Skip to Content

Vanderbilt-Ingram Cancer CenterVanderbilt-Ingram Cancer Center

 

Mark R. Denison, M.D.

Craig-Weaver Professor of Pediatrics (Pediatric Infectious Disease)
Professor of Pathology, Microbiology and Immunology
Researcher

Contact Information:

Vanderbilt University Medical Center
D-7235 Medical Center North
Nashville, TN 37232-2581
615-322-2250

Education
  • M.D. - University of Kansas, 1980
  • Fellowship - Thomas Jefferson University Medical Center, 1985
  • Residency - University of Iowa Healthcare, 1983
  • Internship - University of Iowa Healthcare, 1981
 
Research Description

The Denison Lab studies the coronaviruses, a family of plus-strand RNA viruses that cause important infections in many animals and colds in humans. A new coronavirus recently has been identified as the cause of severe acute respiratory syndrome (SARS). The Denison laboratory studies the model coronavirus, mouse hepatitis virus (MHV) to understand the replication, cell biology, and protein functions of coronaviruses. The laboratory uses biochemical and genetic approaches, including the recent introduction of reverse genetic approaches, to define the specific functions of replicase proteins in the formation and function of viral replication complexes. In addition, the laboratory has a program to define the replication of the SARS coronavirus (SARS-CoV) and develop virus mutants as live virus vaccine candidates. The Denison laboratory has an active training program for students and postdoctoral fellows to develop new investigators in viral cell biology, molecular biology, and genetics. .

Publications
  • Frangoul H, Domm J, Denison MR, Calder C, Black J. H1N1 infection mimicking the clinical presentation of gastrointestinal GVHD in a patient following allo-SCT. Bone Marrow Transplant [print-electronic]. 2011 Jan; 46(1): 152-3. PMID: 20383217, PII: bmt201066, DOI: 10.1038/bmt.2010.66, ISSN: 1476-5365.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20383217.
  • Gadlage MJ, Denison MR. Exchange of the coronavirus replicase polyprotein cleavage sites alters protease specificity and processing. J. Virol [print-electronic]. 2010 Jul; 84(13): 6894-8. PMID: 20427532, PMCID: PMC2903247, PII: JVI.00752-10, DOI: 10.1128/JVI.00752-10, ISSN: 1098-5514.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20427532.
  • Dulek DE, Williams JV, Creech CB, Schulert AK, Frangoul HA, Domm J, Denison MR, Chappell JD. Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus. Clin. Infect. Dis. 2010 Jun 6/1/2010; 50(11): 1493-6. PMID: 20415572, DOI: 10.1086/652655, ISSN: 1537-6591.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20415572.
  • Eckerle LD, Becker MM, Halpin RA, Li K, Venter E, Lu X, Scherbakova S, Graham RL, Baric RS, Stockwell TB, Spiro DJ, Denison MR. Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing. PLoS Pathog. 2010 May; 6(5): e1000896. PMID: 20463816, PMCID: PMC2865531, DOI: 10.1371/journal.ppat.1000896, ISSN: 1553-7374.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/20463816.
  • Gadlage MJ, Sparks JS, Beachboard DC, Cox RG, Doyle JD, Stobart CC, Denison MR. Murine hepatitis virus nonstructural protein 4 regulates virus-induced membrane modifications and replication complex function. J. Virol [print-electronic]. 2010 Jan; 84(1): 280-90. PMID: 19846526, PMCID: PMC2798404, PII: JVI.01772-09, DOI: 10.1128/JVI.01772-09, ISSN: 1098-5514.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19846526.
  • Becker MM, Graham RL, Donaldson EF, Rockx B, Sims AC, Sheahan T, Pickles RJ, Corti D, Johnston RE, Baric RS, Denison MR. Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice. Proc. Natl. Acad. Sci. U.S.A [print-electronic]. 2008 Dec 12/16/2008; 105(50): 19944-9. PMID: 19036930, PMCID: PMC2588415, PII: 0808116105, DOI: 10.1073/pnas.0808116105, ISSN: 1091-6490.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/19036930.
  • Gadlage MJ, Graham RL, Denison MR. Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization. J. Virol [print-electronic]. 2008 Dec; 82(23): 11964-9. PMID: 18815297, PMCID: PMC2583644, PII: JVI.01126-07, DOI: 10.1128/JVI.01126-07, ISSN: 1098-5514.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18815297.
  • Denison MR. Seeking membranes: positive-strand RNA virus replication complexes. PLoS Biol. 2008 Oct 10/28/2008; 6(10): e270. PMID: 18959488, PMCID: PMC2573941, PII: 08-PLBI-P-3557, DOI: 10.1371/journal.pbio.0060270, ISSN: 1545-7885.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18959488.
  • Sparks JS, Donaldson EF, Lu X, Baric RS, Denison MR. A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing. J. Virol [print-electronic]. 2008 Jun; 82(12): 5999-6008. PMID: 18385240, PMCID: PMC2395152, PII: JVI.00203-08, DOI: 10.1128/JVI.00203-08, ISSN: 1098-5514.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/18385240.
  • Graham RL, Sparks JS, Eckerle LD, Sims AC, Denison MR. SARS coronavirus replicase proteins in pathogenesis. Virus Res [print-electronic]. 2008 Apr; 133(1): 88-100. PMID: 17397959, PMCID: PMC2637536, PII: S0168-1702(07)00057-3, DOI: 10.1016/j.virusres.2007.02.017, ISSN: 0168-1702.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17397959.
  • Eckerle LD, Lu X, Sperry SM, Choi L, Denison MR. High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants. J. Virol [print-electronic]. 2007 Nov; 81(22): 12135-44. PMID: 17804504, PMCID: PMC2169014, PII: JVI.01296-07, DOI: 10.1128/JVI.01296-07, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17804504.
  • Sparks JS, Lu X, Denison MR. Genetic analysis of Murine hepatitis virus nsp4 in virus replication. J. Virol [print-electronic]. 2007 Nov; 81(22): 12554-63. PMID: 17855548, PMCID: PMC2169011, PII: JVI.01257-07, DOI: 10.1128/JVI.01257-07, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17855548.
  • Graham RL, Denison MR. Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3. J. Virol [print-electronic]. 2006 Dec; 80(23): 11610-20. PMID: 16971428, PMCID: PMC1642617, PII: JVI.01428-06, DOI: 10.1128/JVI.01428-06, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16971428.
  • Eckerle LD, Brockway SM, Sperry SM, Lu X, Denison MR. Effects of mutagenesis of murine hepatitis virus nsp1 and nsp14 on replication in culture. Adv. Exp. Med. Biol. 2006; 581: 55-60. PMID: 17037504, DOI: 10.1007/978-0-387-33012-9_8, ISSN: 0065-2598.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17037504.
  • Graham RL, Sims AC, Baric RS, Denison MR. The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication. Adv. Exp. Med. Biol. 2006; 581: 67-72. PMID: 17037506, DOI: 10.1007/978-0-387-33012-9_10, ISSN: 0065-2598.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/17037506.
  • Graham RL, Sims AC, Brockway SM, Baric RS, Denison MR. The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication. J. Virol. 2005 Nov; 79(21): 13399-411. PMID: 16227261, PMCID: PMC1262610, PII: 79/21/13399, DOI: 10.1128/JVI.79.21.13399-13411.2005, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16227261.
  • Brockway SM, Denison MR. Mutagenesis of the murine hepatitis virus nsp1-coding region identifies residues important for protein processing, viral RNA synthesis, and viral replication. Virology. 2005 Sep 9/30/2005; 340(2): 209-23. PMID: 16051301, PII: S0042-6822(05)00377-6, DOI: 10.1016/j.virol.2005.06.035, ISSN: 0042-6822.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/16051301.
  • Sperry SM, Kazi L, Graham RL, Baric RS, Weiss SR, Denison MR. Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice. J. Virol. 2005 Mar; 79(6): 3391-400. PMID: 15731233, PMCID: PMC1075728, PII: 79/6/3391, DOI: 10.1128/JVI.79.6.3391-3400.2005, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15731233.
  • Brockway SM, Lu XT, Peters TR, Dermody TS, Denison MR. Intracellular localization and protein interactions of the gene 1 protein p28 during mouse hepatitis virus replication. J. Virol. 2004 Nov; 78(21): 11551-62. PMID: 15479796, PMCID: PMC523235, PII: 78/21/11551, DOI: 10.1128/JVI.78.21.11551-11562.2004, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15479796.
  • Denison MR. Severe acute respiratory syndrome coronavirus pathogenesis, disease and vaccines: an update. Pediatr. Infect. Dis. J. 2004 Nov; 23(11 Suppl): S207-14. PMID: 15577575, PII: 00006454-200411001-00005, ISSN: 0891-3668.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15577575.
  • Prentice E, McAuliffe J, Lu X, Subbarao K, Denison MR. Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins. J. Virol. 2004 Sep; 78(18): 9977-86. PMID: 15331731, PMCID: PMC514967, PII: 78/18/9977, DOI: 10.1128/JVI.78.18.9977-9986.2004, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15331731.
  • Denison MR, Yount B, Brockway SM, Graham RL, Sims AC, Lu X, Baric RS. Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication. J. Virol. 2004 Jun; 78(11): 5957-65. PMID: 15140993, PMCID: PMC415798, PII: 78/11/5957, DOI: 10.1128/JVI.78.11.5957-5965.2004, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/15140993.
  • Prentice E, Jerome WG, Yoshimori T, Mizushima N, Denison MR. Coronavirus replication complex formation utilizes components of cellular autophagy. J. Biol. Chem [print-electronic]. 2004 Mar 3/12/2004; 279(11): 10136-41. PMID: 14699140, PII: M306124200, DOI: 10.1074/jbc.M306124200, ISSN: 0021-9258.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/14699140.
  • Brockway SM, Clay CT, Lu XT, Denison MR. Characterization of the expression, intracellular localization, and replication complex association of the putative mouse hepatitis virus RNA-dependent RNA polymerase. J. Virol. 2003 Oct; 77(19): 10515-27. PMID: 12970436, PMCID: PMC228489, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/12970436.
  • Hostetler MA, Suara RO, Denison MR. Unilateral facial paralysis occurring in an infant with enteroviral otitis media and aseptic meningitis. J Emerg Med. 2002 Apr; 22(3): 267-71. PMID: 11932090, PII: S0736467901004838, ISSN: 0736-4679.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11932090.
  • Bost AG, Prentice E, Denison MR. Mouse hepatitis virus replicase protein complexes are translocated to sites of M protein accumulation in the ERGIC at late times of infection. Virology. 2001 Jun 6/20/2001; 285(1): 21-9. PMID: 11414802, PII: S0042-6822(01)90932-8, DOI: 10.1006/viro.2001.0932, ISSN: 0042-6822.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11414802.
  • Bost AG, Prentice E, and Denison MR. Mouse hepatitis virus replicase protein complexes are translocated to sites of M protein accumulation in the ERGIC at late times of infection. Virology. 2001; 285: 21-9.
  • Denison MR, Sims AC. MHV-A59 gene 1 proteins are associated with two distinct membrane populations. Adv. Exp. Med. Biol. 2001; 494: 655-61. PMID: 11774541, ISSN: 0065-2598.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11774541.
  • Prentice E, Denison MR. The cell biology of coronavirus infection. Adv. Exp. Med. Biol. 2001; 494: 609-14. PMID: 11774533, ISSN: 0065-2598.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11774533.
  • Sims AC, Ostermann J, Denison MR. Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes. J. Virol. 2000 Jun; 74(12): 5647-54. PMID: 10823872, PMCID: PMC112052, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10823872.
  • Bost AG, Carnahan RH, Lu XT, Denison MR. Four proteins processed from the replicase gene polyprotein of mouse hepatitis virus colocalize in the cell periphery and adjacent to sites of virion assembly. J. Virol. 2000 Apr; 74(7): 3379-87. PMID: 10708455, PMCID: PMC111839, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10708455.
  • Bost AG; Carnahan RH; Lu XT; Denison MR. Four proteins processed from the replicase gene polyprotein of mouse hepatitis virus colocalize in the cell periphery and adjacent to sites of virion assembly. J. Virol. 2000; 74((7)): 3379-87.
    Available from: http://medline.cos.com/cgi-bin/getRec?10708455.
  • Sims AC, Ostermann J, and Denison MR. Mouse hepatitis virus gene 1 proteins associate with distinct intracellular membranes. J. Virol. 2000; 74: 5647-54.
  • Denison MR, Spaan WJ, van der Meer Y, Gibson CA, Sims AC, Prentice E, Lu XT. The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localizes in complexes that are active in viral RNA synthesis. J. Virol. 1999 Aug; 73(8): 6862-71. PMID: 10400784, PMCID: PMC112771, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/10400784.
  • Denison MR, Spaan WJ, van der Meer Y, Gibson CA, Sims AC, Prentice E, Lu XT. The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localized in complexes that are active in viral RNA synthesis. J. Virol. 1999; (8)((73)): 6862-71.
    Available from: http://medline.cos.com/cgi-bin/getRec?10400784.
  • van der Meer Y, Snijder EJ, Dobbe JC, Schleich S, Denison MR, Spaan WJM, and Krijnse-Locker J. Localization of mouse hepatitis virus nonstructural proteins and RNA synthesis indicates a role for late endosomes in viral replication. J Virol. 1999; 73((9)): 7641-57.
  • Lu XT, Sims AC, Denison MR. Mouse hepatitis virus 3C-like protease cleaves a 22-kilodalton protein from the open reading frame 1a polyprotein in virus-infected cells and in vitro. J. Virol. 1998 Mar; 72(3): 2265-71. PMID: 9499085, PMCID: PMC109524, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9499085.
  • Denison MR, Sims AC, Gibson CA, Lu XT. Processing of the MHV-A59 gene 1 polyprotein by the 3C-like proteinase. Adv. Exp. Med. Biol. 1998; 440: 121-7. PMID: 9782273, ISSN: 0065-2598.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9782273.
  • Gibson CA and Denison MR. Coronavirus picornain-like cysteine proteinase. Handbook of Proteolytic Enzymes. 1998; 726-9.
  • Gibson CA, Chen J, Monroe SA, Denison MR. Expression and processing of nonstructural proteins of the human astroviruses. Adv. Exp. Med. Biol. 1998; 440: 387-91. PMID: 9782307, ISSN: 0065-2598.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9782307.
  • Lu, XT, Sims AC, and Denison MR. Mouse hepatitis virus 3C-Like protease cleaves a 22 -Kilodalton protein from the open reading frame 1a polyprotein in virus-infected cells and in vitro. J Virol. 1998; 72((3)): 2265-71.
  • Sims AC, Lu XT, Denison MR. Expression, purification, and activity of recombinant MHV-A59 3CLpro. Adv. Exp. Med. Biol. 1998; 440: 129-34. PMID: 9782274, ISSN: 0065-2598.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9782274.
  • Sims AC, Lu XT, and Denison MR. Expression, purification and activity of recombinant MHV-A59 3CLpro. Advances in Experimental Medicine and Biology. 1998; 440: 129-34.
  • Lu Y, Denison MR. Determinants of mouse hepatitis virus 3C-like proteinase activity. Virology. 1997 Apr 4/14/1997; 230(2): 335-42. PMID: 9143289, PII: S0042-6822(97)98479-8, DOI: 10.1006/viro.1997.8479, ISSN: 0042-6822.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/9143289.
  • Lu, YQ and Denison MR. Determinants of mouse hepatitis virus 3C-like proteinase activity. Virology. 1997; 230: 335-42.
  • Fisher RG, Denison MR. Veillonella parvula bacteremia without an underlying source. J. Clin. Microbiol. 1996 Dec; 34(12): 3235-6. PMID: 8940482, PMCID: PMC229493, ISSN: 0095-1137.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8940482.
  • Lu X, Lu Y, Denison MR. Intracellular and in vitro-translated 27-kDa proteins contain the 3C-like proteinase activity of the coronavirus MHV-A59. Virology. 1996 Aug 8/15/1996; 222(2): 375-82. PMID: 8806521, PII: S0042-6822(96)90434-1, DOI: 10.1006/viro.1996.0434, ISSN: 0042-6822.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8806521.
  • Kolquist KA, Vnencak-Jones CL, Swift L, Page DL, Johnson JE, Denison MR. Fatal fat embolism syndrome in a child with undiagnosed hemoglobin S/beta+ thalassemia: a complication of acute parvovirus B19 infection. Pediatr Pathol Lab Med. 1996 Jan; 16(1): 71-82. PMID: 8963632, ISSN: 1077-1042.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8963632.
  • Lu XT, Lu YQ, and Denison, MR. Intracellular and in vitro translated 27 kDa proteins contain the 3C-like proteinase activity of the coronavirus MHV-A59. Virology. 1996; 222: 375-82.
  • Lu Y, Lu X, Denison MR. Identification and characterization of a serine-like proteinase of the murine coronavirus MHV-A59. J. Virol. 1995 Jun; 69(6): 3554-9. PMID: 7745703, PMCID: PMC189070, ISSN: 0022-538X.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7745703.
  • Kim JC, Spence RA, Currier PF, Lu X, Denison MR. Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d. Virology. 1995 Apr 4/1/1995; 208(1): 1-8. PMID: 11831690, PII: S0042-6822(85)71123-3, DOI: 10.1006/viro.1995.1123, ISSN: 0042-6822.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/11831690.
  • Denison MR, Hughes SA, Weiss SR. Identification and characterization of a 65-kDa protein processed from the gene 1 polyprotein of the murine coronavirus MHV-A59. Virology. 1995 Feb 2/20/1995; 207(1): 316-20. PMID: 7871746, PII: S0042-6822(85)71085-9, DOI: 10.1006/viro.1995.1085, ISSN: 0042-6822.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/7871746.
  • Denison MR, Hughes SA, and Weiss SR. Identification and characterization of a 65 kilodalton protein processed from the gene 1 polyprotein of the murine coronavirus MHV- A59. Virology. 1995; 207((1)): 316-20.
    Available from: http://medline.cos.com/cgi-bin/getRec?10400784.
  • Denison MR, Kim JC, Ross T. Inhibition of coronavirus MHV-A59 replication by proteinase inhibitors. Adv. Exp. Med. Biol. 1995; 380: 391-7. PMID: 8830514, ISSN: 0065-2598.
    Available from: http://www.ncbi.nlm.nih.gov/pubmed/8830514.
  • Denison MR. Viral Pharyngitis. Seminars in Pediatric Infectious Diseases. 1995; 6((2)): 62-8.
  • Kim JC, Spence RA, Currier PF, Lu X and Denison MR. Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d. Virology. 1995; 208: 1-8.
  • Lu YQ, Lu XT, and Denison MR. Identification and characterization of a serine-like proteinase of the murine coronavirus MHV-A59. Journal of Virology. 1995; 69((6)): 3554-9.
  • Weiss SR, Hughes SA, Bonilla PJ, Turner JD, Leibowitz JL, and Denison MR. Coronavirus polyprotein processing. Archives of Virology. 1994; 9((suppl)): 349-58.
  • Hughes, S. A., M. R. Denison, P. Bonilla, J. L. Leibowitz, R. S. Baric and S. R. Weiss. A newly identified MHV-A59 ORF1a polypeptide p65 is temperature sensitive in two RNA negative mutants. Advances in Experimental Medicine & Biology. 1993; 342: 221-6.
  • Denison, M.R., Zoltick, P.W., Hughes, S.A., Giangreco, B., Olson, A.L., Perlman, S., Leibowitz, J.L., and Weiss, S.R. Intracellular processing of the N-terminal ORF la proteins of the coronavirus MHV-A59 requires multiple proteolytic events. Virology. 1992; 189: 274-84.
  • Denison M.R., Zoltick, P.W., Leibowitz, J.L., Pachuk, C.J., and Weiss, S.R. Identification of polypeptides encoded in ORF la of the putative polymerase gene of the murine coronavirus MHV-A59. J. Virology. 1991; 65: 3706-82.
  • Denison MR and Perlman S. Translation and processing of MHV-A59 virion RNA in reticulocyte lysates and infected cells. Coronaviruses. 1987; 155.
  • Denison, M.R., and Perlman, S. Identification of Putative Polymerase Gene Product in Cells Infected with Mouse Murine Coronavirus A59. Virology. 1987; 157: 565-8.
  • Denison, M.R., and Perlman, S. Translation and Processing of Mouse Hepatitis Virus Virion RNA in a Cell-Free System. J. Virol. 1986; 60((1)): 12-8.
  • Denison MR, Kim JC, and Ross T. Inhibitor of coronavirus MHV-A59 replication by proteinase inhibitors. Coronaviruses.
  • Denison MR, Sims AC, Gibson CA, and Lu XT. Processing of the MHV-A59 gene 1 polyprotein by the 3C-like proteinase. Advances in Experimental Medicine and Biology. 440: 121-8.
  • Gibson CA, Chen J, Monroe SA, and Denison MR. Expression and processing of the nonstructural proteins of the human astroviruses. Advances in Experimental Medicine and Biology. 440: 387-94.
  • Turner, BJ, Denison MR, Eppes SC, Houchens R, Fanning T, and Markson LE. Survival experience of 789 children with the acquired immunodeficiency syndrome. Pediatric Infectious Disease Journal. 12: 310-20.