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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 
James E.  Loyd

James E. Loyd, M.D.

Rudy W. Jacobson Professor of Medicine (Allergy, Pulmonary, and Critical Care)
Director, Familial Primary Pulmonary Arterial Hypertension Registry
Director, Familial Idiopathic Pulmonary Fibrosis Registry
Researcher

Contact Information:

Vanderbilt University Medical Center
C1208, MCN
1161 21st Ave.
Nashville, TN 37232-2650
615-322-3412

Education
  • M.D. - West Virginia University, 1973
  • Fellowship - Vanderbilt University Medical Center, 1978
  • Residency - Vanderbilt University Medical Center, 1976
  • Internship - Vanderbilt University Medical Center, 1974
 
Publications
  • Larkin EK, Newman JH, Austin ED, Hemnes AR, Wheeler L, Robbins IM, West JD, Phillips JA, Hamid R, Loyd JE. Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2012 Nov 11/1/2012; 186(9): 892-6. PMID: 22923661, PMCID: PMC3530218, PII: rccm.201205-0886OC, DOI: 10.1164/rccm.201205-0886OC, ISSN: 1535-4970.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22923661.
  • Austin ED, Ma L, LeDuc C, Berman Rosenzweig E, Borczuk A, Phillips JA, Palomero T, Sumazin P, Kim HR, Talati MH, West J, Loyd JE, Chung WK. Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension. Circ Cardiovasc Genet [print-electronic]. 2012 Jun; 5(3): 336-43. PMID: 22474227, PMCID: PMC3380156, PII: CIRCGENETICS.111.961888, DOI: 10.1161/CIRCGENETICS.111.961888, ISSN: 1942-3268.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22474227.
  • Polosukhin VV, Degryse AL, Newcomb DC, Jones BR, Ware LB, Lee JW, Loyd JE, Blackwell TS, Lawson WE. Intratracheal bleomycin causes airway remodeling and airflow obstruction in mice. Exp. Lung Res. 2012 Apr; 38(3): 135-46. PMID: 22394287, PMCID: PMC4046254, DOI: 10.3109/01902148.2012.658595, ISSN: 1521-0499.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22394287.
  • Austin ED, Hamid R, Hemnes AR, Loyd JE, Blackwell T, Yu C, Phillips Iii JA, Gaddipati R, Gladson S, Gu E, West J, Lane KB. BMPR2 expression is suppressed by signaling through the estrogen receptor. Biol Sex Differ. 2012; 3(1): 6. PMID: 22348410, PMCID: PMC3310853, PII: 2042-6410-3-6, DOI: 10.1186/2042-6410-3-6, ISSN: 2042-6410.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22348410.
  • Austin ED, Menon S, Hemnes AR, Robinson LR, Talati M, Fox KL, Cogan JD, Hamid R, Hedges LK, Robbins I, Lane K, Newman JH, Loyd JE, West J. Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression. Pulm Circ. 2011 Jul; 1(3): 389-98. PMID: 22140629, PMCID: PMC3224431, PII: PC-1-389, DOI: 10.4103/2045-8932.87308, ISSN: 2045-8940.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22140629.
  • Fessel JP, Loyd JE, Austin ED. The genetics of pulmonary arterial hypertension in the post-BMPR2 era. Pulm Circ. 2011 Jul; 1(3): 305-19. PMID: 22140620, PMCID: PMC3224422, PII: PC-1-305, DOI: 10.4103/2045-8932.87293, ISSN: 2045-8940.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22140620.
  • Lawson WE, Loyd JE, Degryse AL. Genetics in pulmonary fibrosis--familial cases provide clues to the pathogenesis of idiopathic pulmonary fibrosis. Am. J. Med. Sci. 2011 Jun; 341(6): 439-43. PMID: 21613931, PMCID: PMC3103077, PII: 00000441-201106000-00005, DOI: 10.1097/MAJ.0b013e31821a9d7a, ISSN: 1538-2990.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21613931.
  • Loyd JE. Pulmonary arterial hypertension: insights from genetic studies. Proc Am Thorac Soc. 2011 May; 8(2): 154-7. PMID: 21543793, PMCID: PMC3131832, PII: 8/2/154, DOI: 10.1513/pats.201007-047MS, ISSN: 1943-5665.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21543793.
  • Albers EL, Pugh ME, Hill KD, Wang L, Loyd JE, Doyle TP. Percutaneous vascular stent implantation as treatment for central vascular obstruction due to fibrosing mediastinitis. Circulation [print-electronic]. 2011 Apr 4/5/2011; 123(13): 1391-9. PMID: 21422386, PMCID: PMC3095436, PII: CIRCULATIONAHA.110.949180, DOI: 10.1161/CIRCULATIONAHA.110.949180, ISSN: 1524-4539.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21422386.
  • Majka S, Hagen M, Blackwell T, Harral J, Johnson JA, Gendron R, Paradis H, Crona D, Loyd JE, Nozik-Grayck E, Stenmark KR, West J. Physiologic and molecular consequences of endothelial Bmpr2 mutation. Respir. Res. 2011; 12: 84. PMID: 21696628, PMCID: PMC3141420, PII: 1465-9921-12-84, DOI: 10.1186/1465-9921-12-84, ISSN: 1465-993X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21696628.
  • Johnson JA, Loyd JE, Wheat LJ, Netterville JL. A case series and review of histoplasmosis infection in the neck. Arch. Otolaryngol. Head Neck Surg. 2010 Sep; 136(9): 916-9. PMID: 20855687, PII: 136/9/916, DOI: 10.1001/archoto.2010.143, ISSN: 1538-361X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20855687.
  • Talati M, West J, Blackwell TR, Loyd JE, Meyrick B. BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension. Am. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2010 Sep; 299(3): L363-73. PMID: 20562228, PMCID: PMC2951074, PII: ajplung.00295.2009, DOI: 10.1152/ajplung.00295.2009, ISSN: 1522-1504.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20562228.
  • Crossno PF, Polosukhin VV, Blackwell TS, Johnson JE, Markin C, Moore PE, Worrell JA, Stahlman MT, Phillips JA, Loyd JE, Cogan JD, Lawson WE. Identification of early interstitial lung disease in an individual with genetic variations in ABCA3 and SFTPC. Chest. 2010 Apr; 137(4): 969-73. PMID: 20371530, PMCID: PMC2851554, PII: 137/4/969, DOI: 10.1378/chest.09-0790, ISSN: 1931-3543.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20371530.
  • Austin ED, Rock MT, Mosse CA, Vnencak-Jones CL, Yoder SM, Robbins IM, Loyd JE, Meyrick BO. T lymphocyte subset abnormalities in the blood and lung in pulmonary arterial hypertension. Respir Med [print-electronic]. 2010 Mar; 104(3): 454-62. PMID: 19880300, PMCID: PMC2826574, PII: S0954-6111(09)00325-4, DOI: 10.1016/j.rmed.2009.10.004, ISSN: 1532-3064.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19880300.
  • Hamid R, Hedges LK, Austin E, Phillips JA, Loyd JE, Cogan JD. Transcripts from a novel BMPR2 termination mutation escape nonsense mediated decay by downstream translation re-initiation: implications for treating pulmonary hypertension. Clin. Genet [print-electronic]. 2010 Mar; 77(3): 280-6. PMID: 20095988, PMCID: PMC3741656, PII: CGE1311, DOI: 10.1111/j.1399-0004.2009.01311.x, ISSN: 1399-0004.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20095988.
  • Lancaster LH, Mason WR, Parnell JA, Rice TW, Loyd JE, Milstone AP, Collard HR, Malow BA. Obstructive sleep apnea is common in idiopathic pulmonary fibrosis. Chest [print-electronic]. 2009 Sep; 136(3): 772-8. PMID: 19567497, PMCID: PMC2775994, PII: chest.08-2776, DOI: 10.1378/chest.08-2776, ISSN: 1931-3543.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19567497.
  • Austin ED, Loyd JE, Phillips JA. Genetics of pulmonary arterial hypertension. Semin Respir Crit Care Med [print-electronic]. 2009 Aug; 30(4): 386-98. PMID: 19634078, PMCID: PMC3737593, DOI: 10.1055/s-0029-1233308, ISSN: 1098-9048.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19634078.
  • Thomas LD, Milstone AP, Miller GG, Loyd JE, Stephen Dummer J. Long-term outcomes of cytomegalovirus infection and disease after lung or heart-lung transplantation with a delayed ganciclovir regimen. Clin Transplant [print-electronic]. 2009 Aug; 23(4): 476-83. PMID: 19453645, PII: CTR990, DOI: 10.1111/j.1399-0012.2009.00990.x, ISSN: 1399-0012.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19453645.
  • Austin ED, Phillips JA, Cogan JD, Hamid R, Yu C, Stanton KC, Phillips CA, Wheeler LA, Robbins IM, Newman JH, Loyd JE. Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension. Respir. Res. 2009; 10: 87. PMID: 19785764, PMCID: PMC2762975, PII: 1465-9921-10-87, DOI: 10.1186/1465-9921-10-87, ISSN: 1465-993X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19785764.
  • Johnson JA, Vnencak-Jones CL, Cogan JD, Loyd JE, West J. Copy-number variation in BMPR2 is not associated with the pathogenesis of pulmonary arterial hypertension. BMC Med. Genet. 2009; 10: 58. PMID: 19531247, PMCID: PMC2706815, PII: 1471-2350-10-58, DOI: 10.1186/1471-2350-10-58, ISSN: 1471-2350.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19531247.