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John P. Wikswo, Jr., Ph.D.

Gordon A. Cain University Professor
A. B. Learned Professor of Living State Physics
Professor of Biomedical Engineering, Molecular Physiology & Biophysics, Physics
Director, Vanderbilt Institute for Integrative Biosystems Research & Education
Researcher

Contact Information:

Vanderbilt University Department of Physics and Astronomy
6301 Stevenson Center
Nashville, TN 37235
615-343-4124
Fax: 615-322-4977

Profile

John Wikswo's current research efforts focus upon development of a variety of advanced cellular instrumentation and mathematical models for cellular metabolic and signaling dynamics, and creating microphysiological systems and organs-on-chips for testing of drug toxicity and efficacy and for basic research in systems biology.

Education
B.A., Physics, University of Virginia, 1970 M.S., Physics, Stanford University, 1973 Ph.D., Physics, Stanford University, 1975 Research Fellow in Cardiology, Stanford University School of Medicine, 1975-1977
Research Description

John Wikswo and his group are at present working in three areas: the study of the linear and non-linear electrical properties of cardiac tissue during stimulation, propagation, and recovery for threshold- and defibrillation-strength shocks; the magnetic measurement of cellular action currents in cardiac and intestinal tissue, as can be observed using SQUID magnetometry; and the development and application of micro- and nano-scale devices for instrumenting and controlling the single biological cell and small populations of cells. His long-term program to understand the effects of defibrillation-strength shocks on cardiac tissue now includes studies of charge and electroporation and molecular diffusion. The magnetic studies of action currents range from determining the information content of the magnetocardiogram in isolated rabbit hearts to the non-invasive diagnosis of intestinal ischemia in humans. The project to instrument and control single cells is addressing issues as varied as the use of cells to identify and discriminate chemical and biological warfare agents by metabolic phenotype; the development and application of BioMEMS (BioMicroElectroMechanical Systems) devices to understand the molecular signaling associated with chemotaxis, cellular motility, angiogenesis, and metastasis; and the nature of the signaling and metabolic activity associated with the immune response.

Publications
  • J.P. Wikswo and A.P. Porter. "Biology Coming Full Circle: Joining the Whole and the Parts". 2015.
  • Dukes AD, Samson PC, Keene JD, Davis LM, Wikswo JP, Rosenthal SJ. Single-nanocrystal spectroscopy of white-light-emitting CdSe nanocrystals. J Phys Chem A [print-electronic]. 2011 Apr 4/28/2011; 115(16): 4076-81. PMID: 21338163, DOI: 10.1021/jp1109509, ISSN: 1520-5215.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21338163.
  • J.R. Enders, C.R. Goodwin, C.C. Marasco, K.T. Seale, J.P. Wikswo, and J.A. McLean. "Advanced Structural Mass Spectrometry for Systems Biology: Pulling the Needles From Haystacks". Current Trends in Mass Spectrometry. 2011.
  • R.A. Gray and J.P. Wikswo. "Several Small Shocks Beat One Large One". Nature. 2011; 475: 181-2.
  • D.A. Markov, E.M. Lillie, P.C. Samson, J.P. Wikswo, and L.J. McCawley. "Chips & Tips: A Method for Periodic Sterile Sample Collection During Continuous Cell Culture in Microfluidic Devices". Lab Chip. 2010; Published online August 17.
  • K.T. Seale, S.L. Faley, J. Chamberlain, and J. Wikswo. "Macro to Nano: A Simple Method for Transporting Cultured Cells From Milliliter Scale to Nanoliter Scale". Experimental Biology and Medicine. 2010; 235: 777-83.
  • J. Greene, J.W. Henderson, Jr., and J.P. Wikswo. "Rapid and Precise Determination of Cellular Amino Acid Flux Rates Using HPLC with Automated Derivatization with Absorbance Detection". 2009.
  • J.P. Wikswo and B.J. Roth. "Virtual Electrode Theory of Pacing". In Cardiac Bioelectric Therapy: Mechanisms and Practical Implications, I. Efimov, M. Kroll, and P. Tchou, Eds., (Springer). 2009; Chapter 4.3.
  • K.T. Seale, C. Janetopoulos, and J.P. Wikswo. "Micro-Mirrors for Nanoscale Three-Dimensional Microscopy". ACS Nano. 2009; 3((3)): 493-7.
  • Holcomb MR, Bekele RY, Lima EA, Wikswo JP. Universal serial bus powered and controlled isolated constant-current physiological stimulator. Rev Sci Instrum. 2008 Dec; 79(12): 126103. PMID: 19123594, PMCID: PMC2736648, DOI: 10.1063/1.3030861, ISSN: 1089-7623.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19123594.
  • Sidorov VY, Holcomb MR, Woods MC, Gray RA, Wikswo JP. Effects of unipolar stimulation on voltage and calcium distributions in the isolated rabbit heart. Basic Res. Cardiol [print-electronic]. 2008 Nov; 103(6): 537-51. PMID: 18642125, PMCID: PMC2742888, DOI: 10.1007/s00395-008-0740-1, ISSN: 1435-1803.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18642125.
  • Faley S, Seale K, Hughey J, Schaffer DK, VanCompernolle S, McKinney B, Baudenbacher F, Unutmaz D, Wikswo JP. Microfluidic platform for real-time signaling analysis of multiple single T cells in parallel. Lab Chip [print-electronic]. 2008 Oct; 8(10): 1700-12. PMID: 18813394, PMCID: PMC4160168, DOI: 10.1039/b719799c, ISSN: 1473-0197.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18813394.
  • Gruver JS, Wikswo JP, Chung CY. 3'-phosphoinositides regulate the coordination of speed and accuracy during chemotaxis. Biophys. J [print-electronic]. 2008 Oct; 95(8): 4057-67. PMID: 18676656, PMCID: PMC2553113, PII: S0006-3495(08)78543-6, DOI: 10.1529/biophysj.108.130179, ISSN: 1542-0086.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18676656.
  • Seale KT, Reiserer RS, Markov DA, Ges IA, Wright C, Janetopoulos C, Wikswo JP. Mirrored pyramidal wells for simultaneous multiple vantage point microscopy. J Microsc. 2008 Oct; 232(1): 1-6. PMID: 19017196, PMCID: PMC3789065, PII: JMI2110, DOI: 10.1111/j.1365-2818.2008.02110.x, ISSN: 1365-2818.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19017196.
  • Addae-Mensah KA, Wikswo JP. Measurement techniques for cellular biomechanics in vitro. Exp. Biol. Med. (Maywood) [print-electronic]. 2008 Jul; 233(7): 792-809. PMID: 18445766, PMCID: PMC4156015, PII: 0710-MR-278, DOI: 10.3181/0710-MR-278, ISSN: 1535-3702.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18445766.
  • Irimia A, Wikswo JP. Gastrointestinal arrhythmias are associated with statistically significant fluctuations in systemic information dimension. Physiol Meas [print-electronic]. 2008 May; 29(5): N33-40. PMID: 18427160, PII: S0967-3334(08)65429-5, DOI: 10.1088/0967-3334/29/5/N01, ISSN: 0967-3334.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18427160.
  • Xu J, Reiserer R, Tellinghuisen J, Wikswo JP, Baudenbacher FJ. A microfabricated nanocalorimeter: design, characterization, and chemical calibration. Anal. Chem [print-electronic]. 2008 Apr 4/15/2008; 80(8): 2728-33. PMID: 18351750, PMCID: PMC4155943, DOI: 10.1021/ac702213d, ISSN: 1520-6882.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18351750.
  • Harris MP, Kim E, Weidow B, Wikswo JP, Quaranta V. Migration of isogenic cell lines quantified by dynamic multivariate analysis of single-cell motility. Cell Adh Migr. 2008 Apr; 2(2): 127-36. PMID: 19271355, PMCID: PMC2634586, ISSN: 1933-6926.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19271355.
  • Evertson DW, Holcomb MR, Eames MC, Bray MA, Sidorov VY, Xu J, Wingard H, Dobrovolny HM, Woods MC, Gauthier DJ, Wikswo JP. High-resolution high-speed panoramic cardiac imaging system. IEEE Trans Biomed Eng. 2008 Mar; 55(3): 1241-3. PMID: 18334422, PMCID: PMC2561274, DOI: 10.1109/TBME.2007.912417, ISSN: 0018-9294.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18334422.
  • Abbas RA, Lin SF, Mashburn D, Xu J, Wikswo JP. A phased-array stimulator system for studying planar and curved cardiac activation wavefronts. IEEE Trans Biomed Eng. 2008 Jan; 55(1): 222-9. PMID: 18232365, PMCID: PMC2742885, DOI: 10.1109/TBME.2007.901039, ISSN: 0018-9294.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18232365.
  • B.R. Gorman and J.P. Wikswo. "Characterization of Transport in Microfluidic Gradient Generators". Microfluid Nanofluid. 2008; 4((4)): 273-85.
  • J. Sai, D. Raman, Y. Liu, J. Wikswo, and A. Richmond. "Parallel PI3K-Dependent and Src-Dependent Pathways Lead to CXCL8-Mediated Rac2-Activation and Chemotaxis". J. Biological Chemistry. 2008; 283((39)): 26538-47.
  • W. Georgescu, J. Jourquin, L. Estrada, A.R.A. Anderson, V. Quaranta, and J.P. Wikswo. "Model-Controlled Hydrodynamic Focusing to Generate Multiple Overlapping Gradients of Surface-Immobilized Proteins in Microfluidic Devices". Lab Chip. 2008; 8: 238-44.
  • W. Wang, L.M. Shor, E.J. LeBoeuf, J.P. Wikswo, G.L. Taghon, and D.S. Kosson. "Protozoan Migration in Bent Microfluidic Channels". Applied and Environmental Microbiology. 2008; 74((6)): 1945-9.
  • Y. Liu, J. Sai, A. Richmond, and J. Wikswo. "Microfluidic Switching System for Analyzing Chemotaxis Responses of Wortmannin-Inhibited HL-60 Cells". Biomedical Microdevices. 2008; 10: 499-507.
  • D.F. Salisbury, A. Price, R.D. Collins, and J.P. Wikswo. "Max at Vanderbilt". Max Delbruck and the New Perception of Biology, 1906-1981: A Centenary Celebration. 2007; University of Salamanca, October 9-10, 2006, W. Shropshire, Jr., Ed. (AuthorHouse, Bloomington, IN).
  • D.N. Mashburn, S.J. Hinkson, M.C. Woods, J.M. Gilligan, M.R. Holcomb, and J.P. Wikswo. "A High Voltage Cardiac Stimulator for Field Shocks of a Whole Heart in a Bath". Rev. Sci. Instrum. 2007; 78: 104302.
  • K.A. Addae-Mensah, N.J. Kassenbaum, M.J. Bowers II, R.S. Reiserer, S.J. Rosenthal, P.E. Moore, and J.P. Wikswo. "A Flexible, Quantum Dot-Labeled Cantilever Post Array for Studying Cellular Microforces". Sensors and Actuators. 2007; 136: 385-97.
  • K.A. Addae-Mensah, R.S. Reiserer, and J.P. Wikswo. "Poly(Vinyl Alcohol) as a Structure Release Layer for Microfabrication of Polymer Composite Structures". J. Micromech. Microeng. 2007; 17: N41-N46.
  • S. Huang and J. Wikswo. "Dimensions of Systems Biology". Reviews of Physiology, Biochemistry, and Pharmacology. 2007; 157: 81-104.
  • S.K. Vajandar, D. Xu, D.A. Markov, J.P. Wikswo, W. Hofmeister, and D. Li. "SiO2-Coated Porous Anodic Alumina Membranes for High Flow Rate Electroosmotic Pumping". Nanotechnology. 2007; 18: 275705.
  • Woods MC, Sidorov VY, Holcomb MR, Beaudoin DL, Roth BJ, Wikswo JP. Virtual electrode effects around an artificial heterogeneity during field stimulation of cardiac tissue. Heart Rhythm [print-electronic]. 2006 Jun; 3(6): 751-2. PMID: 16731485, PII: S1547-5271(05)02337-4, DOI: 10.1016/j.hrthm.2005.11.003, ISSN: 1547-5271.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16731485.
  • E. Juzeliunas, Y.P. Ma, and J.P. Wikswo. "Magnetometric Corrosion Sensing Under Hydrodynamic Conditions". J. Solid State Electrochemistry. 2006; 10: 700-7.
  • E.A. Lima, A. Irimia, and J.P. Wikswo, Jr. "The Magnetic Inverse Problem". The SQUID Handbook, J. Clarke and A. Braginski, Eds., (Wiley-VCH, Verlag, Berlin). 2006; Vol. 2, Chap. 10.
  • J. Sai, G. Walker, J. Wikswo, and A. Richmond. "The IL Sequence in the LLKIL Motif in CXCR2 is Required for Full Ligand Induced Activation of Erk, Akt and Chemotaxis in HL60 Cells". J. Biol. Chem. 2006; 281(47): 35931-42.
  • M.R. Warnement, S.L. Faley, J.P. Wikswo, and S.J. Rosenthal. "Quantum Dot Probes for Monitoring Dynamic Cellular Response: Reporters of T Cell Activation". IEEE Trans. NanoBioscience. 2006; 5(4): 268-72.
  • R.A. Gray, A. Iyer, M.-A. Bray, and J.P. Wikswo. "Voltage-Calcium State-Space Dynamics During Initiation of Reentry". Heart Rhythm. 2006; 3((2)): 247-8.
  • R.A. Malkin, D.X. Guan, and J.P. Wikswo. "Experimental Evidence of Improved Transthoracic Defibrillation with Electroporation-Type Pulses". IEEE Trans. BME. 2006; 53(10): 1901-10.
  • S.E. Eklund, J. Wikswo, F. Baudenbacher, A. Prokop, and D.E. Cliffel. "Multianalyte Microphysiometry as a Tool in Metabolomics and Systems Biology". J. Electroanalytical Chemistry. 2006; 587: 333-9.
  • Bradshaw LA, Roy OP, O'Mahony GP, Myers AG, McDowell JG, Wikswo JP, Richards WO. Biomagnetic detection of injury currents in rabbit ischemic intestine. Dig. Dis. Sci. 2005 Sep; 50(9): 1561-8. PMID: 16133952, DOI: 10.1007/s10620-005-2898-9, ISSN: 0163-2116.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16133952.
  • Wang W, Shor LM, LeBoeuf EJ, Wikswo JP, Kosson DS. Mobility of protozoa through narrow channels. Appl. Environ. Microbiol. 2005 Aug; 71(8): 4628-37. PMID: 16085857, PMCID: PMC1183301, PII: 71/8/4628, DOI: 10.1128/AEM.71.8.4628-4637.2005, ISSN: 0099-2240.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16085857.
  • Walker GM, Sai J, Richmond A, Stremler M, Chung CY, Wikswo JP. Effects of flow and diffusion on chemotaxis studies in a microfabricated gradient generator. Lab Chip [print-electronic]. 2005 Jun; 5(6): 611-8. PMID: 15915253, PMCID: PMC2665276, DOI: 10.1039/b417245k, ISSN: 1473-0197.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15915253.
  • Yang Z, Shen W, Rottman JN, Wikswo JP, Murray KT. Rapid stimulation causes electrical remodeling in cultured atrial myocytes. J. Mol. Cell. Cardiol [print-electronic]. 2005 Feb; 38(2): 299-308. PMID: 15698836, PII: S0022-2828(04)00336-0, DOI: 10.1016/j.yjmcc.2004.11.015, ISSN: 0022-2828.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15698836.
  • Bradshaw LA, Myers A, Richards WO, Drake W, Wikswo JP. Vector projection of biomagnetic fields. Med Biol Eng Comput. 2005 Jan; 43(1): 85-93. PMID: 15742724, ISSN: 0140-0118.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15742724.
  • Holzer JR, Fong LE, Sidorov VY, Wikswo JP, Baudenbacher F. High resolution magnetic images of planar wave fronts reveal bidomain properties of cardiac tissue. Biophys. J [print-electronic]. 2004 Dec; 87(6): 4326-32. PMID: 15377521, PMCID: PMC1304939, PII: S0006-3495(04)73894-1, DOI: 10.1529/biophysj.104.049163, ISSN: 0006-3495.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15377521.
  • A. Prokop, Z. Prokop, D. Schaffer, E. Kozlov, J.P. Wikswo, D. Cliffel, and F. Baudenbacher. "NanoLiterBioReactor: Monitoring of Long-Term Mammalian Cell Physiology at Nanofabricated Scale". Biomedical Microdevices. 2004; 6((4)): 325-39.
  • E. Juzeliũnas, Y.P. Ma, and J.P. Wikswo. "Remote Sensing of Aluminum Alloy Corrosion by SQUID Magnetometry". J. Solid State Electrochem. 2004; 8: 435-41.
  • E.B. Chancellor, J.P. Wikswo, F. Baudenbacher, M. Radparvar, and D. Osterman. "Heat Conduction Calorimeter for Massively Parallel High Throughput Measurements with Picoliter Sample Volumes". Applied Physics Letters. 2004; 85((12)): 2408-10.
  • J.P. Wikswo. "SQUIDs Remain Best Tools for Measuring Brains Magnetic Field". Physics Today. 2004; 52((2)): 15-7.
  • K.R. Cooper, Y. Ma, J.P. Wikswo, and R.G. Kelly. "Simultaneous Monitoring of the Corrosion Activity and Moisture Inside Aircraft Lap Joints". Corrosion Engineering, Science and Technology. 2004; 39((4)): 339-45.
  • Bray MA, Wikswo JP. Examination of optical depth effects on fluorescence imaging of cardiac propagation. Biophys. J. 2003 Dec; 85(6): 4134-45. PMID: 14645100, PMCID: PMC1303712, PII: S0006-3495(03)74825-5, DOI: 10.1016/S0006-3495(03)74825-5, ISSN: 0006-3495.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14645100.
  • Sidorov VY, Aliev RR, Woods MC, Baudenbacher F, Baudenbacher P, Wikswo JP. Spatiotemporal dynamics of damped propagation in excitable cardiac tissue. Phys. Rev. Lett [print-electronic]. 2003 Nov 11/14/2003; 91(20): 208104. PMID: 14683402, DOI: 10.1103/PhysRevLett.91.208104, ISSN: 0031-9007.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14683402.
  • Bradshaw LA, Myers AG, Redmond A, Wikswo JP, Richards WO. Biomagnetic detection of gastric electrical activity in normal and vagotomized rabbits. Neurogastroenterol. Motil. 2003 Oct; 15(5): 475-82. PMID: 14507349, PII: 432, ISSN: 1350-1925.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14507349.
  • Bray MA, Wikswo JP. Interaction dynamics of a pair of vortex filament rings. Phys. Rev. Lett [print-electronic]. 2003 Jun 6/13/2003; 90(23): 238303. PMID: 12857294, DOI: 10.1103/PhysRevLett.90.238303, ISSN: 0031-9007.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12857294.
  • Sidorov VY, Woods MC, Wikswo JP. Effects of elevated extracellular potassium on the stimulation mechanism of diastolic cardiac tissue. Biophys. J. 2003 May; 84(5): 3470-9. PMID: 12719272, PMCID: PMC1302903, PII: S0006-3495(03)70067-8, DOI: 10.1016/S0006-3495(03)70067-8, ISSN: 0006-3495.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12719272.
  • Ladipo JK, Seidel SA, Bradshaw LA, Halter S, Wikswo JP, Richards WO. Histopathologic changes during mesenteric ischaemia and reperfusion. West Afr J Med. 2003 Jan; 22(1): 59-62. PMID: 12769310, ISSN: 0189-160X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12769310.
  • L.A. Bradshaw, A.G. Myers, J.P. Wikswo, Jr., and W.O. Richards. "A SpatioTemporal Dipole Simulation of Gastriointestinal Magnetic Fields". IEEE Trans. Biomed. Engr. 2003; 50((7)): 836-47.
  • S.E. Eklund, D.E. Cliffel, E. Kozlov, A. Prokop, J. Wikswo, and F. Baudenbacher. "Modification of the CytosensorTM Microphysiometer to Simultaneously Measure Extracellular Acidification and Oxygen Consumption Rates". Analytica Chimica Acta. 2003; 496: 93-101.
  • Bray MA, Wikswo JP. Considerations in phase plane analysis for nonstationary reentrant cardiac behavior. Phys Rev E Stat Nonlin Soft Matter Phys [print-electronic]. 2002 May; 65(5 Pt 1): 51902. PMID: 12059588, DOI: 10.1103/PhysRevE.65.051902, ISSN: 1539-3755.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12059588.
  • F. Baudenbacher, N.T. Peters, P. Baudenbacher, and J.P. Wikswo. "High Resolution Imaging of Biomagnetic Fields Generated by Action Currents in Cardiac Tissue Using a LTS-SQUID Microscope". Physica C. 2002; 368: 24-31.
  • F. Baudenbacher, N.T. Peters, and J.P. Wikswo, Jr. "High Resolution Low-Temperature Superconductivity SQUID Microscopes for Imaging Magnetic Fields of Samples at Room Temperature". Rev. Sci. Instrum. 2002; 73((3)): 1247-54.
  • G. Choudhury, W.G. Jenks, J.P. Wikswo, Jr., and C.G. Bublitz. "Effects of Parasite Attributes and Injected Current Parameters on Electromagnetic Detection of Parasites in Fish Muscle". J. Food Science: Food Engineering and Physical Properties. 2002; 67((9)): 3381-7.
  • M.-A. Bray and J.P. Wikswo, Jr. "Three-Dimensional Visualization of Phase Singularities on the Isolated Rabbit Heart". J. Cardiovas. Electrophysiol. 2002; 13((12)): 1311.
  • M.-A. Bray and J.P. Wikswo. "Use of Topological Charge to Determine Singularity and Filament Location in a Numerical Model of Scroll Wave Activity". IEEE Trans. BME. 2002; 49((10)): 1086-93.
  • Y.P. Ma, J.P. Wikswo, M. Samuleviiene, K. Leinartas, and E. Juzeliunas. "Magnetic Fields Induced by Electrochemical Reactions: Aluminum Alloy Corrosion Sensing by SQUID Magnetometry on a Macroscopic Scale". J. Phys. Chem. B. 2002; 106((48)): 12549-55.
  • B.P. Weiss, F.J. Baudenbacher, J.P. Wikswo, and J.L. Kirschvink. "Magnetic Microscopy Promises a Leap in Sensitivity and Resolution". EoS. 2001; 82: 513-8.
  • K.K. Parker, L.K. Taylor, J.B. Atkinson, D.E. Hansen, and J.P. Wikswo, Jr. "The Effects of Tubulin-Binding Agents on Stretch-Induced Ventricular Arrhythmias". European Journal of Pharmacology. 2001; 417: 131-40.
  • L.A. Bradshaw and J.P. Wikswo, Jr. "Spatial Filter Approach for Evaluation of the Surface Laplacian of the Electroencephalogram and Magnetoencephalogram". Annals of Biomed. Eng. 2001; 29: 202-13.
  • L.A. Bradshaw, R.S. Wijesinghe, and J.P. Wikswo, Jr. "Spatial Filter Approach for Comparison of the Forward and Inverse Problems of Electroencephalography and Magnetoencephalography". Annals of Biomed. Eng. 2001; 29: 214-26.
  • L.A. Bradshaw, W.O. Richards, and J.P. Wikswo, Jr. "Volume Conductor Effects on the Spatial Resolution of Magnetic Fields and Electric Potentials from Gastrointestinal Electrical Activity". Med. Biol. Eng. Comput. 2001; 39: 35-43.
  • M.-A. Bray, S.-F.Lin, R.R. Aliev, B.J. Roth, and J.P. Wikswo, Jr. "Experimental and Theoretical Analysis of Phase Singularity Dynamics in Cardiac Tissue". J. Cardiovasc. Electrophysiol. 2001; 12: 716-22.
  • S.-F. Lin and J.P. Wikswo, Jr. "New Perspectives in Electrophysiology from the Cardiac Bidomain". In: Optical Mapping of Cardiac Excitation and Arrhythmias. 2001; D.S. Rosenbaum and J. Jalife, Eds.,((Futura Publishing Co., Inc., New York, Chapter 19)).
  • B.P. Weiss, J.L. Kirschvink F.J. Baudenbacher, H. Vali, N.T. Peters, F.A. Macdonald, and J.P. Wikswo, Jr. "A Low-Temperature Transfer of ALH84001 from Mars to Earth". Science. 2000; 290((5492)): 791-5.
  • G. Skennerton, A. Abedi, R.G. Kelly, and J.P. Wikswo, Jr. "Magnetic Measurements of the Response of Corrosion Activity within Aircraft Lap Joints to Accelerated Corrosion Testing". J. Corrosion Science and Engr., on http:// www.cp.umist.ac.uk/jcse/vol3/paper2/v3p2.html. 2000;
    Available from: http:// www.cp.umist.ac.uk/jcse/vol3/paper2/v3p2.html.
  • J. Wu, D.M. Roden, and J.P. Wikswo, Jr. "Delayed Activation and Retrograde Propagation in Cardiac Muscle: Implication of Virtual Electrode Effects". Annals of Biomed. Eng. 2000; 28: 1318-25.
  • J.P. Wikswo. "Applications of SQUID Magnetometers to Biomagnetism and Nondestructive Evaluation". In: Applications of Superconductivity. 2000; H. Weinstock, Ed.,((Kluwer Academic Publishers, The Netherlands)).
  • M.-A. Bray, S.-F. Lin, and J.P. Wikswo, Jr. "Three-Dimensional Surface Reconstruction and Fluorescent Visualization of Cardiac Activation". IEEE Trans. BME. 2000; 47((10)): 1382-91.
  • R.R. Aliev, W.O. Richards, and J.P. Wikswo, Jr. "A Simple Non-Linear Model of Electrical Activity in the Intestine". J. Theor. Biology. 2000; 204: 21-8.
  • Bradshaw LA, Ladipo JK, Staton DJ, Wikswo JP, Richards WO. The human vector magnetogastrogram and magnetoenterogram. IEEE Trans Biomed Eng. 1999 Aug; 46(8): 959-70. PMID: 10431461, ISSN: 0018-9294.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10431461.
  • A. Abedi, J.J. Fellenstein, A.J. Lucas, and J.P. Wikswo, Jr. "A SQUID Magnetometer System for Quantitative Analysis and Imaging of Hidden Corrosion Activity in Aircraft Aluminum Structures". Rev. Sci. Instrum. 1999; 70((12)): 4640-51.
  • J.R. Kirtley and J.P. Wikswo, Jr. "Scanning SQUID Microscopy". Annu. Rev. Mater. Sci. 1999; 29: 117-48.
  • S.A. Seidel, L.A. Bradshaw, J.K. Ladipo, J.P. Wikswo, Jr., and W.O. Richards. "Noninvasive Detection of Ischemic Bowel". J. Vascular Surgery. 1999; 30((2)): 309-19.
  • S.F. Lin and J.P. Wikswo, J. "Panoramic Optical Imaging of Electrical Propagation in Isolated Heart". J. Biomed. Opt. 1999; 4((2)): 200-7.
  • S.F. Lin, B.J. Roth, and J.P. Wikswo, Jr. "Quatrefoil Reentry in Myocardium: An Optical Imaging Study of the Induction Mechanism". J. Cardiovasc. Electrophysiol. 1999; 10: 574-86.
  • T.A. Cruse, A.P. Ewing, and J.P. Wikswo, Jr. "Green's Function Formulation of Laplace's Equation for Electromagnetic Crack Detection". Computational Mechanics. 1999; 23((5/6)): 420-9.
  • B.J. Roth and J.P. Wikswo. "Comments on 'Hall-Effect Imaging'". IEEE Trans. BME. 1998; 45((10)): 1294-6.
  • B.J. Roth, S.-F. Lin, and J.P. Wikswo, Jr. "Unipolar Stimulation of Cardiac Tissue". J. Electrocardiol. 1998; 31: 6-12.
  • D. Li, Y.P. Ma, W.F. Flanagan, B.D. Lichter, and J.P. Wikswo, Jr. "Detection of Hidden Corrosion of Aircraft Aluminum Alloys by Magnetometry Using a Superconducting Quantum Interference Device". Corrosion. 1997; 53((2)): 93-8.
  • J. Wu and J.P. Wikswo. "Effects of Bath Resistance on Action Potentials in the Squid Giant Axon: Myocardial Implications". Biophys. J. 1997; 73: 2347-58.
  • K.K. Parker and J.P. Wikswo, Jr. "A Model of the Magnetic Fields Created by Single Motor Unit Compound Action Potentials in Skeletal Muscle". IEEE Trans. Biomed. Eng. 1997; 44((10)): 948-57.
  • L.A. Bradshaw, S.H. Allos, J.P. Wikswo, Jr., and W.O. Richards. "Correlation and Comparison of Magnetic and Electric Detection of Small Intestinal Electrical Activity". Am. J. Physiol. 1997; 272: G1159-G1167.
  • S.F. Lin, R.A. Abbas, and J.P. Wikswo, Jr. "High-Resolution High-Speed Synchronous Epifluorescence Imaging of Cardiac Activation". Rev. Sci. Instr. 1997; 68((1)): 213-7.
  • S.H. Allos, D.J. Staton, L.A. Bradshaw, S. Halter, J.P. Wikswo, Jr., and W.O. Richards. "Superconducting Quantum Interference Device Magnetometer for Diagnosis of Ischemia Caused by Mesenteric Venous Thrombosis". World J. Surg. 1997; 21: 173-8.
  • W.G. Jenks, I.M. Thomas, and J.P. Wikswo, Jr. "SQUIDs". Encyclopedia of Applied Physics. 1997; G.L. Trigg, E.S. Vera, and W. Greulich, Eds.,((VCH Publishers, Inc., New York, NY)).
  • W.G. Jenks, S.S.H. Sadeghi, and J.P. Wikswo, Jr. "SQUIDs for Non-Destructive Evaluation". J. Physics D: Applied Physics. 1997; 30((3)): 293-323.
  • B.J. Roth and J.P. Wikswo, Jr. "The Effect of Externally Applied Electrical Fields on Myocardial Tissue". Proceedings of the IEEE. 1996; 84: 379-91.
  • D. Li, Y.P. Ma, W.F. Flanagan, B.D. Lichter, and J.P. Wikswo, Jr. "Application of Superconducting Magnetometry in the Study of Aircraft Aluminum Alloy Corrosion". Corrosion. 1996; 52((3)): 219-31.
  • J.P. Wikswo, Jr. "High-Resolution Magnetic Imaging: Cellular Action Currents and Other Applications". In: SQUID Sensors: Fundamentals, Fabrication and Applications. 1996; H. Weinstock, Ed.,((Kluwer Academic Publishers, The Netherlands)).
  • J.P. Wikswo, Jr. "The Magnetic Inverse Problem". In: SQUID Sensors: Fundamentals, Fabrication and Applications. 1996; H. Weinstock, Ed.,((Kluwer Academic Publishers, The Netherlands)).
  • N.G. Sepulveda and J.P. Wikswo, Jr. "A Numerical Study of the Use of Magnetometers to Detect Hidden Flaws in Conducting Objects". J. Applied Physics. 1996; 79((4)): 2122-35.
  • P.H. Bunton, W.P. Henry, and J.P. Wikswo, Jr. "A Simple Integrated Circuit Model of Propagation Along an Excitable Axon". Am. J. Phys. 1996; 64((5)): 602-6.
  • S. Tan, Y.P. Ma, I.M. Thomas, and J.P. Wikswo, Jr. "Reconstruction of Two-Dimensional Magnetization and Susceptibility Distributions from the Magnetic Field of Soft Magnetic Materials". IEEE Trans. Mag. 1996; 32((1)): 230-4.
  • W.G. Jenks, C.G. Bublitz, G.S. Choudhury, Y.P. Ma, and J.P. Wikswo, Jr. "Detection of Parasites in Fish by Superconducting Quantum Interference Device Magnetometry". Journal of Food Science. 1996; 61((5)): 865-9.
  • W.O. Richards, L.A. Bradshaw, D.J. Staton, C.L. Garrard, F. Liu, S. Buchanan, and J.P. Wikswo, Jr. "Magnetoenterography (MENG): Noninvasive Measurement of Bioelectric Activity in Human Small Intestine". Digestive Diseases and Sciences. 1996; 41((12)): 2293-301.
  • D. Li, Y.P. Ma, W.F. Flanagan, B.D. Lichter, and J.P. Wikswo, Jr. "Detecting In-Situ Active Corrosion by a SQUID Magnetometer". Journal of Minerals, Metals, and Materials. 1995; 47((9)): 36-9.
  • J.P. Wikswo, Jr. "SQUID Magnetometers for Biomagnetism and Non-Destructive Testing: Important Questions and Initial Answers". IEEE Trans. on Applied Supercond. 1995; 5((2)): 74-120.
  • J.P. Wikswo, Jr. "Tissue Anisotropy, the Cardiac Bidomain and the Virtual Cathode Effect". In: Cardiac Electrophysiology: From Cell to Bedside, Second Edition, D.P. Zipes and J. Jalife, Eds. 1995; ((W.B. Sauders, Orlando)): 348-61.
  • J.P. Wikswo, Jr., S.F. Lin, and R.A. Abbas. "Virtual Electrodes in Cardiac Tissue: A Common Mechanism for Anodal and Cathodal Stimulation". Biophys. J. 1995; 69: 2195-210.
  • N.G. Sepulveda and J.P. Wikswo, Jr. "Line Follower for Finite Element Post-Processing and Current Imaging". Communications in Numerical Methods and Engineering. 1995; 11: 1025-32.
  • S. Tan, N.G. Sepulveda, and J.P. Wikswo, Jr. "A New Finite-Element Approach to Reconstruct a Bounded and Discontinuous Two-Dimensional Current Image From a Magnetic Field Map". J. Comp. Phys. 1995; 122: 150-64.
  • W.O. Richards, C.L. Garrard, S.H. Allos, L.A. Bradshaw, D.J. Staton, and J.P. Wikswo, Jr. "Noninvasive Diagnosis of Mesenteric Ischemia Using a SQUID Magnetometer". Annals of Surgery. 1995; 221((6)): 696-705.
  • Y.P. Ma and J.P. Wikswo, Jr. "Techniques for Depth-Selective, Low-Frequency Eddy Current Analysis for SQUID-Based Non-Destructive Testing". J. Nondestr. Eval. 1995; 14((3)): 149-67.
  • Wikswo JP. The complexities of cardiac cables: virtual electrode effects. Biophys. J. 1994 Mar; 66(3 Pt 1): 551-3. PMID: 8011888, PMCID: PMC1275753, ISSN: 0006-3495.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8011888.
  • B.J. Roth and J.P. Wikswo, Jr. "Electrical Stimulation of Cardiac Tissue: A Bidomain Model With Active Membrane Properties". IEEE Trans. Biomed. Eng. 1994; 41((3)): 232-40.
  • B.J. Roth, P.J. Basser and J.P. Wikswo, Jr. "A Theoretical Model of Magneto-Acoustic Imaging of Bioelectric Currents". IEEE Trans. Biomed. Eng. 1994; 41((8)): 723-8.
  • J. Golzarian, D.J. Staton, J.P. Wikswo, Jr., R.N. Friedman, and W.O. Richards. "Diagnosing Intestinal Ischemia Using a Noncontact Superconducting Quantum Interference Device". Am. J. Surgery. 1994; 167: 586-92.
  • J.P. Barach and J.P. Wikswo, Jr. "Magnetic Fields From Simulated Cardiac Action Currents". IEEE Trans. Biomed. Eng. 1994; 41: 969-74.
  • J.P. Wikswo, Jr. and S.J. Williamson. "Biomagnetism". 1994 McGraw-Hill Yearbook of Science & Technology. 1994; ((McGraw-Hill, Inc., New York)).
  • N.G. Sepulveda and J.P. Wikswo, Jr. "Bipolar Stimulation of Cardiac Tissue Using an Anisotropic Bidomain Model". J. Cardiovasc. Electrophys. 1994; 5((3)): 258-67.
  • N.G. Sepulveda, I.M. Thomas, and J.P. Wikswo, Jr. "Magnetic Susceptibility Tomography for Three-Dimensional Imaging of Diamagnetic and Paramagnetic Objects". IEEE Trans. Mag. 1994; 30((6)): 5062-9.
  • Wikswo JP, Gevins A, Williamson SJ. The future of the EEG and MEG. Electroencephalogr Clin Neurophysiol. 1993 Jul; 87(1): 1-9. PMID: 7687949, ISSN: 0013-4694.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7687949.
  • D.C. Hurley, Y.P. Ma, S. Tan, and J.P. Wikswo, Jr. "Imaging of Small Defects in Nonmagnetic Tubing Using a SQUID Magnetometer". Res. Nondestr. Eval. 1993; 5: 1-29.
  • I.M. Thomas, S.M. Freake, S.J. Swithenby, and J.P. Wikswo, Jr.. "A Distributed Quasi-static Ionic Current Source in the 3-4 Day Old Chicken Embryo". Phys. Med. Biol. 1993; 38: 1311-28.
  • J.M. van Egeraat and J.P. Wikswo, Jr. "A Model for Axonal Propagation Incorporating Both Radial and Axial Ionic Transport". Biophys. J. 1993; 64: 1287-98.
  • J.M. van Egeraat, R. Stasaski, J.P. Barach, R.N. Friedman, and J.P. Wikswo, Jr. "The Biomagnetic Signature of a Crushed Axon: A Comparison of Theory and Experiment". Biophys. J. 1993; 64: 1299-305.
  • J.P. Wikswo, Jr., D.B. Crum, W.P. Henry, Y.P. Ma, N.G. Sepulveda, and D.J. Staton. "An Improved Method for Magnetic Identification and Localization of Cracks in Conductors". J. Nondestr. Eval. 1993; 12((2)): 109-19.
  • S.F. Lin, R.A. Abbas, and J.P. Wikswo. "Magnetic Locailization of the Origin of Self-Sustained Oscillation in SQUID Giant Axons". Biol. Bull. 1993; 185: 300-1.
  • I.M. Thomas, T.C. Moyer, and J.P. Wikswo, Jr. "High Resolution Magnetic Susceptibility Imaging of Geological Thin Sections: Pilot Study of a Pyroclastic Sample from the Bishop Tuff". Geophys. Res. Letters. 1992; 19((21)): 2139-42.
  • J. Turgeon, T.A. Wisialowski, W. Wong, W.A. Altemeier, J.P. Wikswo, Jr., and D.M. Roden. "Suppression of Longitudinal Versus Transverse Conduction by Sodium Channel Block: Effects of Sodium Bolus". Circulation. 1992; 85: 2221-6.
  • J.P. Barach and J.P. Wikswo, Jr. "A Numerical Reconstruction of the Effects of Late Stimulation on a Cardiac Ventricular Action Potential". Comp. & Biomed. Res. 1992; 25: 212-7.
  • J.P. Wikswo, Jr. and S.J. Williamson. "Magnetic Source Imaging: Cell, Tissue, and Brain". In: Physics News in 1991, P.F. Schewe, Ed. 1992; ((American Institute of Physics, New York)).
  • N.G. Sepulveda, D.J. Staton, and J.P. Wikswo, Jr. "A Mathematical Analysis of the Magnetic Field Produced By Flaws in Two-Dimensional Current-Carrying Conductors". J. Nondestr. Eval. 1992; 11((2)): 89-101.
  • D.J. Staton, Y.P. Ma, N.G. Sepulveda, and J.P. Wikswo, Jr. "High-Resolution Magnetic Mapping Using a SQUID Magnetometer Array". IEEE Trans. Mag. 1991; MAG-27((2)): 3237-40.
  • F.L.H. Gielen, R.N. Friedman, and J.P. Wikswo, Jr. "In Vivo Magnetic and Electric Recordings from Nerve Bundles and Single Motor Units in Mammalian Skeletal Muscle: Correlations with Muscle Force". J. Gen. Physiol. 1991; 98: 1043-61.
  • J.P. Barach and J.P. Wikswo, Jr. "The Effect of Action Potential Propagation on a Numerical Simulation of a Cardiac Fiber Subjected to Secondary External Stimulus". Comp. & Biomed. Res. 1991; 24: 435-52.
  • J.P. Wikswo, Jr. and J.M. vanEgeraat. "Cellular Magnetic Fields: Fundamental and Applied Measurements on Nerve Axons, Peripheral Nerve Bundles, and Skeletal Muscle". J. Clin. Neurophysiology. 1991; 8((2)): 170-88.
  • J.P. Wikswo, Jr., W. Altemeier, J.R. Balser, H.A. Kopelman, T. Wisialowski, and D.M. Roden. "Virtual Cathode Effects During Stimulation of Cardiac Muscle: Two-Dimensional In Vivo Measurements". Circ. Res. 1991; 68: 513-30.
  • R.S. Wijesinghe and J.P. Wikswo, Jr. "A Model for Compound Action Potentials and Currents in a Nerve Bundle II: A Sensitivity Analysis of Model Parameters for the Forward and Inverse Calculations". Annals of Biomed. Eng. 1991; 19: 73-96.
  • R.S. Wijesinghe, F.L.H. Gielen, and J.P. Wikswo, Jr. "A Model for Compound Action Potentials and Currents in a Nerve Bundle I: The Forward Calculation". Annals of Biomed. Eng. 1991; 19: 43-72.
  • R.S. Wijesinghe, F.L.H. Gielen, and J.P. Wikswo, Jr. "A Model for Compound Action Potentials and Currents in a Nerve Bundle III: A Comparison of the Conduction Velocity Distributions Calculated from Compound Action Currents and Potentials". Annals of Biomed. Eng. 1991; 19: 97-121.
  • Y.P. Ma and J.P. Wikswo, Jr. "Magnetic Shield for Wide-Bandwidth Magnetic Measurements for Nondestructive Testing and Biomagnetism". Rev. Sci. Instr. 1991; 62((11)): 2654-61.
  • B.J. Roth and J.P. Wikswo, Jr. "Apodized Pickup Coils for Improved Spatial Resolution of SQUID Magnetometers". Rev. Sci. Instr. 1990; 61: 2439-48.
  • J.M. van Egeraat, R.N. Friedman, and J.P. Wikswo, Jr. "Magnetic Field of a Single Muscle Fiber: First Measurements and a Core Conductor Model". Biophys. J. 1990; 57: 663-7.
  • J.P. Wikswo, Jr. "Biomagnetic Sources and Their Models". 1990; S.J. Williamson, M. Hoke, G. Stroink, and M. Kotani, Eds.,((Plenum, New York)).
  • N.G. Sepulveda, J.P. Wikswo, Jr., and D.S. Echt. "Finite Element Analysis of Cardiac Defibrillation Current Distributions". IEEE Trans. Biomed. Eng. 1990; 37: 354-65.
  • S. Tan, B.J. Roth, and J.P. Wikswo, Jr. "The Magnetic Field of Cortical Current Sources: The Application of a Spatial Filtering Model to the Forward and Inverse Problem". Electroencep. and Clin. Neurophys. 1990; 76: 73-85.
  • B.J. Roth and J.P. Wikswo, Jr. "Longitudinal Resistance in Cardiac Muscle and its Effects on Propagation". Cell Interactions and Gap Junctions. 1989; N. Sperelakis and W.C. Cole, Eds.,((CRC Press, Boca Raton)).
  • B.J. Roth, N.G. Sepulveda, and J.P. Wikswo, Jr. "Using a Magnetometer to Image a Two-dimensional Current Distribution". J. Appl. Phys. 1989; 65: 361-72.
  • J.P. Wikswo, Jr. "A Review of Intermediate Physics for Medicine and Biology by R.K. Hobbie". Physics Today. 1989; ((42)): 75-6.
  • N.G. Sepulveda, B.J. Roth, and J.P. Wikswo, Jr. "Current Injection into a Two-Dimensional Anisotropic Bidomain". Biophys. J. 1989; 55: 987-99.
  • B.J. Roth, F.L.H. Gielen, and J.P. Wikswo, Jr. "Spatial and Temporal Frequency-Dependent Conductivities in Volume Conduction Calculations of Skeletal Muscle". Mathematical Biosciences. 1988; 88: 159-89.
  • B.J. Roth, W.-Q. Guo, and J.P. Wikswo, Jr. "The Effects of Spiral Anisotropy on the Electric Potential and the Magnetic Field at the Apex of the Heart". Mathematical Biosciences. 1988; 88: 191-221.
  • J.P. Wikswo, Jr. and B.J. Roth. "Magnetic Determination of the Spatial Extent of a Single Cortical Current Source: A Theoretical Analysis". Electroenceph. and Clin. Neurophys. 1988; 69: 266-76.
  • R. Maniewski, T. Katila, T. Poutanen, P. Siltanen, T. Varpula, and J.P. Wikswo, Jr. "Magnetic Measurements of Cardiac Mechanical Activity". IEEE Trans. Biomed. Eng. 1988; 35: 662-70.
  • A.K. Bajaj, H.A. Kopelman, J.P. Wikswo, Jr., F. Cassidy, R.L. Woosley, and D.M. Roden. "Frequency- and Orientation-Dependent Effects of Mexiletine and Quinidine on Conduction in the Intact Dog Heart". Circulation. 1987; 75: 1065-73.
  • J.P. Barach and J.P. Wikswo, Jr. "Computer Simulation of Action Potential Propagation in Septated Nerve Fibers". Biophys. J. 1987; 51: 177-83.
  • N.G. Sepulveda and J.P. Wikswo, Jr. "Electric and Magnetic Fields from Two-Dimensional Anisotropic Bisyncytia". Biophys. J. 1987; 51: 557-68.
  • B.J. Roth and J.P. Wikswo, Jr. "A Bi-Domain Model for the Extracellular Potential and Magnetic Field of Cardiac Tissue". IEEE Trans. Biomed. Eng. 1986; BME-33: 467-9.
  • B.J. Roth and J.P. Wikswo, Jr. "Electrically-Silent Magnetic Fields". Biophys. J. 1986; 50: 739-45.
  • F.L.H. Gielen, B.J. Roth, and J.P. Wikswo, Jr. "Capabilities of a Toroid-Amplifier System for Magnetic Measurement of Current in Biological Tissue". IEEE Trans. Biomed. Eng. 1986; BME-33: 910-21.
  • M.C. Leifer, J.P. Wikswo, Jr., J. Griffin, W.M. Barry, and D.C. Harrison. "The Effects of the Heart-Lung Boundary on the Magnetocardiogram". J. Electrocard. 1986; 19: 23-32.
  • V.R. Hentz, J.P. Wikswo, Jr., and G.S. Abraham. "Magnetic Measurements of Nerve Action Current: A New Intraoperative Technique". Peripheral Nerve Repair and Regeneration. 1986; 1: 27-36.
  • B.J. Roth and J.P. Wikswo, Jr. "The Electrical Potential and the Magnetic Field of an Axon in a Nerve Bundle". Mathematical Biosciences. 1985; 76: 37-57.
  • B.J. Roth and J.P. Wikswo, Jr. "The Magnetic Field of a Single Axon: A Comparison of Theory and Experiment". Biophys. J. 1985; 48: 93-109.
  • D.P. Russell and J.P. Wikswo, Jr. "Optimisation of State Selection and Focusing of a Neutral Atomic Hydrogen Beam by a Hexapole Magnet". J. Physics. 1985; 18: 933-40.
  • J.A. Freeman, P.B. Manis, G.J. Snipes, B.N. Mayes, P.C. Samson, J.P. Wikswo, Jr., and D.B. Freeman. "Steady Growth Cone Currents Revealed by a Novel Circularly Vibrating Probe: A Possible Mechanism Underlying Neurite Growth". In: Biology of the Nerve Growth Cone. S.B. Kater and P. Letourneau, Eds., J. Neuroscience Res. 1985; (Special Monongraph), pp. 26-38 (1984).
  • J.E. Barnhill, J.P. Wikswo, Jr., A.K. Dawson, S. Gundersen, R.M.S. Robertson, D. Robertson, R. Virmani, and R.F. Smith. "The QRS Complex During Transient Myocardial Ischemia: Studies in Patients with Variant Angina Pectoris and in a Canine Preparation". Circulation. 1985; 71((5)): 901-11.
  • J.K. Woosley, B.J. Roth, and J.P. Wikswo, Jr. "The Magnetic Field of a Single Nerve Axon: A Volume Conductor Model". Mathematical Biosciences. 1985; 76: 1-36.
  • J.P. Barach, B.J. Roth, and J.P. Wikswo, Jr. "Magnetic Measurement of Action Currents in a Single Nerve Axon: A Core Conductor Model". IEEE Trans. Biomed. Eng. 1985; BME-32: 136-40.
  • J.P. Wikswo, Jr. and K.R. Swinney. "Scalar Multipole Expansions and Their Dipole Equivalents". J. Appl. Phys. 1985; 57: 4301-8.
  • J.P. Wikswo, Jr. and K.R. Swinney. "A Comparison of Scalar Multipole Expansions". J. Appl. Phys. 1984; 56: 3039-49.
  • R.F. Smith, J.E. Barnhill, and J.P. Wikswo, Jr. "Early Use of Timolol in Acute Myocardial Infarction". N. England J. Med. 1984; 310: 1667.
  • J.P. Wikswo, Jr. "Cellular Action Currents". In: Biomagnetism, An Interdisciplinary Approach. 1983; S.J. Williamson, G.-L. Romani, L. Kaufman, and I. Modena, Eds.,((Plenum, New York)).
  • J.P. Wikswo, Jr. "Theoretical Aspects of the ECG-MCG Relationship". In: Biomagnetism, An Interdisciplinary Approach. 1983; S.J. Williamson, G.-L. Romani, L. Kaufman, and I. Modena, Eds.,((Plenum, New York)).
  • J.P. Wikswo, Jr., P.C. Samson, and R.P. Giffard. "A Low-Noise, Low Input Impedance Amplifier for Magnetic Measurements of Nerve Action Currents". IEEE Trans. Biomed. Eng. 1983; BME-30: 215-21.
  • M.C. Leifer and J.P. Wikswo, Jr. "Optimization of a SQUID Clip-On Current Probe". Rev. Sci. Instr. 1983; 54: 1017-22.
  • J.P. Wikswo, Jr. "Improved Instrumentation for Measuring the Magnetic Field of Cellular Action Currents". Rev. Sci. Instr. 1982; 53: 1846-50.
  • J.P. Wikswo, Jr. and J.P. Barach. "Possible Sources of New Information in the Magnetocardiogram". J. Theoretical Biol. 1982; 95: 721-9.
  • J.P. Wikswo, Jr., S.C. Gundersen, W. Murphy, A.K. Dawson, and R.F. Smith. "Sequential QRS Vector Subtractions in Acute Myocardial Infarction in Humans". Circ. Res. 1981; 49: 1055-62.
  • L.J. Schaad, B.A. Hess, J.P. Wikswo, Jr., and W.M. Fairbank. "Quark Chemistry". Phys. Rev. A. 1981; 23: 1600-7.
  • J.P. Barach, J.A. Freeman and J.P. Wikswo, Jr. "Experiments on the Magnetic Field of Nerve Action Potentials". J. Appl. Phys. 1980; 51: 4532-8.
  • J.P. Wikswo, Jr. "Non-Invasive Magnetic Detection of Cardiac Mechanical Activity: Theory". Medical Physics. 1980; 7: 297-306.
  • J.P. Wikswo, Jr. and J.P. Barach. "An Estimate of the Steady Magnetic Field Strength Required to Influence Nerve Conduction". IEEE Trans. Biomed. Eng. 1980; BME-27: 722-3.
  • J.P. Wikswo, Jr., J.E. Opfer, and W.M. Fairbank. "Non-Invasive Magnetic Detection of Cardiac Mechanical Activity: Experiment". Medical Physics. 1980; 7: 307-14.
  • J.P. Wikswo, Jr., J.P. Barach, and J.A. Freeman. "Magnetic Field of a Nerve Impulse: First Measurements". Science. 1980; 208: 53-5.
  • K.R. Swinney and J.P. Wikswo, Jr. "A Calculation of the Magnetic Field of a Nerve Action Potential". Biophys. J. 1980; 32: 719-32.
  • J.P. Wikswo, Jr., J.A.V. Malmivuo, W.H. Barry, M.C. Leifer, and W.M. Fairbank. "Theory and Application of Magnetocardiography". In: Cardiovascular Physics. 1979; D.N. Ghista, E. Van Vollenhoven, and W. Yang, Eds.,((Karger, Basil)).
  • J.P. Wikswo, Jr. "The Calculation of the Magnetic Field from a Current Distribution: Application to Finite Element Techniques". IEEE Trans. Mag. 1978; MAG-14: 1076-7.
  • J.A.V. Malmivuo and J.P. Wikswo, Jr. "A New Practical Lead System for Vector Magnetocardiography". Proc. IEEE. 1977; 65: 809-11.
  • J.A.V. Malmivuo, J.P. Wikswo, Jr., W.H. Barry, D.C. Harrison, and W.M. Fairbank. "Consistent System of Rectangular and Spherical Co-ordinates for Electrocardiography and Magnetocardiography". Med. Biol. Eng. and Comput. 1977; 15: 413-5.
  • W.H. Barry, D.C. Harrison, W.M. Fairbank, K. Lehrman, J.A.V. Malmivuo, and J.P. Wikswo, Jr. "Measurement of the Human Magnetic Heart Vector". Science. 1977; 198: 1159-62.
  • R.D. Sandell, J.P. Wikswo, Jr., J.M. Pickler, and B.S. Deaver, Jr. "Quantized Fluctuations in the Josephson Oscillations of a Shunted Superconducting Point Contact". J. Appl. Phys. 1973; 44: 3312-8.
  • A. Irimia, K.R. Swinney, and J.P. Wikswo. "Partial Independence of Bioelectric and Biomagentic Fields and Its Implications for Encephalography and Cardiography". Phys. Rev. E. 79: 51908-1.
  • A.A. Werdich, E.A. Lima, B. Ivanov, I. Ges, J.P. Wikswo, and F.J. Baudenbacher. "A Microfluidic Device to Confine a Single Cardiac Myocyte in a Sub-Nanoliter Volume on a Planar Microelectrode Array for Cellular Activity Detection". Lab Chip. 4: 357-62.
  • B. Ayati, C. Edwards, G.F. Webb, and J.P. Wikswo. "A Mathematical Model of Bone Remodeling Dynamics for Normal Bone Cell Populations and Myeloma Bone Disease". Biology Direct. 5: 28.
  • B. He, R. Baird, R. Butera, A. Datta, S. George, B. Hecht, A. Hero, G. Lazzi, R.C. Lee, J. Liang, M. Neuman, G. Peng, E. Perreault, M. Ramasubramanian, M. Wang, J. Wikswo, G.-Z. Yang, and Y.-T. Zhang. "Grand Challenges in Interfacing Engineering with Life Sciences and Medicine".
  • C.C. Marasco, C.R. Goodwin, D.G. Winder, N.L. Schramm-Sapyta, J.A. McLean, and J.P. Wikswo. "Systems-Level View of Cocaine Addiction: The Interconnect of the Human and Nervous Systems".
  • C.C. Marasco, J.R. Enders, K.T. Seale, J.A. McLean, and J.P. Wikswo. "Real-Time Cellular Exometabolome Analysis with a Microfluidic-Mass Spectrometry Platform".
  • C.R. Goodwin, B.C. Covington, D.K. Derewacz, C.R. McNees, J.P. Wikswo, J.A. McLean, and B.O. Bachmann. "Structuring Microbial Metabolic Responses to Multiplexed Stimuli Via Self-Organizing Metabolomics Maps".
  • C.R. Goodwin, S.D. Sherrod, C.C. Marasco, B.O. Bachmann, N. Schramm-Sapyta, J.P. Wikswo, and J.A. McLean. "Phenotypic Mapping of Metabolic Profiles Using Self-Organizing Maps of High-Dimensional Mass Spectrometry Data".
  • D. Jowhar, G. Wright, P.C. Samson, J.P. Wikswo, and C. Janetopoulos. "Open Access Microfluidic Device for the Study of Cell Migration During Chemotaxis". Integrative Biology. 2: 648-58.
  • D. Markov, S. Manuel, L. Shor, S. Opalenik, J. Wikswo, and P. Samson. "Tape Underlayment Rotary-Node (TURN) Valves for Simple On-Chip Microfluidic Flow Control". Biomed. Microdevices. 12: 135-44.
  • D. Patel, R. Naik, R. Boyer, J. Wikswo, and E. Vasilevskis. "Method to Identify Saline-Contaminated Electrolyte Profiles".
  • D. Wlodkowic, S. Faley, M. Zagnoni, J.P. Wikswo, and J.M. Cooper. "Microfluidic Single-Cell Array Cytometry for the Analysis of Tumor Apoptosis". Anal. Chem. 13((81)): 5517-23.
  • D.A. Markov, J.Q. Lu, P.C. Samson, J.P. Wikswo, and L.J. McCawley. "Thick-Tissue Bioreactor as a Platform for Long-Term Organotypic Culture and Drug Delivery". Lab Chip. 12: 4560-8.
  • D.A. Markov, P.C. Samson, D.K. Schaffer, A. Dhummakupt, J.P. Wikswo, and L.M. Shor. "Window on a Microworld: Simple Microfluidic Systems for Studying Microbial Transport in Porous Media". JoVE. 39: 1-4.
  • D.J. Alcendor, F.E. Block III, D.E. Cliffel, J.S. Daniels, K.L.J. Ellacott, C.R. Goodwin, L.H. Hofmeister, D. Li, D.A. Markov, J. May, L.J. McCawley, B.A. McLaughlin, J.A. McLean, K.D. Niswender, V. Pensabene, K.T. Seale, S.D. Sherrod, H-J. Sung, D.L. Tabb. D.J. Webb, and J.P. Wikswo. "Neurovascular Unit on a Chip: Implications for Translational Applications".
  • E.A. Lima, R.M. Snider, R.S. Reiserer, J.R. McKenzie, D.W. Kimmel, S.E. Eklund, D.E. Cliffel, and J.P. Wikswo. "Multichamber Multipotentiostat System for Cellular Microphysiometry".
  • G. Rachakonda, K.R. Sekhar, D. Jowhar, P.C. Samson, J.P. Wikswo, R.D. Beauchamp, P.K. Datta, and M.L. Freeman. "Increased Cell Migration and Plasticity in Nrf2 Deficienct Cancer Cell Lines". Oncogene. 29(25): 3703-14.
  • J. Deng, A. Dhummakupt, P. Samson, J. Wikswo, and L. Shor. "Dynamic Dosing Assay Relating Real-Time Respiration Responses of Staphylococcus aureus Biofilms to Changing Micro-Chemical Conditions".
  • J. Sai, M. Rogers, K. Hockemeyer, J.P. Wikswo, and A. Richmond. "The Study of Chemotaxis and Cell-Cell Interactions in Cancer with Microfluidic Devices".
  • J. Wikswo, A. Prokop, F. Baudenbacher, D. Cliffel, B. Csukas, and M. Velkovsky. "Engineering Challenges of BioNEMS: The Integration of Microfluidics, and Micro- and Nanodevices, Models, and External Control for Systems Biology". IEE Proc. Nanobiotechnology. 153(4): 81-101.
  • J.A. Brown, S.D. Sherrod, C.R. Goodwin, B. Brewer, L. Yang, K.A. Garbett, D. Li, J.A. McLean, J.P. Wikswo, and K. Mirnics. "Metabolic Consequences of Interleukin-6 Challenge in Developing Neurons and Astroglia".
  • J.A. Brown, V. Pensabene, D.A. Markov, V. Allwardt, D.M. Neely, M. Shi, C.M. Britt, O.S. Hoilett, Q. Yang, B.M. Brewer, P.C. Samson, L.J. McCawley, J.M. May, D.J. Webb, D. Li, A.B. Bowman, R.S. Reiserer, and J.P. Wikswo. "Recreating Blood-Brain Barrier Physiology and Structure on Chip: A Novel Neurovascular Microfluidic Bioreactor".
  • J.P. Wikswo, E.L. Curtis, Z.E. Eagleton, B.C. Evans, A. Kole, L.H. Hofmeister, and W.J. Matloff. "Scaling and Systems Biology for Integrating Multiple Organs-on-a-Chip".
  • J.P. Wikswo, F.E. Block III, D.E. Cliffel, C.R. Goodwin, C.C. Marasco, D.A. Markov, D.L. McLean, J.A. McLean, J.R. McKenzie, R.S. Reiserer, P.C. Samson, D.K. Schaffer, K.T. Seale, and S.D. Sherrod. "Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems".
  • J.P. Wikswo. "The Relevance and Potential Roles of Microphysiological Systems in Biology and Medicine".
  • J.R. Enders, C.C. Marasco, A. Kole, B. Nguyen, S. Sundarapandian, K.T. Seale, J.P. Wikswo, and J.A. McLean. "Towards Monitoring Real-Time Cellular Response Using an Integrated MALDI/nESI-Ion Mobility-Mass Spectrometery Platforma". IET Systems Biology. 4((6)): 416-27.
  • J.R. Enders, C.C. Marasco, J.P. Wikswo, and J.A. McLean. "A Dual-Column Solid Phase Extraction Strategy for Online Collection and Preparation of Continuously Flowing Effluent Streams for Mass Spectrometry". Analytical Chemistry. 84((20)): 8467-74.
  • J.R. McKenzie, A.C. Cognata, A.N. Davis, J.P. Wikswo, and D.E. Cliffel. "Real-Time Monitoring of Cellular Bioenergetics with a Multianalyte Screen-Printed Electrode".
  • J.R. McKenzie, D.E. Cliffel, and J.P. Wikswo. "Electrochemical Monitoring of Cellular Metabolism".
  • K. Hines, S. Ashfaq, J. Davidson, S. Opalenik, J. Wikswo, and J. McLean. "Biomolecular Signatures of Diabetic Wound Healing by Structural Mass Spectrometry".
  • K. Hockemeyer, C. Janetopoulous, A. Terekhov, W. Hofmeister, A. Vilgelm, L. Costa, J.P. Wikswo, and A. Richmond. "Engineered Three-Dimensional Microfluidic Device for Interrogating Cell-Cell Interactions in the Tumor Microenvironment".
  • K.A. Addae-Mensah, S. Retterer, S.R. Opalenik, D. Thomas, N.V. Lavrik, and J.P. Wikswo. "Cryogenic Etching of Silicon: An Alternative Method for Fabrication of Vertical Microcantilever Master Molds". Journal of Microelectromechanical Systems. 19((1)): 64-74.
  • K.J. Drake, M.S. Shotwell, J.P. Wikswo, and V.Y. Sidorov. "Glutamine and Glutamate Limit the Shortening of Action Potential Duration in Anoxia-Challenged Rabbit Hearts".
  • K.J. Drake, V.Y. Sidorov, O.P. McGuinness, D.H. Wasserman, and J.P. Wikswo. "Amino Acids as Metabolic Substrates During Cardiac Ischemia". Experimental Biology and Medicine. 237: 1369-78.
  • K.K. McBride, B.J. Roth, V.Y. Sidorov, J.P. Wikswo, and F.J.Baudenbacher. "Measurements of Transmembrane Potential and Magnetic Field at the Apex of the Heart". Biophys. J. 99: 3113-8.
  • M. Velkovsky, R. Snider, D. Cliffel, and J.P. Wikswo. "Modeling the Measurements of Cellular Fluxes in Microbioreactor Devices Using Thin Enzyme Electrodes". J. Math. Chem. 49: 251-75.
  • M.C. Woods. I. Uzelac, M.R. Holcomb, J.P. Wikswo, and V.Y. Sidorov. "Diagnostic Field Stimulation: The Role of Shock Duration in Epicardial Activation and Propagation".
  • M.D. Schmidt, R.R. Vallabhajosyula, J.W. Jenkins, J.E. Hood, A.S. Soni, J.P. Wikswo, and H. Lipson. "Automated Refinement and Inference of Analytical Models for Metabolic Networks". Physical Biology. 8((5)): 55011.
  • M.M. Maleckar, M.C. Woods, V.Y. Sidorov, M.R. Holcomb, D.N. Mashburn, J.P. Wikswo, and N.A. Trayanova. "Polarity Reversal Lowers Activation Time During Diastolic Field Stimulation of the Rabbit Ventricles: Insights Into Mechanisms". Am. J. Physiol.-Heart Circ. Physiol. 295: H1626-H1633.
  • M.R. Holcomb, M.C. Woods, I. Uzelac, J.P. Wikswo, J.M. Gilligan, and V.Y. Sidorov. "The Potential of Dual Camera Systems for Multimodal Imaging of Cardiac Electrophysiology and Metabolism". Experimental Biology and Medicine. 234((11)): 1355-73.
  • M.S. Shotwell, K.J. Drake, V.Y. Sidorov, and J.P. Wikswo. "Mechanistic Analysis of Challenge-Response Experiments".
  • M.W. Irvin, A. Zijlstra, J.P. Wikswo, and A. Pozzi. "Techniques and Assays for the Study of Angiogenesis".
  • P.R. LeDuc, W.C. Messner, and J.P. Wikswo. "How Do Control-Based Approaches Enter into Biology?". Annu. Rev. Biomed. Eng. 13: 369-96.
  • R. Yang, S.C. Lenaghan, J.P. Wikswo, and M. Zhang. "External Control of the GAL Network in S. cerevisiae: A View from Control Theory". PLoS ONE. 6((4)): e19353.
  • R.A. Gray, D.N. Mashburn, V.Y. Sidorov, B.J. Roth, P. Pathmanathan, and J.P. Wikswo. "Transmembrane Current Imaging in the Heart During Pacing and Fibrillation".
  • R.A. Gray, D.N. Mashburn, V.Y. Sidorov, and J.P. Wikswo. "Quantification of Transmembrane Currents During Action Potential Propagation in the Heart".
  • R.A. Gray, J.P. Wikswo, and N.F. Otani. "Origin Choice and Petal Loss in the Flower Garden of Spiral Wave Tip Trajectories". Chaos. 19((3)): 33118-1.
  • R.M. Snider, J.R. McKenzie, L. Kraft, E. Kozlov, J.P. Wikswo, and D.E. Cliffel. "The Effects of Cholera Toxin on Cellular Energy Metabolism Toxins". Toxins. 2((4)): 632-4.
  • S. Chowdhury, P. Svec, C. Wang, K. Seale, J.P. Wikswo, W. Losert, and S.K. Gupta. "Automated Cell Transport in Optical Tweezers-Assisted Microfluidic Chambers".
  • S. Hummel, V. Quaranta, and J. Wikswo. "The Biohacker: A Threat to National Security".
  • S.E. Eklund, R.G. Thompson, R.M. Snider, C.K. Carney, D.W. Wright, J.P. Wikswo, and D.E. Cliffel. "Metabolic Discrimination of Select List Agents by Monitoring Cellular Responses in a Multianalyte Microphysiometer". Sensors. 9((3)): 2117-33.
  • S.G. Darby, M.R. Moore, T.A. Friedlander, D.K. Schaffer, R.S. Reiserer, J.P. Wikswo, and K.T. Seale. "A Metering Rotary Nanopump for Microfluidic Systems". Lab Chip. 10: 3218-26.
  • S.L. Faley, M. Copland, D. Wlodkowic, W. Kolch, K.T. Seale, J.P. Wikswo, and J.M. Cooper. "Microfluidic Single Cell Arrays to Interrogate Signalling Dynamics of Individual, Patient-derived Hematopoietic Stem Cells". Lab Chip. 9((18)): 2659-64.
  • T.F. Byrd, L.T. Hoang, M.E. Pfister, E.M. Werner, S.E. Arndt, J.W. Chamberlain, J.J. Hughey, B.A. Nguyen, E.J. Schneibel, L.L. Wertz, J.S. Whitfield, J.P. Wikswo, and K.T. Seale. "The Microfluidic Multitrap Nanophysiometer for Hematologic Cancer Cell Characterization Reveals Temporal Sensitivity of the Calcein-AM Efflux Assay".
  • V.Y. Sidorov, I. Uzelac, and J.P. Wikswo. "Regional Increase of Extracellular Potassium Leads to Electrical Instability and Reentry Occurence Through the Spatial Heterogeneity of APD Restitution". Am. J. Physiol.-Heart Circ. Physiol. 301: H209-H220.
  • W. Georgescu, J.P. Wikswo, and V. Quaranta. "CellAnimation: An Open Source MATLAB Framework for Microscopy Assays". Bioinformatics. 28((1)): 138-9.
  • W.J. Ashby, J.P. Wikswo, and A. Zijlstra. "Magnetically Attachable Stencils and the Non-Destructive Analysis of the Contribution Made by the Underlying Matrix to Cell Migration". Biomaterials. 33((33)): 8189-203.
  • Y. Liu, D.A. Markov, J.P. Wikswo, and L.J. McCawley. "Microfabricated Scaffold-Confined Endothelial Morphogenesis in Three-Dimensional Culture". Biomedical Microdevices. 13: 837-46.
  • Y. Yan, L. Jiang, K.J. Aufderheide, G.A. Wright, A. Terekhov, L. Costa, K. Qin, W.T. McCleery, J.J. Fellenstein, A. Ustione, J.B. Robertson, C.H. Johnson, D.W. Piston, M.S. Hutson, J.P. Wikswo, W. Hofmeister, and C. Janetopoulos. "A Microfluidic-Enabled Mechanical Microcompressor for the Immobilization of Live Single- and Multi-Cellular Specimens".