Skip to Content

Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 
Kelli  Boyd

Kelli Boyd, DVM, Ph.D.

Associate Professor of Pathology, Microbiology and Immunology
Pathologist

Contact Information:

615-322-3596
Fax: 615-343-7682

Profile

Dr. Boyd is board certified by American College of Veterinary Pathologists in anatomic pathology.  She has been working at the intersection of comparative pathology and translational medicine since 2001.  She has developed a specific expertise in the pathology of genetically engineered mice with a stong emphasis on cancer research. She works collaboratively to provide pathology support for VICC investigators using animal model systems.

Education
  • BS Mississippi State University 1992
  • DVM Mississippi State University 1996
  • PhD University of Georgia 2001
 
Publications
  • Watanabe M, Mishin VP, Brown SA, Russell CJ, Boyd K, Babu YS, Taylor G, Xiong X, Yan X, Portner A, Alymova IV. Effect of hemagglutinin-neuraminidase inhibitors BCX 2798 and BCX 2855 on growth and pathogenicity of Sendai/human parainfluenza type 3 chimera virus in mice. Antimicrob. Agents Chemother [print-electronic]. 2009 Sep; 53(9): 3942-51. PMID: 19564364, PMCID: PMC2737897, PII: AAC.00220-09, DOI: 10.1128/AAC.00220-09, ISSN: 1098-6596.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19564364.
  • Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H. The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat. Immunol [print-electronic]. 2009 Jul; 10(7): 769-77. PMID: 19483717, PMCID: PMC2732340, PII: ni.1743, DOI: 10.1038/ni.1743, ISSN: 1529-2916.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19483717.
  • Thomas PG, Dash P, Aldridge JR, Ellebedy AH, Reynolds C, Funk AJ, Martin WJ, Lamkanfi M, Webby RJ, Boyd KL, Doherty PC, Kanneganti TD. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity [print-electronic]. 2009 Apr 4/17/2009; 30(4): 566-75. PMID: 19362023, PMCID: PMC2765464, PII: S1074-7613(09)00140-X, DOI: 10.1016/j.immuni.2009.02.006, ISSN: 1097-4180.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19362023.
  • Lamkanfi M, Moreira LO, Makena P, Spierings DC, Boyd K, Murray PJ, Green DR, Kanneganti TD. Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival. Blood [print-electronic]. 2009 Mar 3/19/2009; 113(12): 2742-5. PMID: 19168786, PMCID: PMC2661861, PII: blood-2008-09-178038, DOI: 10.1182/blood-2008-09-178038, ISSN: 1528-0020.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19168786.
  • Steimer DA, Boyd K, Takeuchi O, Fisher JK, Zambetti GP, Opferman JT. Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. Blood [print-electronic]. 2009 Mar 3/19/2009; 113(12): 2805-15. PMID: 19064728, PMCID: PMC2661864, PII: blood-2008-05-159145, DOI: 10.1182/blood-2008-05-159145, ISSN: 1528-0020.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19064728.
  • Karlström A, Boyd KL, English BK, McCullers JA. Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenza. J. Infect. Dis. 2009 Feb 2/1/2009; 199(3): 311-9. PMID: 19113989, PMCID: PMC2687083, DOI: 10.1086/596051, ISSN: 0022-1899.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19113989.
  • Pestina TI, Hargrove PW, Jay D, Gray JT, Boyd KM, Persons DA. Correction of murine sickle cell disease using gamma-globin lentiviral vectors to mediate high-level expression of fetal hemoglobin. Mol. Ther [print-electronic]. 2009 Feb; 17(2): 245-52. PMID: 19050697, PMCID: PMC2670570, PII: mt2008259, DOI: 10.1038/mt.2008.259, ISSN: 1525-0024.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19050697.
  • Yang L, Boyd K, Kaste SC, Kamdem Kamdem L, Rahija RJ, Relling MV. A mouse model for glucocorticoid-induced osteonecrosis: effect of a steroid holiday. J. Orthop. Res. 2009 Feb; 27(2): 169-75. PMID: 18683891, PMCID: PMC2718787, DOI: 10.1002/jor.20733, ISSN: 1554-527X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18683891.
  • Alymova IV, Taylor G, Mishin VP, Watanabe M, Murti KG, Boyd K, Chand P, Babu YS, Portner A. Loss of the N-linked glycan at residue 173 of human parainfluenza virus type 1 hemagglutinin-neuraminidase exposes a second receptor-binding site. J. Virol [print-electronic]. 2008 Sep; 82(17): 8400-10. PMID: 18579600, PMCID: PMC2519627, PII: JVI.00474-08, DOI: 10.1128/JVI.00474-08, ISSN: 1098-5514.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18579600.
  • Krishnamurthy P, Schwab M, Takenaka K, Nachagari D, Morgan J, Leslie M, Du W, Boyd K, Cheok M, Nakauchi H, Marzolini C, Kim RB, Poonkuzhali B, Schuetz E, Evans W, Relling M, Schuetz JD. Transporter-mediated protection against thiopurine-induced hematopoietic toxicity. Cancer Res. 2008 Jul 7/1/2008; 68(13): 4983-9. PMID: 18593894, PMCID: PMC3323115, PII: 68/13/4983, DOI: 10.1158/0008-5472.CAN-07-6790, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18593894.
  • Tian Y, Pate C, Andreolotti A, Wang L, Tuomanen E, Boyd K, Claro E, Jackowski S. Cytokine secretion requires phosphatidylcholine synthesis. J. Cell Biol. 2008 Jun 6/16/2008; 181(6): 945-57. PMID: 18559668, PMCID: PMC2426940, PII: jcb.200706152, DOI: 10.1083/jcb.200706152, ISSN: 1540-8140.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18559668.
  • Holst J, Wang H, Eder KD, Workman CJ, Boyd KL, Baquet Z, Singh H, Forbes K, Chruscinski A, Smeyne R, van Oers NS, Utz PJ, Vignali DA. Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nat. Immunol [print-electronic]. 2008 Jun; 9(6): 658-66. PMID: 18469818, PII: ni.1611, DOI: 10.1038/ni.1611, ISSN: 1529-2916.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18469818.
  • Chao JR, Parganas E, Boyd K, Hong CY, Opferman JT, Ihle JN. Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature [print-electronic]. 2008 Mar 3/6/2008; 452(7183): 98-102. PMID: 18288109, PII: nature06604, DOI: 10.1038/nature06604, ISSN: 1476-4687.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18288109.
  • Marino R, Martinez C, Boyd K, Dominici M, Hofmann TJ, Horwitz EM. Transplantable marrow osteoprogenitors engraft in discrete saturable sites in the marrow microenvironment. Exp. Hematol [print-electronic]. 2008 Mar; 36(3): 360-8. PMID: 18179857, PMCID: PMC3391997, PII: S0301-472X(07)00658-3, DOI: 10.1016/j.exphem.2007.11.002, ISSN: 0301-472X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18179857.
  • Zhan X, Hurwitz JL, Krishnamurthy S, Takimoto T, Boyd K, Scroggs RA, Surman S, Portner A, Slobod KS. Respiratory syncytial virus (RSV) fusion protein expressed by recombinant Sendai virus elicits B-cell and T-cell responses in cotton rats and confers protection against RSV subtypes A and B. Vaccine [print-electronic]. 2007 Dec 12/17/2007; 25(52): 8782-93. PMID: 18037543, PMCID: PMC2238687, PII: S0264-410X(07)01191-7, DOI: 10.1016/j.vaccine.2007.10.038, ISSN: 0264-410X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18037543.
  • Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 2007 Nov 11/22/2007; 450(7169): 566-9. PMID: 18033300, PII: nature06306, DOI: 10.1038/nature06306, ISSN: 1476-4687.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18033300.
  • Torchia EC, Boyd K, Rehg JE, Qu C, Baker SJ. EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol. Cell. Biol [print-electronic]. 2007 Nov; 27(22): 7918-34. PMID: 17875932, PMCID: PMC2169157, PII: MCB.00099-07, DOI: 10.1128/MCB.00099-07, ISSN: 1098-5549.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17875932.
  • Ajioka I, Martins RA, Bayazitov IT, Donovan S, Johnson DA, Frase S, Cicero SA, Boyd K, Zakharenko SS, Dyer MA. Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell. 2007 Oct 10/19/2007; 131(2): 378-90. PMID: 17956737, PMCID: PMC2203617, PII: S0092-8674(07)01224-X, DOI: 10.1016/j.cell.2007.09.036, ISSN: 0092-8674.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17956737.
  • McAuley JL, Hornung F, Boyd KL, Smith AM, McKeon R, Bennink J, Yewdell JW, McCullers JA. Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe. 2007 Oct 10/11/2007; 2(4): 240-9. PMID: 18005742, PMCID: PMC2083255, PII: S1931-3128(07)00216-8, DOI: 10.1016/j.chom.2007.09.001, ISSN: 1934-6069.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18005742.
  • Hulse-Post DJ, Franks J, Boyd K, Salomon R, Hoffmann E, Yen HL, Webby RJ, Walker D, Nguyen TD, Webster RG. Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks. J. Virol [print-electronic]. 2007 Aug; 81(16): 8515-24. PMID: 17553873, PMCID: PMC1951362, PII: JVI.00435-07, DOI: 10.1128/JVI.00435-07, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17553873.
  • Ozbek U, Kandilci A, van Baal S, Bonten J, Boyd K, Franken P, Fodde R, Grosveld GC. SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice. Am. J. Pathol [print-electronic]. 2007 Aug; 171(2): 654-66. PMID: 17569777, PMCID: PMC1934515, PII: S0002-9440(10)61998-0, DOI: 10.2353/ajpath.2007.060934, ISSN: 0002-9440.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17569777.
  • Vigerust DJ, Ulett KB, Boyd KL, Madsen J, Hawgood S, McCullers JA. N-linked glycosylation attenuates H3N2 influenza viruses. J. Virol [print-electronic]. 2007 Aug; 81(16): 8593-600. PMID: 17553891, PMCID: PMC1951338, PII: JVI.00769-07, DOI: 10.1128/JVI.00769-07, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17553891.
  • Inoue A, Li T, Roby SK, Valentine MB, Inoue M, Boyd K, Kidd VJ, Lahti JM. Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. Cell Cycle [print-electronic]. 2007 Jul 7/1/2007; 6(13): 1646-54. PMID: 17611414, PII: 4411, ISSN: 1551-4005.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17611414.
  • Keller UB, Old JB, Dorsey FC, Nilsson JA, Nilsson L, MacLean KH, Chung L, Yang C, Spruck C, Boyd K, Reed SI, Cleveland JL. Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis. EMBO J [print-electronic]. 2007 May 5/16/2007; 26(10): 2562-74. PMID: 17464290, PMCID: PMC1868903, PII: 7601691, DOI: 10.1038/sj.emboj.7601691, ISSN: 0261-4189.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17464290.
  • Li N, Boyd K, Dempsey PJ, Vignali DA. Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development. J. Immunol. 2007 Apr 4/1/2007; 178(7): 4214-21. PMID: 17371977, PII: 178/7/4214, ISSN: 0022-1767.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17371977.
  • Humberd J, Boyd K, Webster RG. Emergence of influenza A virus variants after prolonged shedding from pheasants. J. Virol [print-electronic]. 2007 Apr; 81(8): 4044-51. PMID: 17267493, PMCID: PMC1866108, PII: JVI.02346-06, DOI: 10.1128/JVI.02346-06, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17267493.
  • Gingras S, Pelletier S, Boyd K, Ihle JN. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). PLoS ONE. 2007; 2(8): e808. PMID: 17726538, PMCID: PMC1950078, DOI: 10.1371/journal.pone.0000808, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17726538.
  • Funk AJ, Rogers TD, Dobbins RM, Boyd K. Exophthalmos and corneal edema in a young ferret. Diagnosis: glaucoma. Lab Anim (NY). 2006 Oct; 35(9): 19, 20-1. PMID: 17008903, PII: laban1006-19, DOI: 10.1038/laban1006-19, ISSN: 0093-7355.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17008903.
  • Park TJ, Boyd K, Curran T. Cardiovascular and craniofacial defects in Crk-null mice. Mol. Cell. Biol. 2006 Aug; 26(16): 6272-82. PMID: 16880535, PMCID: PMC1592792, PII: 26/16/6272, DOI: 10.1128/MCB.00472-06, ISSN: 0270-7306.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16880535.
  • Sun Y, Boyd K, Xu W, Ma J, Jackson CW, Fu A, Shillingford JM, Robinson GW, Hennighausen L, Hitzler JK, Ma Z, Morris SW. Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function. Mol. Cell. Biol. 2006 Aug; 26(15): 5809-26. PMID: 16847333, PMCID: PMC1592762, PII: 26/15/5809, DOI: 10.1128/MCB.00024-06, ISSN: 0270-7306.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16847333.
  • Lee Y, Miller HL, Russell HR, Boyd K, Curran T, McKinnon PJ. Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res. 2006 Jul 7/15/2006; 66(14): 6964-71. PMID: 16849540, PII: 66/14/6964, DOI: 10.1158/0008-5472.CAN-06-0505, ISSN: 0008-5472.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16849540.
  • Xu W, Fukuyama T, Ney PA, Wang D, Rehg J, Boyd K, van Deursen JM, Brindle PK. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood [print-electronic]. 2006 Jun 6/1/2006; 107(11): 4407-16. PMID: 16424387, PMCID: PMC1895794, PII: 2005-08-3263, DOI: 10.1182/blood-2005-08-3263, ISSN: 0006-4971.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16424387.
  • Hill WA, Randolph MM, Lokey SJ, Hayes E, Boyd KL, Mandrell TD. Efficacy and safety of topical selamectin to eradicate pinworm (Syphacia spp.) infections in rats (Rattus norvegicus) and mice (Mus musculus). J. Am. Assoc. Lab. Anim. Sci. 2006 May; 45(3): 23-6. PMID: 16642966, ISSN: 1559-6109.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16642966.
  • Peltola VT, Boyd KL, McAuley JL, Rehg JE, McCullers JA. Bacterial sinusitis and otitis media following influenza virus infection in ferrets. Infect. Immun. 2006 May; 74(5): 2562-7. PMID: 16622191, PMCID: PMC1459735, PII: 74/5/2562, DOI: 10.1128/IAI.74.5.2562-2567.2006, ISSN: 0019-9567.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16622191.
  • Desmots F, Russell HR, Lee Y, Boyd K, McKinnon PJ. The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development. Mol. Cell. Biol. 2005 Dec; 25(23): 10329-37. PMID: 16287848, PMCID: PMC1291232, PII: 25/23/10329, DOI: 10.1128/MCB.25.23.10329-10337.2005, ISSN: 0270-7306.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16287848.
  • Kasper LH, Boussouar F, Boyd K, Xu W, Biesen M, Rehg J, Baudino TA, Cleveland JL, Brindle PK. Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. EMBO J [print-electronic]. 2005 Nov 11/16/2005; 24(22): 3846-58. PMID: 16237459, PMCID: PMC1283945, PII: 7600846, DOI: 10.1038/sj.emboj.7600846, ISSN: 0261-4189.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16237459.
  • Harvey NL, Srinivasan RS, Dillard ME, Johnson NC, Witte MH, Boyd K, Sleeman MW, Oliver G. Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity. Nat. Genet [print-electronic]. 2005 Oct; 37(10): 1072-81. PMID: 16170315, PII: ng1642, DOI: 10.1038/ng1642, ISSN: 1061-4036.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16170315.
  • Dominici M, Tadjali M, Kepes S, Allay ER, Boyd K, Ney PA, Horwitz E, Persons DA. Transgenic mice with pancellular enhanced green fluorescent protein expression in primitive hematopoietic cells and all blood cell progeny. Genesis. 2005 May; 42(1): 17-22. PMID: 15828004, DOI: 10.1002/gene.20121, ISSN: 1526-954X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15828004.
  • Cardone M, Kandilci A, Carella C, Nilsson JA, Brennan JA, Sirma S, Ozbek U, Boyd K, Cleveland JL, Grosveld GC. The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis. Mol. Cell. Biol. 2005 Mar; 25(6): 2395-405. PMID: 15743832, PMCID: PMC1061619, PII: 25/6/2395, DOI: 10.1128/MCB.25.6.2395-2405.2005, ISSN: 0270-7306.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15743832.
  • Alymova IV, Portner A, Takimoto T, Boyd KL, Babu YS, McCullers JA. The novel parainfluenza virus hemagglutinin-neuraminidase inhibitor BCX 2798 prevents lethal synergism between a paramyxovirus and Streptococcus pneumoniae. Antimicrob. Agents Chemother. 2005 Jan; 49(1): 398-405. PMID: 15616320, PMCID: PMC538863, PII: 49/1/398, DOI: 10.1128/AAC.49.1.398-405.2005, ISSN: 0066-4804.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15616320.
  • Nilsson JA, Nilsson LM, Keller U, Yokota Y, Boyd K, Cleveland JL. Id2 is dispensable for myc-induced lymphomagenesis. Cancer Res. 2004 Oct 10/15/2004; 64(20): 7296-301. PMID: 15492249, PII: 64/20/7296, DOI: 10.1158/0008-5472.CAN-04-2133, ISSN: 0008-5472.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15492249.