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John P.  Greer

John P. Greer, M.D.

Professor of Medicine (Hematology/Oncology), Pediatrics
Clinical Director, Hematology and Stem Cell Transplantation
Hematologist/Oncologist

Profile

Dr. Greer is a hematologist/oncologist who specializes in hematological malignancies and stem cell transplantation. His research interests are in the clinicopathologic description of hematologic neoplasms and in the development of therapeutic strategies to treat these disorders.

He has an expertise in T cell lymphomas and has a joint cutaneous lymphoma clinic with Dr.
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Dr. Greer is a hematologist/oncologist who specializes in hematological malignancies and stem cell transplantation. His research interests are in the clinicopathologic description of hematologic neoplasms and in the development of therapeutic strategies to treat these disorders.

He has an expertise in T cell lymphomas and has a joint cutaneous lymphoma clinic with Dr. John Zic in dermatology. Dr. Greer's extramural activities include Chief Editor for Wintrobe's Clinical Hematology (12th edition, 2009) and member of the Lymphoma Committee for ECOG.

His research interests are in the clinicopathologic descriptions of hematologic neoplasms and in the development of therapeutic strategies to treat those disorders. Specific entities he has helped recognize include anaplastic large cell lymphoma, T-cell-rich B-cell lymphoma, and natural killer-like T-cell lymphoma/leukemia.

Education
  • Undergraduate School & Degree: Vanderbilt University B.A.
  • Medical School & Degree: Vanderbilt University School of Medicine, 1976
  • Post Graduate Training: Tulane University; Medical College of Virginia; Vanderbilt University Medical Center
  • Board & Certifications: Internal Medicine; Pediatrics
  • ABIM & Subspecialty: Hematology; Medical Oncology
Research Description

My research interests are in the clinicopathologic descriptions of hematologic neoplasms and in the development of therapeutic strategies to treat these disorders. Specific entities we have helped recognize include anaplastic large cell lymphoma, T-cell-rich B-cell lymphoma, and natural killer-like T-cell lymphoma/leukemia. Since the early 1980's, we have evaluated short course, dose intensive therapy (MEGA) for intermediate to high grade lymphomas, the use of high dose cytarabine consolidation in acute nonlymphocytic leukemia, and the role of transplantation in hematologic neoplasms. We actively participate in phase I-III trials through cooperative groups (Eastern Cooperative Oncology Group and Children's Oncology Group) and with the pharmaceutical industry. We have an emphasis in studies evaluating novel agents directed at molecular pathways, immunotherapy, and transplantation.

Publications
  • Engelhardt BG, Holland DW, Brandt SJ, Chinratanalab W, Goodman SA, Greer JP, Jagasia MH, Kassim AA, Morgan DS, Ruffner KL, Schuening FG, Wolff S, Bitting R, Sulur P, Stein RS. High-dose chemotherapy followed by autologous stem cell transplantation for relapsed or refractory Hodgkin lymphoma: prognostic features and outcomes. Leuk. Lymphoma. 2007 Sep; 48(9): 1728-35. PMID: 17786708, PII: 781802102, DOI: 10.1080/10428190701534374, ISSN: 1042-8194.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17786708.
  • Sepmeyer JA, Greer JP, Koyama T, Zic JA. Open-label pilot study of combination therapy with rosiglitazone and bexarotene in the treatment of cutaneous T-cell lymphoma. J. Am. Acad. Dermatol [print-electronic]. 2007 Apr; 56(4): 584-7. PMID: 17184879, PII: S0190-9622(06)02865-9, DOI: 10.1016/j.jaad.2006.10.033, ISSN: 1097-6787.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17184879.
  • Schmidt AN, Robbins JB, Greer JP, Zic JA. Conjugal transformed mycosis fungoides: the unknown role of viral infection and environmental exposures in the development of cutaneous T-cell lymphoma. J. Am. Acad. Dermatol. 2006 May; 54(5 Suppl): S202-5. PMID: 16631940, PII: S0190-9622(05)03004-5, DOI: 10.1016/j.jaad.2005.09.013, ISSN: 1097-6787.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16631940.
  • Salmon JS, Thompson MA, Arildsen RC, Greer JP. Non-Hodgkin's lymphoma involving the liver: clinical and therapeutic considerations. Clin Lymphoma Myeloma. 2006 Jan; 6(4): 273-80. PMID: 16507204, PII: S1557-9190(11)70402-4, ISSN: 1557-9190.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16507204.
  • Greer JP. Therapy of peripheral T/NK neoplasms. Hematology Am Soc Hematol Educ Program. 2006; 331-7. PMID: 17124080, PII: 2006/1/331, DOI: 10.1182/asheducation-2006.1.331, ISSN: 1520-4391.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17124080.
  • Jagasia MH, Greer JP, Morgan DS, Mineishi S, Kassim AA, Ruffner KL, Chen H, Schuening FG. Pegfilgrastim after high-dose chemotherapy and autologous peripheral blood stem cell transplant: phase II study. Bone Marrow Transplant. 2005 Jun; 35(12): 1165-9. PMID: 15880129, PII: 1704994, DOI: 10.1038/sj.bmt.1704994, ISSN: 0268-3369.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15880129.
  • Stein RS, Wolff SN, Greer JP, Flexner JM, Goodman S, Jagasia M, Brandt SJ, Morgan DS, Arrowsmith E, McCurley TL. Age and cytogenetics as predictors of event free survival in patients with acute non-lymphocytic leukemia receiving high dose cytosine arabinoside and daunorubicin as consolidation chemotherapy. Leuk. Lymphoma. 2001 Sep; 42(5): 913-22. PMID: 11697646, DOI: 10.3109/10428190109097710, ISSN: 1042-8194.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11697646.
  • Delbeke D, Martin WH, Morgan DS, Kinney JC, Feurer I, Kovalsky E, Arrowsmith T, Greer JP. 18F-Flourodeoxyglucose imaging with positron emission tomography for initial staging of Hodgkins disease and lymphoma. Clin Positron Imaging. 2001; ((3)): 10.
  • Dorr R, Karanes C, Spier C, Grogan T, Greer J, Moore J, Weinberger B, Schiller G, Pearce T, Litchman M, Dalton W, Roe D, List AF. Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia. J Clin Oncol. 2001; ((19)): 1589-99.
  • Pavletic ZS, Arrowsmith ER, Bierman PJ, Goodman SA, Vose JM, Tarantolo SR, Stein RS, Bociek G, Greer JP, Wu CD, Kollath JP, Weisenburger DD, Kessinger A, Wolff SN, Armitage JO, Bishop MR. Outcome of allogeneic stem cell transplantation for B cell chronic lymphocytic leukemia. Bone Marrow Transplant. 2000 Apr; 25(7): 717-22. PMID: 10745256, DOI: 10.1038/sj.bmt.1702237, ISSN: 0268-3369.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10745256.
  • Stein RS, Greer JP, Goodman S, Brandt SJ, Morgan DS, Macon WR, McCurley TL, Wolff SN. Intensified preparative regimens and autologous transplantation in refractory or relapsed intermediate grade non-Hodgkin's lymphoma. Bone Marrow Transplant. 2000 Feb; 25(3): 257-62. PMID: 10673696, DOI: 10.1038/sj.bmt.1702132, ISSN: 0268-3369.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10673696.
  • Stein RS, Greer JP, Goodman S, Kallianpur A, Ahmed MS, Wolff SN. High -dose therapy with autologous or allogeneic transplantation as salvage therapy for small cleaved cell lymphoma of follicular center cell origin. Bone Marrow Transplant. 1999; 23227-233.
  • Kravtsov VD, Greer JP, Whitlock JA, Koury MJ. Use of the microculture kinetic assay of apoptosis to determine chemosensitivities of leukemias. Blood. 1998 Aug 8/1/1998; 92(3): 968-80. PMID: 9680366, ISSN: 0006-4971.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9680366.
  • Whitlock JA, Wells RJ, Hord JD, Janco RL, Greer JP, Gay JC, Edwards JR, McCurley TL, Lukens JN. High-dose cytosine arabinoside and etoposide: an effective regimen without anthracyclines for refractory childhood acute non-lymphocytic leukemia. Leukemia. 1997 Feb; 11(2): 185-9. PMID: 9009078, ISSN: 0887-6924.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9009078.
  • Stein RS, Greer JP, Flexner JM, Goodman S, Wolff SN. Etoposide and mitoxantrone as a second cycle of consolidation therapy following high dose cytosine arabinoside and daunorubicin in patients with acute non-lymphocytic leukemia in remission: a pilot study. Leuk. Lymphoma. 1996 Sep; 23(1-2): 93-8. PMID: 9021690, DOI: 10.3109/10428199609054806, ISSN: 1042-8194.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9021690.
  • Hammer RD, Glick AD, Greer JP, Collins RD, Cousar JB. Splenic marginal zone lymphoma. A distinct B-cell neoplasm. Am. J. Surg. Pathol. 1996 May; 20(5): 613-26. PMID: 8619426, ISSN: 0147-5185.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8619426.
  • List AF, Spier CS, Grogan TM, Johnson C, Roe DJ, Greer JP, Wolff SN, Broxterman HJ, Scheffer GL, Scheper RJ, Dalton WS. Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia. Blood. 1996 Mar 3/15/1996; 87(6): 2464-9. PMID: 8630412, ISSN: 0006-4971.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8630412.
  • Macon WR, Williams ME, Greer JP, Hammer RD, Glick AD, Collins RD, Cousar JB. Natrual killer-like T-cell lymphomas: Aggressive CD56+ peripheral T-cell lymphomas of large granular lymphocytes, possibly arising from thymic-independent T-cells. Blood. 1996; 871474-1483.
  • Greer JP, Macon WR, Lamar RE, Wolff SN, Stein RS, Flexner JM, Collins RD, Cousar JB. T-cell-rich B-cell lymphomas: diagnosis and response to therapy of 44 patients. J. Clin. Oncol. 1995 Jul; 13(7): 1742-50. PMID: 7602364, ISSN: 0732-183X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7602364.
  • Waits TM, Greco FA, Greer JP, Johnson DH, Wolff SN, Stein RS, McMaster ML, Hainsworth JD. Effective therapy for poor-prognosis non-Hodgkin's lymphoma with 8 weeks of high-dose-intensity combination chemotherapy. J. Clin. Oncol. 1993 May; 11(5): 943-9. PMID: 7683712, ISSN: 0732-183X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7683712.
  • List AF, Spier C, Greer J, Wolff S, Hutter J, Door R, Salmon S, Futscher B, Baer M, Dalton W. Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia. J Clinc Oncol. 1993; ((11)): 1652-60.
  • Whitlock JA, Greer JP, Lukens JN. Epipodophyllotoxin-related leukemia. Identification of a new subset of secondary leukemia. Cancer. 1991 Aug 8/1/1991; 68(3): 600-4. PMID: 1648435, ISSN: 0008-543X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1648435.
  • McMaster ML, Greer JP, Wolff SN, Johnson DH, Greco FA, Stein RS, Cousar JB, Flexner JM, Hainsworth JD. Results of treatment with high intensity, brief duration chemotherapy in poor prognosis non-Hodgkin's lymphoma. Cancer. 1991 Jul 7/15/1991; 68(2): 233-41. PMID: 1712662, ISSN: 0008-543X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1712662.
  • Greer JP, Kinney MC, Collins RD, Salhany KE, Wolff SN, Hainsworth JD, Flexner JM, Stein RS. Clinical features of 31 patients with Ki-1 anaplastic large-cell lymphoma. J. Clin. Oncol. 1991 Apr; 9(4): 539-47. PMID: 1648596, ISSN: 0732-183X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1648596.
  • Reece DE, Barnett MJ, Conners JM, Fairey RN, Greer JP, Herzig GP, Herzig RH, Klingerman HC, OReilly SE, Shepherd JD, Spinelli JJ, Voss NJ, Wolff SN, Phillips GP. Intensive chemotherapy with cyclophosphamide, carmustine, and etoposide followed by autologous bone marrow transplantation for relapsed Hodgkins disease. J Clinc Oncol. 1991; ((9)): 1871-9.
  • Stein RS, Greer JP, Flexner JM, Hainsworth JD, Collins RD, Macon WR, Cousar JB. Large-cell lymphomas: clinical and prognostic features. J. Clin. Oncol. 1990 Aug; 8(8): 1370-9. PMID: 2199623, ISSN: 0732-183X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2199623.
  • Wolff SN, Herzig RH, Fay JW, Phillips GL, Lazarus HM, Flexner JM, Stein RS, Greer JP, Cooper B, Herzig GP. High-dose cytarabine and daunorubicin as consolidation therapy for acute myeloid leukemia in first remission: long-term follow-up and results. J. Clin. Oncol. 1989 Sep; 7(9): 1260-7. PMID: 2769327, ISSN: 0732-183X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2769327.
  • Armitage JO, Greer JP, Levine AM, Weisenburger DD, Formenti SC, Bast M, Conley S, Pierson J, Linder J, Cousar JB. Peripheral T-cell lymphoma. Cancer. 1989 Jan 1/1/1989; 63(1): 158-63. PMID: 2783376, ISSN: 0008-543X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2783376.
  • Greer JP, Cousar JB, Miller RF, Vogler LB, Goodin JC, Graber SE, Collins RD. T4+ (helper phenotype) chronic lymphocytic leukemia: case report with liver failure and literature review. Med. Pediatr. Oncol. 1988; 16(5): 356-62. PMID: 2972899, ISSN: 0098-1532.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2972899.
  • McCurley TL, Greer JP, Glick AD. Terminal deoxynucleotidyl transferase (TdT) in acute nonlymphocytic leukemia. A clinical, morphologic, cytochemical, immunologic and ultrastructural study. Am J Clin Pathol. 1988; ((90)): 421-30.
  • Stein RS, Magee MJ, Lenox RK, Cousar JB, Collins RD, Flexner JM, Ray W, Greer JP. Malignant lymphomas of follicular center cell origin in man. VI. Large cleaved cell lymphoma. Cancer. 1987 Dec 12/1/1987; 60(11): 2704-11. PMID: 3677005, ISSN: 0008-543X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3677005.
  • Wolff SN, Herzig RH, Phillips GL, Lazarus HM, Greer JP, Stein RS, Ray WA, Herzig GP. High-dose cytosine arabinoside and daunorubicin as consolidation therapy for acute nonlymphocytic leukemia in first remission: An up date. Sem Oncol. 1987; ((2)): 12-7.
  • Greer JP, Kinney MC, Cousar JB, Flexner JM, Dupont WD, Graber SE, Greco FA, Collins RD, Stein RS. Lymphocyte-depleted Hodgkin's disease. Clinicopathologic review of 25 patients. Am. J. Med. 1986 Aug; 81(2): 208-14. PMID: 3740079, PII: 0002-9343(86)90253-6, ISSN: 0002-9343.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3740079.
  • Greer JP, York JC, Cousar JB, Mitchell RT, Flexner JM, Collins RD, Stein RS. Peripheral T-cell lymphoma: a clinicopathologic study of 42 cases. J. Clin. Oncol. 1984 Jul; 2(7): 788-98. PMID: 6376720, ISSN: 0732-183X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/6376720.