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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 

John H. Newman, M.D.

Elsa S. Hanigan Professor of Pulmonary Medicine
Professor of Medicine (Allergy, Pulmonary & Critical Care Medicine)
Director, Pulmonary & Critical Care Fellowship Program
Researcher

Contact Information:

Veterans Administration Medical Center
111 Med Svc VAMC
Nashville, TN 37212
615-327-4751

Education
  • M.D. - Columbia University, 1971
  • Fellowship - University of Colorado Hospital, 1979
  • Residency - Johns Hopkins Hospital and Health System, 1974
  • Residency - Columbia Presbyterian Medical Center, 1973
  • Internship - Columbia Presbyterian Medical Center, 1972
 
Publications
  • Talati MH, Brittain EL, Fessel JP, Penner N, Atkinson J, Funke M, Grueter C, Jerome WG, Freeman M, Newman JH, West J, Hemnes AR. Mechanisms of Lipid Accumulation in the Bone Morphogenic Protein Receptor 2 Mutant Right Ventricle. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Apr 4/14/2016; PMID: 27077479, DOI: 10.1164/rccm.201507-1444OC, ISSN: 1535-4970.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27077479.
  • Talati MH, Brittain EL, Fessel JP, Penner N, Atkinson J, Funke M, Grueter C, Jerome WG, Freeman M, Newman JH, West J, Hemnes AR. Mechanisms of Lipid Accumulation in the Bone Morphogenic Protein Receptor 2 Mutant Right Ventricle. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Apr 4/14/2016; PMID: 27077479, DOI: 10.1164/rccm.201507-1444OC, ISSN: 1535-4970.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27077479.
  • Brittain EL, Talati M, Fessel JP, Zhu H, Penner N, Calcutt MW, West J, Funke M, Lewis GD, Gerszten RE, Hamid R, Pugh ME, Austin ED, Newman JH, Hemnes AR. Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension. Circulation [print-electronic]. 2016 Mar 3/22/2016; PMID: 27006481, PII: CIRCULATIONAHA.115.019351, DOI: 10.1161/CIRCULATIONAHA.115.019351, ISSN: 1524-4539.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27006481.
  • Brittain EL, Talati M, Fessel JP, Zhu H, Penner N, Calcutt MW, West J, Funke M, Lewis GD, Gerszten RE, Hamid R, Pugh ME, Austin ED, Newman JH, Hemnes AR. Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension. Circulation [print-electronic]. 2016 Mar 3/22/2016; PMID: 27006481, PII: CIRCULATIONAHA.115.019351, DOI: 10.1161/CIRCULATIONAHA.115.019351, ISSN: 1524-4539.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27006481.
  • Hemnes AR, Zhao M, West J, Newman JH, Rich S, Archer SL, Robbins IM, Blackwell TS, Cogan J, Loyd JE, Zhao Z, Gaskill C, Jetter C, Kropski JA, Majka SM, Austin ED. Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Feb 2/29/2016; PMID: 26926454, DOI: 10.1164/rccm.201508-1678OC, ISSN: 1535-4970.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26926454.
  • Hemnes AR, Zhao M, West J, Newman JH, Rich S, Archer SL, Robbins IM, Blackwell TS, Cogan J, Loyd JE, Zhao Z, Gaskill C, Jetter C, Kropski JA, Majka SM, Austin ED. Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2016 Feb 2/29/2016; PMID: 26926454, DOI: 10.1164/rccm.201508-1678OC, ISSN: 1535-4970.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26926454.
  • Machado RD, Southgate L, Eichstaedt CA, Aldred MA, Austin ED, Best DH, Chung WK, Benjamin N, Elliott CG, Eyries M, Fischer C, Gräf S, Hinderhofer K, Humbert M, Keiles SB, Loyd JE, Morrell NW, Newman JH, Soubrier F, Trembath RC, Viales RR, Grünig E. Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects. Hum. Mutat [print-electronic]. 2015 Dec; 36(12): 1113-27. PMID: 26387786, PMCID: PMC4822159, DOI: 10.1002/humu.22904, ISSN: 1098-1004.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26387786.
  • Machado RD, Southgate L, Eichstaedt CA, Aldred MA, Austin ED, Best DH, Chung WK, Benjamin N, Elliott CG, Eyries M, Fischer C, Gräf S, Hinderhofer K, Humbert M, Keiles SB, Loyd JE, Morrell NW, Newman JH, Soubrier F, Trembath RC, Viales RR, Grünig E. Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects. Hum. Mutat [print-electronic]. 2015 Dec; 36(12): 1113-27. PMID: 26387786, PMCID: PMC4822159, DOI: 10.1002/humu.22904, ISSN: 1098-1004.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26387786.
  • Mishra A, Mohammad G, Norboo T, Newman JH, Pasha MA. Lungs at high-altitude: genomic insights into hypoxic responses. J. Appl. Physiol [print-electronic]. 2015 Jul 7/1/2015; 119(1): 1-15. PMID: 25911686, PII: japplphysiol.00513.2014, DOI: 10.1152/japplphysiol.00513.2014, ISSN: 1522-1601.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25911686.
  • Mishra A, Mohammad G, Norboo T, Newman JH, Pasha MA. Lungs at high-altitude: genomic insights into hypoxic responses. J. Appl. Physiol [print-electronic]. 2015 Jul 7/1/2015; 119(1): 1-15. PMID: 25911686, PII: japplphysiol.00513.2014, DOI: 10.1152/japplphysiol.00513.2014, ISSN: 1522-1601.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25911686.
  • Trammell AW, Pugh ME, Newman JH, Hemnes AR, Robbins IM. Use of pulmonary arterial hypertension-approved therapy in the treatment of non-group 1 pulmonary hypertension at US referral centers. Pulm Circ. 2015 Jun; 5(2): 356-63. PMID: 26064462, PMCID: PMC4449248, PII: PC2013183, DOI: 10.1086/681264, ISSN: 2045-8932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26064462.
  • Trammell AW, Pugh ME, Newman JH, Hemnes AR, Robbins IM. Use of pulmonary arterial hypertension-approved therapy in the treatment of non-group 1 pulmonary hypertension at US referral centers. Pulm Circ. 2015 Jun; 5(2): 356-63. PMID: 26064462, PMCID: PMC4449248, PII: PC2013183, DOI: 10.1086/681264, ISSN: 2045-8932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26064462.
  • Hemnes AR, Trammell AW, Archer SL, Rich S, Yu C, Nian H, Penner N, Funke M, Wheeler L, Robbins IM, Austin ED, Newman JH, West J. Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension. Circulation [print-electronic]. 2015 Jan 1/27/2015; 131(4): 401-9; discussion 409. PMID: 25361553, PMCID: PMC4308423, PII: CIRCULATIONAHA.114.013317, DOI: 10.1161/CIRCULATIONAHA.114.013317, ISSN: 1524-4539.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25361553.
  • Hemnes AR, Trammell AW, Archer SL, Rich S, Yu C, Nian H, Penner N, Funke M, Wheeler L, Robbins IM, Austin ED, Newman JH, West J. Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension. Circulation [print-electronic]. 2015 Jan 1/27/2015; 131(4): 401-9; discussion 409. PMID: 25361553, PMCID: PMC4308423, PII: CIRCULATIONAHA.114.013317, DOI: 10.1161/CIRCULATIONAHA.114.013317, ISSN: 1524-4539.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25361553.
  • Newman JH, Holt TN, Cogan JD, Womack B, Phillips JA, Li C, Kendall Z, Stenmark KR, Thomas MG, Brown RD, Riddle SR, West JD, Hamid R. Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension. Nat Commun. 2015; 6: 6863. PMID: 25873470, PMCID: PMC4399003, PII: ncomms7863, DOI: 10.1038/ncomms7863, ISSN: 2041-1723.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25873470.
  • Newman JH, Holt TN, Cogan JD, Womack B, Phillips JA, Li C, Kendall Z, Stenmark KR, Thomas MG, Brown RD, Riddle SR, West JD, Hamid R. Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension. Nat Commun. 2015; 6: 6863. PMID: 25873470, PMCID: PMC4399003, PII: ncomms7863, DOI: 10.1038/ncomms7863, ISSN: 2041-1723.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25873470.
  • Newman JH. The first annual Drug Discovery and Development Symposium for Pulmonary Hypertension. Pulm Circ. 2014 Dec; 4(4): 533-4. PMID: 25610591, PMCID: PMC4278615, PII: PC2013198, DOI: 10.1086/679063, ISSN: 2045-8932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25610591.
  • Newman JH. The first annual Drug Discovery and Development Symposium for Pulmonary Hypertension. Pulm Circ. 2014 Dec; 4(4): 533-4. PMID: 25610591, PMCID: PMC4278615, PII: PC2013198, DOI: 10.1086/679063, ISSN: 2045-8932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25610591.
  • Pugh ME, Hemnes AR, Trammell A, Newman JH, Robbins IM. Variability in hemodynamic evaluation of pulmonary hypertension at large referral centers. Pulm Circ. 2014 Dec; 4(4): 679-84. PMID: 25610603, PMCID: PMC4278627, PII: PC2013117, DOI: 10.1086/678514, ISSN: 2045-8932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25610603.
  • Pugh ME, Hemnes AR, Trammell A, Newman JH, Robbins IM. Variability in hemodynamic evaluation of pulmonary hypertension at large referral centers. Pulm Circ. 2014 Dec; 4(4): 679-84. PMID: 25610603, PMCID: PMC4278627, PII: PC2013117, DOI: 10.1086/678514, ISSN: 2045-8932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25610603.
  • Robbins IM, Hemnes AR, Pugh ME, Brittain EL, Zhao DX, Piana RN, Fong PP, Newman JH. High prevalence of occult pulmonary venous hypertension revealed by fluid challenge in pulmonary hypertension. Circ Heart Fail [print-electronic]. 2014 Jan; 7(1): 116-22. PMID: 24297689, PMCID: PMC3934572, PII: CIRCHEARTFAILURE.113.000468, DOI: 10.1161/CIRCHEARTFAILURE.113.000468, ISSN: 1941-3297.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24297689.
  • Robbins IM, Hemnes AR, Pugh ME, Brittain EL, Zhao DX, Piana RN, Fong PP, Newman JH. High prevalence of occult pulmonary venous hypertension revealed by fluid challenge in pulmonary hypertension. Circ Heart Fail [print-electronic]. 2014 Jan; 7(1): 116-22. PMID: 24297689, PMCID: PMC3934572, PII: CIRCHEARTFAILURE.113.000468, DOI: 10.1161/CIRCHEARTFAILURE.113.000468, ISSN: 1941-3297.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24297689.
  • Soubrier F, Chung WK, Machado R, Grünig E, Aldred M, Geraci M, Loyd JE, Elliott CG, Trembath RC, Newman JH, Humbert M. Genetics and genomics of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 2013 Dec 12/24/2013; 62(25 Suppl): D13-21. PMID: 24355637, PII: S0735-1097(13)05878-6, DOI: 10.1016/j.jacc.2013.10.035, ISSN: 1558-3597.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24355637.
  • Soubrier F, Chung WK, Machado R, Grünig E, Aldred M, Geraci M, Loyd JE, Elliott CG, Trembath RC, Newman JH, Humbert M. Genetics and genomics of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 2013 Dec 12/24/2013; 62(25 Suppl): D13-21. PMID: 24355637, PII: S0735-1097(13)05878-6, DOI: 10.1016/j.jacc.2013.10.035, ISSN: 1558-3597.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24355637.
  • Brittain EL, Pugh ME, Wheeler LA, Robbins IM, Loyd JE, Newman JH, Larkin EK, Austin ED, Hemnes AR. Shorter survival in familial versus idiopathic pulmonary arterial hypertension is associated with hemodynamic markers of impaired right ventricular function. Pulm Circ [print-electronic]. 2013 Sep; 3(3): 589-98. PMID: 24618543, PMCID: PMC4070798, DOI: 10.1086/674326, ISSN: 2045-8932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24618543.
  • Brittain EL, Pugh ME, Wheeler LA, Robbins IM, Loyd JE, Newman JH, Larkin EK, Austin ED, Hemnes AR. Shorter survival in familial versus idiopathic pulmonary arterial hypertension is associated with hemodynamic markers of impaired right ventricular function. Pulm Circ [print-electronic]. 2013 Sep; 3(3): 589-98. PMID: 24618543, PMCID: PMC4070798, DOI: 10.1086/674326, ISSN: 2045-8932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24618543.
  • Bates MG, Hollingsworth KG, Newman JH, Jakovljevic DG, Blamire AM, MacGowan GA, Keavney BD, Chinnery PF, Turnbull DM, Taylor RW, Trenell MI, Gorman GS. Concentric hypertrophic remodelling and subendocardial dysfunction in mitochondrial DNA point mutation carriers. Eur Heart J Cardiovasc Imaging [print-electronic]. 2013 Jul; 14(7): 650-8. PMID: 23129433, PMCID: PMC3681541, PII: jes226, DOI: 10.1093/ehjci/jes226, ISSN: 2047-2412.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23129433.
  • Bryant AJ, Newman JH. Alcohol intolerance associated with Hodgkin lymphoma. CMAJ [print-electronic]. 2013 May 5/14/2013; 185(8): E353. PMID: 23091182, PMCID: PMC3652965, PII: cmaj.120974, DOI: 10.1503/cmaj.120974, ISSN: 1488-2329.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23091182.
  • Pugh ME, Newman JH, Williams DB, Brittain E, Robbins IM, Hemnes AR. Hemodynamic improvement of pulmonary arterial hypertension after bariatric surgery: potential role for metabolic regulation. Diabetes Care. 2013 Mar; 36(3): e32-3. PMID: 23431096, PMCID: PMC3579352, PII: 36/3/e32, DOI: 10.2337/dc12-1650, ISSN: 1935-5548.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23431096.
  • Newman JH, Elliott GC, Haworth GS, Zampaglione E, Brar S, Gibbs SJ, Sandoval J. Clinical trials in pulmonary hypertension: Time for a consortium. Pulm Circ. 2013 Jan; 3(1): 245-51. PMID: 23662202, PMCID: PMC3641735, PII: PC-3-245, DOI: 10.4103/2045-8932.109922, ISSN: 2045-8932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23662202.
  • Newman JH, Elliott GC, Haworth GS, Zampaglione E, Brar S, Gibbs SJ, Sandoval J. Clinical trials in pulmonary hypertension: Time for a consortium. Pulm Circ. 2013 Jan; 3(1): 245-51. PMID: 23662202, PMCID: PMC3641735, PII: PC-3-245, DOI: 10.4103/2045-8932.109922, ISSN: 2045-8932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23662202.
  • Brittain EL, Pugh ME, Wang L, Newman AL, Robbins IM, Newman JH, Hemnes AR. Predictors of diastolic-to-wedge gradient in patients evaluated for pulmonary hypertension. PLoS ONE. 2013; 8(10): e76461. PMID: 24124561, PMCID: PMC3790694, PII: PONE-D-13-27489, DOI: 10.1371/journal.pone.0076461, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24124561.
  • Brittain EL, Pugh ME, Wang L, Newman AL, Robbins IM, Newman JH, Hemnes AR. Predictors of diastolic-to-wedge gradient in patients evaluated for pulmonary hypertension. PLoS ONE. 2013; 8(10): e76461. PMID: 24124561, PMCID: PMC3790694, PII: PONE-D-13-27489, DOI: 10.1371/journal.pone.0076461, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24124561.
  • Pugh ME, Buchowski MS, Robbins IM, Newman JH, Hemnes AR. Physical activity limitation as measured by accelerometry in pulmonary arterial hypertension. Chest. 2012 Dec; 142(6): 1391-8. PMID: 22576635, PMCID: PMC3515022, PII: chest.12-0150, DOI: 10.1378/chest.12-0150, ISSN: 1931-3543.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22576635.
  • Larkin EK, Newman JH, Austin ED, Hemnes AR, Wheeler L, Robbins IM, West JD, Phillips JA, Hamid R, Loyd JE. Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2012 Nov 11/1/2012; 186(9): 892-6. PMID: 22923661, PMCID: PMC3530218, PII: rccm.201205-0886OC, DOI: 10.1164/rccm.201205-0886OC, ISSN: 1535-4970.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22923661.
  • Hemnes AR, Maynard KB, Champion HC, Gleaves L, Penner N, West J, Newman JH. Testosterone negatively regulates right ventricular load stress responses in mice. Pulm Circ. 2012 Jul; 2(3): 352-8. PMID: 23130103, PMCID: PMC3487303, PII: PC-2-352, DOI: 10.4103/2045-8932.101647, ISSN: 2045-8940.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23130103.
  • Hemnes AR, Pugh ME, Newman AL, Robbins IM, Tolle J, Austin ED, Newman JH. End tidal CO(2) tension: pulmonary arterial hypertension vs pulmonary venous hypertension and response to treatment. Chest [print-electronic]. 2011 Nov; 140(5): 1267-73. PMID: 21622547, PII: chest.11-0155, DOI: 10.1378/chest.11-0155, ISSN: 1931-3543.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21622547.
  • Newman JH, Holt TN, Hedges LK, Womack B, Memon SS, Willers ED, Wheeler L, Phillips JA, Hamid R. High-altitude pulmonary hypertension in cattle (brisket disease): Candidate genes and gene expression profiling of peripheral blood mononuclear cells. Pulm Circ. 2011 Oct; 1(4): 462-9. PMID: 22530101, PMCID: PMC3329076, PII: PC-1-462, DOI: 10.4103/2045-8932.93545, ISSN: 2045-8940.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22530101.
  • Pugh ME, Robbins IM, Rice TW, West J, Newman JH, Hemnes AR. Unrecognized glucose intolerance is common in pulmonary arterial hypertension. J. Heart Lung Transplant [print-electronic]. 2011 Aug; 30(8): 904-11. PMID: 21493097, PMCID: PMC3129440, PII: S1053-2498(11)00831-X, DOI: 10.1016/j.healun.2011.02.016, ISSN: 1557-3117.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21493097.
  • King MS, Eisenberg R, Newman JH, Tolle JJ, Harrell FE, Nian H, Ninan M, Lambright ES, Sheller JR, Johnson JE, Miller RF. Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan. N. Engl. J. Med. 2011 Jul 7/21/2011; 365(3): 222-30. PMID: 21774710, PMCID: PMC3296566, DOI: 10.1056/NEJMoa1101388, ISSN: 1533-4406.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21774710.
  • Austin ED, Menon S, Hemnes AR, Robinson LR, Talati M, Fox KL, Cogan JD, Hamid R, Hedges LK, Robbins I, Lane K, Newman JH, Loyd JE, West J. Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression. Pulm Circ. 2011 Jul; 1(3): 389-98. PMID: 22140629, PMCID: PMC3224431, PII: PC-1-389, DOI: 10.4103/2045-8932.87308, ISSN: 2045-8940.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22140629.
  • Pasha MA, Newman JH. High-altitude disorders: pulmonary hypertension: pulmonary vascular disease: the global perspective. Chest. 2010 Jun; 137(6 Suppl): 13S-19S. PMID: 20522576, PII: 137/6_suppl/13S, DOI: 10.1378/chest.09-2445, ISSN: 1931-3543.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20522576.
  • Hemnes AR, Newman AL, Rosenbaum B, Barrett TW, Zhou C, Rice TW, Newman JH. Bedside end-tidal CO2 tension as a screening tool to exclude pulmonary embolism. Eur. Respir. J [print-electronic]. 2010 Apr; 35(4): 735-41. PMID: 19717480, PII: 09031936.00084709, DOI: 10.1183/09031936.00084709, ISSN: 1399-3003.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19717480.
  • Arastu MH, Vijayaraghavan J, Chissell H, Hull JB, Newman JH, Robinson JR. Early failure of a mobile-bearing unicompartmental knee replacement. Knee Surg Sports Traumatol Arthrosc [print-electronic]. 2009 Oct; 17(10): 1178-83. PMID: 19333578, DOI: 10.1007/s00167-009-0779-z, ISSN: 1433-7347.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19333578.
  • Robbins IM, Newman JH, Johnson RF, Hemnes AR, Fremont RD, Piana RN, Zhao DX, Byrne DW. Association of the metabolic syndrome with pulmonary venous hypertension. Chest [print-electronic]. 2009 Jul; 136(1): 31-6. PMID: 19188551, PMCID: PMC2716716, PII: chest.08-2008, DOI: 10.1378/chest.08-2008, ISSN: 1931-3543.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19188551.
  • Hassoun PM, Mouthon L, Barberà JA, Eddahibi S, Flores SC, Grimminger F, Jones PL, Maitland ML, Michelakis ED, Morrell NW, Newman JH, Rabinovitch M, Schermuly R, Stenmark KR, Voelkel NF, Yuan JX, Humbert M. Inflammation, growth factors, and pulmonary vascular remodeling. J. Am. Coll. Cardiol. 2009 Jun 6/30/2009; 54(1 Suppl): S10-9. PMID: 19555853, PII: S0735-1097(09)01208-X, DOI: 10.1016/j.jacc.2009.04.006, ISSN: 1558-3597.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19555853.
  • Machado RD, Eickelberg O, Elliott CG, Geraci MW, Hanaoka M, Loyd JE, Newman JH, Phillips JA, Soubrier F, Trembath RC, Chung WK. Genetics and genomics of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 2009 Jun 6/30/2009; 54(1 Suppl): S32-42. PMID: 19555857, PMCID: PMC3725550, PII: S0735-1097(09)01220-0, DOI: 10.1016/j.jacc.2009.04.015, ISSN: 1558-3597.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19555857.
  • Hamid R, Newman JH. Evidence for inflammatory signaling in idiopathic pulmonary artery hypertension: TRPC6 and nuclear factor-kappaB [editorial]. Circulation. 2009 May 5/5/2009; 119(17): 2297-8. PMID: 19414653, PII: 119/17/2297, DOI: 10.1161/CIRCULATIONAHA.109.855197, ISSN: 1524-4539.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19414653.
  • Hamid R, Cogan JD, Hedges LK, Austin E, Phillips JA, Newman JH, Loyd JE. Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele. Hum. Mutat. 2009 Apr; 30(4): 649-54. PMID: 19206171, PMCID: PMC2663001, DOI: 10.1002/humu.20922, ISSN: 1098-1004.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19206171.
  • Austin ED, Phillips JA, Cogan JD, Hamid R, Yu C, Stanton KC, Phillips CA, Wheeler LA, Robbins IM, Newman JH, Loyd JE. Truncating and missense BMPR2 mutations differentially affect the severity of heritable pulmonary arterial hypertension. Respir. Res. 2009; 10: 87. PMID: 19785764, PMCID: PMC2762975, PII: 1465-9921-10-87, DOI: 10.1186/1465-9921-10-87, ISSN: 1465-993X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19785764.
  • Phillips JA, Poling JS, Phillips CA, Stanton KC, Austin ED, Cogan JD, Wheeler L, Yu C, Newman JH, Dietz HC, Loyd JE. Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension. Genet. Med. 2008 May; 10(5): 359-65. PMID: 18496036, PII: 00125817-200805000-00010, DOI: 10.1097/GIM.0b013e318172dcdf, ISSN: 1530-0366.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18496036.
  • Newman JH, Phillips JA, Loyd JE. Narrative review: the enigma of pulmonary arterial hypertension: new insights from genetic studies. Ann. Intern. Med. 2008 Feb 2/19/2008; 148(4): 278-83. PMID: 18283205, PII: 148/4/278, ISSN: 1539-3704.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18283205.
  • Willers ED, Newman JH, Loyd JE, Robbins IM, Wheeler LA, Prince MA, Stanton KC, Cogan JA, Runo JR, Byrne D, Humbert M, Simonneau G, Sztrymf B, Morse JA, Knowles JA, Roberts KE, McElroy JJ, Barst RJ, Phillips JA. Serotonin transporter polymorphisms in familial and idiopathic pulmonary arterial hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2006 Apr 4/1/2006; 173(7): 798-802. PMID: 16339917, PMCID: PMC2662954, PII: 200509-1361OC, DOI: 10.1164/rccm.200509-1361OC, ISSN: 1073-449X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16339917.
  • Newman JH. Pulmonary hypertension. Am. J. Respir. Crit. Care Med [print-electronic]. 2005 Nov 11/1/2005; 172(9): 1072-7. PMID: 15994464, PMCID: PMC2718396, PII: 200505-684OE, DOI: 10.1164/rccm.200505-684OE, ISSN: 1073-449X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15994464.
  • Newman JH, Fanburg BL, Archer SL, Badesch DB, Barst RJ, Garcia JG, Kao PN, Knowles JA, Loyd JE, McGoon MD, Morse JH, Nichols WC, Rabinovitch M, Rodman DM, Stevens T, Tuder RM, Voelkel NF, Gail DB, . Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop. Circulation. 2004 Jun 6/22/2004; 109(24): 2947-52. PMID: 15210611, PII: 109/24/2947, DOI: 10.1161/01.CIR.0000132476.87231.6F, ISSN: 1524-4539.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15210611.
  • Newman JH, Trembath RC, Morse JA, Grunig E, Loyd JE, Adnot S, Coccolo F, Ventura C, Phillips JA, Knowles JA, Janssen B, Eickelberg O, Eddahibi S, Herve P, Nichols WC, Elliott G. Genetic basis of pulmonary arterial hypertension: current understanding and future directions. J. Am. Coll. Cardiol. 2004 Jun 6/16/2004; 43(12 Suppl S): 33S-39S. PMID: 15194176, PII: S0735109704004371, DOI: 10.1016/j.jacc.2004.02.028, ISSN: 0735-1097.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15194176.
  • Runo JR, Vnencak-Jones CL, Prince M, Loyd JE, Wheeler L, Robbins IM, Lane KB, Newman JH, Johnson J, Nichols WC, Phillips JA. Pulmonary veno-occlusive disease caused by an inherited mutation in bone morphogenetic protein receptor II. Am. J. Respir. Crit. Care Med [print-electronic]. 2003 Mar 3/15/2003; 167(6): 889-94. PMID: 12446270, PII: 200208-861OC, DOI: 10.1164/rccm.200208-861OC, ISSN: 1073-449X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12446270.
  • Koizumi T, Johnston D, Bjertnaes LJ, Banerjee MR, Newman JH. Inhibition of endogenous nitric oxide during endotoxemia in awake sheep - effects of Nomega-nitro-l-arginine on the distribution of pulmonary vascular resistance and prostanoid products. Exp. Lung Res. 2002 Sep; 28(6): 473-84. PMID: 12217213, DOI: 10.1080/01902140290096737, ISSN: 0190-2148.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12217213.
  • Thomas AQ, Gaddipati R, Newman JH, Loyd JE. Genetics of primary pulmonary hypertension. Clin. Chest Med. 2001 Sep; 22(3): 477-91, ix. PMID: 11590842, ISSN: 0272-5231.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11590842.
  • Newman JH, Wheeler L, Lane KB, Loyd E, Gaddipati R, Phillips JA, Loyd JE. Mutation in the gene for bone morphogenetic protein receptor II as a cause of primary pulmonary hypertension in a large kindred. N. Engl. J. Med. 2001 Aug 8/2/2001; 345(5): 319-24. PMID: 11484688, DOI: 10.1056/NEJM200108023450502, ISSN: 0028-4793.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11484688.
  • Koizumi T, Roselli RJ, Parker RE, Hermo-Weiler CI, Banerjee M, Newman JH. Clearance of filtered fluid from the lung during exercise: role of hyperpnea. Am. J. Respir. Crit. Care Med. 2001 Mar; 163(3 Pt 1): 614-8. PMID: 11254513, DOI: 10.1164/ajrccm.163.3.2004205, ISSN: 1073-449X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11254513.
  • Bjertnaes LJ, Koizumi T, Newman JH. Inhaled nitric oxide reduces lung fluid filtration after endotoxin in awake sheep. Am. J. Respir. Crit. Care Med. 1998 Nov; 158(5 Pt 1): 1416-23. PMID: 9817688, DOI: 10.1164/ajrccm.158.5.9607020, ISSN: 1073-449X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9817688.
  • Hermo-Weiler CI, Koizumi T, Parker R, Newman JH. Pulmonary vasoconstriction induced by mitral valve obstruction in sheep. J. Appl. Physiol. 1998 Nov; 85(5): 1655-60. PMID: 9804566, ISSN: 8750-7587.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9804566.
  • Robbins IM, Christman BW, Newman JH, Matlock R, Loyd JE. A survey of diagnostic practices and the use of epoprostenol in patients with primary pulmonary hypertension. Chest. 1998 Nov; 114(5): 1269-75. PMID: 9824000, ISSN: 0012-3692.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9824000.
  • Loyd JE, Slovis B, Phillips JA, Butler MG, Foroud TM, Conneally PM, Newman JH. The presence of genetic anticipation suggests that the molecular basis of familial primary pulmonary hypertension may be trinucleotide repeat expansion. Chest. 1997 Jun; 111(6 Suppl): 82S-83S. PMID: 9184540, ISSN: 0012-3692.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9184540.
  • Newman JH. Recent trends in venous thrombosis and pulmonary embolism. Trans. Am. Clin. Climatol. Assoc. 1997; 108: 173-82; discussion 183. PMID: 9108676, PMCID: PMC2376588, ISSN: 0065-7778.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9108676.
  • Carmichael LC, Newman JH. Lymphocytic pleural exudate in a patient receiving amiodarone. Br J Clin Pract. 1996 Jun; 50(4): 228-30. PMID: 8759573, ISSN: 0007-0947.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8759573.
  • Koizumi T, Hermo CI, Bjertnaes LJ, Banerjee M, Newman JH, Kubo K. Nitric oxide and nitroglycerin reversal of pulmonary vasoconstriction induced by alpha-activation during exercise. Am. J. Physiol. 1996 Mar; 270(3 Pt 2): H875-80. PMID: 8780181, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8780181.
  • Loyd JE, Butler MG, Foroud TM, Conneally PM, Phillips JA, Newman JH. Genetic anticipation and abnormal gender ratio at birth in familial primary pulmonary hypertension. Am. J. Respir. Crit. Care Med. 1995 Jul; 152(1): 93-7. PMID: 7599869, DOI: 10.1164/ajrccm.152.1.7599869, ISSN: 1073-449X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7599869.
  • Koizumi T, Gupta R, Banerjee M, Newman JH. Changes in pulmonary vascular tone during exercise. Effects of nitric oxide (NO) synthase inhibition, L-arginine infusion, and NO inhalation. J. Clin. Invest. 1994 Dec; 94(6): 2275-82. PMID: 7527429, PMCID: PMC330054, DOI: 10.1172/JCI117590, ISSN: 0021-9738.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7527429.
  • Kane DW, Tesauro T, Koizumi T, Gupta R, Newman JH. Exercise-induced pulmonary vasoconstriction during combined blockade of nitric oxide synthase and beta adrenergic receptors. J. Clin. Invest. 1994 Feb; 93(2): 677-83. PMID: 7509345, PMCID: PMC293899, DOI: 10.1172/JCI117020, ISSN: 0021-9738.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7509345.
  • Kane DW, Tesauro T, Newman JH. Adrenergic modulation of the pulmonary circulation during strenuous exercise in sheep. Am. Rev. Respir. Dis. 1993 May; 147(5): 1233-8. PMID: 8484636, DOI: 10.1164/ajrccm/147.5.1233, ISSN: 0003-0805.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8484636.
  • Newman JH, Cochran CP, Roselli RJ, Parker RE, King LS. Pressure and flow changes in the pulmonary circulation in exercising sheep: evidence for elevated microvascular pressure. Am. Rev. Respir. Dis. 1993 Apr; 147(4): 921-6. PMID: 8466128, DOI: 10.1164/ajrccm/147.4.921, ISSN: 0003-0805.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8466128.
  • Kang KH, Morrow JD, Roberts LJ, Newman JH, Banerjee M. Airway and vascular effects of 8-epi-prostaglandin F2 alpha in isolated perfused rat lung. J. Appl. Physiol. 1993 Jan; 74(1): 460-5. PMID: 8444728, ISSN: 8750-7587.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8444728.
  • Banerjee M, Kang KH, Morrow JD, Roberts LJ, Newman JH. Effects of a novel prostaglandin, 8-epi-PGF2 alpha, in rabbit lung in situ. Am. J. Physiol. 1992 Sep; 263(3 Pt 2): H660-3. PMID: 1415588, ISSN: 0002-9513.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1415588.
  • Christman BW, McPherson CD, Newman JH, King GA, Bernard GR, Groves BM, Loyd JE. An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N. Engl. J. Med. 1992 Jul 7/9/1992; 327(2): 70-5. PMID: 1603138, DOI: 10.1056/NEJM199207093270202, ISSN: 0028-4793.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1603138.
  • Kubo K, King LS, Kobayashi T, Newman JH. Differing effects of nitrogen mustard and hydroxyurea on lung O2 toxicity in adult sheep. Am. Rev. Respir. Dis. 1992 Jan; 145(1): 13-8. PMID: 1731575, DOI: 10.1164/ajrccm/145.1.13, ISSN: 0003-0805.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1731575.
  • Kobayashi T, Shiki Y, Meyrick B, Burr IM, Newman JH. Simultaneous exposure of sheep to endotoxin and 100% oxygen. Am. Rev. Respir. Dis. 1991 Sep; 144(3 Pt 1): 600-5. PMID: 1892300, DOI: 10.1164/ajrccm/144.3_Pt_1.600, ISSN: 0003-0805.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1892300.
  • Beard JT, Newman JH, Loyd JE, Byrd BF. Doppler estimation of changes in pulmonary artery pressure during hypoxic breathing. J Am Soc Echocardiogr. 1991 Mar; 4(2): 121-30. PMID: 2036224, ISSN: 0894-7317.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2036224.
  • King LS, Fukushima M, Banerjee M, Kang KH, Newman JH, Biaggioni I. Pulmonary vascular effects of prostaglandin D2, but not its systemic vascular or airway effects, are mediated through thromboxane receptor activation. Circ. Res. 1991 Feb; 68(2): 352-8. PMID: 1825033, ISSN: 0009-7330.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/1825033.
  • Fukushima M, King LS, Kang KH, Banerjee M, Newman JH. Lung mechanics and airway reactivity in sheep during development of oxygen toxicity. J. Appl. Physiol. 1990 Nov; 69(5): 1779-85. PMID: 2272971, ISSN: 8750-7587.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2272971.
  • Biaggioni I, King LS, Enayat N, Robertson D, Newman JH. Adenosine produces pulmonary vasoconstriction in sheep. Evidence for thromboxane A2/prostaglandin endoperoxide-receptor activation. Circ. Res. 1989 Dec; 65(6): 1516-25. PMID: 2582587, ISSN: 0009-7330.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2582587.
  • Shields GW, Sheller JR, Newman JH, Duke SS, Gillette AW, Malcom AW, Meyrick BO, Brigham KL. Airway responsiveness in isolated perfused rat lungs: effect of thoracic irradiation. Respir Physiol. 1989 Nov; 78(2): 135-44. PMID: 2609024, ISSN: 0034-5687.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2609024.
  • Newman JH, Ross JC. Primary pulmonary hypertension: a look at the future. J. Am. Coll. Cardiol. 1989 Sep; 14(3): 551-5. PMID: 2671094, PII: 0735-1097(89)90091-0, ISSN: 0735-1097.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2671094.
  • Duke SS, King LS, Jones MR, Newman JH, Brigham KL, Forbes JT. Human recombinant interleukin 2-activated sheep lymphocytes lyse sheep pulmonary microvascular endothelial cells. Cell. Immunol. 1989 Aug; 122(1): 188-99. PMID: 2787699, ISSN: 0008-8749.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2787699.
  • Loyd JE, Atkinson JB, Pietra GG, Virmani R, Newman JH. Heterogeneity of pathologic lesions in familial primary pulmonary hypertension. Am. Rev. Respir. Dis. 1988 Oct; 138(4): 952-7. PMID: 3202470, DOI: 10.1164/ajrccm/138.4.952, ISSN: 0003-0805.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3202470.
  • Wheeler AP, Jaquiss RD, Newman JH. Physician practices in the treatment of pulmonary embolism and deep venous thrombosis. Arch. Intern. Med. 1988 Jun; 148(6): 1321-5. PMID: 3377615, ISSN: 0003-9926.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3377615.
  • Newman JH, Butka BJ, Parker RE, Roselli RJ. Effect of progressive exercise on lung fluid balance in sheep. J. Appl. Physiol. 1988 May; 64(5): 2125-31. PMID: 3391911, ISSN: 8750-7587.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3391911.
  • Johnson MD, Newman JH, Baxter JW. Neuroleptic malignant syndrome presenting as adult respiratory distress syndrome and disseminated intravascular coagulation. South. Med. J. 1988 Apr; 81(4): 543-5. PMID: 3358184, ISSN: 0038-4348.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3358184.
  • Newman JH. Lung vascular injury. Chest. 1988 Mar; 93(3 Suppl): 139S-146S. PMID: 2830084, ISSN: 0012-3692.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2830084.
  • Newman JH, Wilkins JK. Fabrication of a customized cuirass for patients with severe thoracic asymmetry. Am. Rev. Respir. Dis. 1988 Jan; 137(1): 202-3. PMID: 3337464, DOI: 10.1164/ajrccm/137.1.202, ISSN: 0003-0805.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/3337464.