Vanderbilt-Ingram Cancer Center

Publications

• Pozzi, A, Popescu, V, Yang, S, Mei, S, Shi, M, Puolitaival, SM, Caprioli, RM, Capdevila, JH The anti-tumorigenic properties of peroxisomal proliferator-activated receptor alpha are arachidonic acid epoxygenase-mediated. J Biol Chem, 285(17), 12840-50, 2010.
• Yang, S, Wei, S, Pozzi, A, Capdevila, JH The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis. Arch Biochem Biophys, 489(1-2), 82-91, 2009.
• Gainer, JV, Lipkowitz, MS, Yu, C, Waterman, MR, Dawson, EP, Capdevila, JH, Brown, NJ, , Association of a CYP4A11 variant and blood pressure in black men. J Am Soc Nephrol, 19(8), 1606-12, 2008.
• Chen, JK, Chen, J, Imig, JD, Wei, S, Hachey, DL, Guthi, JS, Falck, JR, Capdevila, JH, Harris, RC Identification of novel endogenous cytochrome p450 arachidonate metabolites with high affinity for cannabinoid receptors. J Biol Chem, 283(36), 24514-24, 2008.
• Pozzi, A, Capdevila, JH PPARalpha Ligands as Antitumorigenic and Antiangiogenic Agents. PPAR Res, 2008906542, 2008.
• Chen, J, Chen, JK, Falck, JR, Anjaiah, S, Capdevila, JH, Harris, RC Mitogenic activity and signaling mechanism of 2-(14,15- epoxyeicosatrienoyl)glycerol, a novel cytochrome p450 arachidonate metabolite. Mol Cell Biol, 27(8), 3023-34, 2007.
• Pozzi, A, Ibanez, MR, Gatica, AE, Yang, S, Wei, S, Mei, S, Falck, JR, Capdevila, JH Peroxisomal proliferator activated receptor(alpha)-dependent inhibition of endothelial cell proliferation and tumorigenesis. J Biol Chem, 2007.
• Capdevila, JH Regulation of ion transport and blood pressure by cytochrome p450 monooxygenases. Curr Opin Nephrol Hypertens, 16(5), 465-70, 2007.
• Capdevila, JH, Falck, JR, Imig, JD Roles of the cytochrome P450 arachidonic acid monooxygenases in the control of systemic blood pressure and experimental hypertension. Kidney Int, 72(6), 683-9, 2007.
• Wei, S, Brittin, JJ, Falck, JR, Anjaiah, S, Nithipatikom, K, Cui, L, Campbell, WB, Capdevila, JH Chiral resolution of the epoxyeicosatrienoic acids, arachidonic acid epoxygenase metabolites. Anal Biochem, 2006.
• Nakagawa, K, Holla, VR, Wei, Y, Wang, WH, Gatica, A, Wei, S, Mei, S, Miller, CM, Cha, DR, Price, E, Zent, R, Pozzi, A, Breyer, MD, Guan, Y, Falck, JR, Waterman, MR, Capdevila, JH Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J Clin Invest, 116(6), 1696-702, 2006.
• Pozzi, A, Macias-Perez, I, Abair, T, Wei, S, Su, Y, Zent, R, Falck, JR, Capdevila, JH Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids. J Biol Chem, 280(29), 27138-46, 2005.
• Du, L, Yermalitsky, V, Ladd, PA, Capdevila, JH, Mernaugh, R, Keeney, DS Evidence that cytochrome P450 CYP2B19 is the major source of epoxyeicosatrienoic acids in mouse skin. Arch Biochem Biophys, 435(1), 125-33, 2005.
• Gainer, JV, Bellamine, A, Dawson, EP, Womble, KE, Grant, SW, Wang, Y, Cupples, LA, Guo, CY, Demissie, S, O''Donnell, CJ, Brown, NJ, Waterman, MR, Capdevila, JH Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation, 111(1), 63-9, 2005.
• Pozzi, A, Yan, X, Macias-Perez, I, Wei, S, Hata, AN, Breyer, RM, Morrow, JD, Capdevila, JH Colon carcinoma cell growth is associated with prostaglandin E2/EP4 receptor-evoked ERK activation. J Biol Chem, 279(28), 29797-804, 2004.
• Nakagawa, Kiyoshi, Marji, Jackleen S, Schwartzman, Michal L, Waterman, Michael R, Capdevila, Jorge H Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension. Am J Physiol Regul Integr Comp Physiol, 284(4), R1055-62, 2003.
• Bellamine, Aouatef, Wang, Yarong, Waterman, Michael R, Gainer, James V, Dawson, Elliot P, Brown, Nancy J, Capdevila, Jorge H Characterization of the CYP4A11 gene, a second CYP4A gene in humans. Arch Biochem Biophys, 409(1), 221-7, 2003.
• Ladd, Patricia A, Du, Liping, Capdevila, Jorge H, Mernaugh, Raymond, Keeney, Diane S Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes. J Biol Chem, 278(37), 35184-92, 2003.
• Capdevila, Jorge H, Nakagawa, Kiyoshi, Holla, Vijaykumar The CYP P450 arachidonate monooxygenases: enzymatic relays for the control of kidney function and blood pressure. Adv Exp Med Biol, 52539-46, 2003.
• Capdevila, Jorge H, Falck, John R Biochemical and molecular properties of the cytochrome P450 arachidonic acid monooxygenases. Prostaglandins Other Lipid Mediat, 68-69325-44, 2002.
• Chen, Jian-Kang, Capdevila, Jorge, Harris, Raymond C Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells. Proc Natl Acad Sci U S A, 99(9), 6029-34, 2002.
• Capdevila, J H, Harris, R C, Falck, J R Microsomal cytochrome P450 and eicosanoid metabolism. Cell Mol Life Sci, 59(5), 780-9, 2002.
• Cowart, L Ashley, Wei, Shouzuo, Hsu, Mei-Hui, Johnson, Eric F, Krishna, Murali U, Falck, John R, Capdevila, Jorge H The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands. J Biol Chem, 277(38), 35105-12, 2002.
• Holla, V R, Adas, F, Imig, J D, Zhao, X, Price, E, Olsen, N, Kovacs, W J, Magnuson, M A, Keeney, D S, Breyer, M D, Falck, J R, Waterman, M R, Capdevila, J H Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci U S A, 98(9), 5211-6, 2001.
• Chen, J K, Capdevila, J, Harris, R C Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosis. Mol Cell Biol, 21(18), 6322-31, 2001.
• Mohapatra, S., Capdevila, J.H., Murphy, R.C., Hevko, J.M., and Falck, J "Efficient total synthesis of 5-oxo-6(E),8(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autocoid." Tet. Letts., 424109-4110, 2001.
• Imig, J.D., Zhao, X., Falck, J.R., Wei, S., and Capdevila, J.H "Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid." J. Hypertens., 19983-992, 2001.
• Cowart, L A, Falck, J R, Capdevila, J H Structural determinants of active site binding affinity and metabolism by cytochrome P450 BM-3. Arch Biochem Biophys, 387(1), 117-24, 2001.
• Capdevila, J H, Falck, J R The CYP P450 arachidonic acid monooxygenases: from cell signaling to blood pressure regulation. Biochem Biophys Res Commun, 285(3), 571-6, 2001.
• Capdevila, J H, Falck, J R Biochemical and molecular characteristics of the cytochrome P450 arachidonic acid monooxygenase. Prostaglandins Other Lipid Mediat, 62(3), 271-92, 2000.
• Helvig, C, Capdevila, J H Biochemical characterization of rat P450 2C11 fused to rat or bacterial NADPH-P450 reductase domains. Biochemistry, 39(17), 5196-205, 2000.
• Capdevila, J H, Falck, J R, Harris, R C Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. J Lipid Res, 41(2), 163-81, 2000.
• Chen, J K, Capdevila, J, Harris, R C Overexpression of C-terminal Src kinase blocks 14, 15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesis. J Biol Chem, 275(18), 13789-92, 2000.
• Falck, J.R., Krishna, M.U., and Capdevila, J.H "Preparation of L--phosphatidyl-D-myo-inositol 3-phosphate (3-PIP) and 3,5-bisphosphate (3,5-PIP2)." Biorg. Med. Chem. Lett., 101711-1713, 2000.
• Falck, J.R., Krishna, U., and Capdevila, J.H "A synthesis of L--phosphatidyl-D-myo-inositol 4,5-bisphosphate (4,5-PIP2) and glyceryl lipid analogs." Tetrahedron Lett., 408771-8774, 1999.
• Chen, J., Capdevila, J.H., Zeldin, D.C., and Rosenberg, R.L "Inhibition of L-type channels by epoxyeicosatrienoic acids." Mol. Pharmacol., 55288-295, 1999.
• Holla, V R, Makita, K, Zaphiropoulos, P G, Capdevila, J H The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading. J Clin Invest, 104(6), 751-60, 1999.
• Chen, J K, Wang, D W, Falck, J R, Capdevila, J, Harris, R C Transfection of an active cytochrome P450 arachidonic acid epoxygenase indicates that 14,15-epoxyeicosatrienoic acid functions as an intracellular second messenger in response to epidermal growth factor. J Biol Chem, 274(8), 4764-9, 1999.
• Keeney, D S, Skinner, C, Travers, J B, Capdevila, J H, Nanney, L B, King, L E, Waterman, M R Differentiating keratinocytes express a novel cytochrome P450 enzyme, CYP2B19, having arachidonate monooxygenase activity. J Biol Chem, 273(48), 32071-9, 1998.
• Chen, J K, Falck, J R, Reddy, K M, Capdevila, J, Harris, R C Epoxyeicosatrienoic acids and their sulfonimide derivatives stimulate tyrosine phosphorylation and induce mitogenesis in renal epithelial cells. J Biol Chem, 273(44), 29254-61, 1998.
• Helvig, C, Dishman, E, Capdevila, J H Molecular, enzymatic, and regulatory characterization of rat kidney cytochromes P450 4A2 and 4A3. Biochemistry, 37(36), 12546-58, 1998.
• Graham-Lorence, S., Truan, G., Peterson, J.A., Falck, J.R., Wei, S., Helvig, C., and Capdevila, J.H "An active site substitution, F87V, converts cytochrome P450 BM-3 into a regio- and stereoselective 14(S), 15(R)-arachidonic acid epoxygenase." J. Biol. Chem., 2721127-1135, 1997.
• Reddy, K.K., Ye, J., Falck, J.R., and Capdevila, J.H "Intracellular second messengers: Synthesis of L-a-phosphatidyl-D-myo-inositol 3,4-bisphosphate and analogs." Bioorganic and Medicinal Chemistry Letters, 72115-2116, 1997.
• Makita, K, Falck, J R, Capdevila, J H Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system. FASEB J, 10(13), 1456-63, 1996.
• Capdevila, J H, Wei, S, Helvig, C, Falck, J R, Belosludtsev, Y, Truan, G, Graham-Lorence, S E, Peterson, J A The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3. J Biol Chem, 271(37), 22663-71, 1996.
• Sakairi, Y, Jacobson, H R, Noland, T D, Capdevila, J H, Falck, J R, Breyer, M D 5,6-EET inhibits ion transport in collecting duct by stimulating endogenous prostaglandin synthesis. Am J Physiol, 268(5 Pt 2), F931-9, 1995.
• Brash, A R, Boeglin, W E, Capdevila, J H, Yeola, S, Blair, I A 7-HETE, 10-HETE, and 13-HETE are major products of NADPH-dependent arachidonic acid metabolism in rat liver microsomes: analysis of their stereochemistry, and the stereochemistry of their acid-catalyzed rearrangement. Arch Biochem Biophys, 321(2), 485-92, 1995.
• Heckman, B., Mioskoski, C., Sun-Lumin, Falck, J.R., Wei, S., and Capdevila, J.H "Chiral acetals: Stereocontrolled synthesis of 16-, 17- and 18-hydroxyeicosatetraenoic acids, cytochrome P450 arachidonate metabolites." Tetrahedron Lett., 371425-1428, 1995.
• Zeldin, D C, Wei, S, Falck, J R, Hammock, B D, Snapper, J R, Capdevila, J H Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis. Arch Biochem Biophys, 316(1), 443-51, 1995.
• Zeldin, D C, DuBois, R N, Falck, J R, Capdevila, J H Molecular cloning, expression and characterization of an endogenous human cytochrome P450 arachidonic acid epoxygenase isoform. Arch Biochem Biophys, 322(1), 76-86, 1995.
• Burns, K D, Capdevila, J, Wei, S, Breyer, M D, Homma, T, Harris, R C Role of cytochrome P-450 epoxygenase metabolites in EGF signaling in renal proximal tubule. Am J Physiol, 269(4 Pt 1), C831-40, 1995.
• Capdevila, J H, Morrow, J D, Belosludtsev, Y Y, Beauchamp, D R, DuBois, R N, Falck, J R The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s). Biochemistry, 34(10), 3325-37, 1995.
• Zeldin, D C, Plitman, J D, Kobayashi, J, Miller, R F, Snapper, J R, Falck, J R, Szarek, J L, Philpot, R M, Capdevila, J H The rabbit pulmonary cytochrome P450 arachidonic acid metabolic pathway: characterization and significance. J Clin Invest, 95(5), 2150-60, 1995.
• Makita, K, Takahashi, K, Karara, A, Jacobson, H R, Falck, J R, Capdevila, J H Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet. J Clin Invest, 94(6), 2414-20, 1994.
• Takahashi, K, Harris, R C, Capdevila, J H, Karara, A, Makita, K, Jacobson, H R, Munger, K A, Badr, K F Induction of renal arachidonate cytochrome P-450 epoxygenase after uninephrectomy: counterregulation of hyperfiltration. J Am Soc Nephrol, 3(8), 1496-500, 1993.
• Karara, A, Makita, K, Jacobson, H R, Falck, J R, Guengerich, F P, DuBois, R N, Capdevila, J H Molecular cloning, expression, and enzymatic characterization of the rat kidney cytochrome P-450 arachidonic acid epoxygenase. J Biol Chem, 268(18), 13565-70, 1993.
• Zeldin, D C, Kobayashi, J, Falck, J R, Winder, B S, Hammock, B D, Snapper, J R, Capdevila, J H Regio- and enantiofacial selectivity of epoxyeicosatrienoic acid hydration by cytosolic epoxide hydrolase. J Biol Chem, 268(9), 6402-7, 1993.
• Karara, A, Wei, S, Spady, D, Swift, L, Capdevila, J H, Falck, J R Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma. Biochem Biophys Res Commun, 182(3), 1320-5, 1992.
• Capdevila, J H, Wei, S, Yan, J, Karara, A, Jacobson, H R, Falck, J R, Guengerich, F P, DuBois, R N Cytochrome P-450 arachidonic acid epoxygenase. Regulatory control of the renal epoxygenase by dietary salt loading. J Biol Chem, 267(30), 21720-6, 1992.
• Capdevila, J H, Falck, J R, Estabrook, R W Cytochrome P450 and the arachidonate cascade. FASEB J, 6(2), 731-6, 1992.
• Jajoo, H K, Capdevila, J H, Falck, J R, Bhatt, R K, Blair, I A Metabolism of 12(R)-hydroxyeicosatetraenoic acid by rat liver microsomes. Biochim Biophys Acta, 1123(1), 110-6, 1992.
• Capdevila, J H, Wei, S, Kumar, A, Kobayashi, J, Snapper, J R, Zeldin, D C, Bhatt, R K, Falck, J R Resolution of dihydroxyeicosanoates and of dihydroxyeicosatrienoates by chiral phase chromatography. Anal Biochem, 207(2), 236-40, 1992.
• Karara, A, Dishman, E, Falck, J R, Capdevila, J H Endogenous epoxyeicosatrienoyl-phospholipids. A novel class of cellular glycerolipids containing epoxidized arachidonate moieties. J Biol Chem, 266(12), 7561-9, 1991.
• Katoh, T, Takahashi, K, Capdevila, J, Karara, A, Falck, J R, Jacobson, H R, Badr, K F Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney. Am J Physiol, 261(4 Pt 2), F578-86, 1991.
• Karara, A, Dishman, E, Jacobson, H, Falck, J R, Capdevila, J H Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex. FEBS Lett, 268(1), 227-30, 1990.
• Takahashi, K, Capdevila, J, Karara, A, Falck, J R, Jacobson, H R, Badr, K F Cytochrome P-450 arachidonate metabolites in rat kidney: characterization and hemodynamic responses. Am J Physiol, 258(4 Pt 2), F781-9, 1990.
• Capdevila, J H, Karara, A, Waxman, D J, Martin, M V, Falck, J R, Guenguerich, F P Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. J Biol Chem, 265(19), 10865-71, 1990.
• Harris, R C, Homma, T, Jacobson, H R, Capdevila, J Epoxyeicosatrienoic acids activate Na+/H+ exchange and are mitogenic in cultured rat glomerular mesangial cells. J Cell Physiol, 144(3), 429-37, 1990.
• Karara, A, Dishman, E, Blair, I, Falck, J R, Capdevila, J H Endogenous epoxyeicosatrienoic acids. Cytochrome P-450 controlled stereoselectivity of the hepatic arachidonic acid epoxygenase. J Biol Chem, 264(33), 19822-7, 1989.
• Hammonds, T D, Blair, I A, Falck, J R, Capdevila, J H Resolution of epoxyeicosatrienoate enantiomers by chiral phase chromatography. Anal Biochem, 182(2), 300-3, 1989.
• Capdevila, J, Gil, L, Orellana, M, Marnett, L J, Mason, J I, Yadagiri, P, Falck, J R Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism. Arch Biochem Biophys, 261(2), 257-63, 1988.
• Capdevila, J H, Mosset, P, Yadagiri, P, Lumin, S, Falck, J R NADPH-dependent microsomal metabolism of 14,15-epoxyeicosatrienoic acid to diepoxides and epoxyalcohols. Arch Biochem Biophys, 261(1), 122-33, 1988.