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Jo-David Fine, M.D. , M.P.H

Professor of Medicine (Dermatology) and Pediatrics
Head, National
Dermatologist

Profile

Pertinent clinical interests include the diagnosis and treatment of all types of skin cancers, as well as paraneoplastic conditions involving the skin (pemphigus; other), autoimmune manifestations and diseases of the skin, and bullous diseases, most notably inherited and acquired epidermolysis bullosa. Research interests revolve around basement membrane and extracellular matrix biology, adhesion proteins, wound healing, and the clinical epidemiology of skin diseases (to include the epidemiology of skin cancers in the setting of inherited epidermolysis bullosa).

Education
  • Yale College, B.S. (Chemistry), 1972
  • Univ of KY College of Medicine, M.D. (with honors), 1976
  • Univ. of North Carolina School of Public Health, M.P.H. (epidemiology), 1992
Publications
  • Ng YZ, Pourreyron C, Salas-Alanis JC, Dayal JH, Cepeda-Valdes R, Yan W, Wright S, Chen M, Fine JD, Hogg FJ, McGrath JA, Murrell DF, Leigh IM, Lane EB, South AP. Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa. Cancer Res [print-electronic]. 2012 Jul 7/15/2012; 72(14): 3522-34. PMID: 22564523, PII: 0008-5472.CAN-11-2996, DOI: 10.1158/0008-5472.CAN-11-2996, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22564523.
  • Fine JD. Squamous cell carcinoma and junctional epidermolysis bullosa [letter]. J. Am. Acad. Dermatol. 2012 May; 66(5): 856-7; author reply 857. PMID: 22507578, PII: S0190-9622(12)00147-8, DOI: 10.1016/j.jaad.2012.01.045, ISSN: 1097-6787.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22507578.
  • Fine JD. Inherited epidermolysis bullosa: recent basic and clinical advances. Curr. Opin. Pediatr. 2010 Aug; 22(4): 453-8. PMID: 20616732, DOI: 10.1097/MOP.0b013e32833bb74f, ISSN: 1531-698X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20616732.
  • Bubier JA, Sproule TJ, Alley LM, Webb CM, Fine JD, Roopenian DC, Sundberg JP. A mouse model of generalized non-Herlitz junctional epidermolysis bullosa. J. Invest. Dermatol [print-electronic]. 2010 Jul; 130(7): 1819-28. PMID: 20336083, PMCID: PMC3010368, PII: jid201046, DOI: 10.1038/jid.2010.46, ISSN: 1523-1747.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20336083.
  • Fine JD. Inherited epidermolysis bullosa: past, present, and future. Ann. N. Y. Acad. Sci. 2010 Apr; 1194: 213-22. PMID: 20536471, PII: NYAS5463, DOI: 10.1111/j.1749-6632.2010.05463.x, ISSN: 1749-6632.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20536471.
  • Wilford C, Fine JD, Boyd AS, Sanyal S, Abraham JL, Kantrow SM. Nephrogenic systemic fibrosis: report of an additional case with granulomatous inflammation. Am J Dermatopathol. 2010 Feb; 32(1): 71-5. PMID: 19940755, DOI: 10.1097/DAD.0b013e3181b0b859, ISSN: 1533-0311.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19940755.
  • Fine JD. Prevalence of autoantibodies to bullous pemphigoid antigens within the normal population [editorial]. Arch Dermatol. 2010 Jan; 146(1): 74-5. PMID: 20083697, PII: 146/1/74, DOI: 10.1001/archdermatol.2009.324, ISSN: 1538-3652.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20083697.
  • Fine JD. Inherited epidermolysis bullosa. Orphanet J Rare Dis. 2010; 5: 12. PMID: 20507631, PMCID: PMC2892432, PII: 1750-1172-5-12, DOI: 10.1186/1750-1172-5-12, ISSN: 1750-1172.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20507631.
  • Fine JD, Mellerio JE. Extracutaneous manifestations and complications of inherited epidermolysis bullosa: part I. Epithelial associated tissues. J. Am. Acad. Dermatol. 2009 Sep; 61(3): 367-84; quiz 385. PMID: 19700010, PII: S0190-9622(09)00705-1, DOI: 10.1016/j.jaad.2009.03.052, ISSN: 1097-6787.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19700010.
  • Fine JD, Mellerio JE. Extracutaneous manifestations and complications of inherited epidermolysis bullosa: part II. Other organs. J. Am. Acad. Dermatol. 2009 Sep; 61(3): 387-402; quiz 403. PMID: 19700011, PII: S0190-9622(09)00700-2, DOI: 10.1016/j.jaad.2009.03.053, ISSN: 1097-6787.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19700011.
  • Fine JD, Johnson LB, Weiner M, Li KP, Suchindran C. Epidermolysis bullosa and the risk of life-threatening cancers: the National EB Registry experience, 1986-2006. J. Am. Acad. Dermatol [print-electronic]. 2009 Feb; 60(2): 203-11. PMID: 19026465, PII: S0190-9622(08)01216-4, DOI: 10.1016/j.jaad.2008.09.035, ISSN: 1097-6787.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19026465.
  • Fine JD, Hall M, Weiner M, Li KP, Suchindran C. The risk of cardiomyopathy in inherited epidermolysis bullosa. Br. J. Dermatol [print-electronic]. 2008 Sep; 159(3): 677-82. PMID: 18616785, PMCID: PMC2592258, PII: BJD8697, DOI: 10.1111/j.1365-2133.2008.08697.x, ISSN: 1365-2133.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18616785.
  • Fine JD, Eady RA, Bauer EA, Bauer JW, Bruckner-Tuderman L, Heagerty A, Hintner H, Hovnanian A, Jonkman MF, Leigh I, McGrath JA, Mellerio JE, Murrell DF, Shimizu H, Uitto J, Vahlquist A, Woodley D, Zambruno G. The classification of inherited epidermolysis bullosa (EB): Report of the Third International Consensus Meeting on Diagnosis and Classification of EB. J. Am. Acad. Dermatol [print-electronic]. 2008 Jun; 58(6): 931-50. PMID: 18374450, PII: S0190-9622(08)00208-9, DOI: 10.1016/j.jaad.2008.02.004, ISSN: 1097-6787.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18374450.
  • Fine JD, Johnson LB, Weiner M, Suchindran C. Cause-specific risks of childhood death in inherited epidermolysis bullosa. J. Pediatr [print-electronic]. 2008 Feb; 152(2): 276-80. PMID: 18206702, PII: S0022-3476(07)00646-4, DOI: 10.1016/j.jpeds.2007.06.039, ISSN: 1097-6833.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18206702.
  • Fine JD, Johnson LB, Weiner M, Suchindran C. Gastrointestinal complications of inherited epidermolysis bullosa: cumulative experience of the National Epidermolysis Bullosa Registry. J. Pediatr. Gastroenterol. Nutr. 2008 Feb; 46(2): 147-58. PMID: 18223373, PII: 00005176-200802000-00005, DOI: 10.1097/MPG.0b013e31812f5667, ISSN: 1536-4801.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18223373.
  • Rubin AI, Moran K, Fine JD, Wargon O, Murrell DF. Urethral meatal stenosis in junctional epidermolysis bullosa: a rare complication effectively treated with a novel and simple modality. Int. J. Dermatol. 2007 Oct; 46(10): 1076-7. PMID: 17910719, PII: IJD3065, DOI: 10.1111/j.1365-4632.2006.03065.x, ISSN: 0011-9059.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17910719.
  • Fine JD, Johnson LB, Weiner M, Suchindran C. Tracheolaryngeal complications of inherited epidermolysis bullosa: cumulative experience of the national epidermolysis bullosa registry. Laryngoscope. 2007 Sep; 117(9): 1652-60. PMID: 17762793, PII: 00005537-200709000-00024, DOI: 10.1097/MLG.0b013e318093ed8e, ISSN: 0023-852X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17762793.
  • Fine JD. Epidermolysis bullosa: a genetic disease of altered cell adhesion and wound healing, and the possible clinical utility of topically applied thymosin beta4. Ann. N. Y. Acad. Sci [print-electronic]. 2007 Sep; 1112: 396-406. PMID: 17468231, PII: annals.1415.017, DOI: 10.1196/annals.1415.017, ISSN: 0077-8923.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17468231.
  • Fine JD, Johnson LB, Weiner M, Suchindran C. Impact of inherited epidermolysis bullosa on parental interpersonal relationships, marital status and family size. Br. J. Dermatol. 2005 May; 152(5): 1009-14. PMID: 15888161, PII: BJD6339, DOI: 10.1111/j.1365-2133.2004.06339.x, ISSN: 0007-0963.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15888161.
  • Fine JD, Johnson LB, Weiner M, Stein A, Cash S, Deleoz J, Devries DT, Suchindran C. Pseudosyndactyly and musculoskeletal contractures in inherited epidermolysis bullosa: experience of the National Epidermolysis Bullosa Registry, 1986-2002. J Hand Surg Br. 2005 Feb; 30(1): 14-22. PMID: 15620486, PII: S0266-7681(04)00207-4, DOI: 10.1016/j.jhsb.2004.07.006, ISSN: 0266-7681.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15620486.