The VICC.ORG Directory of Doctors, Healthcare Providers & Researchers
Jinming Yang, Ph.D.
Research Instructor of Cancer Biology
Researcher
Contact Information:
Vanderbilt University Medical Center
434 Preston Building
Nashville, TN 37232-6840
615-343-7780
Fax: 615-936-2911
Research Specialty
The Role of NF-kB in melanoma tumorigenesis and therapy
Publications
- Jinming Yang, Ryan Splittgerber, Fiona E. Yull , Sara Kantrow, Gregory D. Ayers4, Michael Karin5 and Ann Richmond "Conditional Ablation of Ikkβ Inhibits Melanoma Tumor Development." J Clinical Investigation, 120(7), 2010.
- Yang, J, Zaja-Milatovic, S, Thu, YM, Lee, F, Smykla, R, Richmond, A Molecular determinants of melanoma malignancy: selecting targets for improved efficacy of chemotherapy. Mol Cancer Ther, 8(3), 636-47, 2009.
- Yang, J, Richmond, AJ Monitoring NF-kappaB mediated chemokine transcription in tumorigenesis. Methods Enzymol, 460347-55, 2009.
- Richmond, A, Yang, J, Su, Y The good and the bad of chemokines/chemokine receptors in melanoma. Pigment Cell Melanoma Res, 22(2), 175-86, 2009.
- Yang, J, Su, Y, Richmond, A Antioxidants tiron and N-acetyl-L-cysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species-independent NF-kappaB pathway. Free Radic Biol Med, 42(9), 1369-80, 2007.
- Li, M, Zhang, X, Zheng, X, Lian, D, Zhang, ZX, Ge, W, Yang, J, Vladau, C, Suzuki, M, Chen, D, Zhong, R, Garcia, B, Jevnikar, AM, Min, WP Immune modulation and tolerance induction by RelB-silenced dendritic cells through RNA interference. J Immunol, 178(9), 5480-7, 2007.
- Yang, J, Pan, WH, Clawson, GA, Richmond, A Systemic targeting inhibitor of kappaB kinase inhibits melanoma tumor growth. Cancer Res, 67(7), 3127-34, 2007.
- Yang, J, Amiri, KI, Burke, JR, Schmid, JA, Richmond, A BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. Clin Cancer Res, 12(3 Pt 1), 950-60, 2006.
- Yang, J. ; Amiri, K. ; Horton, L. ; Richmond, A. "Constitutive Activation of NF-[kappa]B in Melanoma Offers a Potential Target for Therapy." Pigment Cell Research., 17(4), 430-431, 2004.
- Yang, J, Richmond, A The angiostatic activity of interferon-inducible protein-10/CXCL10 in human melanoma depends on binding to CXCR3 but not to glycosaminoglycan. Mol Ther, 9(6), 846-55, 2004.
- Wang, H, Hosiawa, KA, Min, W, Yang, J, Zhang, X, Garcia, B, Ichim, TE, Zhou, D, Lian, D, Kelvin, DJ, Zhong, R Cytokines regulate the pattern of rejection and susceptibility to cyclosporine therapy in different mouse recipient strains after cardiac allografting. J Immunol, 171(7), 3823-36, 2003.
- Meaklim, J, Yang, J, Drummer, OH, Killalea, S, Staikos, V, Horomidis, S, Rutherford, D, Ioannides-Demos, LL, Lim, S, McLean, AJ, McNeil, JJ Fenitrothion: toxicokinetics and toxicologic evaluation in human volunteers. Environ Health Perspect, 111(3), 305-8, 2003.
- Min, WP, Zhou, D, Ichim, TE, Strejan, GH, Xia, X, Yang, J, Huang, X, Garcia, B, White, D, Dutartre, P, Jevnikar, AM, Zhong, R Inhibitory feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance. J Immunol, 170(3), 1304-12, 2003.
- Yang, J, Bernier, SM, Ichim, TE, Li, M, Xia, X, Zhou, D, Huang, X, Strejan, GH, White, DJ, Zhong, R, Min, WP LF15-0195 generates tolerogenic dendritic cells by suppression of NF-kappaB signaling through inhibition of IKK activity. J Leukoc Biol, 74(3), 438-47, 2003.
- Min, WP, Zhou, D, Ichim, TE, Xia, X, Zhang, X, Yang, J, Huang, X, Garcia, B, Dutartre, P, Jevnikar, AM, Strejan, GH, Zhong, R Synergistic tolerance induced by LF15-0195 and anti-CD45RB monoclonal antibody through suppressive dendritic cells. Transplantation, 75(8), 1160-5, 2003.
- Yang, J, Richmond, A Constitutive IkappaB kinase activity correlates with nuclear factor-kappaB activation in human melanoma cells. Cancer Res, 61(12), 4901-9, 2001.
- Yang, J, Luan, J, Yu, Y, Li, C, DePinho, RA, Chin, L, Richmond, A Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame. Cancer Res, 61(22), 8150-7, 2001.
- Yang, J, Fan, GH, Wadzinski, BE, Sakurai, H, Richmond, A Protein phosphatase 2A interacts with and directly dephosphorylates RelA. J Biol Chem, 276(51), 47828-33, 2001.
- Chu, ZL, Shin, YA, Yang, JM, DiDonato, JA, Ballard, DW IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1. J Biol Chem, 274(22), 15297-300, 1999.
- Yang, J, Han, DW, Zhao, Y. "LPS selectively damages antioxidant system in the chemical-induced cancer rats." China J Pathophysiology, 15(3), 214-6, 1999.
- Yang, JM, Han, DW, Xie, CM, Liang, QC, Zhao, YC, Ma, XH Endotoxins enhance hepatocarcinogenesis induced by oral intake of thioacetamide in rats. World J Gastroenterol, 4(2), 128-132, 1998.
- Yang, J., Lang QC, Xie CM "The effects of endotoxin on expression of ras, p53 and bcl-2 oncoproteins in the thioacetamide-induced hepatocarcinogenesis in rats." China National J. New Gastroenterology, 29(1), 18-22, 1997.
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