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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 
Jin  Chen

Jin Chen, M.D., Ph.D.

Professor of Medicine
Professor of Cell and Development Biology
Professor of Cancer Biology
Researcher

Contact Information:

Vanderbilt University Medical Center
T-3219 Medical Center North
Nashville, TN 37232-2681
615-343-3819

Profile

Dr. Jin Chen is a professor of Medicine at Vanderbilt University School of Medicine. She holds joint appointments as Professor of Cancer Biology and Professor of Cell & Developmental Biology, and is a member of Vanderbilt-Ingram Cancer Center. Her laboratory performed pioneering studies on determining EphA2 receptor function in tumor initiation, metastatic progression and tumor angiogenesis.
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Dr. Jin Chen is a professor of Medicine at Vanderbilt University School of Medicine. She holds joint appointments as Professor of Cancer Biology and Professor of Cell & Developmental Biology, and is a member of Vanderbilt-Ingram Cancer Center. Her laboratory performed pioneering studies on determining EphA2 receptor function in tumor initiation, metastatic progression and tumor angiogenesis. Dr. Chen's laboratory is currently funded by grants from National Cancer Institute, Department of Defense, and Department of Veterans Affairs. She regularly serves on grant review panels at the National Institute of Health, American Cancer Society, and Department of Defense. She is currently serving on the Board of Directors at Cancer Biology Training Consortium (CABTRAC).

Education
  • 1984 M.D., Shanghai First Medical College, China
  • 1991 Ph.D., Harvard University, Cambridge, MA
  • 1992 Fellow, MIT, Cambridge, MA
  • 1993-1996 Fellow, Vanderbilt University, Nashville, TN
Research Description

Our major focus has been to characterize the role of Eph receptor tyrosine kinases and their ligands, ephrins, in tumor metabolism, cancer metastasis, and tumor angiogenesis. Our approach involves a combination of oncogenomics and proteomics, confocal microscopy and imaging, transgenic and knock out animal models, and traditional cell biology and biochemistry techniques.

Eph RTKs and their ligands are dysregulated in tumor tissues and expression of these molecules is associated with clinical outcome of various cancer types. In particular, EphA2 receptor plays critical roles in both tumor cells and tumor blood vessels. Our laboratory demonstrated that epithelial EphA2 is required for cell proliferation and tumor initiation. We also showed that vascular endothelial EphA2 promotes tumor progression through angiogenesis. As EphA2 regulates both tumor cells and host microenvironment, it is a good target for cancer therapy. Several anti-EphA2 agents have been developed and we are testing selective small molecule Eph receptor kinase inhibitors. Current projects in the lab include:

1. Role of ephrin-A1, the ligand for EphA2 RTK, in tumor metabolism in breast cancer.
2. EphA2 in K-Ras and TKI-resistant EGFR mutant lung cancer and cancer stem cells.
3. Dissecting opposing roles of EphA2 and EphA3 in lung cancer.
4. Regulation of angiocrine signaling in tumor progression, metastasis, and stem cell function.



Publications
  • Amato KR, Wang S, Tan L, Hastings AK, Song W, Lovly CM, Meador CB, Ye F, Lu P, Balko JM, Colvin DC, Cates JM, Pao W, Gray NS, Chen J. EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. Cancer Res [print-electronic]. 2016 Jan 1/15/2016; 76(2): 305-18. PMID: 26744526, PMCID: PMC4715957, PII: 0008-5472.CAN-15-0717, DOI: 10.1158/0008-5472.CAN-15-0717, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26744526.
  • Wang S, Amato KR, Song W, Youngblood V, Lee K, Boothby M, Brantley-Sieders DM, Chen J. Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways. Mol. Cell. Biol [print-electronic]. 2015 Apr; 35(7): 1299-313. PMID: 25582201, PMCID: PMC4355541, PII: MCB.00306-14, DOI: 10.1128/MCB.00306-14, ISSN: 1098-5549.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25582201.
  • Youngblood V, Wang S, Song W, Walter D, Hwang Y, Chen J, Brantley-Sieders DM. Elevated Slit2 Activity Impairs VEGF-Induced Angiogenesis and Tumor Neovascularization in EphA2-Deficient Endothelium. Mol. Cancer Res [print-electronic]. 2015 Mar; 13(3): 524-37. PMID: 25504371, PMCID: PMC4416411, PII: 1541-7786.MCR-14-0142, DOI: 10.1158/1541-7786.MCR-14-0142, ISSN: 1557-3125.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25504371.
  • Chen J, Song W, Amato K. Eph receptor tyrosine kinases in cancer stem cells. Cytokine Growth Factor Rev [print-electronic]. 2015 Feb; 26(1): 1-6. PMID: 24933439, PMCID: PMC4234705, PII: S1359-6101(14)00043-4, DOI: 10.1016/j.cytogfr.2014.05.001, ISSN: 1879-0305.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24933439.
  • McCormack DR, Walsh AJ, Sit W, Arteaga CL, Chen J, Cook RS, Skala MC. In vivo hyperspectral imaging of microvessel response to trastuzumab treatment in breast cancer xenografts. Biomed Opt Express. 2014 Jul 7/1/2014; 5(7): 2247-61. PMID: 25071962, PMCID: PMC4102362, PII: 210394, DOI: 10.1364/BOE.5.002247, ISSN: 2156-7085.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25071962.
  • Song W, Ma Y, Wang J, Brantley-Sieders D, Chen J. JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer. Cancer Res [print-electronic]. 2014 May 5/1/2014; 74(9): 2444-54. PMID: 24607842, PMCID: PMC4008716, PII: 0008-5472.CAN-13-2136, DOI: 10.1158/0008-5472.CAN-13-2136, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24607842.
  • Amato KR, Wang S, Hastings AK, Youngblood VM, Santapuram PR, Chen H, Cates JM, Colvin DC, Ye F, Brantley-Sieders DM, Cook RS, Tan L, Gray NS, Chen J. Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC. J. Clin. Invest [print-electronic]. 2014 May; 124(5): 2037-49. PMID: 24713656, PMCID: PMC4001547, PII: 72522, DOI: 10.1172/JCI72522, ISSN: 1558-8238.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24713656.
  • Takahashi K, Matafonov A, Sumarriva K, Ito H, Lauhan C, Zemel D, Tsuboi N, Chen J, Reynolds A, Takahashi T. CD148 tyrosine phosphatase promotes cadherin cell adhesion. PLoS ONE. 2014; 9(11): e112753. PMID: 25386896, PMCID: PMC4227875, PII: PONE-D-14-33624, DOI: 10.1371/journal.pone.0112753, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25386896.
  • Boissier P, Chen J, Huynh-Do U. EphA2 signaling following endocytosis: role of Tiam1. Traffic [print-electronic]. 2013 Dec; 14(12): 1255-71. PMID: 24112471, PMCID: PMC3859973, DOI: 10.1111/tra.12123, ISSN: 1600-0854.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24112471.
  • Zhuang G, Song W, Amato K, Hwang Y, Lee K, Boothby M, Ye F, Guo Y, Shyr Y, Lin L, Carbone DP, Brantley-Sieders DM, Chen J. Effects of cancer-associated EPHA3 mutations on lung cancer. J. Natl. Cancer Inst [print-electronic]. 2012 Aug 8/8/2012; 104(15): 1182-97. PMID: 22829656, PMCID: PMC3611812, PII: djs297, DOI: 10.1093/jnci/djs297, ISSN: 1460-2105.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22829656.
  • Hahn AS, Kaufmann JK, Wies E, Naschberger E, Panteleev-Ivlev J, Schmidt K, Holzer A, Schmidt M, Chen J, König S, Ensser A, Myoung J, Brockmeyer NH, Stürzl M, Fleckenstein B, Neipel F. The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma–associated herpesvirus. Nat. Med. 2012 Jun; 18(6): 961-6. PMID: 22635007, PMCID: PMC3645317, PII: nm.2805, DOI: 10.1038/nm.2805, ISSN: 1546-170X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22635007.
  • Lee K, Nam KT, Cho SH, Gudapati P, Hwang Y, Park DS, Potter R, Chen J, Volanakis E, Boothby M. Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia. J. Exp. Med [print-electronic]. 2012 Apr 4/9/2012; 209(4): 713-28. PMID: 22473959, PMCID: PMC3328370, PII: jem.20111470, DOI: 10.1084/jem.20111470, ISSN: 1540-9538.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22473959.
  • Funk SD, Yurdagul A, Albert P, Traylor JG, Jin L, Chen J, Orr AW. EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis. Arterioscler. Thromb. Vasc. Biol [print-electronic]. 2012 Mar; 32(3): 686-95. PMID: 22247258, PMCID: PMC3325141, PII: ATVBAHA.111.242792, DOI: 10.1161/ATVBAHA.111.242792, ISSN: 1524-4636.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22247258.
  • Chen J. Regulation of tumor initiation and metastatic progression by Eph receptor tyrosine kinases. Adv. Cancer Res. 2012; 114: 1-20. PMID: 22588054, PMCID: PMC3626259, PII: B978-0-12-386503-8.00001-6, DOI: 10.1016/B978-0-12-386503-8.00001-6, ISSN: 0065-230X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22588054.
  • Rao M, Song W, Jiang A, Shyr Y, Lev S, Greenstein D, Brantley-Sieders D, Chen J. VAMP-associated protein B (VAPB) promotes breast tumor growth by modulation of Akt activity. PLoS ONE [print-electronic]. 2012; 7(10): e46281. PMID: 23049696, PMCID: PMC3462209, PII: PONE-D-12-16139, DOI: 10.1371/journal.pone.0046281, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23049696.
  • Brantley-Sieders DM, Dunaway CM, Rao M, Short S, Hwang Y, Gao Y, Li D, Jiang A, Shyr Y, Wu JY, Chen J. Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium. Cancer Res [print-electronic]. 2011 Feb 2/1/2011; 71(3): 976-87. PMID: 21148069, PMCID: PMC3032824, PII: 0008-5472.CAN-10-3396, DOI: 10.1158/0008-5472.CAN-10-3396, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21148069.
  • Dunaway CM, Hwang Y, Lindsley CW, Cook RS, Wu JY, Boothby M, Chen J, Brantley-Sieders DM. Cooperative signaling between Slit2 and Ephrin-A1 regulates a balance between angiogenesis and angiostasis. Mol. Cell. Biol [print-electronic]. 2011 Feb; 31(3): 404-16. PMID: 21135133, PMCID: PMC3028625, PII: MCB.00667-10, DOI: 10.1128/MCB.00667-10, ISSN: 1098-5549.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21135133.
  • Brantley-Sieders DM, Jiang A, Sarma K, Badu-Nkansah A, Walter DL, Shyr Y, Chen J. Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome. PLoS ONE [print-electronic]. 2011; 6(9): e24426. PMID: 21935409, PMCID: PMC3174170, PII: PONE-D-11-14906, DOI: 10.1371/journal.pone.0024426, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21935409.
  • Frieden LA, Townsend TA, Vaught DB, Delaughter DM, Hwang Y, Barnett JV, Chen J. Regulation of heart valve morphogenesis by Eph receptor ligand, ephrin-A1. Dev. Dyn [print-electronic]. 2010 Dec; 239(12): 3226-34. PMID: 20960543, PMCID: PMC3023820, DOI: 10.1002/dvdy.22458, ISSN: 1097-0177.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20960543.
  • Min Y, Ren X, Vaught DB, Chen J, Donnelly E, Lynch CC, Lin PC. Tie2 signaling regulates osteoclastogenesis and osteolytic bone invasion of breast cancer. Cancer Res [print-electronic]. 2010 Apr 4/1/2010; 70(7): 2819-28. PMID: 20233869, PMCID: PMC2848896, PII: 0008-5472.CAN-09-1915, DOI: 10.1158/0008-5472.CAN-09-1915, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20233869.
  • Zhuang G, Brantley-Sieders DM, Vaught D, Yu J, Xie L, Wells S, Jackson D, Muraoka-Cook R, Arteaga C, Chen J. Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy. Cancer Res [print-electronic]. 2010 Jan 1/1/2010; 70(1): 299-308. PMID: 20028874, PMCID: PMC3859619, PII: 0008-5472.CAN-09-1845, DOI: 10.1158/0008-5472.CAN-09-1845, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20028874.
  • Brantley-Sieders DM, Zhuang G, Vaught D, Freeman T, Hwang Y, Hicks D, Chen J. Host deficiency in Vav2/3 guanine nucleotide exchange factors impairs tumor growth, survival, and angiogenesis in vivo. Mol. Cancer Res [print-electronic]. 2009 May; 7(5): 615-23. PMID: 19435813, PMCID: PMC2739740, PII: 1541-7786.MCR-08-0401, DOI: 10.1158/1541-7786.MCR-08-0401, ISSN: 1541-7786.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19435813.
  • Vaught D, Chen J, Brantley-Sieders DM. Regulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinase. Mol. Biol. Cell [print-electronic]. 2009 May; 20(10): 2572-81. PMID: 19321667, PMCID: PMC2682598, PII: E08-04-0378, DOI: 10.1091/mbc.E08-04-0378, ISSN: 1939-4586.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19321667.
  • Bogan C, Chen J, O'Sullivan MG, Cormier RT. Loss of EphA2 receptor tyrosine kinase reduces ApcMin/+ tumorigenesis. Int. J. Cancer. 2009 Mar 3/15/2009; 124(6): 1366-71. PMID: 19089910, DOI: 10.1002/ijc.24083, ISSN: 1097-0215.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19089910.
  • Chen J, Zhuang G, Frieden L, Debinski W. Eph receptors and Ephrins in cancer: common themes and controversies. Cancer Res. 2008 Dec 12/15/2008; 68(24): 10031-3. PMID: 19074866, PMCID: PMC2605675, PII: 68/24/10031, DOI: 10.1158/0008-5472.CAN-08-3010, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19074866.
  • Fang WB, Brantley-Sieders DM, Hwang Y, Ham AJ, Chen J. Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase. J. Biol. Chem [print-electronic]. 2008 Jun 6/6/2008; 283(23): 16017-26. PMID: 18387945, PMCID: PMC2414276, PII: M709934200, DOI: 10.1074/jbc.M709934200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18387945.
  • Fang WB, Ireton RC, Zhuang G, Takahashi T, Reynolds A, Chen J. Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism. J. Cell. Sci [print-electronic]. 2008 Feb 2/1/2008; 121(Pt 3): 358-68. PMID: 18198190, PII: jcs.017145, DOI: 10.1242/jcs.017145, ISSN: 0021-9533.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18198190.
  • Brantley-Sieders DM, Zhuang G, Hicks D, Fang WB, Hwang Y, Cates JM, Coffman K, Jackson D, Bruckheimer E, Muraoka-Cook RS, Chen J. The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J. Clin. Invest. 2008 Jan; 118(1): 64-78. PMID: 18079969, PMCID: PMC2129239, DOI: 10.1172/JCI33154, ISSN: 0021-9738.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18079969.
  • Vaught D, Brantley-Sieders DM, Chen J. Eph receptors in breast cancer: roles in tumor promotion and tumor suppression. Breast Cancer Res [print-electronic]. 2008; 10(6): 217. PMID: 19144211, PMCID: PMC2656900, PII: bcr2207, DOI: 10.1186/bcr2207, ISSN: 1465-542X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19144211.
  • Zhuang G, Hunter S, Hwang Y, Chen J. Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation. J. Biol. Chem [print-electronic]. 2007 Jan 1/26/2007; 282(4): 2683-94. PMID: 17135240, PII: M608509200, DOI: 10.1074/jbc.M608509200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17135240.
  • Brantley-Sieders DM, Fang WB, Hwang Y, Hicks D, Chen J. Ephrin-A1 facilitates mammary tumor metastasis through an angiogenesis-dependent mechanism mediated by EphA receptor and vascular endothelial growth factor in mice. Cancer Res. 2006 Nov 11/1/2006; 66(21): 10315-24. PMID: 17079451, PII: 66/21/10315, DOI: 10.1158/0008-5472.CAN-06-1560, ISSN: 0008-5472.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17079451.
  • Brissova M, Shostak A, Shiota M, Wiebe PO, Poffenberger G, Kantz J, Chen Z, Carr C, Jerome WG, Chen J, Baldwin HS, Nicholson W, Bader DM, Jetton T, Gannon M, Powers AC. Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes. 2006 Nov; 55(11): 2974-85. PMID: 17065333, PII: 55/11/2974, DOI: 10.2337/db06-0690, ISSN: 0012-1797.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17065333.
  • Hunter SG, Zhuang G, Brantley-Sieders D, Swat W, Cowan CW, Chen J. Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis. Mol. Cell. Biol. 2006 Jul; 26(13): 4830-42. PMID: 16782872, PMCID: PMC1489141, PII: 26/13/4830, DOI: 10.1128/MCB.02215-05, ISSN: 0270-7306.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16782872.
  • Chen J, Hicks D, Brantley-Sieders D, Cheng N, McCollum GW, Qi-Werdich X, Penn J. Inhibition of retinal neovascularization by soluble EphA2 receptor. Exp. Eye Res [print-electronic]. 2006 Apr; 82(4): 664-73. PMID: 16359662, PII: S0014-4835(05)00293-9, DOI: 10.1016/j.exer.2005.09.004, ISSN: 0014-4835.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16359662.
  • Fang WB, Brantley-Sieders DM, Parker MA, Reith AD, Chen J. A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis. Oncogene. 2005 Nov 11/24/2005; 24(53): 7859-68. PMID: 16103880, PII: 1208937, DOI: 10.1038/sj.onc.1208937, ISSN: 0950-9232.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16103880.
  • Brantley-Sieders DM, Fang WB, Hicks DJ, Zhuang G, Shyr Y, Chen J. Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression. FASEB J [print-electronic]. 2005 Nov; 19(13): 1884-6. PMID: 16166198, PII: 05-4038fje, DOI: 10.1096/fj.05-4038fje, ISSN: 1530-6860.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16166198.
  • Ireton RC, Chen J. EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics. Curr Cancer Drug Targets. 2005 May; 5(3): 149-57. PMID: 15892616, ISSN: 1568-0096.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15892616.
  • Parker M, Roberts R, Enriquez M, Zhao X, Takahashi T, Pat Cerretti D, Daniel T, Chen J. Reverse endocytosis of transmembrane ephrin-B ligands via a clathrin-mediated pathway. Biochem. Biophys. Res. Commun. 2004 Oct 10/8/2004; 323(1): 17-23. PMID: 15351694, PII: S0006-291X(04)01590-6, DOI: 10.1016/j.bbrc.2004.07.209, ISSN: 0006-291X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15351694.
  • Brantley-Sieders DM, Caughron J, Hicks D, Pozzi A, Ruiz JC, Chen J. EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J. Cell. Sci [print-electronic]. 2004 Apr 4/15/2004; 117(Pt 10): 2037-49. PMID: 15054110, PII: jcs.01061, DOI: 10.1242/jcs.01061, ISSN: 0021-9533.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15054110.
  • Brantley-Sieders D, Schmidt S, Parker M, Chen J. Eph receptor tyrosine kinases in tumor and tumor microenvironment. Curr. Pharm. Des. 2004; 10(27): 3431-42. PMID: 15544526, ISSN: 1381-6128.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15544526.
  • Brantley-Sieders DM, Chen J. Eph receptor tyrosine kinases in angiogenesis: from development to disease. Angiogenesis. 2004; 7(1): 17-28. PMID: 15302992, PII: 5272546, DOI: 10.1023/B:AGEN.0000037340.33788.87, ISSN: 0969-6970.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15302992.
  • Cheng N, Brantley D, Fang WB, Liu H, Fanslow W, Cerretti DP, Bussell KN, Reith A, Jackson D, Chen J. Inhibition of VEGF-dependent multistage carcinogenesis by soluble EphA receptors. Neoplasia. 2003 Sep; 5(5): 445-56. PMID: 14670182, PMCID: PMC1502614, ISSN: 1522-8002.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14670182.
  • DeBusk LM, Chen Y, Nishishita T, Chen J, Thomas JW, Lin PC. Tie2 receptor tyrosine kinase, a major mediator of tumor necrosis factor alpha-induced angiogenesis in rheumatoid arthritis. Arthritis Rheum. 2003 Sep; 48(9): 2461-71. PMID: 13130465, DOI: 10.1002/art.11213, ISSN: 0004-3591.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/13130465.
  • Cheng N, Brantley DM, Liu H, Lin Q, Enriquez M, Gale N, Yancopoulos G, Cerretti DP, Daniel TO, Chen J. Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. Mol. Cancer Res. 2002 Nov; 1(1): 2-11. PMID: 12496364, ISSN: 1541-7786.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12496364.
  • Brantley DM, Cheng N, Thompson EJ, Lin Q, Brekken RA, Thorpe PE, Muraoka RS, Cerretti DP, Pozzi A, Jackson D, Lin C, Chen J. Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo. Oncogene. 2002 Oct 10/10/2002; 21(46): 7011-26. PMID: 12370823, DOI: 10.1038/sj.onc.1205679, ISSN: 0950-9232.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12370823.
  • Huynh-Do U, Vindis C, Liu H, Cerretti DP, McGrew JT, Enriquez M, Chen J, Daniel TO. Ephrin-B1 transduces signals to activate integrin-mediated migration, attachment and angiogenesis. J. Cell. Sci. 2002 Aug 8/1/2002; 115(Pt 15): 3073-81. PMID: 12118063, ISSN: 0021-9533.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12118063.
  • Muraoka RS, Dumont N, Ritter CA, Dugger TC, Brantley DM, Chen J, Easterly E, Roebuck LR, Ryan S, Gotwals PJ, Koteliansky V, Arteaga CL. Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J. Clin. Invest. 2002 Jun; 109(12): 1551-9. PMID: 12070302, PMCID: PMC151012, DOI: 10.1172/JCI15234, ISSN: 0021-9738.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12070302.
  • Chen Y, Rosloniec E, Price J, Boothby M, Chen J. Constitutive expression of BCL-X(L) in the T lineage attenuates collagen-induced arthritis in Bcl-X(L) transgenic mice. Arthritis Rheum. 2002 Feb; 46(2): 514-21. PMID: 11840455, PII: 10.1002/art.10128, ISSN: 0004-3591.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11840455.
  • Cheng N, Brantley DM, Chen J. The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev. 2002 Feb; 13(1): 75-85. PMID: 11750881, PII: S1359610101000314, ISSN: 1359-6101.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11750881.
  • Jo D, Nashabi A, Doxsee C, Lin Q, Unutmaz D, Chen J, Ruley HE. Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase. Nat. Biotechnol. 2001 Oct; 19(10): 929-33. PMID: 11581657, PII: nbt1001-929, DOI: 10.1038/nbt1001-929, ISSN: 1087-0156.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11581657.
  • Cheng N, Chen J. Tumor necrosis factor-alpha induction of endothelial ephrin A1 expression is mediated by a p38 MAPK- and SAPK/JNK-dependent but nuclear factor-kappa B-independent mechanism. J. Biol. Chem [print-electronic]. 2001 Apr 4/27/2001; 276(17): 13771-7. PMID: 11278471, PII: M009147200, DOI: 10.1074/jbc.M009147200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11278471.
  • Chen Y, Rosloniec E, Goral MI, Boothby M, Chen J. Redirection of T cell effector function in vivo and enhanced collagen-induced arthritis mediated by an IL-2R beta/IL-4R alpha chimeric cytokine receptor transgene. J. Immunol. 2001 Mar 3/15/2001; 166(6): 4163-9. PMID: 11238667, ISSN: 0022-1767.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11238667.
  • Seetharaman R, Mora AL, Nabozny G, Boothby M, Chen J. Essential role of T cell NF-kappa B activation in collagen-induced arthritis. J. Immunol. 1999 Aug 8/1/1999; 163(3): 1577-83. PMID: 10415062, PII: ji_v163n3p1577, ISSN: 0022-1767.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10415062.
  • Youn J, Chen J, Goenka S, Aronica MA, Mora AL, Correa V, Sheller JR, Boothby M. In vivo function of an interleukin 2 receptor beta chain (IL-2Rbeta)/IL-4Ralpha cytokine receptor chimera potentiates allergic airway disease. J. Exp. Med. 1998 Nov 11/16/1998; 188(10): 1803-16. PMID: 9815258, PMCID: PMC2212401, ISSN: 0022-1007.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9815258.
  • Chen J, Ruley HE. An enhancer element in the EphA2 (Eck) gene sufficient for rhombomere-specific expression is activated by HOXA1 and HOXB1 homeobox proteins. J. Biol. Chem. 1998 Sep 9/18/1998; 273(38): 24670-5. PMID: 9733765, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9733765.
  • G. Hicks, J. Chen, and H.E. Ruley. Production and use of Retroviruses. Culture of Specialised Cells Series. 1998; 4.
  • Chen J, Nachabah A, Scherer C, Ganju P, Reith A, Bronson R, Ruley HE. Germ-line inactivation of the murine Eck receptor tyrosine kinase by gene trap retroviral insertion. Oncogene. 1996 Mar 3/7/1996; 12(5): 979-88. PMID: 8649815, ISSN: 0950-9232.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8649815.
  • C. Scherer, J. Chen, A. Nachebeh, N. Hopkins and E. Ruley (First two authors contributed equally.). Transcriptional specificity of totipotent embryonic stem cell. Cell Growth and Differentiation. 1996; 7: 1393-401.
  • Hicks GG, Shi EG, Chen J, Roshon M, Williamson D, Scherer C, Ruley HE. Retrovirus gene traps. Meth. Enzymol. 1995; 254: 263-75. PMID: 8531691, ISSN: 0076-6879.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8531691.
  • J. Chen, J. DeGregori, G. Hicks, M. Roshon, E-G Shi, C. Scherer and E. Ruley. Gene Trap Retrovirus. Meth. Mol. Genet. 1994; 4: 123-40.
  • S. Lin, W. Long, J. Chen, and N. Hopkins. Production of germ line chimeras in zebrafish by cell transplants from genetically pigmented to albino embryos. Proc. Natl. Acad. Sci. USA. 1992; 89: 4519-23.
  • J. Chen, G. W. Rebeck, B. Derfler, and L. Samson. The expression of bacterial DNA repair genes in eukaryotic cells; and vice versa. Anticarcinogenesis and Radiation Protection (ed. O. F. Nygaard and A.C. Upton) Plenum Press, New York. 1991; 47-56.
  • J. Chen, and L. Samson. Induction of S. cerevisiae MAG 3MeA DNA glycosylase transcript levels in response to DNA damage. Nucleic Acids Res. 1991; 19: 6427-32.
  • W. Xiao, B. Derfler, J. Chen, and L. Samson. Primary sequence and biological functions of a S. cerevisiae 06-methylguanine/04-methylthymine DNA repair methyltransferase gene. EMBO J. 1991; 10: 2719-2186.
  • J. Chen, B. Derfler, and L. Samson. Saccharomyces cerevisiae 3-methyladenine DNA glycosylase has homology to the AlkA glycosylase of E. coli and is induced in response to DNA alkylation damage. EMBO J. 1990; 9: 4569-75.
  • J. Chen, B. Derfler, A. Maskati, and L. Samson. Cloning a eukaryotic DNA glycosylase repair gene by the suppression of a DNA repair defect in E. coli. Proc. Natl. Acad. Sci. USA. 1989; 86: 7961-5.