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Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 
Leon  Raskin

Leon Raskin, Ph.D., M.Sc.

Assistant Professor of Medicine (Epidemiology)
Researcher

Contact Information:

Vanderbilt Univeristy Medical Center
2525 West End Avenue, Suite 321
Nashville, TN 37232
615-343-5378
Fax: 615-343-5938

Profile

My research interest concentrates on genetic and molecular epidemiology of cancer and other complex diseases, with an emphasis on colorectal cancer and melanoma. I try to identify and characterize genetic variants associated with cancer, understand how genetic susceptibility may be modified by environmental exposures and gene-gene interactions, and translate these findings into public health applications.
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My research interest concentrates on genetic and molecular epidemiology of cancer and other complex diseases, with an emphasis on colorectal cancer and melanoma. I try to identify and characterize genetic variants associated with cancer, understand how genetic susceptibility may be modified by environmental exposures and gene-gene interactions, and translate these findings into public health applications. I also have a particular interest in evaluating novel molecular prognostic markers and studying the molecular pathogenesis of cancer as an integrated part of genetic epidemiology. It is becoming increasingly evident that cancer represents a heterogeneous set of diseases with highly specific molecular signatures and phenotypes, and my research strategy is to exploit these specific phenotypes to gain insight into the epidemiology and pathogenesis of cancers.

Education
  • Postdoctoral training, Department of Internal Medicine, University of Michigan, Ann Arbor, MI
  • PhD, Epidemiology, Technion - Israel Institute of Technology, Haifa, Israel 
  • MSc, Human Genetics, Tel-Aviv University, Tel-Aviv, Israel 
  • Academy of Medicine, Omsk, Russia
  • University of Medicine, Kemerovo, Russia
Research Description

My research focuses on genetic and molecular epidemiology of cancer and other complex diseases, with an emphasis on colorectal cancer, pancreatic cancer, and melanoma. I try to identify and characterize genetic variants associated with cancer, understand how genetic susceptibility may be modified by environmental exposures and gene-gene interactions, and translate these findings into public health applications. I also have a particular interest in evaluating novel molecular prognostic markers and studying the molecular pathogenesis of cancer as an integrated part of genetic epidemiology. It is becoming increasingly evident that cancer represents a heterogeneous set of diseases with highly specific molecular signatures and phenotypes, and my research strategy is to exploit these specific phenotypes to gain insight into the epidemiology and pathogenesis of cancers.

Publications
  • Wang J, Raskin L, Samuels DC, Shyr Y, Guo Y. Genome measures used for quality control are dependent on gene function and ancestry. Bioinformatics [print-electronic]. 2015 Feb 2/1/2015; 31(3): 318-23. PMID: 25297068, PMCID: PMC4308666, PII: btu668, DOI: 10.1093/bioinformatics/btu668, ISSN: 1367-4811.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25297068.
  • Kreinin A, Lisson S, Nesher E, Schneider J, Bergman J, Farhat K, Farah J, Lejbkowicz F, Yadid G, Raskin L, Koman I, Pinhasov A. Blood BDNF level is gender specific in severe depression. PLoS ONE. 2015; 10(5): e0127643. PMID: 26010085, PMCID: PMC4444333, PII: PONE-D-15-00037, DOI: 10.1371/journal.pone.0127643, ISSN: 1932-6203.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26010085.
  • Schumacher FR, Schmit SL, Jiao S, Edlund CK, Wang H, Zhang B, Hsu L, Huang SC, Fischer CP, Harju JF, Idos GE, Lejbkowicz F, Manion FJ, McDonnell K, McNeil CE, Melas M, Rennert HS, Shi W, Thomas DC, Van Den Berg DJ, Hutter CM, Aragaki AK, Butterbach K, Caan BJ, Carlson CS, Chanock SJ, Curtis KR, Fuchs CS, Gala M, Giocannucci EL, Gogarten SM, Hayes RB, Henderson B, Hunter DJ, Jackson RD, Kolonel LN, Kooperberg C, Kury S, LaCroix A, Laurie CC, Laurie CA, Lemire M, Levine D, Ma J, Makar KW, Qu C, Taverna D, Ulrich CM, Wu K, Kono S, West DW, Berndt SI, Bezieau S, Brenner H, Campbell PT, Chan AT, Chang-Claude J, Coetzee GA, Conti DV, Duggan D, Figueiredo JC, Fortini BK, Gallinger SJ, Gauderman WJ, Giles G, Green R, Haile R, Harrison TA, Hoffmeister M, Hopper JL, Hudson TJ, Jacobs E, Iwasaki M, Jee SH, Jenkins M, Jia WH, Joshi A, Li L, Lindor NM, Matsuo K, Moreno V, Mukherjee B, Newcomb PA, Potter JD, Raskin L, Rennert G, Rosse S, Severi G, Schoen RE, Seminara D, Shu XO, Slattery ML, Tsugane S, White E, Xiang YB, Zanke BW, Zheng W, Le Marchand L, Casey G, Gruber SB, Peters U. Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Nat Commun. 2015; 6: 7138. PMID: 26151821, PII: ncomms8138, DOI: 10.1038/ncomms8138, ISSN: 2041-1723.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26151821.
  • Schmit SL, Schumacher FR, Edlund CK, Conti DV, Raskin L, Lejbkowicz F, Pinchev M, Rennert HS, Jenkins MA, Hopper JL, Buchanan DD, Lindor NM, Le Marchand L, Gallinger S, Haile RW, Newcomb PA, Huang SC, Rennert G, Casey G, Gruber SB. A novel colorectal cancer risk locus at 4q32.2 identified from an international genome-wide association study. Carcinogenesis [print-electronic]. 2014 Nov; 35(11): 2512-9. PMID: 25023989, PMCID: PMC4271131, PII: bgu148, DOI: 10.1093/carcin/bgu148, ISSN: 1460-2180.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25023989.
  • Zhang B, Jia WH, Matsuda K, Kweon SS, Matsuo K, Xiang YB, Shin A, Jee SH, Kim DH, Cai Q, Long J, Shi J, Wen W, Yang G, Zhang Y, Li C, Li B, Guo Y, Ren Z, Ji BT, Pan ZZ, Takahashi A, Shin MH, Matsuda F, Gao YT, Oh JH, Kim S, Ahn YO, , Chan AT, Chang-Claude J, Slattery ML, , Gruber SB, Schumacher FR, Stenzel SL, , Casey G, Kim HR, Jeong JY, Park JW, Li HL, Hosono S, Cho SH, Kubo M, Shu XO, Zeng YX, Zheng W. Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Nat. Genet [print-electronic]. 2014 Jun; 46(6): 533-42. PMID: 24836286, PMCID: PMC4068797, PII: ng.2985, DOI: 10.1038/ng.2985, ISSN: 1546-1718.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/24836286.
  • Wang H, Burnett T, Kono S, Haiman CA, Iwasaki M, Wilkens LR, Loo LW, Van Den Berg D, Kolonel LN, Henderson BE, Keku TO, Sandler RS, Signorello LB, Blot WJ, Newcomb PA, Pande M, Amos CI, West DW, B├ęzieau S, Berndt SI, Zanke BW, Hsu L, , Lindor NM, Haile RW, Hopper JL, Jenkins MA, Gallinger S, Casey G, , Stenzel SL, Schumacher FR, Peters U, Gruber SB, , Tsugane S, Stram DO, Le Marchand L. Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. Nat Commun. 2014; 5: 4613. PMID: 25105248, PMCID: PMC4180879, PII: ncomms5613, DOI: 10.1038/ncomms5613, ISSN: 2041-1723.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/25105248.
  • Raskin L, Fullen DR, Giordano TJ, Thomas DG, Frohm ML, Cha KB, Ahn J, Mukherjee B, Johnson TM, Gruber SB. Transcriptome profiling identifies HMGA2 as a biomarker of melanoma progression and prognosis. J. Invest. Dermatol [print-electronic]. 2013 Nov; 133(11): 2585-92. PMID: 23633021, PMCID: PMC4267221, PII: jid2013197, DOI: 10.1038/jid.2013.197, ISSN: 1523-1747.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23633021.
  • Raskin L, Dakubo JC, Palaski N, Greenson JK, Gruber SB. Distinct molecular features of colorectal cancer in Ghana. Cancer Epidemiol [print-electronic]. 2013 Oct; 37(5): 556-61. PMID: 23962701, PMCID: PMC4267222, PII: S1877-7821(13)00115-X, DOI: 10.1016/j.canep.2013.07.007, ISSN: 1877-783X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/23962701.
  • Mukherjee B, Delancey JO, Raskin L, Everett J, Jeter J, Begg CB, Orlow I, Berwick M, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Culver HA, Rosso S, Zanetti R, Kanetsky PA, From L, Gruber SB, . Risk of non-melanoma cancers in first-degree relatives of CDKN2A mutation carriers. J. Natl. Cancer Inst [print-electronic]. 2012 Jun 6/20/2012; 104(12): 953-6. PMID: 22534780, PMCID: PMC3379723, PII: djs221, DOI: 10.1093/jnci/djs221, ISSN: 1460-2105.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22534780.
  • Cote ML, Kam A, Chang CY, Raskin L, Reding KW, Cho KR, Gruber SB, Ali-Fehmi R. A pilot study of microsatellite instability and endometrial cancer survival in white and African American women. Int. J. Gynecol. Pathol. 2012 Jan; 31(1): 66-72. PMID: 22123725, DOI: 10.1097/PGP.0b013e318224329e, ISSN: 1538-7151.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/22123725.
  • Raskin L, Schwenter F, Freytsis M, Tischkowitz M, Wong N, Chong G, Narod SA, Levine DA, Bogomolniy F, Aronson M, Thibodeau SN, Hunt KS, Rennert G, Gallinger S, Gruber SB, Foulkes WD. Characterization of two Ashkenazi Jewish founder mutations in MSH6 gene causing Lynch syndrome. Clin. Genet [print-electronic]. 2011 Jun; 79(6): 512-22. PMID: 21155762, PMCID: PMC4541773, DOI: 10.1111/j.1399-0004.2010.01594.x, ISSN: 1399-0004.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21155762.
  • Vilar E, Bartnik CM, Stenzel SL, Raskin L, Ahn J, Moreno V, Mukherjee B, Iniesta MD, Morgan MA, Rennert G, Gruber SB. MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers. Cancer Res [print-electronic]. 2011 Apr 4/1/2011; 71(7): 2632-42. PMID: 21300766, PMCID: PMC3407272, PII: 0008-5472.CAN-10-1120, DOI: 10.1158/0008-5472.CAN-10-1120, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21300766.
  • Christensen KD, Roberts JS, Shalowitz DI, Everett JN, Kim SY, Raskin L, Gruber SB. Disclosing individual CDKN2A research results to melanoma survivors: interest, impact, and demands on researchers. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2011 Mar; 20(3): 522-9. PMID: 21307304, PMCID: PMC3833711, PII: 1055-9965.EPI-10-1045, DOI: 10.1158/1055-9965.EPI-10-1045, ISSN: 1538-7755.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21307304.
  • Raskin L, Ludgate M, Iyer RK, Ackley TE, Bradford CR, Johnson TM, Fullen DR. Copy number variations and clinical outcome in atypical spitz tumors. Am. J. Surg. Pathol. 2011 Feb; 35(2): 243-52. PMID: 21263245, PII: 00000478-201102000-00009, DOI: 10.1097/PAS.0b013e31820393ee, ISSN: 1532-0979.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21263245.
  • Roberts JS, Shalowitz DI, Christensen KD, Everett JN, Kim SY, Raskin L, Gruber SB. Returning individual research results: development of a cancer genetics education and risk communication protocol. J Empir Res Hum Res Ethics. 2010 Sep; 5(3): 17-30. PMID: 20831418, PMCID: PMC3159194, DOI: 10.1525/jer.2010.5.3.17, ISSN: 1556-2646.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20831418.
  • Gornick MC, Castellsague X, Sanchez G, Giordano TJ, Vinco M, Greenson JK, Capella G, Raskin L, Rennert G, Gruber SB, Moreno V. Human papillomavirus is not associated with colorectal cancer in a large international study. Cancer Causes Control [print-electronic]. 2010 May; 21(5): 737-43. PMID: 20087645, PMCID: PMC4269349, DOI: 10.1007/s10552-010-9502-0, ISSN: 1573-7225.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20087645.
  • Roy S, Raskin L, Raymond VM, Thibodeau SN, Mody RJ, Gruber SB. Pediatric duodenal cancer and biallelic mismatch repair gene mutations. Pediatr Blood Cancer. 2009 Jul; 53(1): 116-20. PMID: 19283792, DOI: 10.1002/pbc.21957, ISSN: 1545-5017.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19283792.
  • Raskin L, Lejbkowicz F, Barnett-Griness O, Dishon S, Almog R, Rennert G. BRCA1 breast cancer risk is modified by CYP19 polymorphisms in Ashkenazi Jews. Cancer Epidemiol. Biomarkers Prev [print-electronic]. 2009 May; 18(5): 1617-23. PMID: 19366906, PII: 1055-9965.EPI-09-0060, DOI: 10.1158/1055-9965.EPI-09-0060, ISSN: 1055-9965.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19366906.
  • Vilar E, Mukherjee B, Kuick R, Raskin L, Misek DE, Taylor JM, Giordano TJ, Hanash SM, Fearon ER, Rennert G, Gruber SB. Gene expression patterns in mismatch repair-deficient colorectal cancers highlight the potential therapeutic role of inhibitors of the phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway. Clin. Cancer Res [print-electronic]. 2009 Apr 4/15/2009; 15(8): 2829-39. PMID: 19351759, PMCID: PMC3425357, PII: 1078-0432.CCR-08-2432, DOI: 10.1158/1078-0432.CCR-08-2432, ISSN: 1078-0432.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19351759.
  • Raskin L, Rennert G, Gruber SB. FOXP3 germline polymorphisms are not associated with risk of breast cancer. Cancer Genet. Cytogenet. 2009 Apr 4/1/2009; 190(1): 40-2. PMID: 19264232, PII: S0165-4608(08)00706-1, DOI: 10.1016/j.cancergencyto.2008.12.005, ISSN: 1873-4456.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19264232.
  • Khoury-Shakour S, Gruber SB, Lejbkowicz F, Rennert HS, Raskin L, Pinchev M, Rennert G. Recreational physical activity modifies the association between a common GH1 polymorphism and colorectal cancer risk. Cancer Epidemiol. Biomarkers Prev. 2008 Dec; 17(12): 3314-8. PMID: 19064544, PMCID: PMC2665206, PII: 17/12/3314, DOI: 10.1158/1055-9965.EPI-08-0062, ISSN: 1055-9965.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19064544.
  • Raskin L, Pinchev M, Arad C, Lejbkowicz F, Tamir A, Rennert HS, Rennert G, Gruber SB. FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli populations. Cancer Epidemiol. Biomarkers Prev. 2008 May; 17(5): 1060-5. PMID: 18483326, PII: 17/5/1060, DOI: 10.1158/1055-9965.EPI-08-0018, ISSN: 1055-9965.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18483326.
  • Antoniou AC, Sinilnikova OM, Simard J, ..., Raskin L (60/78), ..., Easton DF, Chenevix-Trench G.,. RAD51 135G>C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies. 2007;
    Available from: http://www.ncbi.nlm.nih.gov/pubmed?term=17999359.
  • Adato A, Raskin L, Petit C, Bonne-Tamir B. Deafness heterogeneity in a Druze isolate from the Middle East: novel OTOF and PDS mutations, low prevalence of GJB2 35delG mutation and indication for a new DFNB locus. Eur. J. Hum. Genet. 2000 Jun; 8(6): 437-42. PMID: 10878664, DOI: 10.1038/sj.ejhg.5200489, ISSN: 1018-4813.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10878664.