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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 

David Lee Gorden, M.D. , F.A.C.S.

Professor of Surgery (Hepatobiliary and Liver Transplantation)
Liver and Hepatobiliary Surgeon

Research Description

We are particularly interested in tumor- microenvironment interactions in primary and metastatic tumors of the liver.

Publications
  • Martin MD, Kremers GJ, Short KW, Rocheleau JV, Xu L, Piston DW, Matrisian LM, Gorden DL. Rapid extravasation and establishment of breast cancer micrometastases in the liver microenvironment. Mol. Cancer Res [print-electronic]. 2010 Oct; 8(10): 1319-27. PMID: 20724460, PMCID: PMC2981168, PII: 1541-7786.MCR-09-0551, DOI: 10.1158/1541-7786.MCR-09-0551, ISSN: 1557-3125.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20724460.
  • Kappa SF, Gorden DL, Davidson MA, Wright JK, Guillamondegui OD. Intraoperative blood loss predicts hemorrhage-related reoperation after orthotopic liver transplantation. Am Surg. 2010 Sep; 76(9): 969-73. PMID: 20836345, ISSN: 0003-1348.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20836345.
  • Uddin MJ, Crews BC, Blobaum AL, Kingsley PJ, Gorden DL, McIntyre JO, Matrisian LM, Subbaramaiah K, Dannenberg AJ, Piston DW, Marnett LJ. Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents. Cancer Res. 2010 May 5/1/2010; 70(9): 3618-27. PMID: 20430759, PMCID: PMC2864539, PII: 70/9/3618, DOI: 10.1158/0008-5472.CAN-09-2664, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20430759.
  • Zhang B, Halder SK, Kashikar ND, Cho YJ, Datta A, Gorden DL, Datta PK. Antimetastatic role of Smad4 signaling in colorectal cancer. Gastroenterology [print-electronic]. 2010 Mar; 138(3): 969-80.e1. PMID: 19909744, PMCID: PMC2831103, PII: S0016-5085(09)01963-5, DOI: 10.1053/j.gastro.2009.11.004, ISSN: 1528-0012.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19909744.
  • VanSaun MN, Lee IK, Washington MK, Matrisian L, Gorden DL. High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model. Am. J. Pathol [print-electronic]. 2009 Jul; 175(1): 355-64. PMID: 19541928, PMCID: PMC2708821, PII: S0002-9440(10)60550-0, DOI: 10.2353/ajpath.2009.080703, ISSN: 1525-2191.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19541928.
  • Earl TM, Nicoud IB, Pierce JM, Wright JP, Majoras NE, Rubin JE, Pierre KP, Gorden DL, Chari RS. Silencing of TLR4 decreases liver tumor burden in a murine model of colorectal metastasis and hepatic steatosis. Ann. Surg. Oncol [print-electronic]. 2009 Apr; 16(4): 1043-50. PMID: 19165543, DOI: 10.1245/s10434-009-0325-8, ISSN: 1534-4681.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19165543.
  • Tessier DJ, Iglesias R, Chapman WC, Kercher K, Matthews BD, Gorden DL, Brunt LM. Previously unreported high-grade complications of adrenalectomy. Surg Endosc [print-electronic]. 2009 Jan; 23(1): 97-102. PMID: 18443863, DOI: 10.1007/s00464-008-9947-3, ISSN: 1432-2218.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18443863.
  • Lee IK, Jung SE, Gorden DL, Lee YS, Jung DY, Oh ST, Kim JG, Jeon HM, Chang SK. The diagnostic criteria for right colonic diverticulitis: prospective evaluation of 100 patients. Int J Colorectal Dis [print-electronic]. 2008 Dec; 23(12): 1151-7. PMID: 18704462, DOI: 10.1007/s00384-008-0512-2, ISSN: 0179-1958.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18704462.
  • Quarles CC, Lepage M, Gorden DL, Fingleton B, Yankeelov TE, Price RR, Matrisian LM, Gore JC, McIntyre JO. Functional colonography of Min mice using dark lumen dynamic contrast-enhanced MRI. Magn Reson Med. 2008 Sep; 60(3): 718-26. PMID: 18727087, PMCID: PMC2646120, DOI: 10.1002/mrm.21724, ISSN: 1522-2594.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18727087.
  • Castaldo ET, Earl TM, Chari RS, Gorden DL, Merchant NB, Wright JK, Feurer ID, Pinson CW. A clinical comparative analysis of crush/clamp, stapler, and dissecting sealer hepatic transection methods. HPB (Oxford). 2008; 10(5): 321-6. PMID: 18982146, PMCID: PMC2575677, DOI: 10.1080/13651820802320040, ISSN: 1365-182X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18982146.
  • Gorden DL, Fingleton B, Crawford HC, Jansen DE, Lepage M, Matrisian LM. Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment. Int. J. Cancer. 2007 Aug 8/1/2007; 121(3): 495-500. PMID: 17417772, DOI: 10.1002/ijc.22594, ISSN: 0020-7136.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17417772.
  • Lundquist AL, Chari RS, Wood JH, Miller GG, Schaefer HM, Raiford DS, Wright KJ, Gorden DL. Serum sickness following rabbit antithymocyte-globulin induction in a liver transplant recipient: case report and literature review. Liver Transpl. 2007 May; 13(5): 647-50. PMID: 17377915, DOI: 10.1002/lt.21098, ISSN: 1527-6465.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17377915.
  • Nicoud IB, Jones CM, Pierce JM, Earl TM, Matrisian LM, Chari RS, Gorden DL. Warm hepatic ischemia-reperfusion promotes growth of colorectal carcinoma micrometastases in mouse liver via matrix metalloproteinase-9 induction. Cancer Res. 2007 Mar 3/15/2007; 67(6): 2720-8. PMID: 17363593, PII: 67/6/2720, DOI: 10.1158/0008-5472.CAN-06-3923, ISSN: 0008-5472.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17363593.
  • Castaldo ET, Pinson CW, Feurer ID, Wright JK, Gorden DL, Kelly BS, Chari RS. Continuous versus interrupted suture for end-to-end biliary anastomosis during liver transplantation gives equal results. Liver Transpl. 2007 Feb; 13(2): 234-8. PMID: 17256781, DOI: 10.1002/lt.20986, ISSN: 1527-6465.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17256781.
  • Koller FL, Geevarghese SK, Gorden DL. Liver transplantation for hepatocellular carcinoma: current role and future opportunities. Curr. Pharm. Des. 2007; 13(32): 3265-73. PMID: 18045177, ISSN: 1873-4286.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18045177.
  • Buchanan FG, Gorden DL, Matta P, Shi Q, Matrisian LM, DuBois RN. Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2006 Jan 1/31/2006; 103(5): 1492-7. PMID: 16432186, PMCID: PMC1360588, PII: 0510562103, DOI: 10.1073/pnas.0510562103, ISSN: 0027-8424.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16432186.
  • Schrager JJ, Vnencak-Jones CL, Graber SE, Neff AT, Chari RS, Wright KJ, Pinson CW, Stewart JH, Gorden DL. Use of short tandem repeats for DNA fingerprinting to rapidly diagnose graft-versus-host disease in solid organ transplant patients. Transplantation. 2006 Jan 1/15/2006; 81(1): 21-5. PMID: 16421472, PII: 00007890-200601150-00006, ISSN: 0041-1337.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16421472.
  • Acuff HB, Carter KJ, Fingleton B, Gorden DL, Matrisian LM. Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment. Cancer Res. 2006 Jan 1/1/2006; 66(1): 259-66. PMID: 16397239, PMCID: PMC1360653, PII: 66/1/259, DOI: 10.1158/0008-5472.CAN-05-2502, ISSN: 0008-5472.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16397239.
  • Thomas KT, Gorden DL, Chari RS, Wright JK, Feurer ID, Wright Pinson C. Biliary reconstruction using non-penetrating, tissue everting clips versus conventional sewn biliary anastomosis in liver transplantation. HPB (Oxford). 2006; 8(2): 132-6. PMID: 18333261, PMCID: PMC2131420, DOI: 10.1080/13651820510037620, ISSN: 1365-182X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18333261.
  • Austin MT, Feurer ID, Chari RS, Gorden DL, Wright JK, Pinson CW. Survival after pediatric liver transplantation: why does living donation offer an advantage?. Arch Surg. 2005 May; 140(5): 465-70; discussion 470. PMID: 15897442, PII: 140/5/465, DOI: 10.1001/archsurg.140.5.465, ISSN: 0004-0010.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15897442.
  • Thomas KT, Welch D, Trueblood A, Sulur P, Wise P, Gorden DL, Chari RS, Wright JK, Washington K, Pinson CW. Effective treatment of biliary cystadenoma. Ann. Surg. 2005 May; 241(5): 769-73; discussion 773. PMID: 15849512, PMCID: PMC1357131, PII: 00000658-200505000-00010, ISSN: 0003-4932.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15849512.
  • Moore DE, Feurer ID, Speroff T, Gorden DL, Wright JK, Chari RS, Pinson CW. Impact of donor, technical, and recipient risk factors on survival and quality of life after liver transplantation. Arch Surg. 2005 Mar; 140(3): 273-7. PMID: 15781792, PII: 140/3/273, DOI: 10.1001/archsurg.140.3.273, ISSN: 0004-0010.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15781792.
  • Moore DE, Feurer ID, Rodgers S, Shaffer D, Nylander W, Gorden DL, Chari RS, Wright JK, Pinson CW. Is there racial disparity in outcomes after solid organ transplantation?. Am. J. Surg. 2004 Nov; 188(5): 571-4. PMID: 15546572, PII: S0002-9610(04)00366-6, DOI: 10.1016/j.amjsurg.2004.07.033, ISSN: 0002-9610.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15546572.
  • Anderson CD, Meranze S, Bream P, Gorden DL, Wright JK, Pinson CW, Chari RS. Contralateral portal vein embolization for hepatectomy in the setting of hepatic steatosis. Am Surg. 2004 Jul; 70(7): 609-12. PMID: 15279184, ISSN: 0003-1348.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15279184.
  • Moore DE, Feurer ID, Holzman MD, Wudel LJ, Strickland C, Gorden DL, Chari R, Wright JK, Pinson CW. Long-term detrimental effect of bile duct injury on health-related quality of life. Arch Surg. 2004 May; 139(5): 476-81; discussion 481. PMID: 15136346, PII: 139/5/476, DOI: 10.1001/archsurg.139.5.476, ISSN: 0004-0010.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15136346.
  • Moore D, Feurer I, Speroff T, Shaffer D, Nylander W, Kizilisik T, Butler J, Awad J, Gorden DL, Chari R, Wright JK, Pinson CW. Survival and quality of life after organ transplantation in veterans and nonveterans. Am. J. Surg. 2003 Nov; 186(5): 476-80. PMID: 14599610, PII: S0002961003003532, ISSN: 0002-9610.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14599610.
  • Gorden DL, Mandriota SJ, Montesano R, Orci L, Pepper MS. Vascular endothelial growth factor is increased in devascularized rat islets of Langerhans in vitro. Transplantation. 1997 Feb 2/15/1997; 63(3): 436-43. PMID: 9039936, ISSN: 0041-1337.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9039936.
  • Gorden DL, Robert A, Moncada VY, Taylor SI, Mühlhauser J, Carpentier JL. Cell surface alteration in Epstein-Barr virus-transformed cells from patients with extreme insulin resistance. Diabetes. 1990 Aug; 39(8): 924-7. PMID: 2165004, ISSN: 0012-1797.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/2165004.