome WG. Lysosomal sequestration of free and esterified cholesterol from oxidized low density lipoprotein in macrophages of different species. J. Lipid Res. 1998 Jul; 39(7): 1349-61. PMID: 9684737, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9684737.
  • Hantgan RR, Jerome WG, Handt S. Platelets and endothelial cells act in concert to delay thrombolysis--evidence from an in vitro model of the human occlusive thrombus. Thromb. Haemost. 1998 Mar; 79(3): 602-8. PMID: 9531049, PII: 98030602, ISSN: 0340-6245.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9531049.
  • Kellner-Weibel G, Jerome WG, Small DM, Warner GJ, Stoltenborg JK, Kearney MA, Corjay MH, Phillips MC, Rothblat GH. Effects of intracellular free cholesterol accumulation on macrophage viability: a model for foam cell death. Arterioscler. Thromb. Vasc. Biol. 1998 Mar; 18(3): 423-31. PMID: 9514411, ISSN: 1079-5642.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9514411.
  • Hantgan RR, Jerome WG, Handt S. Platelets and endothelial cells act in concert to delay thrombolysis--evidence from an in vitro model of the human occlusive thrombus. 1998.
  • Tansey JT, Thuren TY, Jerome WG, Hantgan RR, Grant K, Waite M. Hydrolysis of phosphatidylcholine by hepatic lipase in discoidal and spheroidal recombinant high-density lipoprotein. Biochemistry. 1997 Oct 10/7/1997; 36(40): 12227-34. PMID: 9315860, PII: bi970356w, DOI: 10.1021/bi970356w, ISSN: 0006-2960.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9315860.
  • Carlson CS, O'Sullivan MG, Jayo MJ, Anderson DK, Harber ES, Jerome WG, Bullock BC, Heberling RL. Fatal disseminated cercopithecine herpesvirus 1 (herpes B infection in cynomolgus monkeys (Macaca fascicularis). Vet. Pathol. 1997 Sep; 34(5): 405-14. PMID: 9381651, ISSN: 0300-9858.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9381651.
  • Jerome WG, Lewis JC. Cellular dynamics in early atherosclerotic lesion progression in white carneau pigeons. Spatial and temporal analysis of monocyte and smooth muscle invasion of the intima. Arterioscler. Thromb. Vasc. Biol. 1997 Apr; 17(4): 654-64. PMID: 9108777, ISSN: 1079-5642.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9108777.
  • Handt S, Jerome WG, Tietze L, Hantgan RR. Plasminogen activator inhibitor-1 secretion of endothelial cells increases fibrinolytic resistance of an in vitro fibrin clot: evidence for a key role of endothelial cells in thrombolytic resistance. Blood. 1996 May 5/15/1996; 87(10): 4204-13. PMID: 8639779, ISSN: 0006-4971.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8639779.
  • Lyles DS, McKenzie MO, Kaptur PE, Grant KW, Jerome WG. Complementation of M gene mutants of vesicular stomatitis virus by plasmid-derived M protein converts spherical extracellular particles into native bullet shapes. Virology. 1996 Mar 3/1/1996; 217(1): 76-87. PMID: 8599238, PII: S0042-6822(96)90095-1, DOI: 10.1006/viro.1996.0095, ISSN: 0042-6822.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8599238.
  • Endenburg SC, Hantgan RR, Lindeboom-Blokzijl L, Lankhof H, Jerome WG, Lewis JC, Sixma JJ, de Groot PG. On the role of von Willebrand factor in promoting platelet adhesion to fibrin in flowing blood. Blood. 1995 Dec 12/1/1995; 86(11): 4158-65. PMID: 7492773, ISSN: 0006-4971.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7492773.
  • Jerome WL. The scientific method [letter]. Br Dent J. 1994 Dec 12/10/1994; 177(11-12): 401. PMID: 7865018, ISSN: 0007-0610.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7865018.
  • Lantz PE, Jerome WG, Jaworski JA. Radiopaque deposits surrounding a contact small-caliber gunshot wound. Am J Forensic Med Pathol. 1994 Mar; 15(1): 10-3. PMID: 8166107, ISSN: 0195-7910.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8166107.
  • Braaten JV, Jerome WG, Hantgan RR. Uncoupling fibrin from integrin receptors hastens fibrinolysis at the platelet-fibrin interface. Blood. 1994 Feb 2/15/1994; 83(4): 982-93. PMID: 8111066, ISSN: 0006-4971.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8111066.
  • Tangirala RK, Jerome WG, Jones NL, Small DM, Johnson WJ, Glick JM, Mahlberg FH, Rothblat GH. Formation of cholesterol monohydrate crystals in macrophage-derived foam cells. J. Lipid Res. 1994 Jan; 35(1): 93-104. PMID: 8138726, ISSN: 0022-2275.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8138726.
  • Tangirala RK, Mahlberg FH, Glick JM, Jerome WG, Rothblat GH. Lysosomal accumulation of unesterified cholesterol in model macrophage foam cells. J. Biol. Chem. 1993 May 5/5/1993; 268(13): 9653-60. PMID: 8486653, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8486653.
  • Braaten JV, Handt S, Jerome WG, Kirkpatrick J, Lewis JC, Hantgan RR. Regulation of fibrinolysis by platelet-released plasminogen activator inhibitor 1: light scattering and ultrastructural examination of lysis of a model platelet-fibrin thrombus. Blood. 1993 Mar 3/1/1993; 81(5): 1290-9. PMID: 8443390, ISSN: 0006-4971.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8443390.
  • Taylor RG, Jerome WG, Lewis JC. Ultrastructural localization of peroxidase in atherosclerotic lesions of pigeons. Exp. Mol. Pathol. 1992 Dec; 57(3): 167-79. PMID: 1337517, ISSN: 0014-4800.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1337517.
  • Jerome WL. Mercury from dental amalgam [letter]. Br Dent J. 1992 Oct 10/24/1992; 173(7): 227-8. PMID: 1419385, ISSN: 0007-0610.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1419385.
  • Thomas MJ, Hedrick CC, Smith S, Pang J, Jerome WG, Willard AS, Shirley PS. Superoxide generation by the human polymorphonuclear leukocyte in response to latex beads. J. Leukoc. Biol. 1992 Jun; 51(6): 591-6. PMID: 1319445, ISSN: 0741-5400.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1319445.
  • Loeser R, Carlson CS, Tulli H, Jerome WG, Miller L, Wallin R. Articular-cartilage matrix gamma-carboxyglutamic acid-containing protein. Characterization and immunolocalization. Biochem. J. 1992 Feb 2/15/1992; 282 ( Pt 1): 1-6. PMID: 1540125, PMCID: PMC1130882, ISSN: 0264-6021.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1540125.
  • Moyer CF, Jerome WG, Taylor R, Tulli H, Reinisch CL. Autoimmune vasculitis in MRL/Mp-lpr/lpr mice: orthochromatic basophils participate in the development of delayed-type hypersensitivity angiitis. Autoimmunity. 1992; 12(3): 159-65. PMID: 1343764, ISSN: 0891-6934.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1343764.
  • Jones NL, Jerome WG, Lewis JC. Pigeon monocyte/macrophage lysosomes during beta VLDL uptake. Induction of acid phosphatase activity. A model for complex arterial lysosomes. Am. J. Pathol. 1991 Aug; 139(2): 383-92. PMID: 1867324, PMCID: PMC1886089, ISSN: 0002-9440.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1867324.
  • Barr DA, Jerome WG, Lewis JC. Morphologic characteristics of naturally occurring atherosclerosis in the brachiocephalic artery of the pigeon. Exp. Mol. Pathol. 1991 Apr; 54(2): 99-111. PMID: 2029938, ISSN: 0014-4800.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2029938.
  • Jerome WG, Minor LK, Glick JM, Rothblat GH, Lewis JC. Lysosomal lipid accumulation in vascular smooth muscle cells. Exp. Mol. Pathol. 1991 Apr; 54(2): 144-58. PMID: 2029935, ISSN: 0014-4800.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2029935.
  • Minor LK, Mahlberg FH, Jerome WG, Lewis JC, Rothblat GH, Glick JM. Lysosomal hydrolysis of lipids in a cell culture model of smooth muscle foam cells. Exp. Mol. Pathol. 1991 Apr; 54(2): 159-71. PMID: 2029936, ISSN: 0014-4800.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2029936.
  • Jerome WG, Lewis JC. Early atherogenesis in White Carneau pigeons: effect of a short-term regression diet. Exp. Mol. Pathol. 1990 Dec; 53(3): 223-38. PMID: 2257930, ISSN: 0014-4800.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2257930.
  • Mahlberg FH, Glick JM, Jerome WG, Rothblat GH. Metabolism of cholesteryl ester lipid droplets in a J774 macrophage foam cell model. Biochim. Biophys. Acta. 1990 Aug 8/6/1990; 1045(3): 291-8. PMID: 2386801, ISSN: 0006-3002.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2386801.
  • Taylor RG, Jerome WG, Lewis JC. Ultrastructural events associated with endothelial cell changes during the initiation and early progression of atherosclerosis. Adv. Exp. Med. Biol. 1990; 273: 89-93. PMID: 2288294, ISSN: 0065-2598.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2288294.
  • Noseda A, White JG, Godwin PL, Jerome WG, Modest EJ. Membrane damage in leukemic cells induced by ether and ester lipids: an electron microscopic study. Exp. Mol. Pathol. 1989 Feb; 50(1): 69-83. PMID: 2920821, ISSN: 0014-4800.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2920821.
  • Jerome WG, Lewis JC. Early atherogenesis in the White Carneau pigeon. III. Lipid accumulation in nascent foam cells. Am. J. Pathol. 1987 Aug; 128(2): 253-64. PMID: 3618727, PMCID: PMC1899621, ISSN: 0002-9440.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3618727.
  • Jerome WG, Lewis JC. Early atherogenesis in White Carneau pigeons. II. Ultrastructural and cytochemical observations. Am. J. Pathol. 1985 May; 119(2): 210-22. PMID: 3993740, PMCID: PMC1887902, ISSN: 0002-9440.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3993740.
  • Lewis JC, Taylor RG, Jerome WG. Foam cell characteristics in coronary arteries and aortas of White Carneau pigeons with moderate hypercholesterolemia. Ann. N. Y. Acad. Sci. 1985; 454: 91-100. PMID: 3865617, ISSN: 0077-8923.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3865617.
  • Jerome WG, Lewis JC. Early atherogenesis in White Carneau pigeons. I. Leukocyte margination and endothelial alterations at the celiac bifurcation. Am. J. Pathol. 1984 Jul; 116(1): 56-68. PMID: 6742108, PMCID: PMC1900365, ISSN: 0002-9440.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/6742108.
  • Jerome WG, Cardell RR. Observations on the role of smooth endoplasmic reticulumin glucocorticoid-induced hepatic glycogen deposition. Tissue Cell. 1983; 15(5): 711-27. PMID: 6648953, PII: 0040-8166(83)90045-9, ISSN: 0040-8166.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/6648953.
  • Jerome WG, Lewis JC, Taylor RG, White MS. Concurrent endothelial cell turnover and leukocyte margination in early atherosclerosis. Scan Electron Microsc. 1983; (Pt 3): 1453-9. PMID: 6648351, ISSN: 0586-5581.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/6648351.
  • Jerome WG. Medical electron microscopy. Invest Urol. 1981 Nov; 19(3): 131-5. PMID: 6795146, ISSN: 0021-0005.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/6795146.