Vanderbilt-Ingram Cancer Center

Publications

• Gadlage, MJ, Denison, MR Exchange of the coronavirus replicase polyprotein cleavage sites alters protease specificity and processing. J Virol, 84(13), 6894-8, 2010.
• Frangoul, H, Domm, J, Denison, MR, Calder, C, Black, J H1N1 infection mimicking the clinical presentation of gastrointestinal GVHD in a patient following allo-SCT. Bone Marrow Transplant, 2010.
• Eckerle, LD, Becker, MM, Halpin, RA, Li, K, Venter, E, Lu, X, Scherbakova, S, Graham, RL, Baric, RS, Stockwell, TB, Spiro, DJ, Denison, MR Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing. PLoS Pathog, 6(5), e1000896, 2010.
• Gadlage, MJ, Sparks, JS, Beachboard, DC, Cox, RG, Doyle, JD, Stobart, CC, Denison, MR Murine hepatitis virus nonstructural protein 4 regulates virus-induced membrane modifications and replication complex function. J Virol, 84(1), 280-90, 2010.
• Dulek, DE, Williams, JV, Creech, CB, Schulert, AK, Frangoul, HA, Domm, J, Denison, MR, Chappell, JD Use of intravenous zanamivir after development of oseltamivir resistance in a critically Ill immunosuppressed child infected with 2009 pandemic influenza A (H1N1) virus. Clin Infect Dis, 50(11), 1493-6, 2010.
• Sparks, JS, Donaldson, EF, Lu, X, Baric, RS, Denison, MR A novel mutation in murine hepatitis virus nsp5, the viral 3C-like proteinase, causes temperature-sensitive defects in viral growth and protein processing. J Virol, 82(12), 5999-6008, 2008.
• Gadlage, MJ, Graham, RL, Denison, MR Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization. J Virol, 82(23), 11964-9, 2008.
• Graham, RL, Sparks, JS, Eckerle, LD, Sims, AC, Denison, MR SARS coronavirus replicase proteins in pathogenesis. Virus Res, 133(1), 88-100, 2008.
• Denison, MR Seeking membranes: positive-strand RNA virus replication complexes. PLoS Biol, 6(10), e270, 2008.
• Becker, MM, Graham, RL, Donaldson, EF, Rockx, B, Sims, AC, Sheahan, T, Pickles, RJ, Corti, D, Johnston, RE, Baric, RS, Denison, MR Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice. Proc Natl Acad Sci U S A, 105(50), 19944-9, 2008.
• Sparks, JS, Lu, X, Denison, MR Genetic analysis of Murine hepatitis virus nsp4 in virus replication. J Virol, 81(22), 12554-63, 2007.
• Eckerle, LD, Lu, X, Sperry, SM, Choi, L, Denison, MR High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants. J Virol, 81(22), 12135-44, 2007.
• Eckerle, LD, Brockway, SM, Sperry, SM, Lu, X, Denison, MR Effects of mutagenesis of murine hepatitis virus nsp1 and nsp14 on replication in culture. Adv Exp Med Biol, 58155-60, 2006.
• Graham, RL, Denison, MR Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3. J Virol, 80(23), 11610-20, 2006.
• Graham, RL, Sims, AC, Baric, RS, Denison, MR The nsp2 proteins of mouse hepatitis virus and SARS coronavirus are dispensable for viral replication. Adv Exp Med Biol, 58167-72, 2006.
• Brockway, SM, Denison, MR Mutagenesis of the murine hepatitis virus nsp1-coding region identifies residues important for protein processing, viral RNA synthesis, and viral replication. Virology, 340(2), 209-23, 2005.
• Sperry, SM, Kazi, L, Graham, RL, Baric, RS, Weiss, SR, Denison, MR Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice. J Virol, 79(6), 3391-400, 2005.
• Graham, RL, Sims, AC, Brockway, SM, Baric, RS, Denison, MR The nsp2 replicase proteins of murine hepatitis virus and severe acute respiratory syndrome coronavirus are dispensable for viral replication. J Virol, 79(21), 13399-411, 2005.
• Denison, MR, Yount, B, Brockway, SM, Graham, RL, Sims, AC, Lu, X, Baric, RS Cleavage between replicase proteins p28 and p65 of mouse hepatitis virus is not required for virus replication. J Virol, 78(11), 5957-65, 2004.
• Prentice, E, Jerome, WG, Yoshimori, T, Mizushima, N, Denison, MR Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem, 279(11), 10136-41, 2004.
• Prentice, E, McAuliffe, J, Lu, X, Subbarao, K, Denison, MR Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins. J Virol, 78(18), 9977-86, 2004.
• Brockway, SM, Lu, XT, Peters, TR, Dermody, TS, Denison, MR Intracellular localization and protein interactions of the gene 1 protein p28 during mouse hepatitis virus replication. J Virol, 78(21), 11551-62, 2004.
• Denison, MR Severe acute respiratory syndrome coronavirus pathogenesis, disease and vaccines: an update. Pediatr Infect Dis J, 23(11 Suppl), S207-14, 2004.
• Brockway, Sarah M, Clay, Corrie T, Lu, Xiao Tao, Denison, Mark R Characterization of the expression, intracellular localization, and replication complex association of the putative mouse hepatitis virus RNA-dependent RNA polymerase. J Virol, 77(19), 10515-27, 2003.
• Hostetler, Mark A, Suara, Rahaman O, Denison, Mark R Unilateral facial paralysis occurring in an infant with enteroviral otitis media and aseptic meningitis. J Emerg Med, 22(3), 267-71, 2002.
• Denison, M R, Sims, A C MHV-A59 gene 1 proteins are associated with two distinct membrane populations. Adv Exp Med Biol, 494655-61, 2001.
• Bost, A G, Prentice, E, Denison, M R Mouse hepatitis virus replicase protein complexes are translocated to sites of M protein accumulation in the ERGIC at late times of infection. Virology, 285(1), 21-9, 2001.
• Bost AG, Prentice E, and Denison MR "Mouse hepatitis virus replicase protein complexes are translocated to sites of M protein accumulation in the ERGIC at late times of infection." Virology, 28521-29, 2001.
• Prentice, E, Denison, M R The cell biology of coronavirus infection. Adv Exp Med Biol, 494609-14, 2001.
• Bost, A G, Carnahan, R H, Lu, X T, Denison, M R Four proteins processed from the replicase gene polyprotein of mouse hepatitis virus colocalize in the cell periphery and adjacent to sites of virion assembly. J Virol, 74(7), 3379-87, 2000.
• Bost AG; Carnahan RH; Lu XT; Denison MR Four proteins processed from the replicase gene polyprotein of mouse hepatitis virus colocalize in the cell periphery and adjacent to sites of virion assembly. J. Virol., 74(7), 3379-87, 2000.
• Sims AC, Ostermann J, and Denison MR "Mouse hepatitis virus gene 1 proteins associate with distinct intracellular membranes." J. Virol, 745647-5654, 2000.
• Sims, A C, Ostermann, J, Denison, M R Mouse hepatitis virus replicase proteins associate with two distinct populations of intracellular membranes. J Virol, 74(12), 5647-54, 2000.
• van der Meer Y, Snijder EJ, Dobbe JC, Schleich S, Denison MR, Spaan WJM, and Krijnse-Locker J "Localization of mouse hepatitis virus nonstructural proteins and RNA synthesis indicates a role for late endosomes in viral replication." J Virol, 73(9), 7641-7657, 1999.
• Denison MR, Spaan WJ, van der Meer Y, Gibson CA, Sims AC, Prentice E, Lu XT The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localized in complexes that are active in viral RNA synthesis. J. Virol., (8)(73), 6862-71, 1999.
• Denison, M R, Spaan, W J, van der Meer, Y, Gibson, C A, Sims, A C, Prentice, E, Lu, X T The putative helicase of the coronavirus mouse hepatitis virus is processed from the replicase gene polyprotein and localizes in complexes that are active in viral RNA synthesis. J Virol, 73(8), 6862-71, 1999.
• Gibson CA, Chen J, Monroe SA, and Denison MR "Expression and processing of the nonstructural proteins of the human astroviruses." Advances in Experimental Medicine and Biology, 440387-394, 1998..
• Denison MR, Sims AC, Gibson CA, and Lu XT "Processing of the MHV-A59 gene 1 polyprotein by the 3C-like proteinase." Advances in Experimental Medicine and Biology, 440121-128, 1998..
• Gibson CA and Denison MR "Coronavirus picornain-like cysteine proteinase." Handbook of Proteolytic Enzymes, 726-729, 1998.
• Gibson, C A, Chen, J, Monroe, S A, Denison, M R Expression and processing of nonstructural proteins of the human astroviruses. Adv Exp Med Biol, 440387-91, 1998.
• Sims AC, Lu XT, and Denison MR "Expression, purification and activity of recombinant MHV-A59 3CLpro." Advances in Experimental Medicine and Biology, 440129-134, 1998.
• Sims, A C, Lu, X T, Denison, M R Expression, purification, and activity of recombinant MHV-A59 3CLpro. Adv Exp Med Biol, 440129-34, 1998.
• Lu, XT, Sims AC, and Denison MR "Mouse hepatitis virus 3C-Like protease cleaves a 22 -Kilodalton protein from the open reading frame 1a polyprotein in virus-infected cells and in vitro." J Virol, 72(3), 2265-2271, 1998.
• Lu, X T, Sims, A C, Denison, M R Mouse hepatitis virus 3C-like protease cleaves a 22-kilodalton protein from the open reading frame 1a polyprotein in virus-infected cells and in vitro. J Virol, 72(3), 2265-71, 1998.
• Denison, M R, Sims, A C, Gibson, C A, Lu, X T Processing of the MHV-A59 gene 1 polyprotein by the 3C-like proteinase. Adv Exp Med Biol, 440121-7, 1998.
• Lu, YQ and Denison MR "Determinants of mouse hepatitis virus 3C-like proteinase activity." Virology , 230335-342, 1997.
• Lu, Y, Denison, M R Determinants of mouse hepatitis virus 3C-like proteinase activity. Virology, 230(2), 335-42, 1997.
• Kolquist, K A, Vnencak-Jones, C L, Swift, L, Page, D L, Johnson, J E, Denison, M R Fatal fat embolism syndrome in a child with undiagnosed hemoglobin S/beta+ thalassemia: a complication of acute parvovirus B19 infection. Pediatr Pathol Lab Med, 16(1), 71-82, 1996.
• Lu XT, Lu YQ, and Denison, MR "Intracellular and in vitro translated 27 kDa proteins contain the 3C-like proteinase activity of the coronavirus MHV-A59." Virology , 222375-382, 1996.
• Lu, X, Lu, Y, Denison, M R Intracellular and in vitro-translated 27-kDa proteins contain the 3C-like proteinase activity of the coronavirus MHV-A59. Virology, 222(2), 375-82, 1996.
• Fisher, R G, Denison, M R Veillonella parvula bacteremia without an underlying source. J Clin Microbiol, 34(12), 3235-6, 1996.
• Denison MR, Kim JC, and Ross T "Inhibitor of coronavirus MHV-A59 replication by proteinase inhibitors." Coronaviruses, 1995..
• Kim JC, Spence RA, Currier PF, Lu X and Denison MR "Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d." Virology , 2081-8, 1995.
• Kim, J C, Spence, R A, Currier, P F, Lu, X, Denison, M R Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d. Virology, 208(1), 1-8, 1995.
• Denison MR, Hughes SA, and Weiss SR Identification and characterization of a 65 kilodalton protein processed from the gene 1 polyprotein of the murine coronavirus MHV- A59. Virology, 207(1), 316-320, 1995.
• Lu YQ, Lu XT, and Denison MR "Identification and characterization of a serine-like proteinase of the murine coronavirus MHV-A59." Journal of Virology , 69(6), 3554-3559, 1995.
• Denison, M R, Hughes, S A, Weiss, S R Identification and characterization of a 65-kDa protein processed from the gene 1 polyprotein of the murine coronavirus MHV-A59. Virology, 207(1), 316-20, 1995.
• Lu, Y, Lu, X, Denison, M R Identification and characterization of a serine-like proteinase of the murine coronavirus MHV-A59. J Virol, 69(6), 3554-9, 1995.
• Denison, M R, Kim, J C, Ross, T Inhibition of coronavirus MHV-A59 replication by proteinase inhibitors. Adv Exp Med Biol, 380391-7, 1995.
• Denison MR "Viral Pharyngitis." Seminars in Pediatric Infectious Diseases, 6(2), 62-68, 1995.
• Weiss SR, Hughes SA, Bonilla PJ, Turner JD, Leibowitz JL, and Denison MR "Coronavirus polyprotein processing." Archives of Virology, 9(suppl), 349-358, 1994.
• Turner, BJ, Denison MR, Eppes SC, Houchens R, Fanning T, and Markson LE "Survival experience of 789 children with the acquired immunodeficiency syndrome." Pediatric Infectious Disease Journal, 12310-20, 1993..
• Hughes, S. A., M. R. Denison, P. Bonilla, J. L. Leibowitz, R. S. Baric and S. R. Weiss "A newly identified MHV-A59 ORF1a polypeptide p65 is temperature sensitive in two RNA negative mutants." Advances in Experimental Medicine & Biology, 342221-6, 1993.
• Denison, M.R., Zoltick, P.W., Hughes, S.A., Giangreco, B., Olson, A.L., Perlman, S., Leibowitz, J.L., and Weiss, S.R "Intracellular processing of the N-terminal ORF la proteins of the coronavirus MHV-A59 requires multiple proteolytic events." Virology, 189274-284, 1992.
• Denison M.R., Zoltick, P.W., Leibowitz, J.L., Pachuk, C.J., and Weiss, S.R "Identification of polypeptides encoded in ORF la of the putative polymerase gene of the murine coronavirus MHV-A59." J. Virology, 653706-3782, 1991.
• Denison, M.R., and Perlman, S "Identification of Putative Polymerase Gene Product in Cells Infected with Mouse Murine Coronavirus A59." Virology , 157565-568, 1987.
• Denison MR and Perlman S "Translation and processing of MHV-A59 virion RNA in reticulocyte lysates and infected cells." Coronaviruses, 155, 1987.
• Denison, M.R., and Perlman, S "Translation and Processing of Mouse Hepatitis Virus Virion RNA in a Cell-Free System." J. Virol., 60(1), 12-18, 1986.