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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 
Jeffrey R.  Smith

Jeffrey R. Smith, M.D., Ph.D.

Associate Professor of Medicine, Cancer Biology
Researcher

Contact Information:

Vanderbilt University Medical Center
535 Light Hall
2215 Garland Avenue
Nashville, TN 37232-0275
615-936-2171

Research Description

Our research group investigates genetic predisposition to cancer, with parallel goals of elucidating causality and contributing to personalized medicine. We apply state-of-the-art genomics technology and custom bioinformatics in large-scale projects of breast and prostate cancer. We have also contributed genomics tools for the zebrafish model organism.

The breast cancer project is a collaborative study with Dr. William Dupont to determine genetic causes of breast cancer within the Nashville Breast Cohort (NBC) and additional breast cancer study populations. The NBC is a cohort of 8000 women with benign forms of breast disease who have been followed for over two decades for the development of invasive breast cancer. The cohort enables investigation of genetic, epidemiologic, and pathologic factors in the progression of premalignant breast lesions to invasive breast cancer.

Our prostate cancer project investigates genetic causes of familial prostate cancer. Prostate cancer has the largest heritable risk of all common cancers, but relatively little is known about the underlying genetic etiology. The study population is comprised of 1000 prostate cancer cases with a family history the disease, and 1000 controls without any personal or family history of prostate cancer (comparing those in the extremes of the distribution of genetic load for prostate cancer).

A third project has developed genetic mapping resources for the zebrafish vertebrate model organism. We identified 1.2 million SNPs, developed a high-resolution genetic map, and characterized the diversity and ancestry of common strains. As an example of the utility of the resource, we demonstrated that sex determination in zebrafish is a complex trait, not involving sex chromosomes.

Publications
  • Chung CP, Solus JF, Oeser A, Li C, Raggi P, Smith JR, Stein CM. Genetic variation and coronary atherosclerosis in patients with systemic lupus erythematosus. Lupus [print-electronic]. 2014 Aug; 23(9): 876-80. PMID: 24699314, PMCID: PMC4185017, PII: 0961203314530019, DOI: 10.1177/0961203314530019, ISSN: 1477-0962.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24699314.
  • Breyer JP, Dorset DC, Clark TA, Bradley KM, Wahlfors TA, McReynolds KM, Maynard WH, Chang SS, Cookson MS, Smith JA, Schleutker J, Dupont WD, Smith JR. An expressed retrogene of the master embryonic stem cell gene POU5F1 is associated with prostate cancer susceptibility. Am. J. Hum. Genet [print-electronic]. 2014 Mar 3/6/2014; 94(3): 395-404. PMID: 24581739, PMCID: PMC3951923, PII: S0002-9297(14)00057-3, DOI: 10.1016/j.ajhg.2014.01.019, ISSN: 1537-6605.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24581739.
  • Gray RS, Wilm TP, Smith J, Bagnat M, Dale RM, Topczewski J, Johnson SL, Solnica-Krezel L. Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations. Dev. Biol [print-electronic]. 2014 Feb 2/1/2014; 386(1): 72-85. PMID: 24333517, PMCID: PMC3938106, PII: S0012-1606(13)00645-3, DOI: 10.1016/j.ydbio.2013.11.028, ISSN: 1095-564X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24333517.
  • Kodaman N, Aldrich MC, Smith JR, Signorello LB, Bradley K, Breyer J, Cohen SS, Long J, Cai Q, Giles J, Bush WS, Blot WJ, Matthews CE, Williams SM. A small number of candidate gene SNPs reveal continental ancestry in African Americans. Ann. Hum. Genet. 2013 Jan; 77(1): 56-66. PMID: 23278390, PMCID: PMC3677760, DOI: 10.1111/j.1469-1809.2012.00738.x, ISSN: 1469-1809.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23278390.
  • Higginbotham KS, Breyer JP, McReynolds KM, Bradley KM, Schuyler PA, Plummer WD, Freudenthal ME, Trentham-Dietz A, Newcomb PA, Parl FF, Sanders ME, Page DL, Egan KM, Dupont WD, Smith JR. A multistage genetic association study identifies breast cancer risk loci at 10q25 and 16q24. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2012 Sep; 21(9): 1565-73. PMID: 22806168, PMCID: PMC3707501, PII: 1055-9965.EPI-12-0386, DOI: 10.1158/1055-9965.EPI-12-0386, ISSN: 1538-7755.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22806168.
  • Breyer JP, Avritt TG, McReynolds KM, Dupont WD, Smith JR. Confirmation of the HOXB13 G84E germline mutation in familial prostate cancer. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2012 Aug; 21(8): 1348-53. PMID: 22714738, PMCID: PMC3415588, PII: 1055-9965.EPI-12-0495, DOI: 10.1158/1055-9965.EPI-12-0495, ISSN: 1538-7755.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22714738.
  • Edwards TL, Velez Edwards DR, Villegas R, Cohen SS, Buchowski MS, Fowke JH, Schlundt D, Long J, Cai Q, Zheng W, Shu XO, Hargreaves MK, Smith J, Williams SM, Signorello LB, Blot WJ, Matthews CE. HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes. Am. J. Epidemiol [print-electronic]. 2012 Jan 1/1/2012; 175(1): 11-21. PMID: 22106445, PMCID: PMC3244609, PII: kwr272, DOI: 10.1093/aje/kwr272, ISSN: 1476-6256.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22106445.
  • Melville DB, Montero-Balaguer M, Levic DS, Bradley K, Smith JR, Hatzopoulos AK, Knapik EW. The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. Dis Model Mech [print-electronic]. 2011 Nov; 4(6): 763-76. PMID: 21729877, PMCID: PMC3209646, PII: dmm.007625, DOI: 10.1242/dmm.007625, ISSN: 1754-8411.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21729877.
  • Cohen SS, Gammon MD, North KE, Millikan RC, Lange EM, Williams SM, Zheng W, Cai Q, Long J, Smith JR, Signorello LB, Blot WJ, Matthews CE. ADIPOQ, ADIPOR1, and ADIPOR2 polymorphisms in relation to serum adiponectin levels and BMI in black and white women. Obesity (Silver Spring) [print-electronic]. 2011 Oct; 19(10): 2053-62. PMID: 21273992, PMCID: PMC3474141, PII: oby2010346, DOI: 10.1038/oby.2010.346, ISSN: 1930-739X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21273992.
  • Crooke PS, Justenhoven C, Brauch H, , Dawling S, Roodi N, Higginbotham KS, Plummer WD, Schuyler PA, Sanders ME, Page DL, Smith JR, Dupont WD, Parl FF. Estrogen metabolism and exposure in a genotypic-phenotypic model for breast cancer risk prediction. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2011 Jul; 20(7): 1502-15. PMID: 21610218, PMCID: PMC3472969, PII: 1055-9965.EPI-11-0060, DOI: 10.1158/1055-9965.EPI-11-0060, ISSN: 1538-7755.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21610218.
  • Bradley KM, Breyer JP, Melville DB, Broman KW, Knapik EW, Smith JR. An SNP-Based Linkage Map for Zebrafish Reveals Sex Determination Loci. G3 (Bethesda). 2011 Jun 6/1/2011; 1(1): 3-9. PMID: 21949597, PMCID: PMC3178105, DOI: 10.1534/g3.111.000190, ISSN: 2160-1836.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21949597.
  • Higginbotham KS, Breyer JP, Bradley KM, Schuyler PA, Plummer WD, Freudenthal ME, Trentham-Dietz A, Newcomb PA, Sanders ME, Page DL, Parl FF, Egan KM, Dupont WD, Smith JR. A multistage association study identifies a breast cancer genetic locus at NCOA7. Cancer Res [print-electronic]. 2011 Jun 6/1/2011; 71(11): 3881-8. PMID: 21610108, PMCID: PMC3137260, PII: 0008-5472.CAN-10-2653, DOI: 10.1158/0008-5472.CAN-10-2653, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21610108.
  • Signorello LB, Shi J, Cai Q, Zheng W, Williams SM, Long J, Cohen SS, Li G, Hollis BW, Smith JR, Blot WJ. Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D Levels among African Americans. PLoS ONE [print-electronic]. 2011; 6(12): e28623. PMID: 22205958, PMCID: PMC3244405, PII: PONE-D-11-12638, DOI: 10.1371/journal.pone.0028623, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22205958.
  • Signorello LB, Williams SM, Zheng W, Smith JR, Long J, Cai Q, Hargreaves MK, Hollis BW, Blot WJ. Blood vitamin d levels in relation to genetic estimation of African ancestry. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2010 Sep; 19(9): 2325-31. PMID: 20647395, PMCID: PMC2938736, PII: 1055-9965.EPI-10-0482, DOI: 10.1158/1055-9965.EPI-10-0482, ISSN: 1538-7755.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20647395.
  • Dupont WD, Breyer JP, Bradley KM, Schuyler PA, Plummer WD, Sanders ME, Page DL, Smith JR. Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk. Cancer. 2010 Jan 1/1/2010; 116(1): 8-19. PMID: 19890961, PMCID: PMC2807897, DOI: 10.1002/cncr.24702, ISSN: 0008-543X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19890961.
  • Gudmundsson J, Sulem P, Gudbjartsson DF, Blondal T, Gylfason A, Agnarsson BA, Benediktsdottir KR, Magnusdottir DN, Orlygsdottir G, Jakobsdottir M, Stacey SN, Sigurdsson A, Wahlfors T, Tammela T, Breyer JP, McReynolds KM, Bradley KM, Saez B, Godino J, Navarrete S, Fuertes F, Murillo L, Polo E, Aben KK, van Oort IM, Suarez BK, Helfand BT, Kan D, Zanon C, Frigge ML, Kristjansson K, Gulcher JR, Einarsson GV, Jonsson E, Catalona WJ, Mayordomo JI, Kiemeney LA, Smith JR, Schleutker J, Barkardottir RB, Kong A, Thorsteinsdottir U, Rafnar T, Stefansson K. Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Nat. Genet [print-electronic]. 2009 Oct; 41(10): 1122-6. PMID: 19767754, PMCID: PMC3562712, PII: ng.448, DOI: 10.1038/ng.448, ISSN: 1546-1718.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19767754.
  • Breyer JP, McReynolds KM, Yaspan BL, Bradley KM, Dupont WD, Smith JR. Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2009 Jul; 18(7): 2137-44. PMID: 19567509, PMCID: PMC2813685, PII: 1055-9965.EPI-08-1223, DOI: 10.1158/1055-9965.EPI-08-1223, ISSN: 1538-7755.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19567509.
  • Breyer JP, Sanders ME, Airey DC, Cai Q, Yaspan BL, Schuyler PA, Dai Q, Boulos F, Olivares MG, Bradley KM, Gao YT, Page DL, Dupont WD, Zheng W, Smith JR. Heritable variation of ERBB2 and breast cancer risk. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2009 Apr; 18(4): 1252-8. PMID: 19336545, PMCID: PMC2730036, PII: 1055-9965.EPI-08-1202, DOI: 10.1158/1055-9965.EPI-08-1202, ISSN: 1055-9965.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19336545.
  • Love HD, Booton SE, Boone BE, Breyer JP, Koyama T, Revelo MP, Shappell SB, Smith JR, Hayward SW. Androgen regulated genes in human prostate xenografts in mice: relation to BPH and prostate cancer. PLoS ONE. 2009; 4(12): e8384. PMID: 20027305, PMCID: PMC2793011, DOI: 10.1371/journal.pone.0008384, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20027305.
  • Ciarleglio CM, Ryckman KK, Servick SV, Hida A, Robbins S, Wells N, Hicks J, Larson SA, Wiedermann JP, Carver K, Hamilton N, Kidd KK, Kidd JR, Smith JR, Friedlaender J, McMahon DG, Williams SM, Summar ML, Johnson CH. Genetic differences in human circadian clock genes among worldwide populations. J. Biol. Rhythms. 2008 Aug; 23(4): 330-40. PMID: 18663240, PMCID: PMC2579796, PII: 23/4/330, DOI: 10.1177/0748730408320284, ISSN: 0748-7304.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18663240.
  • Ye C, Gao YT, Wen W, Breyer JP, Shu XO, Smith JR, Zheng W, Cai Q. Association of mitochondrial DNA displacement loop (CA)n dinucleotide repeat polymorphism with breast cancer risk and survival among Chinese women. Cancer Epidemiol. Biomarkers Prev. 2008 Aug; 17(8): 2117-22. PMID: 18708405, PMCID: PMC2643086, PII: 17/8/2117, DOI: 10.1158/1055-9965.EPI-07-2798, ISSN: 1055-9965.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18708405.
  • Yaspan BL, McReynolds KM, Elmore JB, Breyer JP, Bradley KM, Smith JR. A haplotype at chromosome Xq27.2 confers susceptibility to prostate cancer. Hum. Genet [print-electronic]. 2008 May; 123(4): 379-86. PMID: 18350320, PMCID: PMC2811403, DOI: 10.1007/s00439-008-0486-8, ISSN: 1432-1203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18350320.
  • Gudmundsson J, Sulem P, Rafnar T, Bergthorsson JT, Manolescu A, Gudbjartsson D, Agnarsson BA, Sigurdsson A, Benediktsdottir KR, Blondal T, Jakobsdottir M, Stacey SN, Kostic J, Kristinsson KT, Birgisdottir B, Ghosh S, Magnusdottir DN, Thorlacius S, Thorleifsson G, Zheng SL, Sun J, Chang BL, Elmore JB, Breyer JP, McReynolds KM, Bradley KM, Yaspan BL, Wiklund F, Stattin P, Lindström S, Adami HO, McDonnell SK, Schaid DJ, Cunningham JM, Wang L, Cerhan JR, St Sauver JL, Isaacs SD, Wiley KE, Partin AW, Walsh PC, Polo S, Ruiz-Echarri M, Navarrete S, Fuertes F, Saez B, Godino J, Weijerman PC, Swinkels DW, Aben KK, Witjes JA, Suarez BK, Helfand BT, Frigge ML, Kristjansson K, Ober C, Jonsson E, Einarsson GV, Xu J, Gronberg H, Smith JR, Thibodeau SN, Isaacs WB, Catalona WJ, Mayordomo JI, Kiemeney LA, Barkardottir RB, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat. Genet [print-electronic]. 2008 Mar; 40(3): 281-3. PMID: 18264098, PMCID: PMC3598012, PII: ng.89, DOI: 10.1038/ng.89, ISSN: 1546-1718.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18264098.
  • Cai Q, Kataoka N, Li C, Wen W, Smith JR, Gao YT, Shu XO, Zheng W. Haplotype analyses of CYP19A1 gene variants and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol. Biomarkers Prev. 2008 Jan; 17(1): 27-32. PMID: 18199708, PMCID: PMC2633134, PII: 17/1/27, DOI: 10.1158/1055-9965.EPI-07-0688, ISSN: 1055-9965.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18199708.
  • Yaspan BL, Breyer JP, Cai Q, Dai Q, Elmore JB, Amundson I, Bradley KM, Shu XO, Gao YT, Dupont WD, Zheng W, Smith JR. Haplotype analysis of CYP11A1 identifies promoter variants associated with breast cancer risk. Cancer Res. 2007 Jun 6/15/2007; 67(12): 5673-82. PMID: 17575134, PMCID: PMC2805128, PII: 67/12/5673, DOI: 10.1158/0008-5472.CAN-07-0467, ISSN: 0008-5472.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17575134.
  • Bradley KM, Elmore JB, Breyer JP, Yaspan BL, Jessen JR, Knapik EW, Smith JR. A major zebrafish polymorphism resource for genetic mapping. Genome Biol. 2007; 8(4): R55. PMID: 17428331, PMCID: PMC1896001, PII: gb-2007-8-4-r55, DOI: 10.1186/gb-2007-8-4-r55, ISSN: 1474-760X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17428331.
  • Baffoe-Bonnie AB, Smith JR, Stephan DA, Schleutker J, Carpten JD, Kainu T, Gillanders EM, Matikainen M, Teslovich TM, Tammela T, Sood R, Balshem AM, Scarborough SD, Xu J, Isaacs WB, Trent JM, Kallioniemi OP, Bailey-Wilson JE. A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region. Hum. Genet [print-electronic]. 2005 Aug; 117(4): 307-16. PMID: 15906096, DOI: 10.1007/s00439-005-1306-z, ISSN: 0340-6717.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15906096.
  • Owens SE, Broman KW, Wiltshire T, Elmore JB, Bradley KM, Smith JR, Southard-Smith EM. Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease. Hum. Mol. Genet [print-electronic]. 2005 Jun 6/1/2005; 14(11): 1549-58. PMID: 15843399, PII: ddi163, DOI: 10.1093/hmg/ddi163, ISSN: 0964-6906.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15843399.
  • Boyapati SM, Shu XO, Ruan ZX, Cai Q, Smith JR, Wen W, Gao YT, Zheng W. Polymorphisms in ER-alpha gene interact with estrogen receptor status in breast cancer survival. Clin. Cancer Res. 2005 Feb 2/1/2005; 11(3): 1093-8. PMID: 15709176, PII: 11/3/1093, ISSN: 1078-0432.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15709176.
  • Wen W, Gao YT, Shu XO, Yu H, Cai Q, Smith JR, Zheng W. Insulin-like growth factor-I gene polymorphism and breast cancer risk in Chinese women. Int. J. Cancer. 2005 Jan 1/10/2005; 113(2): 307-11. PMID: 15386404, DOI: 10.1002/ijc.20571, ISSN: 0020-7136.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15386404.
  • Cantrell VA, Owens SE, Chandler RL, Airey DC, Bradley KM, Smith JR, Southard-Smith EM. Interactions between Sox10 and EdnrB modulate penetrance and severity of aganglionosis in the Sox10Dom mouse model of Hirschsprung disease. Hum. Mol. Genet [print-electronic]. 2004 Oct 10/1/2004; 13(19): 2289-301. PMID: 15294878, PII: ddh243, DOI: 10.1093/hmg/ddh243, ISSN: 0964-6906.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15294878.
  • Adegoke OJ, Shu XO, Gao YT, Cai Q, Breyer J, Smith J, Zheng W. Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) and risk of breast cancer. Breast Cancer Res. Treat. 2004 Jun; 85(3): 239-45. PMID: 15111762, PII: 5267594, DOI: 10.1023/B:BREA.0000025419.26423.b8, ISSN: 0167-6806.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15111762.
  • Zheng W, Gao YT, Shu XO, Wen W, Cai Q, Dai Q, Smith JR. Population-based case-control study of CYP11A gene polymorphism and breast cancer risk. Cancer Epidemiol. Biomarkers Prev. 2004 May; 13(5): 709-14. PMID: 15159300, PII: 13/5/709, ISSN: 1055-9965.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15159300.
  • Cai Q, Gao YT, Wen W, Shu XO, Jin F, Smith JR, Zheng W. Association of breast cancer risk with a GT dinucleotide repeat polymorphism upstream of the estrogen receptor-alpha gene. Cancer Res. 2003 Sep 9/15/2003; 63(18): 5727-30. PMID: 14522892, ISSN: 0008-5472.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14522892.
  • Ho GY, Knapp M, Freije D, Nelson WG, Smith JR, Carpten JD, Bailey-Wilson JE, Beaty TH, Petersen G, Xu J, Kamensky V, Walsh PC, Isaacs WB. Transmission/disequilibrium tests of androgen receptor and glutathione S-transferase pi variants in prostate cancer families. Int. J. Cancer. 2002 Apr 4/20/2002; 98(6): 938-42. PMID: 11948476, PII: 10.1002/ijc.10290, ISSN: 0020-7136.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11948476.
  • Carpten J, Nupponen N, Isaacs S, Sood R, Robbins C, Xu J, Faruque M, Moses T, Ewing C, Gillanders E, Hu P, Bujnovszky P, Makalowska I, Baffoe-Bonnie A, Faith D, Smith J, Stephan D, Wiley K, Brownstein M, Gildea D, Kelly B, Jenkins R, Hostetter G, Matikainen M, Schleutker J, Klinger K, Connors T, Xiang Y, Wang Z, De Marzo A, Papadopoulos N, Kallioniemi OP, Burk R, Meyers D, Grönberg H, Meltzer P, Silverman R, Bailey-Wilson J, Walsh P, Isaacs W, Trent J. Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat. Genet [print-electronic]. 2002 Feb; 30(2): 181-4. PMID: 11799394, PII: ng823, DOI: 10.1038/ng823, ISSN: 1061-4036.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11799394.
  • Stephan DA, Howell GR, Teslovich TM, Coffey AJ, Smith L, Bailey-Wilson JE, Malechek L, Gildea D, Smith JR, Gillanders EM, Schleutker J, Hu P, Steingruber HE, Dhami P, Robbins CM, Makalowska I, Carpten JD, Sood R, Mumm S, Reinbold R, Bonner TI, Baffoe-Bonnie A, Bubendorf L, Heiskanen M, Kallioneimi OP, Baxevanis AD, Joseph SS, Zucchi I, Burk RD, Isaacs W, Ross MT, Trent JM. Physical and transcript map of the hereditary prostate cancer region at xq27. Genomics. 2002 Jan; 79(1): 41-50. PMID: 11827456, PII: S0888754301966819, DOI: 10.1006/geno.2001.6681, ISSN: 0888-7543.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11827456.
  • Smith, J., Collins, F., and Gelehrter, T. Molecular Genetics of Common Disease. In: The Genetic Basis of Common Diseases, Second Edition, edited by King, Rotter, and Motulsky. (Oxford Univesity Press). 2002.
  • Xu J, Zheng SL, Chang B, Smith JR, Carpten JD, Stine OC, Isaacs SD, Wiley KE, Henning L, Ewing C, Bujnovszky P, Bleeker ER, Walsh PC, Trent JM, Meyers DA, Isaacs WB. Linkage of prostate cancer susceptibility loci to chromosome 1. Hum. Genet. 2001 Apr; 108(4): 335-45. PMID: 11379880, ISSN: 0340-6717.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11379880.
  • Schleutker J, Matikainen M, Smith J, Koivisto P, Baffoe-Bonnie A, Kainu T, Gillanders E, Sankila R, Pukkala E, Carpten J, Stephan D, Tammela T, Brownstein M, Bailey-Wilson J, Trent J, Kallioniemi OP. A genetic epidemiological study of hereditary prostate cancer (HPC) in Finland: frequent HPCX linkage in families with late-onset disease. Clin. Cancer Res. 2000 Dec; 6(12): 4810-5. PMID: 11156239, ISSN: 1078-0432.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11156239.
  • Bergthorsson JT, Johannesdottir G, Arason A, Benediktsdottir KR, Agnarsson BA, Bailey-Wilson JE, Gillanders E, Smith J, Trent J, Barkardottir RB. Analysis of HPC1, HPCX, and PCaP in Icelandic hereditary prostate cancer. Hum. Genet. 2000 Oct; 107(4): 372-5. PMID: 11129338, ISSN: 0340-6717.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11129338.
  • Xu J. Combined analysis of hereditary prostate cancer linkage to 1q24-25: results from 772 hereditary prostate cancer families from the International Consortium for Prostate Cancer Genetics. Am. J. Hum. Genet. 2000 Mar; 66(3): 945-57. PMID: 10712209, PMCID: PMC1288175, PII: S0002-9297(07)64021-X, ISSN: 0002-9297.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10712209.
  • Carpten JD, Makalowska I, Robbins CM, Scott N, Sood R, Connors TD, Bonner TI, Smith JR, Faruque MU, Stephan DA, Pinkett H, Morgenbesser SD, Su K, Graham C, Gregory SG, Williams H, McDonald L, Baxevanis AD, Klingler KW, Landes GM, Trent JM. A 6-Mb high-resolution physical and transcription map encompassing the hereditary prostate cancer 1 (HPC1) region. Genomics. 2000 Feb 2/15/2000; 64(1): 1-14. PMID: 10708513, PII: S0888-7543(99)96051-2, DOI: 10.1006/geno.1999.6051, ISSN: 0888-7543.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10708513.
  • Berry R, Schaid DJ, Smith JR, French AJ, Schroeder JJ, McDonnell SK, Peterson BJ, Wang ZY, Carpten JD, Roberts SG, Tester DJ, Blute ML, Trent JM, Thibodeau SN. Linkage analyses at the chromosome 1 loci 1q24-25 (HPC1), 1q42.2-43 (PCAP), and 1p36 (CAPB) in families with hereditary prostate cancer. Am. J. Hum. Genet. 2000 Feb; 66(2): 539-46. PMID: 10677314, PMCID: PMC1288107, PII: S0002-9297(07)63428-4, DOI: 10.1086/302771, ISSN: 0002-9297.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10677314.
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