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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 

VICC toll-free number 1-877-936-8422

Jeremy L.  Norris

Jeremy L. Norris, Ph.D.

Research Assistant Professor of Biochemistry
Managing Director, National Resource for Imaging Mass Spectrometry

Contact Information:

9160 Medical Research Building III
465 21st Ave. South
Nashville, TN 37232-8575
615-936-0923
Fax: 615-343-8372

Publications
  • Manier ML, Spraggins JM, Reyzer ML, Norris JL, Caprioli RM. A derivatization and validation strategy for determining the spatial localization of endogenous amine metabolites in tissues using MALDI imaging mass spectrometry. J Mass Spectrom. 2014 Aug; 49(8): 665-73. PMID: 25044893, PMCID: PMC4126081, DOI: 10.1002/jms.3411, ISSN: 1096-9888.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25044893.
  • Gessel MM, Norris JL, Caprioli RM. MALDI imaging mass spectrometry: spatial molecular analysis to enable a new age of discovery. J Proteomics [print-electronic]. 2014 Jul 7/31/2014; 107: 71-82. PMID: 24686089, PMCID: PMC4104210, PII: S1874-3919(14)00143-2, DOI: 10.1016/j.jprot.2014.03.021, ISSN: 1876-7737.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24686089.
  • Schmidt MJ, Horvath S, Ebert P, Norris JL, Seeley EH, Brown J, Gellert L, Everheart M, Garbett KA, Grice TW, Caprioli RM, Mirnics K. Modulation of behavioral networks by selective interneuronal inactivation. Mol. Psychiatry [print-electronic]. 2014 May; 19(5): 580-7. PMID: 24322205, PMCID: PMC4179403, PII: mp2013167, DOI: 10.1038/mp.2013.167, ISSN: 1476-5578.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24322205.
  • Norris JL, Caprioli RM. Imaging mass spectrometry: a new tool for pathology in a molecular age. Proteomics Clin Appl. 2013 Dec; 7(11-12): 733-8. PMID: 24178781, PMCID: PMC3919023, DOI: 10.1002/prca.201300055, ISSN: 1862-8354.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24178781.
  • Norris JL, Caprioli RM. Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research. Chem. Rev [print-electronic]. 2013 Apr 4/10/2013; 113(4): 2309-42. PMID: 23394164, PMCID: PMC3624074, DOI: 10.1021/cr3004295, ISSN: 1520-6890.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23394164.
  • Zavalin A, Todd EM, Rawhouser PD, Yang J, Norris JL, Caprioli RM. Direct imaging of single cells and tissue at sub-cellular spatial resolution using transmission geometry MALDI MS. J Mass Spectrom. 2012 Nov; 47(11): 1473-81. PMID: 23147824, DOI: 10.1002/jms.3108, ISSN: 1096-9888.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23147824.
  • Yang J, Chaurand P, Norris JL, Porter NA, Caprioli RM. Activity-based probes linked with laser-cleavable mass tags for signal amplification in imaging mass spectrometry: analysis of serine hydrolase enzymes in mammalian tissue. Anal. Chem [print-electronic]. 2012 Apr 4/17/2012; 84(8): 3689-95. PMID: 22424244, PMCID: PMC3328658, DOI: 10.1021/ac300203v, ISSN: 1520-6882.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22424244.
  • Kellie JF, Catherman AD, Durbin KR, Tran JC, Tipton JD, Norris JL, Witkowski CE, Thomas PM, Kelleher NL. Robust analysis of the yeast proteome under 50 kDa by molecular-mass-based fractionation and top-down mass spectrometry. Anal. Chem [print-electronic]. 2012 Jan 1/3/2012; 84(1): 209-15. PMID: 22103811, PMCID: PMC3262231, DOI: 10.1021/ac202384v, ISSN: 1520-6882.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22103811.
  • Walworth MJ, ElNaggar MS, Stankovich JJ, Witkowski C, Norris JL, Van Berkel GJ. Direct sampling and analysis from solid-phase extraction cards using an automated liquid extraction surface analysis nanoelectrospray mass spectrometry system. Rapid Commun. Mass Spectrom. 2011 Sep 9/15/2011; 25(17): 2389-96. PMID: 21793068, DOI: 10.1002/rcm.5132, ISSN: 1097-0231.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21793068.
  • Razis E, Selviaridis P, Labropoulos S, Norris JL, Zhu MJ, Song DD, Kalebic T, Torrens M, Kalogera-Fountzila A, Karkavelas G, Karanastasi S, Fletcher JA, Fountzilas G. Phase II study of neoadjuvant imatinib in glioblastoma: evaluation of clinical and molecular effects of the treatment. Clin. Cancer Res [print-electronic]. 2009 Oct 10/1/2009; 15(19): 6258-66. PMID: 19789313, PII: 1078-0432.CCR-08-1867, DOI: 10.1158/1078-0432.CCR-08-1867, ISSN: 1078-0432.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19789313.
  • Harkins JB, Katz BB, Pastor SJ, Osucha P, Hafeman DG, Witkowski CE, Norris JL. Parallel electrophoretic depletion, fractionation, concentration, and desalting of 96 complex biological samples for mass spectrometry. Anal. Chem [print-electronic]. 2008 Apr 4/15/2008; 80(8): 2734-43. PMID: 18331003, DOI: 10.1021/ac702214n, ISSN: 1520-6882.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18331003.
  • Chen EI, Cociorva D, Norris JL, Yates JR. Optimization of mass spectrometry-compatible surfactants for shotgun proteomics. J. Proteome Res [print-electronic]. 2007 Jul; 6(7): 2529-38. PMID: 17530876, PMCID: PMC2570269, DOI: 10.1021/pr060682a, ISSN: 1535-3893.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17530876.
  • M'Koma AE, Blum DL, Norris JL, Koyama T, Billheimer D, Motley S, Ghiassi M, Ferdowsi N, Bhowmick I, Chang SS, Fowke JH, Caprioli RM, Bhowmick NA. Detection of pre-neoplastic and neoplastic prostate disease by MALDI profiling of urine. Biochem. Biophys. Res. Commun [print-electronic]. 2007 Feb 2/16/2007; 353(3): 829-34. PMID: 17194448, PMCID: PMC2562600, PII: S0006-291X(06)02787-2, DOI: 10.1016/j.bbrc.2006.12.111, ISSN: 0006-291X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17194448.
  • Norris JL, Cornett DS, Mobley JA, Andersson M, Seeley EH, Chaurand P, Caprioli RM. Processing MALDI Mass Spectra to Improve Mass Spectral Direct Tissue Analysis. Int J Mass Spectrom. 2007 Feb 2/1/2007; 260(2-3): 212-21. PMID: 17541451, PMCID: PMC1885223, DOI: 10.1016/j.ijms.2006.10.005, ISSN: 1387-3806.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17541451.
  • Norris, JL Cornett, DS Mobley, JA Chaurand, P Caprioli, RM. Processing MALDI Mass Spectra to Aid Biomarker Discovery and Improve Mass Spectral Image Quality. Int J Mass Spectrom. 2007; ((260)): 212-21.
    Available from: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17541451&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum.
  • Chaurand P, Norris JL, Cornett DS, Mobley JA, Caprioli RM. New developments in profiling and imaging of proteins from tissue sections by MALDI mass spectrometry. J. Proteome Res. 2006 Nov; 5(11): 2889-900. PMID: 17081040, DOI: 10.1021/pr060346u, ISSN: 1535-3893.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17081040.
  • Meistermann H, Norris JL, Aerni HR, Cornett DS, Friedlein A, Erskine AR, Augustin A, De Vera Mudry MC, Ruepp S, Suter L, Langen H, Caprioli RM, Ducret A. Biomarker discovery by imaging mass spectrometry: transthyretin is a biomarker for gentamicin-induced nephrotoxicity in rat. Mol. Cell Proteomics [print-electronic]. 2006 Oct; 5(10): 1876-86. PMID: 16705188, PII: M500399-MCP200, DOI: 10.1074/mcp.M500399-MCP200, ISSN: 1535-9476.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16705188.
  • Luka Z, Ham AJ, Norris JL, Yeo EJ, Yermalitsky V, Glenn B, Caprioli RM, Liebler DC, Wagner C. Identification of phosphorylation sites in glycine N-methyltransferase from rat liver. Protein Sci [print-electronic]. 2006 Apr; 15(4): 785-94. PMID: 16522797, PMCID: PMC2242492, PII: ps.051906706, DOI: 10.1110/ps.051906706, ISSN: 0961-8368.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16522797.
  • Norris, JL. Automated Cell-Type Specific Molecular Profiling by Imaging Mass Spectrometry [editorial]. American Biotechnology Laboratory. 2006; 9((24)): 20-2.
    Available from: http://www.iscpubs.com/articles/abl/b0906nor.pdf.
  • Norris JL, Hangauer MJ, Porter NA, Caprioli RM. Nonacid cleavable detergents applied to MALDI mass spectrometry profiling of whole cells. J Mass Spectrom. 2005 Oct; 40(10): 1319-26. PMID: 16220468, DOI: 10.1002/jms.914, ISSN: 1076-5174.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16220468.
  • Norris JL, Porter NA, Caprioli RM. Combination detergent/MALDI matrix: functional cleavable detergents for mass spectrometry. Anal. Chem. 2005 Aug 8/1/2005; 77(15): 5036-40. PMID: 16053319, DOI: 10.1021/ac050460g, ISSN: 0003-2700.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16053319.
  • Pierson J, Norris JL, Aerni HR, Svenningsson P, Caprioli RM, AndrĂ©n PE. Molecular profiling of experimental Parkinson's disease: direct analysis of peptides and proteins on brain tissue sections by MALDI mass spectrometry. J. Proteome Res. 2004 Mar; 3(2): 289-95. PMID: 15113106, ISSN: 1535-3893.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15113106.
  • Masterson DS, Yin H, Chacon A, Hachey DL, Norris JL, Porter NA. Lysine peroxycarbamates: free radical-promoted peptide cleavage. J. Am. Chem. Soc. 2004 Jan 1/28/2004; 126(3): 720-1. PMID: 14733538, DOI: 10.1021/ja038615u, ISSN: 0002-7863.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14733538.
  • Norris JL, Porter NA, Caprioli RM. Mass spectrometry of intracellular and membrane proteins using cleavable detergents. Anal. Chem. 2003 Dec 12/1/2003; 75(23): 6642-7. PMID: 14640740, DOI: 10.1021/ac034802z, ISSN: 0003-2700.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14640740.