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Lourdes  Estrada

Lourdes Estrada, Ph.D.

Assistant Professor of Cancer Biology

Contact Information:

Vanderbilt-Ingram Cancer Center
2220 Pierce Ave, 446A PRB
Nashville, TN 37232-6840
615-936-2869
Fax: 615-936-1190

Education
 
  • Ph.D., University of Michigan, Ann Arbor, Michigan
  • M.S., University of Michigan, Ann Arbor, Michigan
  • B.S., University of Puerto Rico Rio Piedras, Puerto Rico
 
Publications
  • Udyavar AR, Wooten DJ, Hoeksema MD, Bansal M, Califano A, Estrada L, Schnell S, Irish JM, Massion PP, Quaranta V. Novel hybrid phenotype revealed in Small Cell Lung Cancer by a transcription factor network model that can explain tumor heterogeneity. Cancer Res [print-electronic]. 2016 Dec 12/8/2016; PMID: 27932399, PII: 0008-5472.CAN-16-1467, DOI: 10.1158/0008-5472.CAN-16-1467, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27932399.
  • Franco OE, Tyson DR, Konvinse KC, Udyavar AR, Estrada L, Quaranta V, Crawford SE, Hayward SW. Altered TGF-a/ß signaling drives cooperation between breast cancer cell populations. FASEB J [print-electronic]. 2016 Oct; 30(10): 3441-52. PMID: 27383183, PMCID: PMC5024699, PII: fj.201500187RR, DOI: 10.1096/fj.201500187RR, ISSN: 1530-6860.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/27383183.
  • Colvin DC, Jourquin J, Xu J, Does MD, Estrada L, Gore JC. Effects of intracellular organelles on the apparent diffusion coefficient of water molecules in cultured human embryonic kidney cells. Magn Reson Med [print-electronic]. 2011 Mar; 65(3): 796-801. PMID: 21337411, PMCID: PMC3285501, DOI: 10.1002/mrm.22666, ISSN: 1522-2594.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/21337411.
  • Ocak S, Yamashita H, Udyavar AR, Miller AN, Gonzalez AL, Zou Y, Jiang A, Yi Y, Shyr Y, Estrada L, Quaranta V, Massion PP. DNA copy number aberrations in small-cell lung cancer reveal activation of the focal adhesion pathway. Oncogene [print-electronic]. 2010 Dec 12/2/2010; 29(48): 6331-42. PMID: 20802517, PMCID: PMC4637980, PII: onc2010362, DOI: 10.1038/onc.2010.362, ISSN: 1476-5594.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20802517.
  • Anderson AR, Hassanein M, Branch KM, Lu J, Lobdell NA, Maier J, Basanta D, Weidow B, Narasanna A, Arteaga CL, Reynolds AB, Quaranta V, Estrada L, Weaver AM. Microenvironmental independence associated with tumor progression. Cancer Res [print-electronic]. 2009 Nov 11/15/2009; 69(22): 8797-806. PMID: 19887618, PMCID: PMC2783510, PII: 0008-5472.CAN-09-0437, DOI: 10.1158/0008-5472.CAN-09-0437, ISSN: 1538-7445.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19887618.
  • Wang SE, Hinow P, Bryce N, Weaver AM, Estrada L, Arteaga CL, Webb GF. A mathematical model quantifies proliferation and motility effects of TGF-ß on cancer cells. Comput Math Methods Med. 2009 Mar; 10(1): 71-83. PMID: 26000030, PMCID: PMC4437567, DOI: 10.1080/17486700802171993, ISSN: 1748-6718.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/26000030.
  • Kam Y, Karperien A, Weidow B, Estrada L, Anderson AR, Quaranta V. Nest expansion assay: a cancer systems biology approach to in vitro invasion measurements. BMC Res Notes. 2009; 2: 130. PMID: 19594934, PMCID: PMC2716356, PII: 1756-0500-2-130, DOI: 10.1186/1756-0500-2-130, ISSN: 1756-0500.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19594934.
  • Enderling H, Alexander NR, Clark ES, Branch KM, Estrada L, Crooke C, Jourquin J, Lobdell N, Zaman MH, Guelcher SA, Anderson AR, Weaver AM. Dependence of invadopodia function on collagen fiber spacing and cross-linking: computational modeling and experimental evidence. Biophys. J [print-electronic]. 2008 Sep; 95(5): 2203-18. PMID: 18515372, PMCID: PMC2517013, PII: S0006-3495(08)78369-3, DOI: 10.1529/biophysj.108.133199, ISSN: 1542-0086.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18515372.
  • Georgescu W, Jourquin J, Estrada L, Anderson AR, Quaranta V, Wikswo JP. Model-controlled hydrodynamic focusing to generate multiple overlapping gradients of surface-immobilized proteins in microfluidic devices. Lab Chip [print-electronic]. 2008 Feb; 8(2): 238-44. PMID: 18231661, PMCID: PMC4357342, DOI: 10.1039/b716203k, ISSN: 1473-0197.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18231661.
  • Kam Y, Guess C, Estrada L, Weidow B, Quaranta V. A novel circular invasion assay mimics in vivo invasive behavior of cancer cell lines and distinguishes single-cell motility in vitro. BMC Cancer. 2008; 8: 198. PMID: 18625060, PMCID: PMC2491634, PII: 1471-2407-8-198, DOI: 10.1186/1471-2407-8-198, ISSN: 1471-2407.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18625060.
  • Hou P, Estrada L, Kinley AW, Parsons JT, Vojtek AB, Gorski JL. Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape. Hum. Mol. Genet. 2003 Aug 8/15/2003; 12(16): 1981-93. PMID: 12913069, ISSN: 0964-6906.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12913069.
  • Gao J, Estrada L, Cho S, Ellis RE, Gorski JL. The Caenorhabditis elegans homolog of FGD1, the human Cdc42 GEF gene responsible for faciogenital dysplasia, is critical for excretory cell morphogenesis. Hum. Mol. Genet. 2001 Dec 12/15/2001; 10(26): 3049-62. PMID: 11751687, ISSN: 0964-6906.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11751687.
  • Estrada L, Caron E, Gorski JL. Fgd1, the Cdc42 guanine nucleotide exchange factor responsible for faciogenital dysplasia, is localized to the subcortical actin cytoskeleton and Golgi membrane. Hum. Mol. Genet. 2001 Mar 3/1/2001; 10(5): 485-95. PMID: 11181572, ISSN: 0964-6906.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11181572.
  • Gorski JL, Estrada L, Hu C, Liu Z. Skeletal-specific expression of Fgd1 during bone formation and skeletal defects in faciogenital dysplasia (FGDY; Aarskog syndrome). Dev. Dyn. 2000 Aug; 218(4): 573-86. PMID: 10906777, PII: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1015>3.0.CO;2-F, DOI: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1015>3.0.CO;2-F, ISSN: 1058-8388.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10906777.
  • Morishima Y, Kanelakis KC, Silverstein AM, Dittmar KD, Estrada L, Pratt WB. The Hsp organizer protein hop enhances the rate of but is not essential for glucocorticoid receptor folding by the multiprotein Hsp90-based chaperone system. J. Biol. Chem. 2000 Mar 3/10/2000; 275(10): 6894-900. PMID: 10702249, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10702249.
  • Estrada L, Kanelakis KC, Levy GN, Weber WW. Tissue- and gender-specific expression of N-acetyltransferase 2 (Nat2*) during development of the outbred mouse strain CD-1. Drug Metab. Dispos. 2000 Feb; 28(2): 139-46. PMID: 10640510, ISSN: 0090-9556.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10640510.
  • García-Arrarás JE, Estrada-Rodgers L, Santiago R, Torres II, Díaz-Miranda L, Torres-Avillán I. Cellular mechanisms of intestine regeneration in the sea cucumber, Holothuria glaberrima Selenka (Holothuroidea:Echinodermata). J. Exp. Zool. 1998 Jul 7/1/1998; 281(4): 288-304. PMID: 9658592, PII: 10.1002/(SICI)1097-010X(19980701)281:4<288::AID-JEZ5>3.0.CO;2-K, ISSN: 0022-104X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9658592.
  • Estrada-Rodgers L, Levy GN, Weber WW. Substrate selectivity of mouse N-acetyltransferases 1, 2, and 3 expressed in COS-1 cells. Drug Metab. Dispos. 1998 May; 26(5): 502-5. PMID: 9571233, ISSN: 0090-9556.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9571233.
  • Estrada-Rodgers L, Levy GN, Weber WW. Characterization of a hormone response element in the mouse N-acetyltransferase 2 (Nat2*) promoter. Gene Expr. 1998; 7(1): 13-24. PMID: 9572394, ISSN: 1052-2166.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9572394.
  • Levy GN, Rodgers L, Weber WW. Effects of heredity on response to drugs and environmental chemicals: construction of rodent models. Chem. Res. Toxicol. 1996 Dec; 9(8): 1215-24. PMID: 8951222, PII: tx960082y, DOI: 10.1021/tx960082y, ISSN: 0893-228X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8951222.